AP2014007399A0 - Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament - Google Patents

Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament

Info

Publication number
AP2014007399A0
AP2014007399A0 AP2014007399A AP2014007399A AP2014007399A0 AP 2014007399 A0 AP2014007399 A0 AP 2014007399A0 AP 2014007399 A AP2014007399 A AP 2014007399A AP 2014007399 A AP2014007399 A AP 2014007399A AP 2014007399 A0 AP2014007399 A0 AP 2014007399A0
Authority
AP
ARIPO
Prior art keywords
methanones
aza
medicament
phenyl
andthe use
Prior art date
Application number
AP2014007399A
Other languages
English (en)
Inventor
Barbara Bertani
Marco Ferrara
Riccardo Giovannini
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AP2014007399A0 publication Critical patent/AP2014007399A0/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
AP2014007399A 2011-08-03 2012-08-02 Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament AP2014007399A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11176468 2011-08-03
PCT/EP2012/065140 WO2013017657A1 (en) 2011-08-03 2012-08-02 Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament

Publications (1)

Publication Number Publication Date
AP2014007399A0 true AP2014007399A0 (en) 2014-01-31

Family

ID=46598566

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007399A AP2014007399A0 (en) 2011-08-03 2012-08-02 Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament

Country Status (37)

Country Link
US (1) US9012489B2 (me)
EP (1) EP2739615B1 (me)
JP (1) JP5850589B2 (me)
KR (1) KR101944686B1 (me)
CN (2) CN105837562B (me)
AP (1) AP2014007399A0 (me)
AR (1) AR087436A1 (me)
AU (1) AU2012292036C1 (me)
BR (1) BR112014001642B1 (me)
CA (1) CA2843805C (me)
CL (1) CL2014000246A1 (me)
CO (1) CO6870037A2 (me)
CY (1) CY1119326T1 (me)
DK (1) DK2739615T3 (me)
EA (1) EA024933B1 (me)
EC (1) ECSP14013221A (me)
ES (1) ES2623006T3 (me)
GE (1) GEP20166483B (me)
HR (1) HRP20170695T1 (me)
HU (1) HUE033134T2 (me)
IL (1) IL229962A (me)
LT (1) LT2739615T (me)
MA (1) MA35286B1 (me)
ME (1) ME02672B (me)
MX (1) MX347828B (me)
MY (1) MY167396A (me)
PE (1) PE20141352A1 (me)
PH (1) PH12014500276A1 (me)
PL (1) PL2739615T3 (me)
PT (1) PT2739615T (me)
RS (1) RS55927B1 (me)
SI (1) SI2739615T1 (me)
TN (1) TN2014000044A1 (me)
TW (1) TWI543974B (me)
UA (1) UA114405C2 (me)
UY (1) UY34239A (me)
WO (1) WO2013017657A1 (me)

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PL3151669T3 (pl) 2014-06-06 2021-04-19 Basf Se Zastosowanie podstawionych oksadiazoli do zwalczania fitopatogennych grzybów
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
EP3373735A1 (en) 2015-11-13 2018-09-19 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
EA201891146A1 (ru) 2015-11-19 2018-12-28 Басф Се Замещенные оксадиазолы для борьбы с фитопатогенными грибами
AU2017250397A1 (en) 2016-04-11 2018-10-11 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
CN113784966B (zh) 2019-05-01 2024-07-19 勃林格殷格翰国际有限公司 Glyt1抑制剂的固体形式
KR20220125326A (ko) 2020-01-09 2022-09-14 디스크 메디슨, 인크. 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법
CA3188340A1 (en) * 2020-08-13 2022-02-17 Boehringer Ingelheim International Gmbh Treatment of cognitive impairement associated with schizophrenia
CA3195702A1 (en) 2020-10-13 2022-04-21 Boehringer Ingelheim International Gmbh Process of reworking
MX2024006371A (es) * 2021-11-24 2024-07-15 Maplight Therapeutics Inc Métodos para tratar trastornos neurológicos.
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法
TW202348602A (zh) * 2022-06-10 2023-12-16 大陸商成都百裕製藥股份有限公司 吡咯烷衍生物、藥物组合物及其製藥用途
WO2024042043A1 (en) 2022-08-24 2024-02-29 Boehringer Ingelheim International Gmbh A scalable process for the preparation of a glyt-1 inhibitor
CN121443286A (zh) * 2023-05-25 2026-01-30 地图之光治疗股份有限公司 用于治疗神经障碍的组合物
WO2025140479A1 (zh) * 2023-12-29 2025-07-03 苏州科睿思制药有限公司 Iclepertin的晶型及其制备方法和用途

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DE60313898T2 (de) 2003-04-10 2008-01-17 Ranbaxy Laboratories, Ltd. Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
KR20060095865A (ko) 2003-10-14 2006-09-04 화이자 프로덕츠 인크. 글리신 수송 억제제로서의 비시클릭 [3.1.0] 유도체
DE102004035280A1 (de) 2004-07-21 2006-03-16 Robert Bosch Gmbh Kraftstoffinjektor mit direkter mehrstufiger Einspritzventilgliedansteuerung
CA2593453A1 (en) * 2005-01-06 2006-07-13 F. Hoffmann-La Roche Ag Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
AU2005324024B2 (en) * 2005-01-07 2011-02-17 F. Hoffmann-La Roche Ag [4-(Heteroaryl) piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (GlyT-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
DE602006010665D1 (en) * 2005-02-07 2010-01-07 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1
KR101072796B1 (ko) * 2006-06-22 2011-10-14 에프. 호프만-라 로슈 아게 치환된 페닐 메탄온 유도체
NZ573129A (en) 2006-06-28 2011-06-30 Amgen Inc Piperazine acetic acid glycine transporter-1 inhibitors
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
WO2010078348A1 (en) * 2008-12-29 2010-07-08 Vanderbilt University 3.1.0 bicyclic glyt1 inhibitors and methods of making and using same
UA104611C2 (en) 2009-01-27 2014-02-25 Ф. Хоффманн-Ля Рош Аг Aroylamino- and heteroaroylamino-substituted piperidines as glyt-1 inhibitors

Also Published As

Publication number Publication date
MA35286B1 (fr) 2014-07-03
EA201400183A1 (ru) 2014-06-30
AU2012292036A1 (en) 2014-01-16
AR087436A1 (es) 2014-03-26
EA024933B1 (ru) 2016-11-30
NZ619258A (en) 2015-12-24
JP2014524414A (ja) 2014-09-22
UY34239A (es) 2013-02-28
AU2012292036C1 (en) 2017-03-23
CA2843805C (en) 2021-03-23
CN103797005B (zh) 2016-05-11
KR101944686B1 (ko) 2019-02-01
ECSP14013221A (es) 2014-03-31
JP5850589B2 (ja) 2016-02-03
MX2014001252A (es) 2014-05-13
DK2739615T3 (en) 2017-05-08
LT2739615T (lt) 2017-04-10
MY167396A (en) 2018-08-16
KR20140051922A (ko) 2014-05-02
EP2739615A1 (en) 2014-06-11
CL2014000246A1 (es) 2014-08-08
EP2739615B1 (en) 2017-03-15
TWI543974B (zh) 2016-08-01
IL229962A (en) 2016-09-29
US9012489B2 (en) 2015-04-21
CN103797005A (zh) 2014-05-14
WO2013017657A1 (en) 2013-02-07
MX347828B (es) 2017-05-15
PH12014500276A1 (en) 2017-02-01
TN2014000044A1 (en) 2015-07-01
PL2739615T3 (pl) 2017-08-31
CY1119326T1 (el) 2018-02-14
SI2739615T1 (sl) 2017-07-31
CN105837562A (zh) 2016-08-10
CN105837562B (zh) 2020-01-17
PE20141352A1 (es) 2014-10-12
UA114405C2 (uk) 2017-06-12
BR112014001642A2 (pt) 2017-02-14
HRP20170695T1 (hr) 2017-07-28
US20130197011A1 (en) 2013-08-01
PT2739615T (pt) 2017-06-09
AU2012292036B2 (en) 2016-10-06
ES2623006T3 (es) 2017-07-10
BR112014001642B1 (pt) 2022-03-22
CA2843805A1 (en) 2013-02-07
GEP20166483B (en) 2016-05-25
HK1193100A1 (zh) 2014-09-12
RS55927B1 (sr) 2017-09-29
CO6870037A2 (es) 2014-02-20
TW201321364A (zh) 2013-06-01
HUE033134T2 (en) 2017-11-28
ME02672B (me) 2017-06-20

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