BR9608542A - Composição para a liberação sustentada de hormónio do crescimento humano - Google Patents
Composição para a liberação sustentada de hormónio do crescimento humanoInfo
- Publication number
- BR9608542A BR9608542A BR9608542-8A BR9608542A BR9608542A BR 9608542 A BR9608542 A BR 9608542A BR 9608542 A BR9608542 A BR 9608542A BR 9608542 A BR9608542 A BR 9608542A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- sustained release
- biologically active
- hgh
- polymer
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 10
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 10
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 10
- 239000000203 mixture Substances 0.000 title abstract 10
- 238000013268 sustained release Methods 0.000 title abstract 8
- 239000012730 sustained-release form Substances 0.000 title abstract 8
- 238000000034 method Methods 0.000 abstract 6
- 239000002245 particle Substances 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 4
- 229920000249 biocompatible polymer Polymers 0.000 abstract 3
- 230000036765 blood level Effects 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 230000002459 sustained effect Effects 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Medical Informatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
"COMPOSIçãO PARA A LIBERAçãO SUSTENTADA DE HORMÈNIO DO CRESCIMENTO HUMANO", compreendendo uma composição e métodos para formar e utilizar essa composição, para a liberação sustentada de hormónio do crescimento humano (hGH) estabilizado, biologicamente ativo. A composição de liberação sustentada desta invenção compreende uma matriz polimérica de um polímero biocompatível e partículas de hGH estabilizado, biologicamente ativo, onde essas partículas são dispersas dentro do polímero biocompatível. O método da invenção para produzir uma composição para liberação sustentada de hGH biologicamente ativo inclui a dissolução de um polímero biocompatível em um solvente de polímero para formar uma solução de polímero, dispersando as partículas de hGH de metal estabilizado por cátion, biologicamente ativo na solução de polímero, e a seguir solidificando o polímero para formar uma matriz polimérica contendo uma dispersão dessas partículas de hGH. O método para utilizar a composição da invenção é o método de fornecer um nível sang³íneo terapeuticamente eficaz de hGH não agregado, biologicamente ativo em um sujeito por um período sustentado. Neste método, um sujeito recebe uma dose eficaz da composição de liberação sustentada da presente invenção. O método de utilização da composição de liberação sustentada da presente invenção compreende o fornecimento de um nível sang³íneo terapeuticamente eficaz de hormónio do crescimento humano não agregado, biologicamente ativo em um sujeito por um período sustentado, administrando ao sujeito uma dose da dita composição de liberação sustentada.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/473,544 US5654010A (en) | 1992-12-02 | 1995-06-07 | Composition for sustained release of human growth hormone |
| US08/477,725 US5667808A (en) | 1992-12-02 | 1995-06-07 | Composition for sustained release of human growth hormone |
| PCT/US1996/008086 WO1996040072A2 (en) | 1995-06-07 | 1996-06-03 | Composition for sustained release of human growth hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9608542A true BR9608542A (pt) | 1999-11-30 |
Family
ID=27044171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9608542-8A BR9608542A (pt) | 1995-06-07 | 1996-06-03 | Composição para a liberação sustentada de hormónio do crescimento humano |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0831787B1 (pt) |
| JP (1) | JPH11506740A (pt) |
| CN (1) | CN1102854C (pt) |
| AT (1) | ATE204468T1 (pt) |
| AU (1) | AU708756B2 (pt) |
| BR (1) | BR9608542A (pt) |
| CA (1) | CA2223436A1 (pt) |
| CZ (1) | CZ288147B6 (pt) |
| DE (1) | DE69614685T2 (pt) |
| DK (1) | DK0831787T3 (pt) |
| ES (1) | ES2161366T3 (pt) |
| HU (1) | HUP9900870A3 (pt) |
| IL (1) | IL122385A (pt) |
| MX (1) | MX9709698A (pt) |
| NO (1) | NO316104B1 (pt) |
| NZ (1) | NZ310644A (pt) |
| PL (1) | PL184531B1 (pt) |
| PT (1) | PT831787E (pt) |
| RU (1) | RU2161502C2 (pt) |
| SK (1) | SK281571B6 (pt) |
| WO (1) | WO1996040072A2 (pt) |
Families Citing this family (102)
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|---|---|---|---|---|
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| US6306826B1 (en) | 1997-06-04 | 2001-10-23 | The Regents Of The University Of California | Treatment of heart failure with growth hormone |
| US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
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| US6191107B1 (en) | 1997-09-26 | 2001-02-20 | Takeda Chemical Industries, Ltd. | Complex of human growth hormone and zinc |
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| CA3239550A1 (en) | 2021-12-10 | 2023-06-15 | Kenneth Petersen | Treatment of nociceptive pain |
| JP2025515486A (ja) | 2022-04-29 | 2025-05-15 | ピュリノミア バイオテック， インコーポレイテッド | 好酸球駆動性疾患及び障害を治療するための方法及び組成物 |
| WO2025076280A1 (en) | 2023-10-05 | 2025-04-10 | Ashibio, Inc. | Methods and compositions for treating mmp-9 mediated disorders |
| WO2026076260A1 (en) | 2024-10-03 | 2026-04-09 | Ashibio, Inc. | Methods and compositions for mmp-9 inhibition for use with non-genetic heterotopic ossification disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| HUT35524A (en) * | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| WO1994012158A1 (en) * | 1992-12-02 | 1994-06-09 | Alkermes Controlled Therapeutics, Inc. | Controlled release growth hormone containing microspheres |
| DE69426292T2 (de) * | 1993-02-23 | 2001-05-17 | Genentech, Inc. | Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff |
| DK0779806T3 (da) * | 1994-09-09 | 2000-11-27 | Takeda Chemical Industries Ltd | Præparat til forsinket frigivelse indeholdende et metalsalt af et peptid |
-
1996
- 1996-06-03 NZ NZ310644A patent/NZ310644A/xx unknown
- 1996-06-03 HU HU9900870A patent/HUP9900870A3/hu unknown
- 1996-06-03 JP JP9500870A patent/JPH11506740A/ja active Pending
- 1996-06-03 CZ CZ19973907A patent/CZ288147B6/cs not_active IP Right Cessation
- 1996-06-03 RU RU97119935/14A patent/RU2161502C2/ru not_active IP Right Cessation
- 1996-06-03 AT AT96919016T patent/ATE204468T1/de not_active IP Right Cessation
- 1996-06-03 DE DE69614685T patent/DE69614685T2/de not_active Expired - Fee Related
- 1996-06-03 AU AU61469/96A patent/AU708756B2/en not_active Ceased
- 1996-06-03 IL IL12238596A patent/IL122385A/xx not_active IP Right Cessation
- 1996-06-03 SK SK1671-97A patent/SK281571B6/sk unknown
- 1996-06-03 WO PCT/US1996/008086 patent/WO1996040072A2/en not_active Ceased
- 1996-06-03 PT PT96919016T patent/PT831787E/pt unknown
- 1996-06-03 ES ES96919016T patent/ES2161366T3/es not_active Expired - Lifetime
- 1996-06-03 BR BR9608542-8A patent/BR9608542A/pt not_active Application Discontinuation
- 1996-06-03 CN CN96194614A patent/CN1102854C/zh not_active Expired - Fee Related
- 1996-06-03 PL PL96323832A patent/PL184531B1/pl not_active IP Right Cessation
- 1996-06-03 EP EP96919016A patent/EP0831787B1/en not_active Expired - Lifetime
- 1996-06-03 CA CA002223436A patent/CA2223436A1/en not_active Abandoned
- 1996-06-03 DK DK96919016T patent/DK0831787T3/da active
-
1997
- 1997-12-05 MX MX9709698A patent/MX9709698A/es not_active IP Right Cessation
- 1997-12-05 NO NO19975708A patent/NO316104B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6146996A (en) | 1996-12-30 |
| CN1102854C (zh) | 2003-03-12 |
| IL122385A0 (en) | 1998-06-15 |
| NO975708L (no) | 1998-02-05 |
| IL122385A (en) | 2001-01-11 |
| DK0831787T3 (da) | 2001-12-17 |
| NZ310644A (en) | 1999-08-30 |
| MX9709698A (es) | 1998-07-31 |
| CZ390797A3 (cs) | 1998-07-15 |
| ES2161366T3 (es) | 2001-12-01 |
| HUP9900870A2 (hu) | 1999-09-28 |
| PL323832A1 (en) | 1998-04-27 |
| HUP9900870A3 (en) | 2001-04-28 |
| CZ288147B6 (en) | 2001-05-16 |
| PT831787E (pt) | 2002-02-28 |
| CN1187120A (zh) | 1998-07-08 |
| EP0831787B1 (en) | 2001-08-22 |
| DE69614685T2 (de) | 2002-06-27 |
| RU2161502C2 (ru) | 2001-01-10 |
| WO1996040072A2 (en) | 1996-12-19 |
| CA2223436A1 (en) | 1996-12-19 |
| JPH11506740A (ja) | 1999-06-15 |
| WO1996040072A3 (en) | 1997-01-23 |
| ATE204468T1 (de) | 2001-09-15 |
| SK281571B6 (sk) | 2001-05-10 |
| SK167197A3 (en) | 1998-06-03 |
| DE69614685D1 (de) | 2001-09-27 |
| PL184531B1 (pl) | 2002-11-29 |
| NO316104B1 (no) | 2003-12-15 |
| AU708756B2 (en) | 1999-08-12 |
| EP0831787A2 (en) | 1998-04-01 |
| NO975708D0 (no) | 1997-12-05 |
| HK1009089A1 (en) | 1999-09-10 |
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