CA2322425A1 - Nouvelles molecules fdrg de proteines et d'acide nucleique et utilisation desdites molecules - Google Patents

Nouvelles molecules fdrg de proteines et d'acide nucleique et utilisation desdites molecules Download PDF

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Publication number
CA2322425A1
CA2322425A1 CA002322425A CA2322425A CA2322425A1 CA 2322425 A1 CA2322425 A1 CA 2322425A1 CA 002322425 A CA002322425 A CA 002322425A CA 2322425 A CA2322425 A CA 2322425A CA 2322425 A1 CA2322425 A1 CA 2322425A1
Authority
CA
Canada
Prior art keywords
seq
fdrg
nucleic acid
polypeptide
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002322425A
Other languages
English (en)
Inventor
Douglas A. Holtzman
Bruce M. Spiegelman
Clifford Hyunsuk Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Millennium Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2322425A1 publication Critical patent/CA2322425A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne de nouveaux polypeptides, protéines et molécules d'acide nucléique FDRG. Outre des protéines FDRG pleine longueur isolées, la présente invention concerne des protéines de fusion FDRG, des peptides antigéniques et des anticorps anti-FDRG isolés. Elle concerne également des molécules d'acide nucléique FDRG, des vecteurs d'expression recombinés contenant une molécule d'acide nucléique selon la présente invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène FDRG a été introduit ou fonctionnellement modifié. Des procédés de diagnostic, de criblage et thérapeutiques faisant appel aux compositions selon la présente invention sont également décrits.
CA002322425A 1998-03-02 1999-03-02 Nouvelles molecules fdrg de proteines et d'acide nucleique et utilisation desdites molecules Abandoned CA2322425A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3353998A 1998-03-02 1998-03-02
US09/033,539 1998-03-02
PCT/US1999/004548 WO1999045135A1 (fr) 1998-03-02 1999-03-02 Nouvelles molecules fdrg de proteines et d'acide nucleique et utilisation desdites molecules

Publications (1)

Publication Number Publication Date
CA2322425A1 true CA2322425A1 (fr) 1999-09-10

Family

ID=21870993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322425A Abandoned CA2322425A1 (fr) 1998-03-02 1999-03-02 Nouvelles molecules fdrg de proteines et d'acide nucleique et utilisation desdites molecules

Country Status (6)

Country Link
EP (1) EP1058737A4 (fr)
JP (1) JP2002516067A (fr)
AU (1) AU3065799A (fr)
CA (1) CA2322425A1 (fr)
IL (1) IL138216A0 (fr)
WO (1) WO1999045135A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE363489T1 (de) * 1999-03-08 2007-06-15 Genentech Inc In tumoren vervielfältigte gensequenzen und deren diagnostische verwendungen
AU2001249929A1 (en) * 2000-04-07 2001-10-23 Dana-Farber Cancer Institute Inc. Fdrg proteins and nucleic acid molecules and uses therefor
AU2001254967B2 (en) * 2000-05-13 2005-06-23 Bioacta Ltd Anti-angiogenic polypeptides
US6869766B2 (en) 2000-12-22 2005-03-22 The Regents Of The University Of California Gene associated with regulation of adiposity and insulin response
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1704254A2 (fr) * 2004-01-14 2006-09-27 Janssen Pharmaceutica N.V. Procedes d'utilisation de genes cible de recepteur alpha active par proliferateur de peroxisome
EP1586902A3 (fr) * 2004-03-30 2006-02-15 F.Hoffmann-La Roche Ag ANGPTL4/FIAF comme marqueur pour la modulation de PPARdelta
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
WO2006014678A2 (fr) 2004-07-20 2006-02-09 Genentech, Inc. Compositions et methodes d'utilisation de la proteine 4 analogue a l'angiopoietine
WO2006014729A2 (fr) 2004-07-20 2006-02-09 Genentech, Inc. Inhibiteurs de la proteine 4 de type angiopoietine, combinaisons correspondantes et leur utilisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814464A (en) * 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
WO1999032515A2 (fr) * 1997-12-19 1999-07-01 Zymogenetics, Inc. Homologue de l'angiopoietine, adn le codant et procede de production dudit homologue

Also Published As

Publication number Publication date
EP1058737A1 (fr) 2000-12-13
WO1999045135A1 (fr) 1999-09-10
IL138216A0 (en) 2001-10-31
AU3065799A (en) 1999-09-20
JP2002516067A (ja) 2002-06-04
EP1058737A4 (fr) 2003-01-02

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued