BG103852A - Cog-2 selective carprophene for the treatment of pains and inflammations in dogs - Google Patents

Cog-2 selective carprophene for the treatment of pains and inflammations in dogs

Info

Publication number: BG103852A
Authority: BG; Bulgaria
Prior art keywords: cog; activity; acids; inhibition; dogs
Prior art date: 1997-05-05

Application number

BG103852A

Other languages

Bulgarian (bg)

English (en)

Inventor

Kristin LUNDI

Anthony RICKETTS

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-05

Filing date

1999-11-03

Publication date

2000-06-30

1999-11-03 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2000-06-30 Publication of BG103852A publication Critical patent/BG103852A/xx

Links

241000282472 Canis lupus familiaris Species 0.000 title abstract 2
230000004054 inflammatory process Effects 0.000 title abstract 2
101100168093 Caenorhabditis elegans cogc-2 gene Proteins 0.000 title 1
101100011365 Caenorhabditis elegans egl-13 gene Proteins 0.000 title 1
206010061218 Inflammation Diseases 0.000 title 1
208000002193 Pain Diseases 0.000 title 1
230000036407 pain Effects 0.000 title 1
230000000694 effects Effects 0.000 abstract 6
108010037464 Cyclooxygenase 1 Proteins 0.000 abstract 4
108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 4
102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 abstract 4
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 4
230000005764 inhibitory process Effects 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 abstract 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 2
PDODBKYPSUYQGT-UHFFFAOYSA-N acetic acid;1h-indene Chemical class CC(O)=O.C1=CC=C2CC=CC2=C1 PDODBKYPSUYQGT-UHFFFAOYSA-N 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000001741 anti-phlogistic effect Effects 0.000 abstract 1
150000008316 benzisoxazoles Chemical class 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
PUXBGTOOZJQSKH-UHFFFAOYSA-N carprofen Chemical compound C1=C(Cl)C=C2C3=CC=C(C(C(O)=O)C)C=C3NC2=C1 PUXBGTOOZJQSKH-UHFFFAOYSA-N 0.000 abstract 1
239000002131 composite material Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
-1 enol acids Chemical class 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
229960004889 salicylic acid Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)

BG103852A 1997-05-05 1999-11-03 Cog-2 selective carprophene for the treatment of pains and inflammations in dogs BG103852A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4563597P	1997-05-05	1997-05-05
PCT/IB1998/000662 WO1998050033A1 (en)	1997-05-05	1998-05-01	Cox-2 selective carprofen for treating pain and inflammation in dogs

Publications (1)

Publication Number	Publication Date
BG103852A true BG103852A (en)	2000-06-30

Family

ID=21939053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103852A BG103852A (en)	1997-05-05	1999-11-03	Cog-2 selective carprophene for the treatment of pains and inflammations in dogs

Country Status (32)

Country	Link
EP (1)	EP0988034A1 (is)
JP (1)	JP2000513020A (is)
KR (2)	KR20040004406A (is)
CN (1)	CN1255059A (is)
AP (1)	AP9801234A0 (is)
AR (2)	AR011726A1 (is)
AU (1)	AU6932198A (is)
BG (1)	BG103852A (is)
BR (1)	BR9808720A (is)
CA (1)	CA2288759A1 (is)
DZ (1)	DZ2479A1 (is)
EA (1)	EA003696B1 (is)
GT (1)	GT199800063A (is)
HR (1)	HRP980244A2 (is)
HU (1)	HUP0001286A3 (is)
ID (1)	ID21311A (is)
IL (1)	IL132570A0 (is)
IS (1)	IS5220A (is)
MA (1)	MA26491A1 (is)
NO (1)	NO995389L (is)
NZ (1)	NZ500183A (is)
OA (1)	OA11213A (is)
PA (1)	PA8450601A1 (is)
PE (1)	PE72599A1 (is)
PL (1)	PL337003A1 (is)
SK (1)	SK148199A3 (is)
TN (1)	TNSN98059A1 (is)
TW (1)	TW590773B (is)
UY (1)	UY24989A1 (is)
WO (1)	WO1998050033A1 (is)
YU (1)	YU55899A (is)
ZA (1)	ZA983722B (is)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6245797B1 (en)	1997-10-22	2001-06-12	Merck & Co., Inc.	Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease
US6506785B2 (en) *	1998-05-22	2003-01-14	Pfizer, Inc.	Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
AU2003204888B2 (en) *	1998-05-22	2005-07-28	Pfizer Products Inc.	Treating or Preventing the Early Stages of Degeneration of Articular Cartilage or Subchondral Bone in Mammals Using Carprofen and Derivatives
AU764872B2 (en) *	1998-10-23	2003-09-04	Merck Frosst Canada & Co.	Combination product comprising an E-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use
ATE306263T1 (de) *	1999-03-10	2005-10-15	Searle Llc	Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere
AU1592901A (en) *	1999-11-11	2001-06-06	Eli Lilly And Company	Oncolytic combinations for the treatment of cancer
AU2001259974A1 (en) *	2000-05-15	2001-11-26	Merck Frosst Canada & Co	Combination therapy using cox-2 selective inhibitor and thromboxane inhibitor and compositions therefor
IL153303A0 (en)	2000-06-13	2003-07-06	Wyeth Corp	Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors
DE10032132A1 (de) *	2000-07-01	2002-01-17	Lohmann Therapie Syst Lts	Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung
ATE420201T1 (de)	2000-08-07	2009-01-15	Univ Vanderbilt	Nachweis der cox-2 aktivität und von anandamid- metaboliten
AU2002354901A1 (en) *	2001-07-16	2003-03-03	Edward Hogestatt	Compounds with analgesic, antipyretic and/or anti-inflammatory activity
EP1745791B1 (en)	2003-05-07	2013-06-26	Osteologix A/S	Treating cartilage/bone conditions with water-soluble strontium salts
RU2319508C2 (ru) *	2003-07-31	2008-03-20	ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи	Диспергируемый препарат противовоспалительного агента
AU2006248645A1 (en) *	2005-05-20	2006-11-23	Pfizer Limited	Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-delta-ligands
EP2079456B1 (en)	2007-04-04	2012-12-05	Sigmoid Pharma Limited	Pharmaceutical cyclosporin compositions
EP2586428B1 (en)	2007-04-26	2023-11-08	Sublimity Therapeutics Limited	Manufacture of multiple minicapsules
ES2649112T3 (es)	2009-05-18	2018-01-10	Sigmoid Pharma Limited	Composición que comprende gotas de aceite
CN107582526A (zh)	2009-08-12	2018-01-16	希格默伊德药业有限公司	包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en)	2010-11-25	2011-01-12	Sigmoid Pharma Ltd	Composition
GB201212010D0 (en)	2012-07-05	2012-08-22	Sigmoid Pharma Ltd	Formulations
GB201319791D0 (en)	2013-11-08	2013-12-25	Sigmoid Pharma Ltd	Formulations
JP6419857B2 (ja) *	2014-03-06	2018-11-07	アラタナセラピューティクス、インコーポレイテッド	グラピプラント組成物およびその使用方法
US12109218B2 (en)	2014-12-09	2024-10-08	Aratana Therapeutics, Inc.	Compositions of grapiprant and methods for using the same
EP3881829A1 (en)	2014-11-07	2021-09-22	Sublimity Therapeutics Limited	Compositions comprising cyclosporin
US20180264061A1 (en) *	2015-01-09	2018-09-20	Jaguar Animal Health	Methods of Treating Diarrhea in Companion Animals
EP4125874A4 (en) *	2020-03-25	2024-05-01	SRI International	LIPOXYGENASE INHIBITORS
US11116737B1 (en)	2020-04-10	2021-09-14	University Of Georgia Research Foundation, Inc.	Methods of using probenecid for treatment of coronavirus infections
KR102404883B1 (ko)	2020-11-30	2022-06-07	(주)이노보테라퓨틱스	벤즈브로마론을 포함하는 켈로이드 또는 비대흉터 예방 또는 치료용 약학 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3896145A (en) *	1972-07-24	1975-07-22	Hoffmann La Roche	Carbazoles
CA1319886C (en) *	1987-02-03	1993-07-06	Alberto Ferro	Mixed micelle solutions

1998
- 1998-03-02 DZ DZ980089A patent/DZ2479A1/xx active
- 1998-04-30 TW TW087106689A patent/TW590773B/zh not_active IP Right Cessation
- 1998-05-01 WO PCT/IB1998/000662 patent/WO1998050033A1/en not_active Ceased
- 1998-05-01 BR BR9808720-7A patent/BR9808720A/pt not_active IP Right Cessation
- 1998-05-01 CN CN98804845A patent/CN1255059A/zh active Pending
- 1998-05-01 HU HU0001286A patent/HUP0001286A3/hu unknown
- 1998-05-01 CA CA002288759A patent/CA2288759A1/en not_active Abandoned
- 1998-05-01 ID IDP980651A patent/ID21311A/id unknown
- 1998-05-01 SK SK1481-99A patent/SK148199A3/sk unknown
- 1998-05-01 JP JP10547869A patent/JP2000513020A/ja active Pending
- 1998-05-01 AU AU69321/98A patent/AU6932198A/en not_active Abandoned
- 1998-05-01 KR KR10-2003-7005258A patent/KR20040004406A/ko not_active Ceased
- 1998-05-01 PL PL98337003A patent/PL337003A1/xx unknown
- 1998-05-01 EA EA199900895A patent/EA003696B1/ru not_active IP Right Cessation
- 1998-05-01 KR KR1019997010252A patent/KR20010012300A/ko not_active Ceased
- 1998-05-01 EP EP98915041A patent/EP0988034A1/en not_active Withdrawn
- 1998-05-01 YU YU55899A patent/YU55899A/sh unknown
- 1998-05-01 IL IL13257098A patent/IL132570A0/xx unknown
- 1998-05-01 NZ NZ500183A patent/NZ500183A/en unknown
- 1998-05-04 MA MA25059A patent/MA26491A1/fr unknown
- 1998-05-04 AP APAP/P/1998/001234A patent/AP9801234A0/en unknown
- 1998-05-04 GT GT199800063A patent/GT199800063A/es unknown
- 1998-05-04 TN TNTNSN98059A patent/TNSN98059A1/fr unknown
- 1998-05-04 UY UY24989A patent/UY24989A1/es not_active Application Discontinuation
- 1998-05-04 ZA ZA9803722A patent/ZA983722B/xx unknown
- 1998-05-04 PE PE1998000335A patent/PE72599A1/es not_active Application Discontinuation
- 1998-05-05 AR ARP980102089A patent/AR011726A1/es unknown
- 1998-05-05 PA PA19988450601A patent/PA8450601A1/es unknown
- 1998-05-05 HR HR60/045,635A patent/HRP980244A2/hr not_active Application Discontinuation
1999
- 1999-10-19 IS IS5220A patent/IS5220A/is unknown
- 1999-11-02 OA OA9900242A patent/OA11213A/en unknown
- 1999-11-03 BG BG103852A patent/BG103852A/xx unknown
- 1999-11-04 NO NO995389A patent/NO995389L/no not_active Application Discontinuation
2003
- 2003-04-09 AR ARP030101251A patent/AR039628A2/es unknown

Also Published As

Publication number	Publication date
DZ2479A1 (fr)	2003-02-01
EA199900895A1 (ru)	2000-06-26
HUP0001286A2 (hu)	2000-11-28
EP0988034A1 (en)	2000-03-29
AP9801234A0 (en)	1999-11-04
PE72599A1 (es)	1999-08-12
HRP980244A2 (en)	1999-02-28
PL337003A1 (en)	2000-07-31
NO995389D0 (no)	1999-11-04
AR039628A2 (es)	2005-03-02
TNSN98059A1 (fr)	2005-03-15
ZA983722B (en)	1999-11-04
NZ500183A (en)	2002-04-26
NO995389L (no)	2000-01-04
BR9808720A (pt)	2000-07-11
AR011726A1 (es)	2000-08-30
CA2288759A1 (en)	1998-11-12
PA8450601A1 (es)	2000-05-24
MA26491A1 (fr)	2004-12-20
IS5220A (is)	1999-10-19
GT199800063A (es)	1999-10-26
WO1998050033A1 (en)	1998-11-12
IL132570A0 (en)	2001-03-19
JP2000513020A (ja)	2000-10-03
YU55899A (sh)	2003-08-29
SK148199A3 (en)	2001-09-11
KR20010012300A (ko)	2001-02-15
EA003696B1 (ru)	2003-08-28
TW590773B (en)	2004-06-11
KR20040004406A (ko)	2004-01-13
CN1255059A (zh)	2000-05-31
OA11213A (en)	2003-07-14
UY24989A1 (es)	2001-10-25
AU6932198A (en)	1998-11-27
ID21311A (id)	1999-05-20
HUP0001286A3 (en)	2000-12-28

Publication	Publication Date	Title
BG103852A (en)	2000-06-30	Cog-2 selective carprophene for the treatment of pains and inflammations in dogs
DE69805846D1 (de)	2002-07-11	Verwendung von 3-benzoylphenylessigsäuren, deren estern oder amiden zur behandlung von glc1a glaukom
DE59711321D1 (de)	2004-03-25	Neue substituierte pyrazolderivate zur behandlung von herzkreislauferkrankungen
ATE407573T1 (de)	2008-09-15	Verwendung von lokal verabreichten lysine zur verbesserung der vaskularen funktion
EP1003416A4 (en)	2006-08-23	ARRANGEMENT AND METHOD FOR NON-INVASIVELY DETERMINING THE SENSITIVITY OF A PERSON IN RESPECT OF ARRYTHMIES
NO983019L (no)	1998-08-19	Fremgangsmåte for inhibering av fotoaldring av hud
DE69634951D1 (de)	2005-08-25	Topische verwendung von betulinsäure zur behandlung bösartiger melanome
WO1999046279A3 (en)	2001-02-22	INHIBITORS OF TYPE 5 AND TYPE 3 17β-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE
ATE321548T1 (de)	2006-04-15	Verwendung von statin zur behandlung von hauterkrankungen
CA2168963A1 (en)	1995-12-14	Drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation in the lung and model animals of the diseases
HK1040198A1 (zh)	2002-05-31	用於預防和治療內髒痛的加巴噴丁衍生物
DE69526183D1 (de)	2002-05-08	3-benzoylphenylessigsäure-derivate enthaltende topische zusammensetzungen zur behandlung der ophthalmischen entzündungserkrankungen
WO1994020062A3 (en)	1996-08-15	Balanoids as protein kinase c inhibitors
DE69613693D1 (de)	2001-08-09	2-heteroarylalkenylderivate der cyclopentano-heptan(heptaen)säure als therapeutisches mittel zur behandlung des erhöhten augeninnendruckes
RU95111308A (ru)	1996-12-27	Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция
ES2162051T3 (es)	2001-12-16	Preparacion dermatologica para tratar queratosis actinicas.
ATE198477T1 (de)	2001-01-15	Benzothiophenderivate
GR3034575T3 (en)	2001-01-31	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
ZA978400B (en)	1998-03-26	Use of inhibitors of the activity of retinoic acid to promote healing.
ATE198751T1 (de)	2001-02-15	Azoderivate von 5-aminosalicylsäure zur behandlung von enzündlichen darmerkrankungen
CA2362888A1 (en)	2000-08-31	Use of r-aryl propionic acids for producing medicaments to treat diseases in humans and animals, whereby said diseases can be therapeutically influenced by inhibiting the activation of nf-kb
IT1254521B (it)	1995-09-25	Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
DE69735417D1 (de)	2006-05-04	2,5-dihydroxybenzylsulfonderivate zur behandlung von sexuellen störungen
MX26142A (es)	1994-02-28	Derivados de acido benzoico para tratar enfermedades relacionadas con leucotrieno.
ES2182890T3 (es)	2003-03-16	Sintesis de acidos 4-arilo-2-hidroxitetronicos opticamente puros.