CA1270350C - Amino thio dipeptides - Google Patents

Amino thio dipeptides

Info

Publication number: CA1270350C
Authority: CA; Canada
Prior art keywords: dipeptides; amino thio; useful; inhibition activity; amino thiol
Prior art date: 1984-04-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA477942A

Other languages

English (en)

Other versions

CA1270350A (fr

Inventor

Eric M Gordon

Jollie D Godfrey

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-19

Filing date

1985-03-29

Publication date

1990-06-12

1984-04-19 Priority claimed from US06/602,030 external-priority patent/US4500518A/en

1985-03-29 Application filed filed Critical

1985-03-29 Priority to CA000477942A priority Critical patent/CA1270350A/fr

1989-03-31 Priority to CA000595459A priority patent/CA1291482C/fr

1989-03-31 Priority to CA000595458A priority patent/CA1291481C/fr

1990-06-12 Application granted granted Critical

1990-06-12 Publication of CA1270350C publication Critical patent/CA1270350C/fr

1990-06-12 Publication of CA1270350A publication Critical patent/CA1270350A/fr

2007-06-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

108010016626 Dipeptides Proteins 0.000 title abstract 3
-1 Amino thio Chemical group 0.000 title 1
230000000694 effects Effects 0.000 abstract 2
230000005764 inhibitory process Effects 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
102000003729 Neprilysin Human genes 0.000 abstract 1
108090000028 Neprilysin Proteins 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
125000005365 aminothiol group Chemical group 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
RSPCKAHMRANGJZ-UHFFFAOYSA-N thiohydroxylamine Chemical compound SN RSPCKAHMRANGJZ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

CA000477942A 1984-04-19 1985-03-29 Amino thio dipeptides Expired - Lifetime CA1270350A (fr)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
CA000477942A CA1270350A (fr)	1984-04-19	1985-03-29	Amino thio dipeptides
CA000595459A CA1291482C (fr)	1984-04-19	1989-03-31	Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues
CA000595458A CA1291481C (fr)	1984-04-19	1989-03-31	Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US06/602,030 US4500518A (en)	1984-04-19	1984-04-19	Amino thiol dipeptides
US602,030		1984-04-19
CA000477942A CA1270350A (fr)	1984-04-19	1985-03-29	Amino thio dipeptides

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
CA000595459A Division CA1291482C (fr)	1984-04-19	1989-03-31	Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues
CA000595458A Division CA1291481C (fr)	1984-04-19	1989-03-31	Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol

Publications (2)

Publication Number	Publication Date
CA1270350C true CA1270350C (fr)	1990-06-12
CA1270350A CA1270350A (fr)	1990-06-12

Family

ID=25670630

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CA000477942A Expired - Lifetime CA1270350A (fr)	1984-04-19	1985-03-29	Amino thio dipeptides
CA000595459A Expired - Lifetime CA1291482C (fr)	1984-04-19	1989-03-31	Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues
CA000595458A Expired - Fee Related CA1291481C (fr)	1984-04-19	1989-03-31	Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
CA000595459A Expired - Lifetime CA1291482C (fr)	1984-04-19	1989-03-31	Intermediaires utilises dans la preparation de dipeptides d'aminothiol substitues
CA000595458A Expired - Fee Related CA1291481C (fr)	1984-04-19	1989-03-31	Intermediaires utiles dans la preparation de dipetides substitues par un aminothiol

Country Status (1)

Country	Link
CA (3)	CA1270350A (fr)

1985
- 1985-03-29 CA CA000477942A patent/CA1270350A/fr not_active Expired - Lifetime
1989
- 1989-03-31 CA CA000595459A patent/CA1291482C/fr not_active Expired - Lifetime
- 1989-03-31 CA CA000595458A patent/CA1291481C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA1291481C (fr)	1991-10-29
CA1291482C (fr)	1991-10-29
CA1270350A (fr)	1990-06-12

Legal Events

Date	Code	Title	Description
1995-12-12	MKLA	Lapsed
2023-05-26	MKLA	Lapsed	Effective date: 19951212

Publication	Publication Date	Title
DE3478606D1 (en)	1989-07-13	Hydroxy substituted peptide compounds
DE3368639D1 (en)	1987-02-05	Amino and substituted amino phosphinylalkanoyl compounds
DE3265360D1 (en)	1985-09-19	Amino and substituted amino phosphinyl-alkanoyl compositions
DE3277302D1 (en)	1987-10-22	Phosphorus containing compounds
IE812729L (en)	1982-05-24	Carboxyalkyl amino acid derivatives of various substituted¹prolines
IN162814B (fr)	1988-07-09
ZA952098B (en)	1995-12-11	Inhibition of hair growth
DE3366019D1 (en)	1986-10-16	Phosphinylalkanoyl substituted imino acids
AU572284B2 (en)	1988-05-05	Synthesis of urea
CA1269496C (fr)	1990-05-22	Mercaptocycloalcoylcarbonyl- et mercaptoarylcarbonyldipeptides
EP0158947A3 (en)	1988-08-24	Amino thiol dipeptides
CA1269666C (fr)	1990-05-29	Derives de substitution acylalcoylaminocarbonyles d'amino- et d'imino-acides
ES8609728A1 (es)	1986-09-01	Una composicion de conjugado de enzima estabilizado
SE8304031D0 (sv)	1983-07-18	Substituerade peptidforeningar
CA1270350C (fr)	1990-06-12	Amino thio dipeptides
DE3666826D1 (en)	1989-12-14	Human natural inhibitor of collagenases
SU1167881A1 (ru)	1996-03-27	Фенилгидразид морфолинодиэтилуксусной кислоты, обладающий противотуберкулезным действием
ZA853070B (en)	1985-12-24	Substituted dipeptides as inhibitors of enkephalinases