BR112012002251A2 - processo para fabricação de composto da fórmula (1), composto da fórmula (a), composto da fórmula (b), método analítico, composto da fórmula iv, compostos, processos, métodos e usos inovadores - Google Patents

processo para fabricação de composto da fórmula (1), composto da fórmula (a), composto da fórmula (b), método analítico, composto da fórmula iv, compostos, processos, métodos e usos inovadores

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Publication number
BR112012002251A2
BR112012002251A2 BR112012002251A BR112012002251A BR112012002251A2 BR 112012002251 A2 BR112012002251 A2 BR 112012002251A2 BR 112012002251 A BR112012002251 A BR 112012002251A BR 112012002251 A BR112012002251 A BR 112012002251A BR 112012002251 A2 BR112012002251 A2 BR 112012002251A2
Authority
BR
Brazil
Prior art keywords
formula
compound
processes
methods
analytical method
Prior art date
Application number
BR112012002251A
Other languages
English (en)
Other versions
BR112012002251B1 (pt
Inventor
Hans-Juergen Mair
James Anderson Wright
Roumen Nikolaev Radinov
Stefan Hildbrand
Yi Ren
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112012002251A2 publication Critical patent/BR112012002251A2/pt
Publication of BR112012002251B1 publication Critical patent/BR112012002251B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR112012002251A 2009-08-03 2010-07-30 processo para a fabricação do composto de fórmula (1), compostos, composição, método analítico e processo para a fabricação do composto (i) BR112012002251B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09167054 2009-08-03
EP09175101 2009-11-05
PCT/EP2010/061079 WO2011015522A2 (en) 2009-08-03 2010-07-30 Process for the manufacture of pharmaceutically active compounds

Publications (2)

Publication Number Publication Date
BR112012002251A2 true BR112012002251A2 (pt) 2016-06-14
BR112012002251B1 BR112012002251B1 (pt) 2020-05-19

Family

ID=42938195

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012002251A BR112012002251B1 (pt) 2009-08-03 2010-07-30 processo para a fabricação do composto de fórmula (1), compostos, composição, método analítico e processo para a fabricação do composto (i)

Country Status (16)

Country Link
US (3) US8329724B2 (pt)
EP (1) EP2462116B1 (pt)
JP (2) JP5784602B2 (pt)
KR (2) KR101461291B1 (pt)
CN (3) CN102574799B (pt)
AU (1) AU2010280848B2 (pt)
BR (1) BR112012002251B1 (pt)
CA (1) CA2768632C (pt)
DK (1) DK2462116T3 (pt)
ES (1) ES2513441T3 (pt)
IL (2) IL217755A (pt)
MX (3) MX340572B (pt)
PL (1) PL2462116T3 (pt)
SG (3) SG178208A1 (pt)
SI (1) SI2462116T1 (pt)
WO (1) WO2011015522A2 (pt)

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US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
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CN103626765B (zh) * 2012-08-27 2016-08-10 广东东阳光药业有限公司 取代的氮杂吲哚化合物及其盐、组合物和用途
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WO2017066193A1 (en) 2015-10-15 2017-04-20 Princeton Drug Discovery, Llc Novel inhibitors of protein kinases
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ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
US20180334457A1 (en) * 2017-05-18 2018-11-22 Shilpa Medicare Limited Substantially pure vemurafenib and its salts
CN110903254B (zh) * 2018-09-17 2022-11-25 苏州鹏旭医药科技有限公司 一种应用于jak抑制剂类药物杂环中间体的合成方法
CN109081840B (zh) * 2018-11-09 2020-04-24 郑州大学第一附属医院 一种5-溴-7-氮杂吲哚的制备方法
CN109575019B (zh) * 2018-12-26 2020-04-14 苏州闻智生物科技有限公司 一种5-溴-7-氮杂吲哚的制备方法
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EP4097234A1 (en) 2020-01-28 2022-12-07 Université de Strasbourg Antisense oligonucleotide targeting linc00518 for treating melanoma
WO2024003350A1 (en) 2022-06-30 2024-01-04 Universite De Strasbourg Combination therapy for melanoma
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