ATE154349T1 - (2-thienyl)alkylaminderivate mit nervenschützenden eigenschaften - Google Patents

(2-thienyl)alkylaminderivate mit nervenschützenden eigenschaften

Info

Publication number: ATE154349T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; amino; represents hydrogen; represent
Prior art date: 1990-09-26

Application number

AT91918183T

Other languages

English (en)

Inventor

Ronald Conrad Griffith

Richard Jon Schmiesing

Robert John Murray

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-26

Filing date

1991-09-24

Publication date

1997-06-15

1990-09-26 Priority claimed from US07/589,963 external-priority patent/US5109017A/en

1991-09-24 Application filed by Astra Ab filed Critical Astra Ab

1997-06-15 Application granted granted Critical

1997-06-15 Publication of ATE154349T1 publication Critical patent/ATE154349T1/de

Links

-1 2-THIENYL Chemical class 0.000 title abstract 4
150000003973 alkyl amines Chemical class 0.000 title 1
230000000324 neuroprotective effect Effects 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
150000002431 hydrogen Chemical group 0.000 abstract 4
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical group O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91918183T 1990-09-26 1991-09-24 (2-thienyl)alkylaminderivate mit nervenschützenden eigenschaften ATE154349T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58987990A	1990-09-26	1990-09-26
US07/589,963 US5109017A (en)	1990-09-26	1990-09-26	(2-thienyl)alkylamine derivatives having neuroprotective properties

Publications (1)

Publication Number	Publication Date
ATE154349T1 true ATE154349T1 (de)	1997-06-15

Family

ID=27080687

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91918183T ATE154349T1 (de)	1990-09-26	1991-09-24	(2-thienyl)alkylaminderivate mit nervenschützenden eigenschaften

Country Status (11)

Country	Link
EP (1)	EP0557305B1 (de)
JP (1)	JP3108433B2 (de)
AT (1)	ATE154349T1 (de)
DE (1)	DE69126537T2 (de)
DK (1)	DK0557305T3 (de)
ES (1)	ES2103004T3 (de)
GR (1)	GR3024553T3 (de)
HU (1)	HU211322A9 (de)
IE (1)	IE913279A1 (de)
PT (1)	PT99050B (de)
WO (1)	WO1992005169A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0516978A1 (de) *	1991-05-03	1992-12-09	Hoechst Aktiengesellschaft	Enantiomere von substituierten (Aminophenyl)--hetroarylethylaminen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2751652B1 (fr) *	1996-07-24	1998-09-04	Expansia Sa	Derives du thienylcyclohexane, des procedes pour leur preparation et leur utilisation en tant que produits industriels nouveaux pour la synthese de derives thienylcyclohexyles
DE19963175A1 (de) *	1999-12-27	2001-07-12	Gruenenthal Gmbh	Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel
DE10025238A1 (de) *	2000-05-22	2001-11-29	Gruenenthal Gmbh	Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel
HRP20030696A2 (en) *	2001-02-16	2005-04-30	NPS Allelix Corp. Allelix Neuroscience	GlyT-1 INHIBITORS
ATE410057T1 (de)	2004-12-31	2008-10-15	Koppert Bv	Milbenprodukt, seine verwendung, verfahren zur aufzucht der phytoseiiden-raubmilbe amblyseius sirskii, aufzuchtsystem für die aufzucht dieser phytoseiiden-milbe sowie biologische schädlingsbekämpfungsverfahren an einer kultur
EA019149B1 (ru)	2004-12-31	2014-01-30	Копперт Б.В.	Композиция для биологического контроля вредителей на культурных растениях, её применение, контейнер и способы разведения хищного клеща - фитосейида и биологического контроля вредителей на культурных растениях

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL86740A (en) *	1987-06-30	1992-11-15	Tanabe Seiyaku Co	Thiphene derivatives,their preparation and pharmaceutical compositions containing them
JPS6416778A (en) *	1987-07-09	1989-01-20	Tanabe Seiyaku Co	Thiophene derivative
EP0322582A3 (de) *	1987-12-07	1989-09-13	Hoechst-Roussel Pharmaceuticals Incorporated	4-Heteroaryl-1,3-benzodiazepine und 2-substituierte Alpha-(heteroaryl) benzenethanamine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP0346791B1 (de) *	1988-06-14	1994-04-06	G.D. Searle & Co.	1,2-Diarylethylamine zur Behandlung neurotoxischer Verletzungen

1991
- 1991-09-17 IE IE327991A patent/IE913279A1/en not_active IP Right Cessation
- 1991-09-24 DK DK91918183.4T patent/DK0557305T3/da active
- 1991-09-24 WO PCT/US1991/006951 patent/WO1992005169A1/en not_active Ceased
- 1991-09-24 JP JP03516769A patent/JP3108433B2/ja not_active Expired - Fee Related
- 1991-09-24 AT AT91918183T patent/ATE154349T1/de not_active IP Right Cessation
- 1991-09-24 EP EP91918183A patent/EP0557305B1/de not_active Expired - Lifetime
- 1991-09-24 DE DE69126537T patent/DE69126537T2/de not_active Expired - Fee Related
- 1991-09-24 ES ES91918183T patent/ES2103004T3/es not_active Expired - Lifetime
- 1991-09-25 PT PT99050A patent/PT99050B/pt not_active IP Right Cessation
1995
- 1995-06-27 HU HU95P/P00460P patent/HU211322A9/hu unknown
1997
- 1997-08-27 GR GR970402192T patent/GR3024553T3/el unknown

Also Published As

Publication number	Publication date
WO1992005169A1 (en)	1992-04-02
DK0557305T3 (da)	1997-09-08
IE913279A1 (en)	1992-04-08
EP0557305B1 (de)	1997-06-11
PT99050A (pt)	1992-08-31
DE69126537D1 (de)	1997-07-17
HU211322A9 (en)	1995-11-28
JP3108433B2 (ja)	2000-11-13
JPH06501472A (ja)	1994-02-17
PT99050B (pt)	1999-02-26
EP0557305A1 (de)	1993-09-01
GR3024553T3 (en)	1997-12-31
DE69126537T2 (de)	1997-10-02
ES2103004T3 (es)	1997-08-16

Legal Events

Date	Code	Title	Description
1997-11-15	UEP	Publication of translation of european patent specification
2007-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE286026T1 (de)	2005-01-15	Amid-derivate und deren medizinische verwendung
HUP0303037A2 (hu)	2004-03-01	Alzheimer-kór kezelésére alkalmas vegyületek és ezeket tartalmazó gyógyszerkészítmények
ATE339409T1 (de)	2006-10-15	Trizyklische verbindungen
ES2132284T3 (es)	1999-08-16	Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
DZ1694A1 (fr)	2002-02-17	"n-(2-Aminoethyl)-benzothialozones".
NO975666L (no)	1998-02-09	Pyrrolderivater og medisinsk sammensetning
ATE154349T1 (de)	1997-06-15	(2-thienyl)alkylaminderivate mit nervenschützenden eigenschaften
DK26289A (da)	1989-07-22	Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia
MX9100342A (es)	1992-02-28	Carbamatos substituidos de 1-(piridinilamino substituido)-1h-indol-5-ilo,un procedimiento y compuestos para su preparacion y su empleo como medicamentos
NO903388D0 (no)	1990-08-01	Fremgangsmaate for fremstilling av 1-(pyridinylamino)-2-pyrrolidinoner, samt anvendelse som medikamenter.
ATE114301T1 (de)	1994-12-15	N-(mercaptoalkyl) harnstoffe und carbamate.
DK613687D0 (da)	1987-11-23	Kondenserede heterocycliske tetrahydroaminoquinolinoler og beslaegtede forbindelser, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
BRPI0412438A (pt)	2006-09-05	novas amidas aza-heterocìclicas úteis para o tratamento da dor
DE69230498D1 (de)	2000-02-03	2-Pyrazinylethylamin-Derivate und ihre Verwendung als Arzneimittel.
NO903390D0 (no)	1990-08-01	Fremgangsmaate for fremstilling av 2,3-dihydro-1-(pyridinylamino)-indoler og deres anvendelse som legemidler.
DK0485219T3 (da)	1996-07-22	Lægemidler til forebyggelse og behandling af kredsløbsorgansygdomme indeholdende spiro-3-heteroazolidinforbindelser
DE69428206D1 (de)	2001-10-11	Chinolincarbonsäurederivate und ihre salze
DK592589D0 (da)	1989-11-24	Kondenserede heterocycliske derivater af 1,2,3,4-tetrahydroacridin, deres fremstilling og anvendelse
NZ534600A (en)	2006-03-31	Substituted isoquinoline derivatives and their use as anticonvulsants
ATE92058T1 (de)	1993-08-15	Pyrimidin-derivate, 2-(4-(alpha-heteroaryl-alphaaryl-(alpha-alkyl)-methoxy)-butyl)-1-piperaziny > mit serotoninergischer wirkung.
ATE283269T1 (de)	2004-12-15	5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
DK0401779T3 (da)	1995-10-16	4,5,5a,6-Tetrahydro-3H-isoazolo(5,4,3-kl)acridinderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler