CA2063912A1 - Analgesic use of benzobicyclic carboxamides - Google Patents

Analgesic use of benzobicyclic carboxamides

Info

Publication number: CA2063912A1
Authority: CA; Canada
Prior art keywords: hydrogen; amino; formula; complete; atoms necessary
Prior art date: 1991-04-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002063912A

Other languages

English (en)

French (fr)

Inventor

Anthony R. Imondi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-05

Filing date

1992-03-25

Publication date

1992-10-06

1992-03-25 Application filed by Individual filed Critical Individual

1992-10-06 Publication of CA2063912A1 publication Critical patent/CA2063912A1/en

Status Abandoned legal-status Critical Current

Links

230000000202 analgesic effect Effects 0.000 title claims abstract description 20
150000003857 carboxamides Chemical class 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 58
238000000034 method Methods 0.000 claims abstract description 29
150000003839 salts Chemical class 0.000 claims abstract description 8
239000001257 hydrogen Substances 0.000 claims description 45
229910052739 hydrogen Inorganic materials 0.000 claims description 45
125000000217 alkyl group Chemical group 0.000 claims description 23
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 23
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 21
150000002431 hydrogen Chemical class 0.000 claims description 19
125000004429 atom Chemical group 0.000 claims description 16
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
-1 acylamido Chemical group 0.000 claims description 12
125000000753 cycloalkyl group Chemical group 0.000 claims description 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
229910052799 carbon Inorganic materials 0.000 claims description 10
239000000460 chlorine Substances 0.000 claims description 10
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125000004344 phenylpropyl group Chemical group 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
230000028527 righting reflex Effects 0.000 description 1
239000000523 sample Substances 0.000 description 1
230000036280 sedation Effects 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
210000001186 vagus nerve Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CA002063912A 1991-04-05 1992-03-25 Analgesic use of benzobicyclic carboxamides Abandoned CA2063912A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US681,183		1991-04-05
US07/681,183 US5122528A (en)	1983-12-22	1991-04-05	Analgesic use of benzobicyclic carboxamides

Publications (1)

Publication Number	Publication Date
CA2063912A1 true CA2063912A1 (en)	1992-10-06

Family

ID=24734182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002063912A Abandoned CA2063912A1 (en)	1991-04-05	1992-03-25	Analgesic use of benzobicyclic carboxamides

Country Status (6)

Country	Link
US (1)	US5122528A (de)
EP (1)	EP0507637A3 (de)
JP (1)	JPH06172172A (de)
AU (1)	AU1402092A (de)
CA (1)	CA2063912A1 (de)
ZA (1)	ZA922145B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0625149A1 (de) *	1992-02-06	1994-11-23	Smithkline Beecham Plc	Benzopyran-, Benzothiopyran- und Benzofuran-Derivate als 5-HT4-Antagonisten
GB9507882D0 (en) *	1995-04-18	1995-05-31	Pharmacia Spa	Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
ES2327600T3 (es)	1999-02-18	2009-11-02	Novasearch Ag	Uso de antagonistas del receptor de la 5-ht3 para el tratamiento de enfermedades musculoesqueleticas.
JP2005527472A (ja) *	2001-09-12	2005-09-15	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	疾患治療のための置換された７−アザ［２．２．１］ビシクロヘプタン
US6951868B2 (en)	2001-11-09	2005-10-04	Pfizer Inc.	Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
NZ560969A (en)	2005-02-17	2010-08-27	Albany Molecular Res Inc	Benzoxazole carboxamides for treating chemotherapy-induced vomiting and irritable bowel syndrome
KR20180011888A (ko)	2008-11-19	2018-02-02	포럼 파마슈티칼즈 인크.	(ｒ)-７-클로로-ｎ-(퀴누클리딘-３-일)벤조［ｂ］티오펜-２-카르복사미드 및 그 약학적으로 허용가능한 염을 이용한 인지 장애의 치료
AR081402A1 (es)	2010-05-17	2012-08-29	Envivo Pharmaceuticals Inc	Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
CA2872005A1 (en)	2012-05-08	2013-11-14	Forum Pharmaceuticals, Inc.	Methods of maintaining, treating or improving cognitive function

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59186969A (ja) *	1983-04-08	1984-10-23	Yoshitomi Pharmaceut Ind Ltd	ベンゾフラン−およびベンゾピランカルボキサミド誘導体
DE3429830A1 (de) *	1983-08-26	1985-03-07	Sandoz-Patent-GmbH, 7850 Lörrach	Automatische carbonsaeure- und sulfonsaeureester oder -amide
US4888353A (en) *	1986-02-28	1989-12-19	Erbamont, Inc.	Carboxamides useful as antiemetic or antipsychotic agents
FR2557110B1 (fr) *	1983-12-23	1989-11-24	Sandoz Sa	Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
CH667657A5 (de) *	1985-01-07	1988-10-31	Sandoz Ag	Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
DE201165T1 (de) *	1985-03-14	1989-04-20	Beecham Group P.L.C., Brentford	Arzneimittel zur behandlung von emesis, anxietas und "irritable bowel syndrome".
GB8525844D0 (en) *	1985-10-19	1985-11-20	Beecham Group Plc	Compounds
JPH0649700B2 (ja) *	1987-07-21	1994-06-29	吉富製薬株式会社	ベンゾフラン化合物
ZA886585B (en) *	1987-09-08	1990-05-30	Lilly Co Eli	Specific 5-ht,antagonists
CA1304082C (en) *	1987-10-22	1992-06-23	Tetsuya Tahara	Benzoxazine compounds and pharmaceutical use thereof
US4859683A (en) *	1988-02-04	1989-08-22	Rorer Pharmaceutical Corporation	Certain benzoxepins and their pharmaceutical compositions and methods
US4857517A (en) *	1988-02-04	1989-08-15	Rorer Pharmaceutical Corporation	Quinuclidyl benzoxepins as 5-HT3 antagonists
US4863921A (en) *	1988-04-27	1989-09-05	Rorer Pharmaceutical Corporation	Dibenzofurancarboxamides and their pharmaceutical compositions and methods
US4920219A (en) *	1988-11-29	1990-04-24	Rorer Pharmaceutical Corp.	Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents

1991
- 1991-04-05 US US07/681,183 patent/US5122528A/en not_active Expired - Lifetime
1992
- 1992-03-24 ZA ZA922145A patent/ZA922145B/xx unknown
- 1992-03-25 CA CA002063912A patent/CA2063912A1/en not_active Abandoned
- 1992-04-03 JP JP4082396A patent/JPH06172172A/ja not_active Withdrawn
- 1992-04-03 AU AU14020/92A patent/AU1402092A/en not_active Abandoned
- 1992-04-06 EP EP19920303025 patent/EP0507637A3/de not_active Withdrawn

Also Published As

Publication number	Publication date
EP0507637A3 (de)	1992-11-19
AU1402092A (en)	1992-10-08
JPH06172172A (ja)	1994-06-21
EP0507637A2 (de)	1992-10-07
ZA922145B (en)	1993-01-27
US5122528A (en)	1992-06-16

Legal Events

Date	Code	Title	Description
1998-03-25	FZDE	Discontinued

Publication	Publication Date	Title
US5011846A (en)	1991-04-30	Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
TWI224102B (en)	2004-11-21	Serotonergic agents
JPH02237920A (ja)	1990-09-20	胃腸病処置剤
PT98929B (pt)	1999-02-26	Processo para a preparacao de antagonistas de receptores muscarinicos, nomeadamente compostos azabi- ou triciclicos
US5342845A (en)	1994-08-30	Indole derivatives and drugs
AU654984B2 (en)	1994-12-01	Method for alleviating anxiety using benzobicyclic carboxamides
US6107328A (en)	2000-08-22	Use of 5HT1B receptor antagonist for the treatment of vascular disease
JPH03163083A (ja)	1991-07-15	抗咳剤としてのエンドエテノ／エンドエタノ―エポキシモルヒナン誘導体の（＋）―アイソマー
JP2502343B2 (ja)	1996-05-29	薬学的に活性な置換ベンズアミド
CA2063912A1 (en)	1992-10-06	Analgesic use of benzobicyclic carboxamides
EP0518767B1 (de)	2002-03-13	Amid-Analoge-Derivate von bestimmten methanoverbrückten Chinolizinen
CN114149423A (zh)	2022-03-08	四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
IE83573B1 (en)		Derivatives of amide analogs of certain methano bridged quinolizines
CN100400540C (zh)	2008-07-09	作为抗抑郁药的异唑啉衍生物
US5955470A (en)	1999-09-21	Derivatives of amide analogs of certain methano bridged quinolizines
CA2038025C (en)	2005-12-20	Optically active alkylenedioxybenzene derivatives and their use in therapy
US7816362B2 (en)	2010-10-19	Serotonergic agents
JP2004501060A (ja)	2004-01-15	オピオイド受容体に対する親和性を有する３級アミノ化合物
SU1398771A3 (ru)	1988-06-15	Способ получени замещенных бензамидов
US5234948A (en)	1993-08-10	Optically active alkylenedioxybenzene derivatives and their use in therapy
JP2638189B2 (ja)	1997-08-06	カルボン酸イミド又はその酸付加塩及び抗不整脈剤
JPH04500811A (ja)	1992-02-13	ムスカリン様物質レセプター拮抗薬
JP3029870B2 (ja)	2000-04-10	キノリン誘導体
JPH05501711A (ja)	1993-04-02	ムスカリン性受容体拮抗剤
JPH01224374A (ja)	1989-09-07	エルゴリン誘導体