CA2293358A1 - Sulfonamides tricycliques servant a inhiber la farnesyl-proteine transferase - Google Patents

Sulfonamides tricycliques servant a inhiber la farnesyl-proteine transferase Download PDF

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Publication number
CA2293358A1
CA2293358A1 CA002293358A CA2293358A CA2293358A1 CA 2293358 A1 CA2293358 A1 CA 2293358A1 CA 002293358 A CA002293358 A CA 002293358A CA 2293358 A CA2293358 A CA 2293358A CA 2293358 A1 CA2293358 A1 CA 2293358A1
Authority
CA
Canada
Prior art keywords
protein transferase
farnesyl
sulfonamide inhibitors
tricyclic sulfonamide
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002293358A
Other languages
English (en)
Other versions
CA2293358C (fr
Inventor
F. George Njoroge
Bancha Vibulbhan
Arthur G. Taveras
Ronald J. Doll
Viyyoor M. Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2293358A1 publication Critical patent/CA2293358A1/fr
Application granted granted Critical
Publication of CA2293358C publication Critical patent/CA2293358C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA002293358A 1997-06-17 1998-06-15 Sulfonamides tricycliques servant a inhiber la farnesyl-proteine transferase Expired - Fee Related CA2293358C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17
US08/877,050 1997-06-17
PCT/US1998/011508 WO1998057949A1 (fr) 1997-06-17 1998-06-15 Nouveaux sulfonamides tricycliques inhibiteurs de la farnesyle transferase

Publications (2)

Publication Number Publication Date
CA2293358A1 true CA2293358A1 (fr) 1998-12-23
CA2293358C CA2293358C (fr) 2008-08-05

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293358A Expired - Fee Related CA2293358C (fr) 1997-06-17 1998-06-15 Sulfonamides tricycliques servant a inhiber la farnesyl-proteine transferase

Country Status (14)

Country Link
EP (1) EP0989980A1 (fr)
JP (1) JP2002507192A (fr)
KR (1) KR20010013826A (fr)
CN (1) CN1267290A (fr)
AR (1) AR012989A1 (fr)
AU (1) AU8253698A (fr)
CA (1) CA2293358C (fr)
CO (1) CO4940475A1 (fr)
HU (1) HUP0004627A2 (fr)
IL (1) IL133393A0 (fr)
NZ (1) NZ501619A (fr)
PE (1) PE86199A1 (fr)
WO (1) WO1998057949A1 (fr)
ZA (1) ZA985218B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
ES2291368T3 (es) * 2000-11-29 2008-03-01 Schering Corporation Inhibidores de la farnesil protein transferasa.
MX2007005205A (es) 2004-10-29 2007-05-11 Kalypsys Inc Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma.
EP1940815B1 (fr) 2005-10-25 2018-08-15 Kalypsys, Inc. Sels de modulateurs de ppar et procedes de traitement de troubles metaboliques
WO2008091863A1 (fr) 2007-01-23 2008-07-31 Kalypsys, Inc. Composés bicycliques substitués par sulfonyle utilisés comme modulateurs de ppar dans le traitement de la stéatohépatite non alcoolique
BR112015019818A2 (pt) * 2013-02-19 2017-07-18 Icahn School Med Mount Sinai composto, uso de um composto, e, composição farmacêutica

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA947969B (en) * 1993-10-15 1996-07-12 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CN1267290A (zh) 2000-09-20
CO4940475A1 (es) 2000-07-24
IL133393A0 (en) 2001-04-30
AU8253698A (en) 1999-01-04
JP2002507192A (ja) 2002-03-05
ZA985218B (en) 1998-12-15
CA2293358C (fr) 2008-08-05
KR20010013826A (ko) 2001-02-26
NZ501619A (en) 2002-02-01
WO1998057949A1 (fr) 1998-12-23
EP0989980A1 (fr) 2000-04-05
HUP0004627A2 (hu) 2001-10-28
PE86199A1 (es) 1999-09-24
AR012989A1 (es) 2000-11-22

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