BRPI0615394B8 - composições oftálmicas de cetotifeno estabilizadas e conservadas - Google Patents

composições oftálmicas de cetotifeno estabilizadas e conservadas

Info

Publication number
BRPI0615394B8
BRPI0615394B8 BRPI0615394A BRPI0615394A BRPI0615394B8 BR PI0615394 B8 BRPI0615394 B8 BR PI0615394B8 BR PI0615394 A BRPI0615394 A BR PI0615394A BR PI0615394 A BRPI0615394 A BR PI0615394A BR PI0615394 B8 BRPI0615394 B8 BR PI0615394B8
Authority
BR
Brazil
Prior art keywords
stabilized
ophthalmic compositions
preserved
hydrogen peroxide
ketotifen
Prior art date
Application number
BRPI0615394A
Other languages
English (en)
Inventor
Tsao Fu-Pao
P Wong Michelle
Fong Yen Shau
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0615394A2 publication Critical patent/BRPI0615394A2/pt
Publication of BRPI0615394B1 publication Critical patent/BRPI0615394B1/pt
Publication of BRPI0615394B8 publication Critical patent/BRPI0615394B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

composições oftálmicas de cetotifeno estabilizadas e conservadas. a presente invenção refere-se a composições oftálmicas com- preendendo cetotifeno e uma fonte de peróxido de hidrogênio, a dita fonte proporcionando uma quantidade de peróxido de hidrogênio de cerca de 0,001 a cerca de 0,1% (peso/volume) de peróxido de hidrogênio e a métodos para o tratamento e prevenção de conjuntivite alérgica mediante uso das composições aqui proporcionadas.
BRPI0615394A 2005-08-26 2006-08-24 composições oftálmicas de cetotifeno estabilizadas e conservadas BRPI0615394B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/212,959 2005-08-26
US11/212,959 US20070048389A1 (en) 2005-08-26 2005-08-26 Stabilized and preserved ketotifen ophthalmic compositions
PCT/US2006/033161 WO2007025092A2 (en) 2005-08-26 2006-08-24 Stabilized and preserved ketotifen ophthalmic compositions

Publications (3)

Publication Number Publication Date
BRPI0615394A2 BRPI0615394A2 (pt) 2011-05-17
BRPI0615394B1 BRPI0615394B1 (pt) 2020-05-19
BRPI0615394B8 true BRPI0615394B8 (pt) 2021-05-25

Family

ID=37441908

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0615394A BRPI0615394B8 (pt) 2005-08-26 2006-08-24 composições oftálmicas de cetotifeno estabilizadas e conservadas

Country Status (12)

Country Link
US (5) US20070048389A1 (pt)
EP (2) EP1922059B1 (pt)
JP (1) JP5111372B2 (pt)
KR (1) KR20080042144A (pt)
CN (1) CN101252911A (pt)
AU (2) AU2006282978A1 (pt)
BR (1) BRPI0615394B8 (pt)
CA (1) CA2619582C (pt)
ES (2) ES2592914T3 (pt)
MX (1) MX2008002654A (pt)
RU (1) RU2444361C2 (pt)
WO (1) WO2007025092A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010226249A1 (en) * 2009-03-17 2011-10-13 Aciex Therapeutics, Inc. Ophthalmic formulations of ketotifen and methods of use
WO2022006653A1 (en) * 2020-07-09 2022-01-13 Aliya Pharmaceuticals Inc. Anti-cancer activity of perborate salts

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614646A (en) * 1984-12-24 1986-09-30 The Dow Chemical Company Stabilization of peroxide systems in the presence of alkaline earth metal ions
IL91131A (en) * 1988-08-04 1993-06-10 Ciba Geigy Ag Method of preserving ophthalmic solutions using a hydrogen peroxide source and compositions therefor
US5607698A (en) * 1988-08-04 1997-03-04 Ciba-Geigy Corporation Method of preserving ophthalmic solution and compositions therefor
DE4023086A1 (de) * 1990-07-20 1992-01-23 Hoechst Ag Methode zur behandlung von allergischer konjunktivitis
US5958957A (en) * 1996-04-19 1999-09-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US6265444B1 (en) * 1997-05-23 2001-07-24 Insite Vision Incorporated Ophthalmic composition
EP0938896A1 (en) * 1998-01-15 1999-09-01 Novartis AG Autoclavable pharmaceutical compositions containing a chelating agent
WO2000019981A1 (en) * 1998-10-08 2000-04-13 Karagoezian Hampar L Synergistic antimicrobial, dermatological and ophthalmic preparations containing chlorite and hydrogen peroxide
GB9824160D0 (en) * 1998-11-04 1998-12-30 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US6777429B1 (en) * 1999-07-23 2004-08-17 Novartis Ag Ophthalmic composition
RU2266115C2 (ru) * 1999-09-13 2005-12-20 Бридж Фарма, Инк. Оптически активные изомеры кетотифена и их терапевтически активные метаболиты
US6531128B1 (en) * 2000-02-08 2003-03-11 Pharmacia Corporation Methods for treating glaucoma
CA2404226A1 (en) * 2000-03-23 2001-09-27 Takeda Chemical Industries, Ltd. Furoisoquinoline derivatives, process for producing the same and use thereof
JP2004509925A (ja) * 2000-09-28 2004-04-02 ノバルティス　アクチエンゲゼルシャフト 安定化過酸化水素溶液
RU2193403C1 (ru) * 2001-05-23 2002-11-27 Московский научно-исследовательский институт глазных болезней им. Гельмгольца Глазные капли для лечения аллергических конъюнктивитов и кератоконъюнктивитов
AR034372A1 (es) * 2001-06-08 2004-02-18 Novartis Ag Composiciones farmaceuticas
PE20030263A1 (es) * 2001-07-31 2003-04-17 Novartis Ag Composicion farmaceutica oftalmica
US20070092582A1 (en) * 2002-01-18 2007-04-26 Fu-Pao Tsao Methods of preserving ophthalmic solutions and preserved ophthalmic solutions
PT1534313E (pt) * 2002-07-30 2013-01-25 Omeros Corp Soluções e método de irrigação oftalmológica
US20050244509A1 (en) * 2004-03-17 2005-11-03 Fu-Pao Tsao Ophthalmic solutions
US20070048388A1 (en) * 2005-08-26 2007-03-01 Fu-Pao Tsao Stabilized and preserved ketotifen ophthalmic compositions
JP4858306B2 (ja) 2006-07-27 2012-01-18 株式会社デンソー 熱電変換装置の製造方法

Also Published As

Publication number Publication date
ES2585777T3 (es) 2016-10-10
CN101252911A (zh) 2008-08-27
US20120157496A1 (en) 2012-06-21
JP2009506064A (ja) 2009-02-12
CA2619582C (en) 2014-11-18
AU2010235948B2 (en) 2011-09-22
WO2007025092A2 (en) 2007-03-01
EP2343048A3 (en) 2011-08-03
BRPI0615394B1 (pt) 2020-05-19
US20130165480A1 (en) 2013-06-27
US20110028516A1 (en) 2011-02-03
ES2592914T3 (es) 2016-12-02
RU2008111065A (ru) 2009-10-10
JP5111372B2 (ja) 2013-01-09
CA2619582A1 (en) 2007-03-01
AU2010235948A1 (en) 2010-11-11
EP1922059A2 (en) 2008-05-21
WO2007025092A3 (en) 2007-09-27
EP2343048A2 (en) 2011-07-13
MX2008002654A (es) 2008-03-18
EP2343048B1 (en) 2016-05-04
AU2006282978A1 (en) 2007-03-01
RU2444361C2 (ru) 2012-03-10
KR20080042144A (ko) 2008-05-14
US20070048389A1 (en) 2007-03-01
US20080207692A1 (en) 2008-08-28
EP1922059B1 (en) 2016-06-22
BRPI0615394A2 (pt) 2011-05-17

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/05/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/08/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF