BG33296A3 - Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид - Google Patents

Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид

Info

Publication number: BG33296A3
Authority: BG; Bulgaria
Prior art keywords: vincaleucoblastin; carboxyhydrazide; desacetyl; obtaining derivatives; obtaining
Prior art date: 1978-04-20

Application number

BG056469A

Other languages

Bulgarian (bg)

English (en)

Inventor

George Cullinan

Koert Gerzon

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-20

Publication date

1983-01-14

1979-04-20 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1983-01-14 Publication of BG33296A3 publication Critical patent/BG33296A3/xx

Links

229960003048 vinblastine Drugs 0.000 title abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BG056469A 1978-04-20 1979-04-20 Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид BG33296A3 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
BG33296A3 true BG33296A3 (bg)	1983-01-14

Family

ID=25410402

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BG056470A BG33297A3 (bg)	1978-04-20	1979-04-20	Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид
BG056469A BG33296A3 (bg)	1978-04-20	1979-04-20	Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид
BG043323A BG33294A3 (bg)	1978-04-20	1979-04-20	Метод за получаване на антитуморни производни на 4-дезацетил vlвс-3 карбоксхидразид

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BG056470A BG33297A3 (bg)	1978-04-20	1979-04-20	Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG043323A BG33294A3 (bg)	1978-04-20	1979-04-20	Метод за получаване на антитуморни производни на 4-дезацетил vlвс-3 карбоксхидразид

Country Status (32)

Country	Link
US (1)	US4166810A (fr)
EP (1)	EP0005051B1 (fr)
JP (1)	JPS54141798A (fr)
AR (1)	AR228940A1 (fr)
AT (1)	AT369010B (fr)
AU (1)	AU527109B2 (fr)
BE (1)	BE875652A (fr)
BG (3)	BG33297A3 (fr)
CA (1)	CA1097629A (fr)
CH (1)	CH643269A5 (fr)
CS (3)	CS218584B2 (fr)
DD (1)	DD143075A5 (fr)
DE (1)	DE2964130D1 (fr)
DK (1)	DK147484C (fr)
EG (1)	EG14867A (fr)
ES (2)	ES479753A1 (fr)
FI (1)	FI791286A7 (fr)
FR (1)	FR2423495A1 (fr)
GB (1)	GB2019396B (fr)
GR (1)	GR69987B (fr)
HU (1)	HU181431B (fr)
IE (1)	IE48213B1 (fr)
IL (1)	IL57168A (fr)
LU (1)	LU81166A1 (fr)
NZ (1)	NZ190213A (fr)
PH (1)	PH14163A (fr)
PL (3)	PL215911A1 (fr)
PT (1)	PT69496A (fr)
RO (3)	RO81114A (fr)
SU (3)	SU1225490A3 (fr)
YU (1)	YU93179A (fr)
ZA (1)	ZA791856B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DK167984A (da) *	1983-03-30	1984-10-01	Lilly Industries Ltd	Alkaloidderivater
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
EP1389209B1 (fr) *	2001-04-24	2009-04-08	Purdue Research Foundation	Mimetiques de folate et ses conjugues se liant au recepteur de folate
WO2003097647A1 (fr) *	2002-05-15	2003-11-27	Endocyte, Inc.	Conjugues vitamine-mitomycine
DK1592457T3 (da)	2003-01-27	2012-10-22	Endocyte Inc	Folat-vinblastin-konjugat som lægemiddel
JP5149620B2 (ja)	2004-07-23	2013-02-20	エンドサイト，インコーポレイテッド	２価リンカーおよびその結合体
EP1863816B1 (fr) *	2005-03-16	2014-06-25	Endocyte, Inc.	Synthese et purification d'acide pteroique et des conjugues de celui-ci
AU2006279304A1 (en)	2005-08-19	2007-02-22	Endocyte, Inc.	Multi-drug ligand conjugates
EP2382995A3 (fr)	2005-08-19	2013-09-25	Endocyte, Inc.	Conjugués de ligands d'alcaloïdes de Vinca, analogues et dérivés
WO2008100591A2 (fr) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation de la signalisation de l'oxyde nitrique pour normaliser le système vasculaire tumoral
WO2008101231A2 (fr)	2007-02-16	2008-08-21	Endocyte, Inc.	Procédés et compositions de traitement et de diagnostic d'une maladie rénale
CN104127878A (zh) *	2007-03-14	2014-11-05	恩多塞特公司	结合配体连接的微管溶素递药缀合物
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
BRPI0812970A2 (pt) *	2007-06-25	2019-09-24	Endocyte Inc	conjugados contendo espaçadores hidrofílicos
US9187521B2 (en) *	2007-10-25	2015-11-17	Endocyte, Inc.	Tubulysins and processes for preparing
ES2574032T3 (es) *	2009-09-07	2016-06-14	Nipro Patch Co., Ltd.	Preparación absorbible por vía transdérmica
US10080805B2 (en)	2012-02-24	2018-09-25	Purdue Research Foundation	Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
EP2908818A4 (fr)	2012-10-16	2016-07-13	Endocyte Inc	Conjugués d'administration de médicament contenant des acides aminés artificiels et procédés d'utilisation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 RO RO79102376A patent/RO81114A/fr unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/fr not_active Expired
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/fr unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 LU LU81166A patent/LU81166A1/fr unknown
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/fr unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 RO RO79102377A patent/RO81037A/fr unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 FI FI791286A patent/FI791286A7/fi not_active Application Discontinuation
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CA CA325,844A patent/CA1097629A/fr not_active Expired
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-20 BG BG056470A patent/BG33297A3/xx unknown
- 1979-04-20 BG BG056469A patent/BG33296A3/xx unknown
- 1979-04-20 BG BG043323A patent/BG33294A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
BE875652A (fr)	1979-10-18
RO80084B (ro)	1983-01-30
PT69496A (en)	1979-05-01
DK147484B (da)	1984-08-27
PL125470B1 (en)	1983-05-31
HU181431B (en)	1983-07-28
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
BG33297A3 (bg)	1983-01-14
IE790795L (en)	1979-10-20
GB2019396B (en)	1982-09-15
US4166810A (en)	1979-09-04
DD143075A5 (de)	1980-07-30
GB2019396A (en)	1979-10-31
RO81037B (ro)	1983-01-30
BG33294A3 (bg)	1983-01-14
ATA291279A (de)	1982-04-15
EP0005051A1 (fr)	1979-10-31
AU4609779A (en)	1979-10-25
SU1225490A3 (ru)	1986-04-15
RO80084A (fr)	1983-02-01
RO81114B (ro)	1983-01-30
CS218583B2 (en)	1983-02-25
NZ190213A (en)	1982-12-21
RO81037A (fr)	1983-02-01
PH14163A (en)	1981-03-19
DK147484C (da)	1985-03-25
PL215911A1 (fr)	1980-03-24
EP0005051B1 (fr)	1982-12-01
FR2423495B1 (fr)	1983-02-11
CA1097629A (fr)	1981-03-17
SU893135A3 (ru)	1981-12-23
JPS54141798A (en)	1979-11-05
CH643269A5 (fr)	1984-05-30
IL57168A (en)	1983-10-31
FR2423495A1 (fr)	1979-11-16
IE48213B1 (en)	1984-10-31
IL57168A0 (en)	1979-07-25
GR69987B (fr)	1982-07-22
LU81166A1 (fr)	1979-09-07
EG14867A (en)	1986-09-30
SU1061698A3 (ru)	1983-12-15
ZA791856B (en)	1980-11-26
PL119416B1 (en)	1981-12-31
CS218585B2 (en)	1983-02-25
RO81114A (fr)	1983-02-01
AT369010B (de)	1982-11-25
JPS6245873B2 (fr)	1987-09-29
YU93179A (en)	1983-01-21
AR228940A1 (es)	1983-05-13
FI791286A7 (fi)	1981-01-01
CS218584B2 (en)	1983-02-25
DE2964130D1 (en)	1983-01-05
AU527109B2 (en)	1983-02-17
ES479753A1 (es)	1980-08-16

Publication	Publication Date	Title
BG31225A3 (bg)	1981-11-16	Метод за получаване на ациланилидни производни
BG28708A3 (bg)	1980-06-16	Метод за получаване на имидазолови производни
BG33296A3 (bg)	1983-01-14	Метод за получаване на производни на 4- дезацетил- винкалевкобластин с- 3- карбоксихидразид
BG35189A3 (en)	1984-02-15	Method for preparing derivatives of 6- beta- hydroxyalkylpenicillanic acid
BG31497A3 (bg)	1982-01-15	Метод за получаване на 4-амино-5-алкил-сулфонил ортонизамиди
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BG38333A3 (bg)	1985-11-15	Метод за получаване на заместени фенилкарбоксиоксими
BG37993A3 (bg)	1985-09-16	Метод за получаване на 4-хинолонови производни
BG31492A3 (bg)	1982-01-15	Метод за получаване на фенетаноламини
BG36348A3 (en)	1984-10-15	Method for preparing thienopyridinon derivatives
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BG34038A3 (bg)	1983-06-15	Метод за получаване на 7-заместени амино-ацетамидо оксадетиа-цефалоспорини
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BG28565A3 (bg)	1980-05-15	Метод за получаване на пиролхиноксалинони и пиролбензодиазепинони
BG30021A3 (bg)	1981-03-16	Метод за получаване на имидазоизохинолин-диони
BG34612A3 (bg)	1983-10-15	Метод за получаване на пиролидинови производни
BG31947A3 (bg)	1982-04-15	Метод за получаване на ацетидинови производни
BG34461A3 (bg)	1983-09-15	Метод за получаване на производни на 7 бета- аминотиазолилацетамидо- 3- цефем- 4- карбоновата киселина
BG32718A3 (bg)	1982-09-15	Метод за получаване на производни на 4''-деокси-4''- аминоеридромицин-а
BG28066A3 (bg)	1980-02-25	Метод за получаване на пиридобензодиазепинони
BG36347A3 (en)	1984-10-15	Method for preparing thienopyridinon derivatives
BG35037A3 (en)	1984-01-16	Method for preparing phenylaminic derivatives
BG35035A3 (en)	1984-01-16	Method for preparing nitroalkanolic derivatives
BG29285A3 (bg)	1980-10-15	Метод за получаване на 3-ди-n пропилацетокси бензодиазепин-2-они
BG30326A3 (bg)	1981-05-15	Метод за получаване на хетероциклични производни