AU2016356694B2 - Purinones as ubiquitin-specific protease 1 inhibitors - Google Patents

Purinones as ubiquitin-specific protease 1 inhibitors Download PDF

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Publication number
AU2016356694B2
AU2016356694B2 AU2016356694A AU2016356694A AU2016356694B2 AU 2016356694 B2 AU2016356694 B2 AU 2016356694B2 AU 2016356694 A AU2016356694 A AU 2016356694A AU 2016356694 A AU2016356694 A AU 2016356694A AU 2016356694 B2 AU2016356694 B2 AU 2016356694B2
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AU
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Prior art keywords
alkyl
methyl
dihydro
purin
benzyl
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AU2016356694A1 (en
Inventor
Alexandre Joseph Buckmelter
Justin A. Caravella
Bruce Follows
Edward L. Fritzen
Gary Gustafson
Stephanos Ioannidis
Jian Lin
Minghua Wang
Zhongguo Wang
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Forma Therapeutics Inc
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Forma Therapeutics Inc
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Priority to AU2021257988A priority Critical patent/AU2021257988B2/en
Priority to AU2023274204A priority patent/AU2023274204A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2016356694A 2015-11-20 2016-11-18 Purinones as ubiquitin-specific protease 1 inhibitors Active AU2016356694B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021257988A AU2021257988B2 (en) 2015-11-20 2021-10-27 Purinones as ubiquitin-specific protease 1 inhibitors
AU2023274204A AU2023274204A1 (en) 2015-11-20 2023-12-01 Purinones as ubiquitin-specific protease 1 inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258162P 2015-11-20 2015-11-20
US62/258,162 2015-11-20
PCT/US2016/062837 WO2017087837A1 (en) 2015-11-20 2016-11-18 Purinones as ubiquitin-specific protease 1 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021257988A Division AU2021257988B2 (en) 2015-11-20 2021-10-27 Purinones as ubiquitin-specific protease 1 inhibitors

Publications (2)

Publication Number Publication Date
AU2016356694A1 AU2016356694A1 (en) 2018-07-05
AU2016356694B2 true AU2016356694B2 (en) 2021-07-29

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AU2016356694A Active AU2016356694B2 (en) 2015-11-20 2016-11-18 Purinones as ubiquitin-specific protease 1 inhibitors
AU2021257988A Active AU2021257988B2 (en) 2015-11-20 2021-10-27 Purinones as ubiquitin-specific protease 1 inhibitors
AU2023274204A Pending AU2023274204A1 (en) 2015-11-20 2023-12-01 Purinones as ubiquitin-specific protease 1 inhibitors

Family Applications After (2)

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AU2021257988A Active AU2021257988B2 (en) 2015-11-20 2021-10-27 Purinones as ubiquitin-specific protease 1 inhibitors
AU2023274204A Pending AU2023274204A1 (en) 2015-11-20 2023-12-01 Purinones as ubiquitin-specific protease 1 inhibitors

Country Status (13)

Country Link
US (4) US10189841B2 (2)
EP (2) EP3696181A1 (2)
JP (3) JP6964343B2 (2)
KR (1) KR102708936B1 (2)
CN (2) CN108473495B (2)
AU (3) AU2016356694B2 (2)
BR (1) BR112018010216B1 (2)
CA (1) CA3005353A1 (2)
IL (3) IL300788A (2)
MX (2) MX379543B (2)
RU (1) RU2750151C2 (2)
SG (1) SG11201804098TA (2)
WO (1) WO2017087837A1 (2)

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