BG64337B1 - Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа - Google Patents

Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа Download PDF

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Publication number
BG64337B1
BG64337B1 BG104133A BG10413300A BG64337B1 BG 64337 B1 BG64337 B1 BG 64337B1 BG 104133 A BG104133 A BG 104133A BG 10413300 A BG10413300 A BG 10413300A BG 64337 B1 BG64337 B1 BG 64337B1
Authority
BG
Bulgaria
Prior art keywords
hemihydrate
nevirapine
solution
nevirapine hemihydrate
water
Prior art date
Application number
BG104133A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104133A (bg
Inventor
Karl Grozinger
Amale Hawi
Original Assignee
Boehringer Ingelheim Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22006658&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64337(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharmaceuticals, Inc. filed Critical Boehringer Ingelheim Pharmaceuticals, Inc.
Publication of BG104133A publication Critical patent/BG104133A/xx
Publication of BG64337B1 publication Critical patent/BG64337B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG104133A 1997-08-25 2000-02-07 Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа BG64337B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5680397P 1997-08-25 1997-08-25

Publications (2)

Publication Number Publication Date
BG104133A BG104133A (bg) 2000-08-31
BG64337B1 true BG64337B1 (bg) 2004-10-29

Family

ID=22006658

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104133A BG64337B1 (bg) 1997-08-25 2000-02-07 Метод за получаване на невирапин хемихидрат и фармацевтичен състав, който го съдържа

Country Status (37)

Country Link
US (2) US6172059B1 (uk)
EP (1) EP1019058B1 (uk)
JP (1) JP3472261B2 (uk)
KR (1) KR100426516B1 (uk)
CN (1) CN1197578C (uk)
AR (2) AR016869A1 (uk)
AT (1) ATE326971T1 (uk)
AU (1) AU742761B2 (uk)
BG (1) BG64337B1 (uk)
BR (1) BR9811994B1 (uk)
CA (1) CA2301646C (uk)
CL (1) CL2008003111A1 (uk)
CO (1) CO4970742A1 (uk)
CY (1) CY1105228T1 (uk)
CZ (1) CZ290667B6 (uk)
DE (1) DE69834655T2 (uk)
DK (1) DK1019058T3 (uk)
EG (1) EG24075A (uk)
ES (1) ES2265666T3 (uk)
HR (1) HRP980461B1 (uk)
HU (1) HU226063B1 (uk)
ID (1) ID21650A (uk)
IL (1) IL134185A (uk)
MY (1) MY122272A (uk)
NO (1) NO326226B1 (uk)
NZ (1) NZ503414A (uk)
PE (1) PE105799A1 (uk)
PL (1) PL192361B1 (uk)
PT (1) PT1019058E (uk)
RS (1) RS49808B (uk)
RU (1) RU2196584C2 (uk)
SA (1) SA98190680B1 (uk)
TR (1) TR200000490T2 (uk)
TW (1) TW450812B (uk)
UA (1) UA44370C2 (uk)
WO (1) WO1999009990A1 (uk)
ZA (1) ZA987623B (uk)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002092095A1 (en) * 2001-05-11 2002-11-21 Boehringer Ingelheim International Gmbh Use of nevirapine to treat or prevent lipid pathology in patients with hiv that is resistant to nevirapine
WO2003091290A1 (en) * 2002-04-23 2003-11-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for reduction of residual organic solvent in carbomer
BRPI0617074A2 (pt) * 2005-08-31 2011-07-12 Cipla Ltd composição farmacêutica, uso de lamivudina, nevirapina e stavudina, uso de stavudina, lamivudina e nevirapina, método para tratar uma infecção viral em um humano, método para preparar uma composição farmacêutica, método para preparar uma forma de dosagem unitária farmacêutica bicamadas e método para preparar uma forma de dosagem unitária farmacêutica tri-camadas
EP2306980A2 (en) * 2008-06-30 2011-04-13 Tibotec Pharmaceuticals Powders for reconstitution
BR112012011095A2 (pt) * 2009-11-10 2015-10-06 Univ Northwest método para aumentar a solubilidade de uma composição inibidora de transcriptase
DE112010004862T5 (de) * 2009-12-17 2012-12-06 North West University Polymorphe Form von Nevirapin und deren Herstellung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429987A2 (en) * 1989-11-17 1991-06-05 Boehringer Ingelheim Pharmaceuticals Inc. 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5569760A (en) * 1994-02-03 1996-10-29 Boehringer Ingelheim Kg Process for preparing nevirapine
US5571912A (en) * 1990-10-19 1996-11-05 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2019812C (en) * 1989-06-28 2000-11-21 Gunther Schmidt (Deceased) Novel 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids
GB9215178D0 (en) * 1992-07-16 1992-08-26 Glaxo Group Ltd Antiviral combinations
HUT74681A (en) * 1993-12-15 1997-01-28 Merck & Co Inc N-(2-hydroxy-1-indenyl)-2-phenylmethyl-4-hydroxy-5-(2-carboxamido-piperazinyl)-pentaneamide derivatives of hiv protease inhibitor activity and phrmaceutical compositions contining them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
EP0429987A2 (en) * 1989-11-17 1991-06-05 Boehringer Ingelheim Pharmaceuticals Inc. 5,11-Dihydro-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
US5571912A (en) * 1990-10-19 1996-11-05 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines
US5569760A (en) * 1994-02-03 1996-10-29 Boehringer Ingelheim Kg Process for preparing nevirapine

Also Published As

Publication number Publication date
CN1197578C (zh) 2005-04-20
EP1019058A1 (en) 2000-07-19
JP2001513564A (ja) 2001-09-04
EP1019058A4 (en) 2004-11-10
YU9800A (sh) 2001-12-26
ZA987623B (en) 2000-03-22
AR083451A2 (es) 2013-02-27
AU742761B2 (en) 2002-01-10
TR200000490T2 (tr) 2000-08-21
TW450812B (en) 2001-08-21
CZ2000694A3 (cs) 2000-09-13
PE105799A1 (es) 1999-11-16
BG104133A (bg) 2000-08-31
EP1019058B1 (en) 2006-05-24
CZ290667B6 (cs) 2002-09-11
ATE326971T1 (de) 2006-06-15
RU2196584C2 (ru) 2003-01-20
CY1105228T1 (el) 2010-03-03
CA2301646A1 (en) 1999-03-04
DK1019058T3 (da) 2006-06-12
IL134185A (en) 2005-11-20
ES2265666T3 (es) 2007-02-16
HRP980461A2 (en) 1999-06-30
HU226063B1 (hu) 2008-04-28
CN1268055A (zh) 2000-09-27
RS49808B (sr) 2008-08-07
EG24075A (en) 2008-05-11
UA44370C2 (uk) 2002-02-15
NO20000906L (no) 2000-02-24
AR016869A1 (es) 2001-08-01
CA2301646C (en) 2008-11-18
NO326226B1 (no) 2008-10-20
SA98190680B1 (ar) 2006-04-04
AU8777198A (en) 1999-03-16
KR100426516B1 (ko) 2004-04-13
PL338828A1 (en) 2000-11-20
HRP980461B1 (en) 2002-08-31
DE69834655T2 (de) 2006-12-14
US6255481B1 (en) 2001-07-03
IL134185A0 (en) 2001-04-30
BR9811994B1 (pt) 2013-11-19
DE69834655D1 (de) 2006-06-29
BR9811994A (pt) 2000-09-05
PL192361B1 (pl) 2006-10-31
KR20010023257A (ko) 2001-03-26
HK1027975A1 (en) 2001-02-02
CL2008003111A1 (es) 2009-09-11
US6172059B1 (en) 2001-01-09
ID21650A (id) 1999-07-08
CO4970742A1 (es) 2000-11-07
HUP0003093A2 (hu) 2001-08-28
JP3472261B2 (ja) 2003-12-02
NZ503414A (en) 2002-11-26
NO20000906D0 (no) 2000-02-24
MY122272A (en) 2006-04-29
WO1999009990A1 (en) 1999-03-04
PT1019058E (pt) 2006-08-31

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