CA2353596A1 - Methode d'immobilisation d'oligonucleotides - Google Patents
Methode d'immobilisation d'oligonucleotides Download PDFInfo
- Publication number
- CA2353596A1 CA2353596A1 CA002353596A CA2353596A CA2353596A1 CA 2353596 A1 CA2353596 A1 CA 2353596A1 CA 002353596 A CA002353596 A CA 002353596A CA 2353596 A CA2353596 A CA 2353596A CA 2353596 A1 CA2353596 A1 CA 2353596A1
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- nucleic acid
- subunit
- polymer
- moiety
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- Genetics & Genomics (AREA)
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- Engineering & Computer Science (AREA)
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Abstract
L'invention concerne de nouvelles compositions permettant d'introduire dans une cellule une molécule d'acide nucléique capable de moduler le génotype et le phénotype. Le gène peut être introduit dans un hôte mammalien au moyen d'un vecteur d'expression sous forme d'ADN nu ou conjugué à des supports, en particulier des supports cationiques. La conjugaison s'effectue au moyen d'une fraction contenant de l'éthylène reliée à la molécule d'acide nucléique. Les techniques et compositions selon l'invention s'utilisent pour soigner ou traiter n'importe laquelle d'une série de troubles génétiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11089198P | 1998-12-04 | 1998-12-04 | |
| US60/110,891 | 1998-12-04 | ||
| PCT/US1999/028666 WO2000034343A1 (fr) | 1998-12-04 | 1999-12-03 | Methode d'immobilisation d'oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2353596A1 true CA2353596A1 (fr) | 2000-06-15 |
Family
ID=22335488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002353596A Abandoned CA2353596A1 (fr) | 1998-12-04 | 1999-12-03 | Methode d'immobilisation d'oligonucleotides |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1155056A4 (fr) |
| AU (1) | AU1750400A (fr) |
| CA (1) | CA2353596A1 (fr) |
| WO (1) | WO2000034343A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017152149A1 (fr) | 2016-03-03 | 2017-09-08 | University Of Massachusetts | Adn double hélice linéaire à extrémité fermée pour transfert de gène non viral |
| CN110709696B (zh) * | 2017-06-22 | 2022-01-04 | 昭和电工株式会社 | 寡核苷酸的混合物的分离分析方法 |
| AU2021244559A1 (en) | 2020-03-24 | 2022-11-17 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for expressing Gaucher therapeutics |
| MX2022011805A (es) | 2020-03-24 | 2023-01-11 | Generation Bio Co | Vectores de adn no virales y usos de estos para expresar agentes terapéuticos con factor ix. |
| CN117881786A (zh) | 2021-04-27 | 2024-04-12 | 世代生物公司 | 表达治疗性抗体的非病毒dna载体及其用途 |
| WO2023177655A1 (fr) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Compositions vaccinales prime-boost hétérologues et méthodes d'utilisation |
| WO2024040222A1 (fr) | 2022-08-19 | 2024-02-22 | Generation Bio Co. | Adn à extrémités fermées clivable (adnce) et ses procédés d'utilisation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4749647A (en) * | 1984-06-22 | 1988-06-07 | Genetic Systems Corporation | Polymerization-induced separation assay using recognition pairs |
| US5034428A (en) * | 1986-06-19 | 1991-07-23 | Board Of Regents Of The University Of Washington | Immobilized biomolecules and method of making same |
| CA2079109A1 (fr) * | 1990-03-29 | 1991-09-30 | John A. Latham | Produits conjugues a lien disulfure formes d'un oligonucleotide et d'un agent de transport |
| US5658731A (en) * | 1990-04-09 | 1997-08-19 | Europaisches Laboratorium Fur Molekularbiologie | 2'-O-alkylnucleotides as well as polymers which contain such nucleotides |
| FR2679255B1 (fr) * | 1991-07-17 | 1993-10-22 | Bio Merieux | Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation. |
| JPH06121698A (ja) * | 1992-10-12 | 1994-05-06 | Canon Inc | Ｄｎａプローブ用モノマー、ｄｎａプローブ、及びその製造方法 |
| US5630978A (en) * | 1995-06-07 | 1997-05-20 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Preparation of biologically active molecules by molecular imprinting |
| US6001991A (en) * | 1996-10-04 | 1999-12-14 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression |
| US5932711A (en) * | 1997-03-05 | 1999-08-03 | Mosaic Technologies, Inc. | Nucleic acid-containing polymerizable complex |
-
1999
- 1999-12-03 CA CA002353596A patent/CA2353596A1/fr not_active Abandoned
- 1999-12-03 AU AU17504/00A patent/AU1750400A/en not_active Abandoned
- 1999-12-03 EP EP99960649A patent/EP1155056A4/fr not_active Withdrawn
- 1999-12-03 WO PCT/US1999/028666 patent/WO2000034343A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1155056A1 (fr) | 2001-11-21 |
| EP1155056A4 (fr) | 2004-05-12 |
| AU1750400A (en) | 2000-06-26 |
| WO2000034343A1 (fr) | 2000-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |