AU718719B2 - 4-{(thien-2-yl)methyl}imidazole derivatives having alpha2-adrenoceptor agonistic activity - Google Patents

4-{(thien-2-yl)methyl}imidazole derivatives having alpha2-adrenoceptor agonistic activity Download PDF

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Publication number
AU718719B2
AU718719B2 AU25440/97A AU2544097A AU718719B2 AU 718719 B2 AU718719 B2 AU 718719B2 AU 25440/97 A AU25440/97 A AU 25440/97A AU 2544097 A AU2544097 A AU 2544097A AU 718719 B2 AU718719 B2 AU 718719B2
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AU
Australia
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solution
mol
added
concentrated
reaction mixture
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU25440/97A
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English (en)
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AU2544097A (en
Inventor
Robert E. Boyd
Jeffrey B. Press
Chris Royce Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
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Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of AU2544097A publication Critical patent/AU2544097A/en
Assigned to JOHNSON & JOHNSON RESEARCH PTY. LIMITED reassignment JOHNSON & JOHNSON RESEARCH PTY. LIMITED Alteration of Name(s) of Applicant(s) under S113 Assignors: ORTHO PHARMACEUTICAL CORPORATION
Assigned to ORTHO-MCNEIL PHARMACEUTICAL, INC. reassignment ORTHO-MCNEIL PHARMACEUTICAL, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: JOHNSON & JOHNSON RESEARCH PTY. LIMITED
Application granted granted Critical
Publication of AU718719B2 publication Critical patent/AU718719B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU25440/97A 1996-03-28 1997-03-26 4-{(thien-2-yl)methyl}imidazole derivatives having alpha2-adrenoceptor agonistic activity Expired AU718719B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/625,447 US5621113A (en) 1996-03-28 1996-03-28 4-[(thien-2-yl)methyl]-imidazole analgesics
US08/625447 1996-03-28
PCT/US1997/004768 WO1997035857A1 (fr) 1996-03-28 1997-03-26 Derives du 4-[(thien-2-yl)methyl]-imidazole ayant une activite agoniste vis-a-vis de l'adrenorecepteur alpha2

Publications (2)

Publication Number Publication Date
AU2544097A AU2544097A (en) 1997-10-17
AU718719B2 true AU718719B2 (en) 2000-04-20

Family

ID=24506117

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25440/97A Expired AU718719B2 (en) 1996-03-28 1997-03-26 4-{(thien-2-yl)methyl}imidazole derivatives having alpha2-adrenoceptor agonistic activity

Country Status (16)

Country Link
US (1) US5621113A (fr)
EP (1) EP0889891B1 (fr)
JP (1) JP4018145B2 (fr)
AT (1) ATE201869T1 (fr)
AU (1) AU718719B2 (fr)
CA (1) CA2250929C (fr)
DE (1) DE69705114T2 (fr)
DK (1) DK0889891T3 (fr)
ES (1) ES2159857T3 (fr)
GR (1) GR3036508T3 (fr)
NO (1) NO984482L (fr)
NZ (1) NZ332011A (fr)
PT (1) PT889891E (fr)
TW (1) TW382016B (fr)
WO (1) WO1997035857A1 (fr)
ZA (1) ZA972776B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
JP4783502B2 (ja) * 1997-12-04 2011-09-28 アラーガン、インコーポレイテッド α２Ｂまたは２Ｂ／２Ｃアドレナリン受容体において作動剤様活性を示す置換イミダゾール誘導体
US6841684B2 (en) * 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
AU2002254265B2 (en) * 1997-12-04 2008-05-15 Allergan, Inc. Imidiazole derivatives and their use as agonists selective at alpha 2B or 2B/2C adrenergic receptors
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6426356B1 (en) 1998-11-18 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Imidazoethyl thiophenes
US6465486B1 (en) 1999-03-12 2002-10-15 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl/quinolinyl imidazoles
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI894911A0 (fi) * 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
JPH06507392A (ja) * 1991-02-26 1994-08-25 エイアールシー　１，インコーポレイテッド 交感神経性の持続性疼痛の治療のための組成物および方法

Also Published As

Publication number Publication date
ZA972776B (en) 1998-10-01
NO984482L (no) 1998-11-24
NO984482D0 (no) 1998-09-25
ES2159857T3 (es) 2001-10-16
DE69705114D1 (de) 2001-07-12
CA2250929C (fr) 2005-01-04
GR3036508T3 (en) 2001-11-30
AU2544097A (en) 1997-10-17
JP2000507548A (ja) 2000-06-20
EP0889891B1 (fr) 2001-06-06
NZ332011A (en) 2000-02-28
WO1997035857A1 (fr) 1997-10-02
JP4018145B2 (ja) 2007-12-05
DE69705114T2 (de) 2001-10-18
US5621113A (en) 1997-04-15
PT889891E (pt) 2001-09-28
DK0889891T3 (da) 2001-09-03
CA2250929A1 (fr) 1997-10-02
TW382016B (en) 2000-02-11
EP0889891A1 (fr) 1999-01-13
ATE201869T1 (de) 2001-06-15

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