BG103328A - Method for the preparation of n-[2-(dimethylamino)ethyl]-acridine-4-carboxamide - Google Patents

Method for the preparation of n-[2-(dimethylamino)ethyl]-acridine-4-carboxamide

Info

Publication number: BG103328A
Authority: BG; Bulgaria
Prior art keywords: formula; compound; alkyl; accordance; produced
Prior art date: 1996-10-18

Application number

BG103328A

Other languages

Bulgarian (bg)

English (en)

Inventor

William Denny

Swarnalatha Gamage

Julie SPICER

Michael Wright

David HAYMAN

Original Assignee

Xenova Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-18

Filing date

1999-04-13

Publication date

2000-07-31

1996-10-18 Priority claimed from GBGB9621795.5A external-priority patent/GB9621795D0/en

1996-12-20 Priority claimed from GBGB9626457.7A external-priority patent/GB9626457D0/en

1999-04-13 Application filed by Xenova Limited filed Critical Xenova Limited

2000-07-31 Publication of BG103328A publication Critical patent/BG103328A/xx

Links

238000000034 method Methods 0.000 title abstract 3
XBGNERSKEKDZDS-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]acridine-4-carboxamide Chemical compound C1=CC=C2N=C3C(C(=O)NCCN(C)C)=CC=CC3=CC2=C1 XBGNERSKEKDZDS-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 9
238000006243 chemical reaction Methods 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000003973 alkyl amines Chemical class 0.000 abstract 2
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002841 Lewis acid Substances 0.000 abstract 1
229940125665 acridine carboxamide Drugs 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
230000036571 hydration Effects 0.000 abstract 1
238000006703 hydration reaction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Glass Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Adhesives Or Adhesive Processes (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Wire Bonding (AREA)

BG103328A 1996-10-18 1999-04-13 Method for the preparation of n-[2-(dimethylamino)ethyl]-acridine-4-carboxamide BG103328A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9621795.5A GB9621795D0 (en)	1996-10-18	1996-10-18	Pharmaceutical compounds
GBGB9626457.7A GB9626457D0 (en)	1996-12-20	1996-12-20	Process
PCT/GB1997/002884 WO1998017649A1 (en)	1996-10-18	1997-10-17	Process for the preparation of n-[2-(dimethylamino)ethyl]acridine-4-carboxamide

Publications (1)

Publication Number	Publication Date
BG103328A true BG103328A (en)	2000-07-31

Family

ID=26310257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103328A BG103328A (en)	1996-10-18	1999-04-13	Method for the preparation of n-[2-(dimethylamino)ethyl]-acridine-4-carboxamide

Country Status (20)

Country	Link
US (1)	US6111109A (ru)
EP (1)	EP0934277B1 (ru)
JP (1)	JP2001502682A (ru)
KR (1)	KR20000049239A (ru)
AT (1)	ATE232202T1 (ru)
AU (1)	AU741305B2 (ru)
BG (1)	BG103328A (ru)
BR (1)	BR9711945A (ru)
CA (1)	CA2268413A1 (ru)
CZ (1)	CZ135199A3 (ru)
DE (1)	DE69718925D1 (ru)
GB (1)	GB2333293B (ru)
ID (1)	ID21677A (ru)
NO (1)	NO313382B1 (ru)
NZ (1)	NZ334951A (ru)
PL (1)	PL332728A1 (ru)
RU (1)	RU2178785C2 (ru)
SK (1)	SK50599A3 (ru)
TW (1)	TW430658B (ru)
WO (1)	WO1998017649A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070299093A1 (en) *	2005-01-27	2007-12-27	Alma Mater Studiorum-Universitá Di Bologna	Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
CA2595994A1 (en) *	2005-01-27	2006-08-03	Alma Mater Studiorum - Universita' Di Bologna	Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
FR2904317A1 (fr)	2006-07-27	2008-02-01	Inst Nat Sante Rech Med	Analogues d'halogenobenzamides marques a titre de radiopharmaceutiques
EP2085390A1 (en)	2008-01-31	2009-08-05	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors
CN105315205B (zh) *	2015-01-19	2018-03-23	威海惠安康生物科技有限公司	一种以邻硝基苯甲醛和环己醇为原料制备吖啶的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3686180A (en) *	1970-11-04	1972-08-22	Smith Kline French Lab	Substituted 9-lower alkylacridine-4-carboxylic acids
NZ201084A (en) *	1982-06-25	1985-10-11	New Zealand Dev Finance	4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
KR100220538B1 (ko) *	1991-01-11	1999-09-15	뮈쉘 쥐르밀	아크리딘 유도체
US5696131A (en) *	1993-01-22	1997-12-09	Xenova Limited	Treatment of cancers
CZ104197A3 (en) *	1994-10-05	1997-09-17	Glaxo Wellcome Inc	Pharmaceutical preparation

1997
- 1997-10-17 CZ CZ991351A patent/CZ135199A3/cs unknown
- 1997-10-17 US US09/284,570 patent/US6111109A/en not_active Expired - Fee Related
- 1997-10-17 CA CA002268413A patent/CA2268413A1/en not_active Abandoned
- 1997-10-17 PL PL97332728A patent/PL332728A1/xx unknown
- 1997-10-17 RU RU99109986/04A patent/RU2178785C2/ru not_active IP Right Cessation
- 1997-10-17 NZ NZ334951A patent/NZ334951A/xx unknown
- 1997-10-17 JP JP10519107A patent/JP2001502682A/ja active Pending
- 1997-10-17 AT AT97909455T patent/ATE232202T1/de not_active IP Right Cessation
- 1997-10-17 ID IDW990202A patent/ID21677A/id unknown
- 1997-10-17 WO PCT/GB1997/002884 patent/WO1998017649A1/en not_active Ceased
- 1997-10-17 DE DE69718925T patent/DE69718925D1/de not_active Expired - Lifetime
- 1997-10-17 BR BR9711945A patent/BR9711945A/pt unknown
- 1997-10-17 SK SK505-99A patent/SK50599A3/sk unknown
- 1997-10-17 GB GB9908188A patent/GB2333293B/en not_active Expired - Fee Related
- 1997-10-17 TW TW086115308A patent/TW430658B/zh active
- 1997-10-17 KR KR1019990703343A patent/KR20000049239A/ko not_active Ceased
- 1997-10-17 AU AU47136/97A patent/AU741305B2/en not_active Ceased
- 1997-10-17 EP EP97909455A patent/EP0934277B1/en not_active Expired - Lifetime
1999
- 1999-04-13 BG BG103328A patent/BG103328A/xx unknown
- 1999-04-16 NO NO19991835A patent/NO313382B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20000049239A (ko)	2000-07-25
NO991835L (no)	1999-06-16
RU2178785C2 (ru)	2002-01-27
AU4713697A (en)	1998-05-15
GB2333293A (en)	1999-07-21
GB9908188D0 (en)	1999-06-02
EP0934277A1 (en)	1999-08-11
US6111109A (en)	2000-08-29
AU741305B2 (en)	2001-11-29
DE69718925D1 (de)	2003-03-13
SK50599A3 (en)	2000-05-16
TW430658B (en)	2001-04-21
HK1018456A1 (en)	1999-12-24
GB2333293B (en)	2000-07-12
NO991835D0 (no)	1999-04-16
CA2268413A1 (en)	1998-04-30
JP2001502682A (ja)	2001-02-27
ATE232202T1 (de)	2003-02-15
NZ334951A (en)	2000-12-22
ID21677A (id)	1999-07-08
WO1998017649A1 (en)	1998-04-30
PL332728A1 (en)	1999-10-11
BR9711945A (pt)	1999-08-24
EP0934277B1 (en)	2003-02-05
CZ135199A3 (cs)	1999-09-15
NO313382B1 (no)	2002-09-23

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