AU2013273965B2 - Microstructure-based wound closure devices - Google Patents

Microstructure-based wound closure devices Download PDF

Info

Publication number: AU2013273965B2
Authority: AU; Australia
Prior art keywords: wound; wound closure; microstructures; microstructure; arrays
Prior art date: 2012-06-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU2013273965A

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English (en)

Other versions

AU2013273965A1 (en

Inventor

Ronald J. Berenson

Jungho Jin

Marco ROLANDI

Chase RUEBEL

Vittorio RUVOLO

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Washington Center for Commercialization

Original Assignee

University of Washington Center for Commercialization

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-15

Filing date

2013-06-17

Publication date

2017-11-23

2013-06-17 Application filed by University of Washington Center for Commercialization filed Critical University of Washington Center for Commercialization

2014-12-18 Publication of AU2013273965A1 publication Critical patent/AU2013273965A1/en

2017-11-23 Application granted granted Critical

2017-11-23 Publication of AU2013273965B2 publication Critical patent/AU2013273965B2/en

Status Ceased legal-status Critical Current

2033-06-17 Anticipated expiration legal-status Critical

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Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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AU2013273965A 2012-06-15 2013-06-17 Microstructure-based wound closure devices Ceased AU2013273965B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201261660561P	2012-06-15	2012-06-15
US61/660,561		2012-06-15
US201261710246P	2012-10-05	2012-10-05
US61/710,246		2012-10-05
PCT/US2013/046181 WO2013188884A1 (en)	2012-06-15	2013-06-17	Microstructure-based wound closure devices

Publications (2)

Publication Number	Publication Date
AU2013273965A1 AU2013273965A1 (en)	2014-12-18
AU2013273965B2 true AU2013273965B2 (en)	2017-11-23

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US (2)	US10751050B2 (2)
EP (2)	EP3574846A1 (2)
JP (2)	JP6833317B2 (2)
KR (1)	KR20150037826A (2)
AU (1)	AU2013273965B2 (2)
BR (1)	BR112014031438A2 (2)
CA (1)	CA2875227C (2)
ES (1)	ES2743733T3 (2)
HK (1)	HK1209614A1 (2)
IN (1)	IN2014KN02939A (2)
MX (1)	MX2014015365A (2)
NZ (1)	NZ702677A (2)
SG (1)	SG11201408221YA (2)
WO (1)	WO2013188884A1 (2)
ZA (1)	ZA201409196B (2)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11931040B2 (en)	2016-03-01	2024-03-19	Kitotech Medical, Inc.	Microstructure-based systems, apparatus, and methods for wound closure
US11957346B2 (en)	2022-02-18	2024-04-16	Kitotech Medical, Inc.	Force modulating deep skin staples and instruments
US11986613B2 (en)	2020-02-19	2024-05-21	Kitotech Medical, Inc.	Microstructure systems and methods for pain treatment

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2830918C (en)	2011-03-31	2022-07-26	Felmont Farrell Eaves, Iii	Force modulating tissue bridge
CN103889384B (zh)	2011-10-20	2016-06-01	佛尔蒙特·伊夫斯	可移除的覆盖物及交互包装
ES2743733T3 (es)	2012-06-15	2020-02-20	Univ Washington Through Its Center For Commercialization	Dispositivos de cierre de heridas basados en microestructuras
KR101703312B1 (ko) *	2014-02-14	2017-02-07	주식회사 주빅	미세공구조를 포함하는 마이크로구조체-기반 약물전달체
CN103800998B (zh) *	2014-02-24	2016-03-30	苏州大学	一种丝素蛋白凝胶微针系统及其制备方法
KR101724654B1 (ko) *	2014-06-02	2017-04-12	주식회사 아모라이프사이언스	마이크로 니들 패치 및 그의 제조 방법
JPWO2015194260A1 (ja) *	2014-06-18	2017-04-27	凸版印刷株式会社	マイクロニードルユニット
US9986988B2 (en)	2014-11-27	2018-06-05	AOD Holdings, LLC	Surgical retractor
US10279533B1 (en) *	2014-12-22	2019-05-07	10X Technology, Llc	Method and apparatus for fabricating bent microneedles for use as micro-sutures in a wound closure device
US10792042B2 (en)	2015-01-15	2020-10-06	Ethicon, Inc.	Circular staplers having resorbable microneedles containing active agents
US9999759B2 (en)	2015-01-15	2018-06-19	Ethicon, Inc.	Linear staplers having resorbable microneedles containing active agents
EP3315165A4 (en) *	2015-06-23	2019-11-20	Toppan Printing Co., Ltd.	NEEDLE ELEMENT AND METHOD FOR PRODUCING A NEEDLE ELEMENT
US10517592B2 (en) *	2015-10-29	2019-12-31	Ethicon Llc	Surgical stapler buttress assembly with adhesion to wet end effector
CN108882994B (zh) *	2015-11-11	2022-01-25	班德格列普公司	绷带
KR102438234B1 (ko) *	2015-11-16	2022-08-31	삼성전자주식회사	생체신호 센싱패치 및 이를 구비한 생체신호 모니터링 장치
MY188756A (en)	2015-12-28	2021-12-29	Endoderma Co Ltd	Microstructure for transdermal absorption and method for manufacturing same
KR101719319B1 (ko) *	2016-04-05	2017-03-23	주식회사 엘지생활건강	효율적인 피부 천공을 위한 마이크로니들 구조
US11071717B2 (en) *	2016-07-18	2021-07-27	Ana R. Olivero	Anesthetic bandage
ES3037878T3 (en)	2016-09-06	2025-10-07	Biocircuit Tech Inc	Devices for repairing damage to a nerve
TW201815356A (zh) *	2016-10-18	2018-05-01	諾華公司	具有表面紋理的外科手術器械
AU2017345707B2 (en)	2016-10-21	2023-05-18	Brijjit Medical, Inc.	Force modulating tissue bridges, associated tools, kits and methods
KR20180055938A (ko) *	2016-11-09	2018-05-28	김주홍	주름 제거용 패치
KR102343698B1 (ko)	2017-02-24	2021-12-24	히사미쓰 세이야꾸 가부시키가이샤	마이크로니들 디바이스
US20210251628A1 (en) *	2020-02-19	2021-08-19	KitoTech Medical, Inc	Elastic and flexible wound closure device
WO2018230402A2 (en) *	2017-06-12	2018-12-20	Terumo Kabushiki Kaisha	Subcutaneous tissue device
TWI645870B (zh) *	2017-06-27	2019-01-01	韓商安道德瑪股份有限公司	經皮吸收用微結構體及其製造方法
KR102333037B1 (ko) *	2017-08-17	2021-12-01	코스메드 파마소티컬 씨오 쩜 엘티디	입술용 마이크로니들 어레이
USD876641S1 (en)	2017-10-20	2020-02-25	Emrge, Llc.	Medical article for treating a wound and/or scar tissue
USD862695S1 (en)	2017-10-20	2019-10-08	Emrge, Llc	Medical tool for use in applying medical article
US20190125589A1 (en) *	2017-11-02	2019-05-02	BandGrip, Inc.	Bandage And Anchor For Bandages
JP6671616B2 (ja) *	2017-11-02	2020-03-25	コスメディ製薬株式会社	歯科用局所麻酔マイクロニードルアレイ
US11291448B2 (en)	2017-11-15	2022-04-05	BandGrip, Inc.	Mechanical tissue coupling system, applicator therefor and method of use thereof
WO2019168926A1 (en)	2018-02-28	2019-09-06	BandGrip, Inc.	Subcutaneous wound closure assembly and method of use
US12121618B2 (en) *	2018-05-18	2024-10-22	Postech Academy-Industry Foundation	Transdermal drug delivery patch and manufacturing method thereof
JP2021522978A (ja) *	2018-05-18	2021-09-02	ポステックアカデミー−インダストリーファンデーション	経皮透過型薬物伝達パッチおよびその製造方法
CN113556983A (zh) *	2018-10-01	2021-10-26	基托泰克医疗股份有限公司	包括微结构的组织护理器具
EP3875141B1 (en) *	2018-10-31	2022-12-14	FUJIFILM Corporation	Micro-needle array device
WO2020166744A1 (ko) *	2019-02-15	2020-08-20	주식회사 하이로닉	변형 구조 마이크로 니들 및 피부 드레싱용 패드를 이용한 피부 리프팅 방법
WO2020186730A1 (zh) *	2019-03-19	2020-09-24	景润(上海)医疗器械有限公司	四肢深筋膜内无缝线闭合皮肤创口的外科辅助设备
JP7305411B2 (ja) *	2019-04-05	2023-07-10	株式会社三共	スロットマシン
US11904125B2 (en)	2019-06-07	2024-02-20	Massachusetts Institute Of Technology	Manuka honey microneedle
WO2021007344A1 (en) *	2019-07-08	2021-01-14	Board Of Regents Of The University Of Nebraska	Drug delivery using microneedle arrays
GB2586474A (en) *	2019-08-20	2021-02-24	Innoture Ip Ltd	Method of manufacturing microstructures
GB2586475A (en) *	2019-08-20	2021-02-24	Innoture Ip Ltd	Methods
US12458355B2 (en)	2019-10-11	2025-11-04	Brij Medical, Inc.	Medical device for applying force on biological tissue, or the like
WO2021076745A1 (en) *	2019-10-15	2021-04-22	The Regents Of The University Of California	Bio-zipper surgical closure device
US11672635B2 (en) *	2020-04-29	2023-06-13	Bvw Holding Ag	Microstructure soft tissue graft
KR102414580B1 (ko) *	2020-07-17	2022-07-01	한국과학기술연구원	수술 전 감염 방지를 위한 마이크로니들 패치 및 마이크로니들 패치를 이용한 수술 전처리 방법
JP7847577B2 (ja) *	2020-08-04	2026-04-17	ビーブイダブリュインベストエージー	マイクロ構造化された軟組織移植片
CN112716692A (zh) *	2020-12-30	2021-04-30	无锡快邦医疗科技有限公司	伤口治疗用保护垫
USD980434S1 (en)	2021-01-14	2023-03-07	Emrge, Llc	Medical article for treating a wound and/or scar tissue
US20220240935A1 (en)	2021-01-29	2022-08-04	Cheuk Yin Paul Leung	Wound closure device with wide spaced microstructures
EP4059445A1 (en) *	2021-03-18	2022-09-21	HoliStick Medical	Medical implant and catheter device for a medical implant
CN116098669B (zh) *	2023-03-22	2024-02-20	北京麦迪益康商贸有限公司	一种伤口闭合器
CN117679101B (zh) *	2024-02-04	2024-04-05	苏州大学附属第二医院	一种预埋式无痕皮肤缝合器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4430998A (en) *	1982-06-01	1984-02-14	Thoratec Laboratories Corporation	Wound closing device
US20030065360A1 (en) *	2000-05-19	2003-04-03	Daniel Jacobs	Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US20040010276A1 (en) *	2000-05-19	2004-01-15	Daniel Jacobs	Multi-point tissue tension distribution device and method, a chin lift variation
WO2010124712A1 (de) *	2009-04-29	2010-11-04	Aesculap Ag	Wundverschluss
WO2011016230A1 (ja) *	2009-08-07	2011-02-10	株式会社メドレックス	剣山型マイクロニードルのアプリケータデバイス

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3964482A (en)	1971-05-17	1976-06-22	Alza Corporation	Drug delivery device
US3926193A (en) *	1971-12-17	1975-12-16	Harrith M Hasson	Surgical closure having ease of assembly
CA1006064A (en) *	1971-12-17	1977-03-01	Harrith M. Hasson	Surgical closure
US4330357A (en) *	1980-10-23	1982-05-18	Minnesota Mining And Manufacturing Company	Dispenser for liner-wound tape
US5047047A (en) *	1988-10-26	1991-09-10	Inbae Yoon	Wound closing device
US5234462A (en) *	1991-08-29	1993-08-10	Tufts University	Method and kit for accelerating the closing of open skin wounds
FR2690840B1 (fr) *	1992-05-07	1994-08-19	Patrick Frechet	Dispositif d'extension de tissu vivant.
EP1086214B1 (en)	1998-06-10	2009-11-25	Georgia Tech Research Corporation	Microneedle devices and methods of their manufacture
US6503231B1 (en)	1998-06-10	2003-01-07	Georgia Tech Research Corporation	Microneedle device for transport of molecules across tissue
CA2376128C (en)	1999-06-04	2009-01-06	Georgia Tech Research Corporation	Devices and methods for enhanced microneedle penetration of biological barriers
CN101238998A (zh) *	1999-11-15	2008-08-13	维尔克工业有限公司	皮肤附着件
US20040260340A1 (en) *	2000-05-19	2004-12-23	Jacobs Daniel Irwin	Remotely anchored tissue fixation device and method
US7172615B2 (en) *	2000-05-19	2007-02-06	Coapt Systems, Inc.	Remotely anchored tissue fixation device
AU2001264739B2 (en)	2000-05-19	2006-06-15	Microaire Surgical Instruments Llc	Tissue approximation device and a method using it
NZ525551A (en) *	2000-10-26	2005-09-30	Alza Corp	Transdermal drug delivery devices having coated microprotrusions
EP1345646A2 (en)	2000-12-14	2003-09-24	Georgia Tech Research Corporation	Microneedle devices and production thereof
US6663820B2 (en)	2001-03-14	2003-12-16	The Procter & Gamble Company	Method of manufacturing microneedle structures using soft lithography and photolithography
US7422567B2 (en) *	2002-08-29	2008-09-09	Becton, Dickinson And Company	Microabrader with controlled abrasion features
US20040138705A1 (en)	2003-01-09	2004-07-15	Harri Heino	Surgical staple for tissue treatment
US7972347B2 (en) *	2003-06-27	2011-07-05	Surgical Security, Llc	Device for surgical repair, closure, and reconstruction
US20060093658A1 (en)	2004-10-26	2006-05-04	Gayatri Sathyan	Apparatus and method for transdermal delivery of desmopressin
EP2444009A1 (en) *	2005-05-12	2012-04-25	Canica Design Inc.	Dynamic tensioning system and method
WO2007127976A2 (en)	2006-05-01	2007-11-08	Georgia Tech Research Corporation	Particle based molding
EP2054089B1 (en) *	2006-08-03	2018-12-26	The Board of Trustees of the Leland Stanford Junior University	Devices and bandages for the treatment or prevention of scars and/or keloids and methods and kits therefor
WO2008020632A1 (en) *	2006-08-18	2008-02-21	Toppan Printing Co., Ltd.	Microneedle and microneedle patch
EP2152196A1 (en)	2007-05-01	2010-02-17	The Brigham and Women's Hospital, Inc.	Wound healing device
CA3026948C (en) *	2009-12-01	2022-07-12	Ecole Polytechnique Federale De Lausanne	Microfabricated neurostimulation device and methods of making and using the same
CN102985131B (zh) *	2010-04-28	2016-06-29	金伯利-克拉克环球有限公司	用于递送siRNA的医疗装置
US8851284B2 (en) *	2011-05-18	2014-10-07	Thuban, Inc.	Adhesive bandage dispensing arrangements
WO2012167162A2 (en)	2011-06-03	2012-12-06	University Of Washington	Methods for the production of chitin nanofibers and uses thereof
WO2013028966A2 (en)	2011-08-24	2013-02-28	Calgon Carbon Corporation	Activated carbon containing wound dressing
ES2743733T3 (es)	2012-06-15	2020-02-20	Univ Washington Through Its Center For Commercialization	Dispositivos de cierre de heridas basados en microestructuras

2013
- 2013-06-17 ES ES13733182T patent/ES2743733T3/es active Active
- 2013-06-17 KR KR20157000949A patent/KR20150037826A/ko not_active Ceased
- 2013-06-17 WO PCT/US2013/046181 patent/WO2013188884A1/en not_active Ceased
- 2013-06-17 SG SG11201408221YA patent/SG11201408221YA/en unknown
- 2013-06-17 BR BR112014031438A patent/BR112014031438A2/pt not_active IP Right Cessation
- 2013-06-17 IN IN2939KON2014 patent/IN2014KN02939A/en unknown
- 2013-06-17 EP EP19174754.2A patent/EP3574846A1/en not_active Withdrawn
- 2013-06-17 JP JP2015517482A patent/JP6833317B2/ja active Active
- 2013-06-17 HK HK15110283.8A patent/HK1209614A1/xx unknown
- 2013-06-17 US US14/408,244 patent/US10751050B2/en active Active
- 2013-06-17 EP EP13733182.3A patent/EP2861181B1/en active Active
- 2013-06-17 MX MX2014015365A patent/MX2014015365A/es unknown
- 2013-06-17 CA CA2875227A patent/CA2875227C/en active Active
- 2013-06-17 AU AU2013273965A patent/AU2013273965B2/en not_active Ceased
- 2013-06-17 NZ NZ702677A patent/NZ702677A/en not_active IP Right Cessation
2014
- 2014-12-12 ZA ZA2014/09196A patent/ZA201409196B/en unknown
2019
- 2019-01-10 JP JP2019002286A patent/JP6894454B2/ja active Active
2020
- 2020-07-15 US US16/930,217 patent/US20200345366A1/en not_active Abandoned

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4430998A (en) *	1982-06-01	1984-02-14	Thoratec Laboratories Corporation	Wound closing device
US20030065360A1 (en) *	2000-05-19	2003-04-03	Daniel Jacobs	Multi-point tension distribution system device and method of tissue approximation using that device to improve wound healing
US20040010276A1 (en) *	2000-05-19	2004-01-15	Daniel Jacobs	Multi-point tissue tension distribution device and method, a chin lift variation
WO2010124712A1 (de) *	2009-04-29	2010-11-04	Aesculap Ag	Wundverschluss
WO2011016230A1 (ja) *	2009-08-07	2011-02-10	株式会社メドレックス	剣山型マイクロニードルのアプリケータデバイス

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11931040B2 (en)	2016-03-01	2024-03-19	Kitotech Medical, Inc.	Microstructure-based systems, apparatus, and methods for wound closure
US11986613B2 (en)	2020-02-19	2024-05-21	Kitotech Medical, Inc.	Microstructure systems and methods for pain treatment
US11957346B2 (en)	2022-02-18	2024-04-16	Kitotech Medical, Inc.	Force modulating deep skin staples and instruments
US12290260B2 (en)	2022-02-18	2025-05-06	Kitotech Medical, Inc.	Force modulating deep skin staples and instruments

Also Published As

Publication number	Publication date
JP6833317B2 (ja)	2021-02-24
EP3574846A1 (en)	2019-12-04
US20150305739A1 (en)	2015-10-29
ZA201409196B (en)	2015-12-23
CA2875227C (en)	2021-09-14
US10751050B2 (en)	2020-08-25
MX2014015365A (es)	2015-05-11
KR20150037826A (ko)	2015-04-08
CA2875227A1 (en)	2013-12-19
EP2861181B1 (en)	2019-07-24
EP2861181A1 (en)	2015-04-22
NZ702677A (en)	2016-05-27
JP2019072534A (ja)	2019-05-16
JP6894454B2 (ja)	2021-06-30
BR112014031438A2 (pt)	2017-06-27
ES2743733T3 (es)	2020-02-20
US20200345366A1 (en)	2020-11-05
IN2014KN02939A (2)	2015-05-08
SG11201408221YA (en)	2015-01-29
WO2013188884A1 (en)	2013-12-19
JP2015523139A (ja)	2015-08-13
HK1209614A1 (en)	2016-04-08
AU2013273965A1 (en)	2014-12-18

Legal Events

Date	Code	Title	Description
2018-03-22	FGA	Letters patent sealed or granted (standard patent)
2021-01-21	MK14	Patent ceased section 143(a) (annual fees not paid) or expired

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JP6305397B2 (ja)	2018-04-04	個体を治療するための医療製品
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US11813143B2 (en)	2023-11-14	Tissue care devices including microstructures
JP2016513536A (ja)	2016-05-16	可変の縁の幾何学形状を有する創傷または皮膚治療デバイス
US12290260B2 (en)	2025-05-06	Force modulating deep skin staples and instruments
US20220240935A1 (en)	2022-08-04	Wound closure device with wide spaced microstructures
WO2017213534A1 (ru)	2017-12-14	Способ подготовки трансплантанта, перфоратор (варианты) для его реализации и способ лечения ожоговых ран
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