AU676491B2 - Immunopotentiatory agents - Google Patents

Immunopotentiatory agents Download PDF

Info

Publication number: AU676491B2
Authority: AU; Australia
Prior art keywords: compound; alkyl; virus; cancer; carbon atoms
Prior art date: 1992-10-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU48311/93A

Other languages

English (en)

Other versions

AU4831193A (en

Inventor

John Richard Rhodes

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wellcome Foundation Ltd

Original Assignee

Wellcome Foundation Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-01

Filing date

1993-09-30

Publication date

1997-03-13

1992-10-01 Priority claimed from GB929220715A external-priority patent/GB9220715D0/en

1992-12-23 Priority claimed from GB929226874A external-priority patent/GB9226874D0/en

1993-09-30 Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd

1994-04-26 Publication of AU4831193A publication Critical patent/AU4831193A/en

1997-03-13 Application granted granted Critical

1997-03-13 Publication of AU676491B2 publication Critical patent/AU676491B2/en

2013-09-30 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

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YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000000707 stereoselective effect Effects 0.000 description 1
201000011549 stomach cancer Diseases 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
229960005404 sulfamethoxazole Drugs 0.000 description 1
230000001629 suppression Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
150000003536 tetrazoles Chemical class 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
239000003104 tissue culture media Substances 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
201000008827 tuberculosis Diseases 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
239000012646 vaccine adjuvant Substances 0.000 description 1
229940124931 vaccine adjuvant Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical compound CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
244000052613 viral pathogen Species 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Planar Illumination Modules (AREA)
Illuminated Signs And Luminous Advertising (AREA)
Securing Globes, Refractors, Reflectors Or The Like (AREA)

AU48311/93A 1992-10-01 1993-09-30 Immunopotentiatory agents Ceased AU676491B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB929220715A GB9220715D0 (en)	1992-10-01	1992-10-01	Immunopotentiatory agent and physiologically acceptable salts thereof
GB9220715		1992-10-01
GB9226874		1992-12-23
GB929226874A GB9226874D0 (en)	1992-12-23	1992-12-23	Immunopotentiatory agents and physiologically acceptable salts thereof
PCT/GB1993/002039 WO1994007479A2 (en)	1992-10-01	1993-09-30	Immunopotentiatory agents

Publications (2)

Publication Number	Publication Date
AU4831193A AU4831193A (en)	1994-04-26
AU676491B2 true AU676491B2 (en)	1997-03-13

Family

ID=26301715

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU48311/93A Ceased AU676491B2 (en)	1992-10-01	1993-09-30	Immunopotentiatory agents

Country Status (24)

Country	Link
US (1)	US5508310A (2)
EP (3)	EP0678298A3 (2)
JP (2)	JP3717950B2 (2)
KR (1)	KR100348775B1 (2)
CN (1)	CN1213746C (2)
AT (1)	ATE146075T1 (2)
AU (1)	AU676491B2 (2)
CA (1)	CA2124677C (2)
CZ (1)	CZ132794A3 (2)
DE (1)	DE69306545T2 (2)
DK (1)	DK0609606T3 (2)
ES (1)	ES2096215T3 (2)
GR (1)	GR3022541T3 (2)
HR (1)	HRP931243A2 (2)
HU (1)	HUT70482A (2)
IL (1)	IL107157A0 (2)
MX (1)	MX9306079A (2)
NZ (1)	NZ256110A (2)
RU (1)	RU94028670A (2)
SG (1)	SG48993A1 (2)
SI (1)	SI9300514A (2)
SK (1)	SK65294A3 (2)
WO (1)	WO1994007479A2 (2)
YU (1)	YU62793A (2)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3539795A (en) *	1994-08-25	1996-03-14	Medical University Of South Carolina	Methods of treating cold symptoms using pentoxifylline
GB9601544D0 (en) *	1996-01-26	1996-03-27	Smithkline Beecham Plc	Pharmaceuticals
BR9809149A (pt) *	1997-05-20	2000-08-01	Galenica Pharmaceuticals Inc	Análogos de triterpeno saponina dotados de adjuvante e atividade imonoestimulatória
US6080725A (en) *	1997-05-20	2000-06-27	Galenica Pharmaceuticals, Inc.	Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
ES2245805T3 (es) *	1997-10-03	2006-01-16	Galenica Pharmaceuticals, Inc.	Polisacaridos que forman iminas, preparacion de los mismos y el uso de los mismos como adyuvantes de inmunoestimulantes.
WO2000009075A2 (en)	1998-08-14	2000-02-24	Galenica Pharmaceuticals, Inc.	Chemically modified saponins and the use thereof as adjuvants
GB9818627D0 (en) *	1998-08-26	1998-10-21	Glaxo Group Ltd	Improvements in dva vaccination
US6939896B2 (en) *	1999-12-21	2005-09-06	Astrazeneca Ab	Cd45 inhibitors
JP2003518085A (ja) *	1999-12-21	2003-06-03	アストラゼネカアクチボラグ	Ｃｄ４５阻害剤
US7638496B2 (en)	2000-02-15	2009-12-29	Valeant Pharmaceuticals North America	Nucleoside analogs with carboxamidine modified monocyclic base
AU2001245823A1 (en) *	2000-03-17	2001-10-03	Corixa Corporation	Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
PL211872B1 (pl)	2000-03-31	2012-07-31	Purdue Research Foundation	Kompozycja farmaceutyczna
AU2001251491A1 (en) *	2000-04-11	2001-10-23	Galenica Pharmaceuticals, Inc.	Lipophilic aromatic aldehyde and ketone derivatives and the use thereof as immunostimulants and adjuvants
CA2445826C (en) *	2001-05-02	2014-03-25	Purdue Research Foundation	Treatment and diagnosis of macrophage mediated disease
KR20040053136A (ko) *	2001-09-28	2004-06-23	펄듀 리서치 파운데이션	리간드-면역원 공액체를 이용한 치료 방법
US8246969B2 (en)	2001-11-16	2012-08-21	Skinmedica, Inc.	Compositions containing aromatic aldehydes and their use in treatments
US20030157154A1 (en) *	2002-01-04	2003-08-21	Bryan Fuller	Compositions containing hydroxy aromatic aldehydes and their use in treatments
US6911434B2 (en) *	2002-02-04	2005-06-28	Corixa Corporation	Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
WO2004028470A2 (en) *	2002-09-27	2004-04-08	Martek Biosciences Corporation	Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
EP1622554A4 (en) *	2003-05-15	2008-01-02	Bioform Medical Inc	COMPOSITIONS CONTAINING A COMBINATION OF A PHARMACEUTICAL AGENT OR A COSMETIC AGENT AND AN OXY-GROUP-WEARING AROMATIC ALDEHYDE
KR20050118057A (ko) *	2004-04-24	2005-12-15	김상희	아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품
US7622128B2 (en) *	2005-12-13	2009-11-24	University Of Washington	Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
US8168164B2 (en) *	2006-02-03	2012-05-01	Purdue Research Foundation	Targeted conjugates and radiation
JP5554713B2 (ja) *	2007-11-15	2014-07-23	エンドサイト，インク．	接合体を投与する方法
EP2661264B1 (en)	2011-01-07	2018-12-05	Allergan, Inc.	Melanin modification compositions and methods of use
MX383691B (es)	2015-03-06	2025-03-14	Beyondspring Pharmaceuticals Inc	Método de tratamiento de cáncer asociado con una mutación de ras.
US10155748B2 (en)	2015-07-13	2018-12-18	Beyondspring Pharmaceuticals, Inc.	Plinabulin compositions
WO2017139231A1 (en)	2016-02-08	2017-08-17	Beyondspring Pharmaceuticals, Inc.	Compositions containing tucaresol or its analogs
RU2760348C2 (ru)	2016-06-06	2021-11-24	Бейондспринг Фармасьютикалс, Инк.	Способ уменьшения нейтропении
JP2020503363A (ja)	2017-01-06	2020-01-30	ビヨンドスプリングファーマシューティカルズ，インコーポレイテッド	チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt)	2017-02-01	2020-03-31	Beyondspring Pharmaceuticals, Inc.	Método para reduzir neutropenia
KR20200112881A (ko)	2018-01-24	2020-10-05	비욘드스프링 파마수티컬스, 인코포레이티드.	플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
CA3215047A1 (en)	2021-04-09	2022-10-13	Lan Huang	Therapeutic compositions and methods for treating tumors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0173262A2 (de) *	1984-08-24	1986-03-05	Carnivora-Deutschland GmbH	Verwendung von 1,4-Naphthochinon-Derivaten in niedrigen Konzentrationen zur Immunstimulation
EP0217041A1 (de) *	1985-08-09	1987-04-08	Schleicher, Peter, Dr. med.	Mundpflegemittel
EP0499015A1 (en) *	1991-02-15	1992-08-19	Fockerman, Jasmine	Benzopyran phenol derivates for use as antibacterial, antiviral or immunostimulating agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54126731A (en) *	1978-03-20	1979-10-02	Rikagaku Kenkyusho	Carcinostatic agent
JPS5545658A (en) *	1978-09-28	1980-03-31	Rikagaku Kenkyusho	Carcinostatic agent
JPS5569510A (en) *	1978-11-16	1980-05-26	Mitsubishi Chem Ind Ltd	Carcinostatic agent
IT1193786B (it) *	1980-12-18	1988-08-24	Wellcome Found	Composti eterei dotati di attivita' mitigatrice delle emoglobinopatie intermedi e procedimento per la loro preparazione
LU85365A1 (de) *	1984-05-16	1986-01-29	Chimicasa Gmbh	Verfahren und praeparat zur stimulierung des immunsystems
JPS63264409A (ja) *	1988-01-13	1988-11-01	Rikagaku Kenkyusho	制癌剤
JPH03254007A (ja) *	1990-03-01	1991-11-13	Tir Syst Ltd	非吸収性で且つ透過率が可変のカバーを有した照明装置
GB9018061D0 (en) *	1990-08-17	1990-10-03	Wellcome Found	Compositions for vaccines

1993
- 1993-09-17 DE DE69306545T patent/DE69306545T2/de not_active Expired - Lifetime
- 1993-09-17 DK DK93307373.6T patent/DK0609606T3/da active
- 1993-09-17 ES ES93307373T patent/ES2096215T3/es not_active Expired - Lifetime
- 1993-09-17 AT AT93307373T patent/ATE146075T1/de not_active IP Right Cessation
- 1993-09-17 EP EP95110267A patent/EP0678298A3/en not_active Withdrawn
- 1993-09-17 SG SG1996004981A patent/SG48993A1/en unknown
- 1993-09-17 EP EP93307373A patent/EP0609606B1/en not_active Expired - Lifetime
- 1993-09-29 IL IL107157A patent/IL107157A0/xx unknown
- 1993-09-30 KR KR1019940701840A patent/KR100348775B1/ko not_active Expired - Fee Related
- 1993-09-30 HR HR931243A patent/HRP931243A2/hr not_active Application Discontinuation
- 1993-09-30 RU RU94028670/14A patent/RU94028670A/ru unknown
- 1993-09-30 JP JP27730093A patent/JP3717950B2/ja not_active Expired - Fee Related
- 1993-09-30 MX MX9306079A patent/MX9306079A/es unknown
- 1993-09-30 NZ NZ256110A patent/NZ256110A/en unknown
- 1993-09-30 CN CNB931144442A patent/CN1213746C/zh not_active Expired - Fee Related
- 1993-09-30 WO PCT/GB1993/002039 patent/WO1994007479A2/en not_active Ceased
- 1993-09-30 EP EP93921034A patent/EP0614357A1/en not_active Withdrawn
- 1993-09-30 SK SK652-94A patent/SK65294A3/sk unknown
- 1993-09-30 JP JP6508846A patent/JPH07504204A/ja not_active Withdrawn
- 1993-09-30 HU HU9401631A patent/HUT70482A/hu unknown
- 1993-09-30 YU YU62793A patent/YU62793A/sh unknown
- 1993-09-30 CZ CZ941327A patent/CZ132794A3/cs unknown
- 1993-09-30 AU AU48311/93A patent/AU676491B2/en not_active Ceased
- 1993-09-30 SI SI9300514A patent/SI9300514A/sl unknown
- 1993-09-30 CA CA002124677A patent/CA2124677C/en not_active Expired - Fee Related
1995
- 1995-05-19 US US08/446,080 patent/US5508310A/en not_active Expired - Fee Related
1997
- 1997-02-12 GR GR970400229T patent/GR3022541T3/el unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0173262A2 (de) *	1984-08-24	1986-03-05	Carnivora-Deutschland GmbH	Verwendung von 1,4-Naphthochinon-Derivaten in niedrigen Konzentrationen zur Immunstimulation
EP0217041A1 (de) *	1985-08-09	1987-04-08	Schleicher, Peter, Dr. med.	Mundpflegemittel
EP0499015A1 (en) *	1991-02-15	1992-08-19	Fockerman, Jasmine	Benzopyran phenol derivates for use as antibacterial, antiviral or immunostimulating agents

Also Published As

Publication number	Publication date
GR3022541T3 (en)	1997-05-31
JP3717950B2 (ja)	2005-11-16
DE69306545D1 (de)	1997-01-23
CA2124677A1 (en)	1994-04-14
ES2096215T3 (es)	1997-03-01
US5508310A (en)	1996-04-16
NZ256110A (en)	1997-07-27
DE69306545T2 (de)	1997-04-03
EP0614357A1 (en)	1994-09-14
RU94028670A (ru)	1996-05-20
WO1994007479A3 (en)	1994-07-21
CN1213746C (zh)	2005-08-10
EP0678298A3 (en)	1996-05-29
CZ132794A3 (en)	1995-02-15
DK0609606T3 (2)	1997-03-17
MX9306079A (es)	1994-06-30
AU4831193A (en)	1994-04-26
YU62793A (sh)	1998-05-15
SG48993A1 (en)	1998-05-18
WO1994007479A2 (en)	1994-04-14
EP0678298A2 (en)	1995-10-25
JPH072660A (ja)	1995-01-06
HRP931243A2 (en)	1995-12-31
IL107157A0 (en)	1993-12-28
EP0609606B1 (en)	1996-12-11
HUT70482A (en)	1995-10-30
EP0609606A1 (en)	1994-08-10
CN1091005A (zh)	1994-08-24
SK65294A3 (en)	1995-03-08
CA2124677C (en)	2008-09-09
HU9401631D0 (en)	1994-08-29
JPH07504204A (ja)	1995-05-11
SI9300514A (en)	1994-06-30
KR100348775B1 (ko)	2003-02-11
ATE146075T1 (de)	1996-12-15

Publication	Publication Date	Title
AU676491B2 (en)	1997-03-13	Immunopotentiatory agents
US6197743B1 (en)	2001-03-06	Compositions and methods for the treatment of viral disorders
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