BRPI0008197B8 - microcápsulas para a liberação prolongada de fármacos - Google Patents

microcápsulas para a liberação prolongada de fármacos

Info

Publication number
BRPI0008197B8
BRPI0008197B8 BRPI0008197A BR0008197A BRPI0008197B8 BR PI0008197 B8 BRPI0008197 B8 BR PI0008197B8 BR PI0008197 A BRPI0008197 A BR PI0008197A BR 0008197 A BR0008197 A BR 0008197A BR PI0008197 B8 BRPI0008197 B8 BR PI0008197B8
Authority
BR
Brazil
Prior art keywords
microcapsules
drug release
prolonged drug
prolonged
plasticiser
Prior art date
Application number
BRPI0008197A
Other languages
English (en)
Other versions
BR0008197A (pt
BRPI0008197B1 (pt
Inventor
Bonilla Muñoz Angel
PARENTE DUEÑA Antonio
Cumillera Colome David
Garces Garces Josep
Original Assignee
Gp Pharm Sa
Lipotec Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gp Pharm Sa, Lipotec Sa filed Critical Gp Pharm Sa
Publication of BR0008197A publication Critical patent/BR0008197A/pt
Publication of BRPI0008197B1 publication Critical patent/BRPI0008197B1/pt
Publication of BRPI0008197B8 publication Critical patent/BRPI0008197B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"microcápsulas para a liberação prolongada de fármacos". microcápsulas para a liberação lenta de fármacos, que são constituídas por um copolímero láctico-co-glicólico, ao qual foi incorporado um plastificante e que contém em seu interior um fármaco de interesse farmacêutico.
BRPI0008197A 1999-12-17 2000-12-15 microcápsulas para a liberação prolongada de fármacos BRPI0008197B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009902768A ES2169980B1 (es) 1999-12-17 1999-12-17 Microcapsulas para la liberacion prolongada de farmacos.
PCT/ES2000/000475 WO2001043724A1 (es) 1999-12-17 2000-12-15 Microcapsulas para la liberacion prolongada de farmacos

Publications (3)

Publication Number Publication Date
BR0008197A BR0008197A (pt) 2002-01-22
BRPI0008197B1 BRPI0008197B1 (pt) 2017-05-09
BRPI0008197B8 true BRPI0008197B8 (pt) 2021-05-25

Family

ID=8310957

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0008197A BRPI0008197B8 (pt) 1999-12-17 2000-12-15 microcápsulas para a liberação prolongada de fármacos

Country Status (13)

Country Link
US (3) US20020187196A1 (pt)
EP (1) EP1151746B1 (pt)
JP (1) JP5021880B2 (pt)
AT (1) ATE234608T1 (pt)
AU (1) AU774680B2 (pt)
BR (1) BRPI0008197B8 (pt)
CA (1) CA2362769C (pt)
DE (1) DE60001717T2 (pt)
DK (1) DK1151746T3 (pt)
ES (2) ES2169980B1 (pt)
MX (1) MXPA01008348A (pt)
PT (1) PT1151746E (pt)
WO (1) WO2001043724A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US20090110744A1 (en) * 2005-03-01 2009-04-30 Sun Pharma Advanced Research Company Limited Sustained release pharmaceutical compositions
CA2631811C (en) * 2005-12-22 2017-06-20 Novartis Ag Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
ES2324009B1 (es) * 2007-11-23 2010-05-21 Gp Pharm S.A. Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo.
CN104080905B (zh) * 2011-12-22 2016-11-16 生命技术公司 细胞培养基和方法
CN105267153B (zh) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 一种曲普瑞林缓释微粒及其制备方法
CN110954491B (zh) * 2019-12-09 2022-11-15 北京博恩特药业有限公司 用于测量醋酸戈舍瑞林缓释植入剂体外溶出度的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2151185A (en) * 1936-01-16 1939-03-21 Carbide & Carbon Chem Corp Esters of glycol monoesters and acylated hydroxy acids
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
WO1981003565A1 (en) 1980-05-29 1981-12-10 H Nicklaus Stringed musical instrument teaching device and process
GB2132887A (en) * 1982-11-15 1984-07-18 Procter & Gamble Enteric-coated anti-inflammatory compositions
CH661206A5 (fr) 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE61935T1 (de) 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
CH665558A5 (en) 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
CH679207A5 (pt) 1989-07-28 1992-01-15 Debiopharm Sa
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
SE9100610D0 (sv) * 1991-03-04 1991-03-04 Procordia Ortech Ab Bioresorbable material for medical use
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
NZ263685A (en) 1993-03-15 1997-08-22 Univ Michiganthe Board Of Rege Device for controlling heart rhythm comprising eledevice for controlling heart rhythm comprising electrode assembly for attachment to the heart and a ctrode assembly for attachment to the heart and a controlled release matrix comprising an antiarrhytcontrolled release matrix comprising an antiarrhythmic agent hmic agent
CN1191787C (zh) 1995-10-05 2005-03-09 株式会社东芝 X射线摄像装置
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US6589511B1 (en) * 1997-03-18 2003-07-08 Sunstar, Inc. Composition for forming solid particles
GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels

Also Published As

Publication number Publication date
PT1151746E (pt) 2003-07-31
CA2362769C (en) 2008-09-09
ES2169980A1 (es) 2002-07-16
BR0008197A (pt) 2002-01-22
JP5021880B2 (ja) 2012-09-12
DK1151746T3 (da) 2003-07-21
WO2001043724A1 (es) 2001-06-21
MXPA01008348A (es) 2004-03-19
CA2362769A1 (en) 2001-06-21
EP1151746B1 (en) 2003-03-19
DE60001717T2 (de) 2004-03-18
ES2194793T3 (es) 2003-12-01
BRPI0008197B1 (pt) 2017-05-09
ES2169980B1 (es) 2003-11-01
EP1151746A1 (en) 2001-11-07
US20050123618A1 (en) 2005-06-09
AU2173501A (en) 2001-06-25
US20020187196A1 (en) 2002-12-12
ATE234608T1 (de) 2003-04-15
AU774680B2 (en) 2004-07-01
JP2003516960A (ja) 2003-05-20
US9789064B2 (en) 2017-10-17
US20080233198A1 (en) 2008-09-25
DE60001717D1 (de) 2003-04-24

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIDO O PEDIDO COM BASE NOS ARTIGOS 8O E 11 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: GP-PHARM, S.A. (ES)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/12/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 15/12/2020