CA2293713A1 - Composes de bispyrido-cycloheptane utiles pour l'inhibition de farnesyl proteine transferase - Google Patents

Composes de bispyrido-cycloheptane utiles pour l'inhibition de farnesyl proteine transferase Download PDF

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Publication number
CA2293713A1
CA2293713A1 CA002293713A CA2293713A CA2293713A1 CA 2293713 A1 CA2293713 A1 CA 2293713A1 CA 002293713 A CA002293713 A CA 002293713A CA 2293713 A CA2293713 A CA 2293713A CA 2293713 A1 CA2293713 A1 CA 2293713A1
Authority
CA
Canada
Prior art keywords
protein transferase
bispyrido
inhibition
farnesyl protein
compounds useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002293713A
Other languages
English (en)
Other versions
CA2293713C (fr
Inventor
Alan B. Cooper
Jagdish A. Desai
Anil K. Saksena
Viyyoor M. Girijavallabhan
James J.-S. Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2293713A1 publication Critical patent/CA2293713A1/fr
Application granted granted Critical
Publication of CA2293713C publication Critical patent/CA2293713C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002293713A 1997-06-17 1998-06-15 Composes de bispyrido-cycloheptane utiles pour l'inhibition de farnesyl proteine transferase Expired - Fee Related CA2293713C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87774397A 1997-06-17 1997-06-17
US08/877,743 1997-06-17
PCT/US1998/011496 WO1998057961A1 (fr) 1997-06-17 1998-06-15 Composes de bispyrido-cycloheptane utiles pour l'inhibition de farnesyl proteine transferase

Publications (2)

Publication Number Publication Date
CA2293713A1 true CA2293713A1 (fr) 1998-12-23
CA2293713C CA2293713C (fr) 2006-12-05

Family

ID=25370623

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293713A Expired - Fee Related CA2293713C (fr) 1997-06-17 1998-06-15 Composes de bispyrido-cycloheptane utiles pour l'inhibition de farnesyl proteine transferase

Country Status (13)

Country Link
EP (1) EP0989984A1 (fr)
JP (1) JP2002504145A (fr)
KR (1) KR20010013825A (fr)
CN (1) CN1266432A (fr)
AR (1) AR015122A1 (fr)
AU (1) AU744153B2 (fr)
CA (1) CA2293713C (fr)
CO (1) CO4940447A1 (fr)
HU (1) HUP0004274A3 (fr)
IL (1) IL133388A0 (fr)
NZ (1) NZ501418A (fr)
WO (1) WO1998057961A1 (fr)
ZA (1) ZA985214B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2438059A1 (fr) 2009-06-05 2012-04-11 Link Medicine Corporation Dérivés d'aminopyrrolidinone et utilisations de ceux-ci

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG48750A1 (en) * 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
SK86198A3 (en) * 1995-12-22 1999-02-11 Schering Corp Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
ZA985214B (en) 1999-01-07
HUP0004274A3 (en) 2002-03-28
AU8058198A (en) 1999-01-04
HUP0004274A2 (hu) 2001-08-28
JP2002504145A (ja) 2002-02-05
CO4940447A1 (es) 2000-07-24
IL133388A0 (en) 2001-04-30
WO1998057961A1 (fr) 1998-12-23
NZ501418A (en) 2001-04-27
AR015122A1 (es) 2001-04-18
CA2293713C (fr) 2006-12-05
EP0989984A1 (fr) 2000-04-05
CN1266432A (zh) 2000-09-13
KR20010013825A (ko) 2001-02-26
AU744153B2 (en) 2002-02-14

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