BR0015364A - 5-benzil-2,4-diaminopirimidinas substituìdas - Google Patents

5-benzil-2,4-diaminopirimidinas substituìdas

Info

Publication number
BR0015364A
BR0015364A BR0015364-8A BR0015364A BR0015364A BR 0015364 A BR0015364 A BR 0015364A BR 0015364 A BR0015364 A BR 0015364A BR 0015364 A BR0015364 A BR 0015364A
Authority
BR
Brazil
Prior art keywords
diaminopyrimidines
benzyl
substituted
alkyl
cycloalkyl
Prior art date
Application number
BR0015364-8A
Other languages
English (en)
Inventor
Phillipe Guerry
Peter Mohr
Marc Muller
Werner Mueller
Philippe Pflieger
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of BR0015364A publication Critical patent/BR0015364A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"5-BENZIL-2,4-DIAMINOPIRIMIDINAS SUBSTITUìDAS". A invenção refere-se a 5-benzil-2,4-diaminopirimidinas substituídas da fórmula geral (A) em que R^ 1^ é alquila C2-C3 e R^ 2^ é heterociclila, fenila ou naftila, ligada por de um de seus átomos de C e R^ 3^ é alquila C2-C6, alquenila, cicloalquila, cicloalquilalquila, heterociclilalquila, alquilsulfonila, cicloalquilsulfonila, cicloalquilalquilsulfamoíla, heterociclilsulfonila, heterociclilalquilsulfonila ou dialquilsulfamoíla, em que alquila, cicloalquila e alquenila podem carregar até 6 átomos de carbono sozinhas ou em composições e podem carregar até 6 membros do anel heterociclicamente, sozinhas ou em composições e os grupos R^ 2^ e R^ 3^ podem ser substituídos; e a sais de adição de ácido dos compostos. A invenção também refere-se a um método para a produção das 5-benzil-2,4-diaminopirimidinas acima, aos produtos intermediários que são produzidos, a medicamentos correspondentes e ao uso de 5-benzil-2,4-diaminopirimidinas como preparações medicinais. Os produtos possuem propriedades antibióticas e são úteis para combater ou prevenir doenças infecciosas.
BR0015364-8A 1999-11-04 2000-10-27 5-benzil-2,4-diaminopirimidinas substituìdas BR0015364A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH202199 1999-11-04
PCT/CH2000/000575 WO2001032633A1 (de) 1999-11-04 2000-10-27 Substituierte 5-benzyl-2,4-diaminopyrimidine

Publications (1)

Publication Number Publication Date
BR0015364A true BR0015364A (pt) 2004-06-15

Family

ID=4224063

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015364-8A BR0015364A (pt) 1999-11-04 2000-10-27 5-benzil-2,4-diaminopirimidinas substituìdas

Country Status (14)

Country Link
US (1) US6821980B1 (pt)
EP (1) EP1230224B1 (pt)
JP (1) JP3853655B2 (pt)
KR (1) KR20020063888A (pt)
CN (1) CN1186328C (pt)
AT (1) ATE286031T1 (pt)
AU (1) AU769644B2 (pt)
BR (1) BR0015364A (pt)
CA (1) CA2389377A1 (pt)
DE (1) DE50009143D1 (pt)
ES (1) ES2233461T3 (pt)
MX (1) MXPA02004443A (pt)
WO (1) WO2001032633A1 (pt)
ZA (1) ZA200203493B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE319696T1 (de) * 2000-08-08 2006-03-15 Ortho Mcneil Pharm Inc Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden
CZ2003686A3 (cs) 2000-08-08 2003-08-13 Ortho Mcneil Pharmaceutical, Inc. Neimidazolové aryloxypiperidiny
JP5043428B2 (ja) 2003-06-03 2012-10-10 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリール複素環式化合物ならびにその製造および使用方法
CN101429170B (zh) * 2003-06-03 2015-05-13 梅林塔医疗有限公司 联芳基杂环化合物的制备和用途
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
AR046782A1 (es) * 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
US7204529B2 (en) * 2004-11-18 2007-04-17 Honda Motor Co., Ltd. Recessed door lock actuator assembly for a vehicle
DE602006019870D1 (de) 2005-06-08 2011-03-10 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
US8093279B2 (en) * 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
FR2898124B1 (fr) * 2006-03-03 2008-09-12 Centre Nat Rech Scient Derive de resveratol a longue chaine hydroxylee utiles comme neurotrophiques
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
US8026365B2 (en) 2007-05-25 2011-09-27 Hoffman-La Roche Inc. 4,4-disubstituted piperidine derivatives
US20120022057A1 (en) * 2009-03-18 2012-01-26 Schering Corporation Bicyclic compounds as inhibitors of diacyglycerol acyltransferase
CN105566230B (zh) * 2016-01-18 2018-03-27 宁夏医科大学 2,4‑二氨基嘧啶类衍生物及其合成方法
CN106220616B (zh) * 2016-07-25 2019-03-26 宁夏医科大学 2，4-二氨基嘧啶类化合物及其盐、制备方法及其作为抗结核分枝杆菌药物的应用
CN108498477A (zh) * 2017-02-27 2018-09-07 江苏奥赛康药业股份有限公司 一种2-氨基嘧啶类化合物的药用组合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
ES2193205T3 (es) * 1994-11-24 2003-11-01 Basilea Pharmaceutica Ag Nuevas bencil pirimidinas.

Also Published As

Publication number Publication date
EP1230224A1 (de) 2002-08-14
ATE286031T1 (de) 2005-01-15
US6821980B1 (en) 2004-11-23
AU769644B2 (en) 2004-01-29
MXPA02004443A (es) 2002-09-02
ZA200203493B (en) 2003-08-04
JP3853655B2 (ja) 2006-12-06
JP2003516320A (ja) 2003-05-13
CN1387516A (zh) 2002-12-25
EP1230224B1 (de) 2004-12-29
DE50009143D1 (de) 2005-02-03
WO2001032633A1 (de) 2001-05-10
CN1186328C (zh) 2005-01-26
KR20020063888A (ko) 2002-08-05
CA2389377A1 (en) 2002-04-30
AU7897100A (en) 2001-05-14
ES2233461T3 (es) 2005-06-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007.