AU9678598A - Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain - Google Patents

Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain

Info

Publication number
AU9678598A
AU9678598A AU96785/98A AU9678598A AU9678598A AU 9678598 A AU9678598 A AU 9678598A AU 96785/98 A AU96785/98 A AU 96785/98A AU 9678598 A AU9678598 A AU 9678598A AU 9678598 A AU9678598 A AU 9678598A
Authority
AU
Australia
Prior art keywords
glycoprotein
stabilization
disulfide bonds
trimers
ectodomain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU96785/98A
Other languages
English (en)
Inventor
Michael Farzan
Joseph G Sodroski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of AU9678598A publication Critical patent/AU9678598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU96785/98A 1997-10-01 1998-10-01 Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain Abandoned AU9678598A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6081397P 1997-10-01 1997-10-01
US60060813 1997-10-01
US6080897P 1997-10-03 1997-10-03
US60060808 1997-10-03
PCT/US1998/020693 WO1999016883A2 (fr) 1997-10-01 1998-10-01 Stabilisation des glycoproteines trimeres d'enveloppe au moyen de liaisons bisulfure introduites dans un ectodomaine de la glycoproteine gp41

Publications (1)

Publication Number Publication Date
AU9678598A true AU9678598A (en) 1999-04-23

Family

ID=26740384

Family Applications (1)

Application Number Title Priority Date Filing Date
AU96785/98A Abandoned AU9678598A (en) 1997-10-01 1998-10-01 Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain

Country Status (4)

Country Link
EP (1) EP1019511A2 (fr)
AU (1) AU9678598A (fr)
CA (1) CA2305341C (fr)
WO (1) WO1999016883A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2781676B1 (fr) * 1998-07-31 2004-04-02 Pasteur Merieux Serums Vacc Trimere du produit d'expression du gene env de hiv
WO2000039302A2 (fr) 1998-12-31 2000-07-06 Chiron Corporation Expression amelioree de polypeptides hiv et production de particules de type viral
WO2001019958A2 (fr) 1999-09-17 2001-03-22 Dana-Farber Cancer Institute, Inc. Trimeres stabilises solubles de glycoproteines
US7179468B1 (en) 2000-06-08 2007-02-20 Cornell Research Foundation, Inc. Antigen for developing neutralizing antibodies to human immunodeficiency virus
WO2002056831A2 (fr) 2000-12-27 2002-07-25 Dana-Farber Cancer Institute, Inc. Proteoliposomes immunogenes et applications de ceux-ci
AU2002320314A1 (en) 2001-07-05 2003-01-21 Chiron, Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
EP1755667B1 (fr) * 2004-06-01 2013-07-17 Merck Sharp & Dohme Corp. Peptide stable mimetique d'intermediaire de fusion du gp4 du vih
ES2324755B1 (es) * 2007-04-04 2010-05-31 Consejo Superior De Investigaciones Cientificas (Csic) Polipeptido de la proteina gp120 capaz de inhibir el ciclo vital del virus del sida.
US9217011B2 (en) 2007-09-07 2015-12-22 Complix Nv Non-natural proteinaceous scaffold made of three non-covalently associated peptides
EP2161278B1 (fr) * 2008-09-08 2012-05-23 Complix N.V. Échafaudage à bobine à une seule chaîne
EP3303367B1 (fr) * 2015-06-08 2025-06-18 New York University Mimétiques de superenroulement minimal stabilisés
US11891422B2 (en) 2018-11-16 2024-02-06 New York University NEMO coiled coil mimics and methods of using same
CN110184298B (zh) * 2019-05-15 2023-05-16 武汉璟泓科技股份有限公司 Hiv突变型表面糖蛋白及其纳米化抗原与制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704694A (en) 1985-12-16 1987-11-03 Automation Intelligence, Inc. Learned part system
US4976778A (en) 1988-03-08 1990-12-11 Scm Metal Products, Inc. Infiltrated powder metal part and method for making same
WO1993004701A1 (fr) 1991-09-05 1993-03-18 University Of Connecticut Apport cible de polynucleotides ou d'oligonucleotides a des cellules
WO1995022618A1 (fr) 1994-02-22 1995-08-24 Dana-Farber Cancer Institute Systeme de liberation d'acide nucleique, son procede de synthese et ses utilisations

Also Published As

Publication number Publication date
WO1999016883A2 (fr) 1999-04-08
CA2305341C (fr) 2009-01-06
CA2305341A1 (fr) 1999-04-08
EP1019511A2 (fr) 2000-07-19
WO1999016883A3 (fr) 1999-06-17

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase