BR0312736A - Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib - Google Patents
Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxibInfo
- Publication number
- BR0312736A BR0312736A BR0312736-2A BR0312736A BR0312736A BR 0312736 A BR0312736 A BR 0312736A BR 0312736 A BR0312736 A BR 0312736A BR 0312736 A BR0312736 A BR 0312736A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- valdecoxib
- celecoxib
- combination
- Prior art date
Links
- 229960000590 celecoxib Drugs 0.000 title abstract 5
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 title abstract 5
- 229960002004 valdecoxib Drugs 0.000 title abstract 5
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 title abstract 5
- 230000003281 allosteric effect Effects 0.000 title abstract 4
- 102000011722 Matrix Metalloproteinase 13 Human genes 0.000 title 1
- 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 title 1
- 229940122908 Metalloproteinase-13 inhibitor Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 9
- 102100027995 Collagenase 3 Human genes 0.000 abstract 4
- 108050005238 Collagenase 3 Proteins 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
"ASSOCIAçãO DE UM INIBIDOR CARBOXìLICO ALOSTéRICO DA METALOPROTEINASE-13 DE MATRIZ COM CELECOXIB OU VALDECOXIB". Esta invenção proporciona urna associação, compreendendo um inibidor carboxílico alostédco da MMP-13, ou um seu sal farmaceuticamente aceitável, com celecoxib, ou um seu sal farmaceuticamente aceitável, ou com valdecoxib, ou um seu sal farmaceuticamente aceitável. Esta invenção proporciona também um método de tratamento da uma doença que reage à inibição da MMP-13 e da ciclooxigenase-2, compreendendo a administração, a um paciente que sofra dessa doença, da associação da invenção compreendendo um inibidor carboxílico alostérico da MMP-13, ou um seu sal farmaceuticamente aceitável, com celecoxib, ou um seu sal farmaceuticamente aceitável, ou com valdecoxib, ou um seu sal farmaceuticamente aceitável. Esta invenção proporciona também uma formulação farmacêutica, compreendendo a associação da invenção compreendendo um inibidor carboxílico alostérico da MMP-13, ou um seu sal farmaceuticamente aceitável, com celecoxib, ou um seu sal farmaceuticamente aceitável, ou com valdecoxib, ou um seu sal farmaceuticamente aceitável, e um veículo, diluente ou excipiente farmaceuticamente aceitável.A associação da invenção pode ser ainda combinada com outros agentes farmacêuticos dependendo da doença a ser tratada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39690302P | 2002-07-17 | 2002-07-17 | |
| PCT/IB2003/003044 WO2004006912A2 (en) | 2002-07-17 | 2003-07-07 | Combination of an allosteric carboxylic inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312736A true BR0312736A (pt) | 2005-04-26 |
Family
ID=30116069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312736-2A BR0312736A (pt) | 2002-07-17 | 2003-07-07 | Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040019053A1 (pt) |
| EP (1) | EP1530467A2 (pt) |
| JP (1) | JP2006503811A (pt) |
| AU (1) | AU2003281169A1 (pt) |
| BR (1) | BR0312736A (pt) |
| CA (1) | CA2495432A1 (pt) |
| MX (1) | MXPA05000754A (pt) |
| WO (1) | WO2004006912A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| MXPA05000729A (es) * | 2002-07-17 | 2005-04-08 | Warner Lambert Co | Combinacion de un inhibidor alosterico de metaloproteinasa-13 de matriz con celecoxib o valdecoxib. |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| AU2004297235A1 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
| US7682619B2 (en) * | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| KR20180011888A (ko) | 2008-11-19 | 2018-02-02 | 포럼 파마슈티칼즈 인크. | (ｒ)-７-클로로-ｎ-(퀴누클리딘-３-일)벤조［ｂ］티오펜-２-카르복사미드 및 그 약학적으로 허용가능한 염을 이용한 인지 장애의 치료 |
| WO2010129848A2 (en) * | 2009-05-08 | 2010-11-11 | Takeda Pharmaceutical Company Limited | 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamides |
| PE20120324A1 (es) * | 2009-05-11 | 2012-04-17 | Envivo Pharmaceuticals Inc | Combinacion que comprende (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y donezepilo como moduladora de trastornos cognitivos |
| AR081402A1 (es) | 2010-05-17 | 2012-08-29 | Envivo Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| CA3177929A1 (en) | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| WO2016100184A1 (en) | 2014-12-16 | 2016-06-23 | Forum Pharmaceuticals, Inc. | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| CN107614501B (zh) | 2015-05-20 | 2020-01-14 | 广东众生睿创生物科技有限公司 | 羟基嘌呤类化合物及其应用 |
| RU2685417C1 (ru) * | 2015-05-20 | 2019-04-18 | Гуандун Рейновент Биотек Ко., Лтд. | Гидроксипуриновые соединения и их применение |
| MX2017016231A (es) | 2015-06-10 | 2018-11-29 | Axovant Sciences Gmbh | Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3296070A (en) * | 1967-01-03 | Method for the treatment of hypertension | ||
| ES2183935T3 (es) * | 1995-02-13 | 2003-04-01 | Searle & Co | Isoxazoles sustituidos para el tratamiento de la inflamacion. |
| ATE261954T1 (de) * | 1998-07-30 | 2004-04-15 | Warner Lambert Co | Tricyclische sulfonamide und ihre derivate als inhibitoren von matrix-metalloproteinasen |
| JP2000159747A (ja) * | 1998-09-21 | 2000-06-13 | Takeda Chem Ind Ltd | 新規チオ―ル誘導体、その製造法および用途 |
| BR9916536A (pt) * | 1998-12-23 | 2002-01-02 | Searle & Co | Método para o tratamento ou prevenção de um distúrbio de neoplasia em um mamìfero em necessidade deste tratamento ou prevenção, e, combinação |
| EP1081137A1 (en) * | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
| IL138686A0 (en) * | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
| NZ520711A (en) * | 2000-02-10 | 2004-03-26 | Ono Pharmaceutical Co | N-hydroxy-5-ethoxymethyloxy-2(S)-methyl-4(S)-(4- phenoxybenzoyl)aminopentanamide useful for treating osteoarthritis |
| EP1138680A1 (en) * | 2000-03-29 | 2001-10-04 | Pfizer Products Inc. | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors |
| US6455568B2 (en) * | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| WO2002064571A1 (en) * | 2001-02-14 | 2002-08-22 | Warner-Lambert Company Llc | Pyrimidine matrix metalloproteinase inhibitors |
| DOP2002000333A (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
| PA8539501A1 (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
| BR0207865A (pt) * | 2001-02-14 | 2004-03-23 | Warner Lambert Co | Benzotiadiazinas inibidores de metaloproteinases de matriz |
| CA2433778A1 (en) * | 2001-02-14 | 2002-08-22 | William Glen Harter | Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors |
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
| DOP2002000332A (es) * | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
| PA8539301A1 (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Inhibidores de la metaloproteinasa de la matriz |
| US6890915B2 (en) * | 2001-05-25 | 2005-05-10 | Bristol-Myers Squibb Pharma Company | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| WO2003031431A1 (en) * | 2001-10-09 | 2003-04-17 | Bristol-Myers Squibb Company | Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or tnf-$g(a) converting enzyme (tace) |
| US6933298B2 (en) * | 2001-12-08 | 2005-08-23 | Aventis Pharma Deutschland Gmbh | Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases |
| BR0312943A (pt) * | 2002-07-17 | 2005-07-12 | Warner Lambert Co | Combinação de um inibidor alostérico de matriz metaloproteinase-13 com um inibidor seletivo de ciclooxigenase-2 que não é celecoxib ou valdecoxib |
| JP2006503812A (ja) * | 2002-07-17 | 2006-02-02 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | アロステリックカルボキシルマトリックスメタロプロテイナーゼ−１３阻害薬とセレコキシブまたはバルデコキシブではない選択的シクロオキシゲナーゼ−２阻害薬との組み合わせ |
| MXPA05000729A (es) * | 2002-07-17 | 2005-04-08 | Warner Lambert Co | Combinacion de un inhibidor alosterico de metaloproteinasa-13 de matriz con celecoxib o valdecoxib. |
-
2003
- 2003-07-07 BR BR0312736-2A patent/BR0312736A/pt not_active IP Right Cessation
- 2003-07-07 WO PCT/IB2003/003044 patent/WO2004006912A2/en not_active Ceased
- 2003-07-07 JP JP2004520998A patent/JP2006503811A/ja active Pending
- 2003-07-07 EP EP03740953A patent/EP1530467A2/en not_active Withdrawn
- 2003-07-07 CA CA002495432A patent/CA2495432A1/en not_active Abandoned
- 2003-07-07 MX MXPA05000754A patent/MXPA05000754A/es not_active Application Discontinuation
- 2003-07-07 AU AU2003281169A patent/AU2003281169A1/en not_active Abandoned
- 2003-07-15 US US10/619,662 patent/US20040019053A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1530467A2 (en) | 2005-05-18 |
| MXPA05000754A (es) | 2005-04-19 |
| WO2004006912A3 (en) | 2004-06-03 |
| JP2006503811A (ja) | 2006-02-02 |
| WO2004006912A2 (en) | 2004-01-22 |
| US20040019053A1 (en) | 2004-01-29 |
| AU2003281169A1 (en) | 2004-02-02 |
| CA2495432A1 (en) | 2004-01-22 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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