AR099227A1 - Macrociclos con grupos p2 aromáticos como inhibidores del factor xia - Google Patents

Macrociclos con grupos p2 aromáticos como inhibidores del factor xia

Info

Publication number: AR099227A1
Authority: AR; Argentina
Prior art keywords: alkyl; optionally substituted; heterocyclyl; independently selected; carbocyclyl
Prior art date: 2014-01-31

Application number

ARP150100294A

Other languages

English (en)

Spanish (es)

Inventor

R Ewing William

K Dilger Andrew

R Corte James

Dlucca Indawati

Fang Tianan

Yang Wu

Wang Yufeng

Balashanmuga Pabbisetty Kumar

J Orwat Michael

m smith ii Leon

J Pinto Donald

Zhu Yeheng

R Wexler Ruth

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-01-31

Filing date

2015-01-30

Publication date

2016-07-06

2015-01-30 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2016-07-06 Publication of AR099227A1 publication Critical patent/AR099227A1/es

Links

239000003112 inhibitor Substances 0.000 title 1
150000002678 macrocyclic compounds Chemical class 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 abstract 17
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 15
125000004452 carbocyclyl group Chemical group 0.000 abstract 10
229910052736 halogen Inorganic materials 0.000 abstract 9
150000002367 halogens Chemical class 0.000 abstract 9
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
125000003118 aryl group Chemical group 0.000 abstract 7
-1 -S (= O) 2NH2 Chemical group 0.000 abstract 6
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 4
125000002947 alkylene group Chemical group 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 3
125000004450 alkenylene group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000001188 haloalkyl group Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 abstract 1
125000005099 aryl alkyl carbonyl group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004438 haloalkoxy group Chemical group 0.000 abstract 1
125000006809 haloalkylaminocarbonyl group Chemical group 0.000 abstract 1
125000005241 heteroarylamino group Chemical group 0.000 abstract 1
125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1
125000004963 sulfonylalkyl group Chemical group 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

ARP150100294A 2014-01-31 2015-01-30 Macrociclos con grupos p2 aromáticos como inhibidores del factor xia AR099227A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201461933942P	2014-01-31	2014-01-31

Publications (1)

Publication Number	Publication Date
AR099227A1 true AR099227A1 (es)	2016-07-06

Family

ID=58698433

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ARP150100293A AR099550A1 (es)	2014-01-31	2015-01-30	Macrociclos con grupos p2 heterocíclicos como inhibidores del factor xia
ARP150100294A AR099227A1 (es)	2014-01-31	2015-01-30	Macrociclos con grupos p2 aromáticos como inhibidores del factor xia

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ARP150100293A AR099550A1 (es)	2014-01-31	2015-01-30	Macrociclos con grupos p2 heterocíclicos como inhibidores del factor xia

Country Status (2)

Country	Link
AR (2)	AR099550A1 (fr)
MA (2)	MA52331B1 (fr)

2015
- 2015-01-30 MA MA52331A patent/MA52331B1/fr unknown
- 2015-01-30 AR ARP150100293A patent/AR099550A1/es not_active Application Discontinuation
- 2015-01-30 MA MA39307A patent/MA39307B1/fr unknown
- 2015-01-30 AR ARP150100294A patent/AR099227A1/es unknown

Also Published As

Publication number	Publication date
MA39307B1 (fr)	2020-06-30
AR099550A1 (es)	2016-08-03
MA52331B1 (fr)	2022-03-31
MA39307A1 (fr)	2017-10-31
MA52331A1 (fr)	2021-11-30

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Legal Events

Date	Code	Title	Description
2021-05-31	FB	Suspension of granting procedure