CA2206205A1 - Traitement a specificite tissulaire, procedes de diagnostic et compositions faisant appel a des vecteurs a replication deficiente - Google Patents
Traitement a specificite tissulaire, procedes de diagnostic et compositions faisant appel a des vecteurs a replication deficienteInfo
- Publication number
- CA2206205A1 CA2206205A1 CA002206205A CA2206205A CA2206205A1 CA 2206205 A1 CA2206205 A1 CA 2206205A1 CA 002206205 A CA002206205 A CA 002206205A CA 2206205 A CA2206205 A CA 2206205A CA 2206205 A1 CA2206205 A1 CA 2206205A1
- Authority
- CA
- Canada
- Prior art keywords
- vector
- cell
- replication
- cells
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une thérapie génique faisant appel à des systèmes d'apport à vecteurs recombinants, en l'occurrence des vecteurs adénoviraux. L'invention concerne plus particulièrement des vecteurs à réplication déficiente, mais pouvant se répliquer de façon spécifique dans certains tissus anormaux, apportant ainsi une amélioration thérapeutique imputable au vecteur en tant que tel ou imputable aux produits géniques hétérologues codés par le vecteur et distribués à travers lesdits tissus anormaux. Le tissu est de préférence un tissu tumoral. L'invention concerne également des lignées cellulaires destinées à la production de vecteurs recombinants à réplication déficiente, convenant avantageusement à la thérapie génique. L'invention concerne enfin des procédés de criblage d'anomalies tissulaires, en l'occurrence des tumeurs, permettant de détecter des fonctions ou des déficiences fonctionnelles qui autorisent la réplication du vecteur.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34896094A | 1994-11-28 | 1994-11-28 | |
| US08/348,960 | 1994-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2206205A1 true CA2206205A1 (fr) | 1996-06-06 |
Family
ID=23370312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002206205A Abandoned CA2206205A1 (fr) | 1994-11-28 | 1995-11-28 | Traitement a specificite tissulaire, procedes de diagnostic et compositions faisant appel a des vecteurs a replication deficiente |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0792169A1 (fr) |
| JP (1) | JPH10509879A (fr) |
| AU (1) | AU4503796A (fr) |
| CA (1) | CA2206205A1 (fr) |
| WO (1) | WO1996016676A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698443A (en) * | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
| SI0833934T2 (sl) | 1995-06-15 | 2013-04-30 | Crucell Holland B.V. | Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji |
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6265212B1 (en) | 1995-06-15 | 2001-07-24 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6676935B2 (en) | 1995-06-27 | 2004-01-13 | Cell Genesys, Inc. | Tissue specific adenoviral vectors |
| US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US6670188B1 (en) | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| DE19856065A1 (de) * | 1998-12-04 | 2000-06-15 | Centeon Pharma Gmbh | Rekombinanter, adenoviraler Vektor mit limitierter Autoreplikationsfähigkeit in vivo |
| JP2003530301A (ja) | 1999-04-15 | 2003-10-14 | ウェルスタット バイオロジクス コーポレイション | ウイルスを用いた新生物の処置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0792931A3 (fr) * | 1988-10-31 | 1999-05-19 | The Regents Of The University Of California | Produits et procédés de régulation de la suppression du phénotype néoplastique |
| US6410010B1 (en) * | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| EP1637608B1 (fr) * | 1993-10-25 | 2009-07-22 | CANJI, Inc. | Vecteur recombinant d'adenovirus et procédés d'utilisation |
-
1995
- 1995-11-28 CA CA002206205A patent/CA2206205A1/fr not_active Abandoned
- 1995-11-28 AU AU45037/96A patent/AU4503796A/en not_active Abandoned
- 1995-11-28 EP EP95943609A patent/EP0792169A1/fr not_active Withdrawn
- 1995-11-28 WO PCT/US1995/015431 patent/WO1996016676A1/fr not_active Ceased
- 1995-11-28 JP JP8518997A patent/JPH10509879A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996016676A1 (fr) | 1996-06-06 |
| JPH10509879A (ja) | 1998-09-29 |
| EP0792169A1 (fr) | 1997-09-03 |
| AU4503796A (en) | 1996-06-19 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |