CA2179889A1 - Inhibiteurs de serine proteases portant un groupe chelateur - Google Patents

Inhibiteurs de serine proteases portant un groupe chelateur

Info

Publication number
CA2179889A1
CA2179889A1 CA002179889A CA2179889A CA2179889A1 CA 2179889 A1 CA2179889 A1 CA 2179889A1 CA 002179889 A CA002179889 A CA 002179889A CA 2179889 A CA2179889 A CA 2179889A CA 2179889 A1 CA2179889 A1 CA 2179889A1
Authority
CA
Canada
Prior art keywords
group
peptide
formula
acid
chelating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002179889A
Other languages
English (en)
Inventor
Rainer Metternich
Carlo Tapparelli
Anette Wienand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2179889A1 publication Critical patent/CA2179889A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention se rapporte à un peptide inhibant une sérine protéase analogue à la trypsine ou un pseudo-peptide portant un groupe chélateur capable de complexer un élément détectable, le groupe chélateur étant lié à un groupe amino du peptide ou du pseudo-peptide de sorte que ce groupe chélateur n'interfère pas avec la thrombine ou empêche la liaison du peptide ou du pseudo-peptide à celle-ci. L'invention se rapporte de préférence à un composé de la formule (I) ou (II) se présentant sous une forme libre, sous forme de sel ou sous forme d'un complexe, par ex. un complexe avec un élément détectable, à la préparation de ce composé, à son utilisation comme médicament ou, lorsqu'il est complexé avec un radionucléide émettant des rayons ?, comme produit radiopharmaceutique, par ex. pour être utilisé dans la visualisation de thrombus, et à des compositions pharmaceutiques contenant ce composé.
CA002179889A 1994-01-26 1995-01-25 Inhibiteurs de serine proteases portant un groupe chelateur Abandoned CA2179889A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401483.4 1994-01-26
GB9401483A GB9401483D0 (en) 1994-01-26 1994-01-26 Organic compounds

Publications (1)

Publication Number Publication Date
CA2179889A1 true CA2179889A1 (fr) 1995-08-03

Family

ID=10749357

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002179889A Abandoned CA2179889A1 (fr) 1994-01-26 1995-01-25 Inhibiteurs de serine proteases portant un groupe chelateur

Country Status (10)

Country Link
EP (1) EP0741747A1 (fr)
JP (1) JPH09509653A (fr)
AU (1) AU1576495A (fr)
CA (1) CA2179889A1 (fr)
GB (1) GB9401483D0 (fr)
IL (1) IL112423A0 (fr)
PE (1) PE45295A1 (fr)
SG (1) SG47079A1 (fr)
WO (1) WO1995020603A1 (fr)
ZA (1) ZA95636B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515489D0 (en) * 1995-07-28 1995-09-27 Sandoz Ltd Organic compounds
DE10046514A1 (de) 2000-09-15 2002-04-25 Diagnostikforschung Inst Verfahren zur bildlichen Darstellung und Diagnose von Thromben mittels Kernspintomographie unter Verwendung partikulärer Kontrastmittel
CA2535792A1 (fr) 2002-09-09 2004-03-18 Trigen Limited Sels d'acide boronique et leur utilisation dans le traitement de la thrombose
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
AU2010341530B2 (en) 2009-12-22 2016-03-10 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
HUE064412T2 (hu) 2016-06-21 2024-03-28 Orion Ophthalmology LLC Heterociklusos prolinamid-származékok
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DE69023394T2 (de) * 1989-06-16 1996-07-04 Merck Frosst Canada Inc Chelat-Derivate von atrialnatriurethischem Faktor (ANF).
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
US5252721A (en) * 1990-09-28 1993-10-12 Neorx Corporation S3 N chelating compounds
AU2175492A (en) * 1991-04-22 1992-11-17 Mallinckrodt Medical, Inc. Method for detecting and localizing tissues having neurokinine 1 receptors

Also Published As

Publication number Publication date
AU1576495A (en) 1995-08-15
WO1995020603A1 (fr) 1995-08-03
SG47079A1 (en) 1998-03-20
EP0741747A1 (fr) 1996-11-13
IL112423A0 (en) 1995-03-30
JPH09509653A (ja) 1997-09-30
ZA95636B (en) 1996-07-26
GB9401483D0 (en) 1994-03-23
PE45295A1 (es) 1995-12-29

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Legal Events

Date Code Title Description
FZDE Discontinued