CA2386539A1 - Method for production of l-cysteine or l-cysteine derivatives by fermentation - Google Patents

Method for production of l-cysteine or l-cysteine derivatives by fermentation Download PDF

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Publication number
CA2386539A1
CA2386539A1 CA002386539A CA2386539A CA2386539A1 CA 2386539 A1 CA2386539 A1 CA 2386539A1 CA 002386539 A CA002386539 A CA 002386539A CA 2386539 A CA2386539 A CA 2386539A CA 2386539 A1 CA2386539 A1 CA 2386539A1
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Prior art keywords
cysteine
micro
production
fermentation
derivatives
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CA002386539A
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French (fr)
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CA2386539C (en
Inventor
Thomas Maier
Christoph Winterhalter
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Wacker Chemie AG
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Publication of CA2386539A1 publication Critical patent/CA2386539A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a method for production of l-cysteine or l-cysteine derivatives by means of a fermentation with micro-organisms and micro-organisms suitable for said method. The micro-organism strain adapted to fermentative production of l-cysteine or l-cysteine derivatives comprises a deregulated cysteine metabolism which is not dependent upon an altered cysB
activity. Said micro-organism strain is furthermore characterized by an elevated cysB activity, whereby the cysB activity comprises a regulation pattern typical for a wild type cysB.
CA002386539A 1999-10-14 2000-10-05 Method for production of l-cysteine or l-cysteine derivatives by fermentation Expired - Fee Related CA2386539C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19949579.3 1999-10-14
DE19949579A DE19949579C1 (en) 1999-10-14 1999-10-14 Microorganism with deregulated cysteine metabolism, useful for high-level production of cysteine and its derivatives, has increased activity of the CysB transcription regulator
PCT/EP2000/009720 WO2001027307A1 (en) 1999-10-14 2000-10-05 Method for production of l-cysteine or l-cysteine derivatives by fermentation

Publications (2)

Publication Number Publication Date
CA2386539A1 true CA2386539A1 (en) 2001-04-19
CA2386539C CA2386539C (en) 2007-04-17

Family

ID=7925659

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002386539A Expired - Fee Related CA2386539C (en) 1999-10-14 2000-10-05 Method for production of l-cysteine or l-cysteine derivatives by fermentation

Country Status (11)

Country Link
EP (1) EP1220940B2 (en)
JP (1) JP2003511086A (en)
KR (1) KR100505336B1 (en)
CN (1) CN1262646C (en)
AT (1) ATE231918T1 (en)
CA (1) CA2386539C (en)
DE (2) DE19949579C1 (en)
DK (1) DK1220940T3 (en)
SK (1) SK4972002A3 (en)
TW (1) TWI249575B (en)
WO (1) WO2001027307A1 (en)

Cited By (11)

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US8008048B2 (en) 2008-03-06 2011-08-30 Ajinomoto Co., Inc. L-cysteine-producing bacterium and a method for producing L-cysteine
DE102011075656A1 (en) 2011-05-11 2012-03-29 Wacker Chemie Ag Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium
US8293506B2 (en) 2009-02-25 2012-10-23 Ajinomoto Co., Inc. L-cysteine-producing bacterium and a method for producing L-cysteine
WO2013000864A1 (en) 2011-06-30 2013-01-03 Wacker Chemie Ag Method for production of natural l-cysteine by fermentation
US8383372B2 (en) 2008-03-06 2013-02-26 Ajinomoto Co., Inc. L-cysteine producing bacterium and a method for producing L-cysteine
WO2013171098A2 (en) 2012-05-18 2013-11-21 Wacker Chemie Ag Method for the fermentative production of l-cystein and derivates of said amino acid
DE102012216527A1 (en) 2012-09-17 2014-03-20 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine
US9611461B2 (en) 2013-03-19 2017-04-04 National University Corporation NARA Institute of Science and Technology Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability
WO2021197632A1 (en) 2020-04-03 2021-10-07 Wacker Chemie Ag Biocatalyst as a core component of an enzyme-catalyzed redox system for the biocatalytic reduction of cystine
US12246056B2 (en) 2018-11-07 2025-03-11 The Regents Of The University Of Michigan Compositions and methods for the production of cysteine

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DE10046934A1 (en) * 2000-09-21 2002-04-18 Consortium Elektrochem Ind Process for the fermentative production of non-proteinogenic L-amino acids
ES2269712T3 (en) * 2001-07-11 2007-04-01 Degussa Gmbh PROCESS FOR THE PREPARATION OF L-AMINO ACIDS THAT USES ENVIRONMENTAL FAMILY STRAPS.
US7348037B2 (en) 2002-08-16 2008-03-25 Evonik Degussa Gmbh Sulfur-containing animal-feed additives
DE10237479A1 (en) * 2002-08-16 2004-02-26 Degussa Ag Animal feed additive containing sulfur
US20060270013A1 (en) 2003-02-18 2006-11-30 Michel Chateau Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways
WO2004113373A1 (en) * 2003-06-21 2004-12-29 University Of Sheffield Overexpression of the cyddc transporter
DE10331291A1 (en) 2003-07-10 2005-02-17 Consortium für elektrochemische Industrie GmbH Variants of 3-phosphoglycerate dehydrogenase with reduced inhibition by L-serine and genes coding for it
RU2275425C2 (en) * 2003-11-03 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Bacterium belonging to genus escherichia as producer of l-cysteine and method for preparing l-cysteine
JP2009118740A (en) 2006-03-03 2009-06-04 Ajinomoto Co Inc Method for producing l-amino acid
EP2004803A2 (en) 2006-03-23 2008-12-24 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of theenterobacteriaceae family with attenuated expression of a gene coding for small rna
JP2009165355A (en) 2006-04-28 2009-07-30 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
WO2007136133A1 (en) 2006-05-23 2007-11-29 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
WO2008013187A1 (en) 2006-07-25 2008-01-31 Kyowa Hakko Bio Co., Ltd. Method for production of amino acid
RU2006143864A (en) 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES cynT, cynS, cynX, OR cynR, OR THEIR COMBINATION IS DECREASED
JP2010041920A (en) 2006-12-19 2010-02-25 Ajinomoto Co Inc Method for producing l-amino acid
JP5540504B2 (en) 2007-01-22 2014-07-02 味の素株式会社 Microorganism producing L-amino acid and method for producing L-amino acid
DE102007007333A1 (en) 2007-02-14 2008-08-21 Wacker Chemie Ag Process for the purification of L-cysteine
JP2010110216A (en) 2007-02-20 2010-05-20 Ajinomoto Co Inc Method for producing l-amino acid or nucleic acid
JP2010110217A (en) 2007-02-22 2010-05-20 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
JP5319521B2 (en) 2007-04-06 2013-10-16 協和発酵バイオ株式会社 Dipeptide production method
JP2011067095A (en) 2008-01-10 2011-04-07 Ajinomoto Co Inc Method for producing target substance by fermentation process
WO2009093703A1 (en) 2008-01-23 2009-07-30 Ajinomoto Co., Inc. Method of producing l-amino acid
RU2008105793A (en) 2008-02-19 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR DESIGNING OPERONS CONTAINING TRANSLATION-CONJUGATED GENES, BACTERIA CONTAINING SUCH OPERON, METHOD FOR PRODUCING USEFUL METABOLITIS AND METHOD FOR EXPRESS MONITORING
WO2009104731A1 (en) 2008-02-21 2009-08-27 味の素株式会社 L-cysteine-producing bacterium, and method for production of l-cysteine
US20110111458A1 (en) 2008-03-18 2011-05-12 Kyowa Hakko Kirin Co., Ltd. Industrially useful microorganism
US8530203B2 (en) 2008-09-01 2013-09-10 Shinshu University Process for producing useful substance
EP2336347B1 (en) 2008-09-08 2017-03-15 Ajinomoto Co., Inc. An l-amino acid-producing microorganism and a method for producing an l-amino acid
BRPI1007069A2 (en) 2009-01-23 2015-08-25 Ajinomoto Kk Method for producing an 1-amino acid.
US8623619B2 (en) 2009-02-09 2014-01-07 Kyowa Hakko Bio Co., Ltd. Process for producing L-amino acid
US9023622B2 (en) 2009-02-10 2015-05-05 Kyowa Hakko Bio Co., Ltd. Method for producing L-amino acid using a microorganism with decreased aspartate aminotransferase activity
JPWO2010095642A1 (en) 2009-02-18 2012-08-23 国立大学法人信州大学 Method for producing useful substances
JP5359409B2 (en) 2009-03-12 2013-12-04 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
BRPI1014661B1 (en) 2009-07-29 2020-12-15 Ajinomoto Co., Inc. METHOD TO PRODUCE AN L-AMINO ACID
RU2009136544A (en) 2009-10-05 2011-04-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-CISTEINE USING THE ENTEROBACTERIACEAE FAMILY BACTERIA
JP5817529B2 (en) 2009-11-30 2015-11-18 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
JP2013074795A (en) 2010-02-08 2013-04-25 Ajinomoto Co Inc MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID
RU2471868C2 (en) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Mutant adenylate cyclase, dna coding it, bacteria of enterobacteriaceae family containing said dan and method for preparing l-amino acids
RU2482188C2 (en) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR PREPARING L-ARGININE WITH USE OF BACTERIA OF GENUS Escherichia WHEREIN astCADBE OPERON IS INACTIVATED
RU2501858C2 (en) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR OBTAINING L-AMINOACID USING BACTERIUM OF Enterobacteriaceae FAMILY
BR112013006031A2 (en) 2010-09-14 2016-06-07 Ajinomoto Kk bacteria, and method for producing a sulfur-containing amino acid, a related substance, or a mixture thereof.
JP2014036576A (en) 2010-12-10 2014-02-27 Ajinomoto Co Inc Method for producing l-amino acids
EP2479279A1 (en) 2011-01-20 2012-07-25 Evonik Degussa GmbH Method for producing sulphuric amino acids by means of fermentation
CN103384723B (en) 2011-02-09 2020-08-14 协和发酵生化株式会社 Method for producing target substance by fermentation method
JP2014087259A (en) 2011-02-22 2014-05-15 Ajinomoto Co Inc L-cysteine-producing bacterium, and production method of l-cysteine
EP2695940B1 (en) * 2011-04-01 2016-11-30 Ajinomoto Co., Inc. Method for producing l-cysteine
JP2014131487A (en) 2011-04-18 2014-07-17 Ajinomoto Co Inc Method for producing l-cysteine
RU2011134436A (en) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACID USING THE ENTEROBACTERIACEAE FAMILY POSSESSING AN INCREASED EXPRESSION OF GENES OF THE CASCADE OF THE FORMATION OF FLAGELLS AND CELL MOBILITY
EP2628792A1 (en) 2012-02-17 2013-08-21 Evonik Industries AG Cell with reduced ppGppase activity
WO2013154182A1 (en) 2012-04-13 2013-10-17 協和発酵バイオ株式会社 Method for producing amino acid
PL2700715T3 (en) 2012-08-20 2019-03-29 Evonik Degussa Gmbh Method for manufacturing L-amino acids using improved strains of the enterobacteriaceae family by means of fermentation
RU2013118637A (en) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE yjjK GENE IS ADJUSTABLE
DE102013209274A1 (en) 2013-05-17 2014-11-20 Wacker Chemie Ag Microorganism and method for fermentative overproduction of gamma-glutamylcysteine and derivatives of this dipeptide
JP2016165225A (en) 2013-07-09 2016-09-15 味の素株式会社 Method for producing useful substance
RU2013140115A (en) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED
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EP2886651B1 (en) 2013-10-21 2018-08-22 Ajinomoto Co., Inc. Method for producing l-amino acid
RU2014105547A (en) 2014-02-14 2015-08-20 Адзиномото Ко., Инк. METHOD FOR PRODUCING L-AMINO ACIDS USING THE ENTEROBACTERIACEAE FAMILY HAVING A SUPER EXPRESSED GENE yajL
RU2015120052A (en) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. A method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family in which gshA gene expression is weakened
WO2017146195A1 (en) 2016-02-25 2017-08-31 Ajinomoto Co., Inc. A method for producing l-amino acids using a bacterium of the family enterobacteriaceae overexpressing a gene encoding an iron exporter
JP7066977B2 (en) 2017-04-03 2022-05-16 味の素株式会社 Manufacturing method of L-amino acid
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102112286B1 (en) * 2018-12-05 2020-05-19 서울대학교산학협력단 Gene related to acid resistance and methanotrophs comprising the same
BR112021014194A2 (en) 2019-02-22 2021-12-28 Ajinomoto Kk Method for producing an l-amino acid
BR112021017870A2 (en) 2019-04-05 2021-12-07 Ajinomoto Kk Method for producing an l-amino acid
JP7655312B2 (en) 2019-09-25 2025-04-02 味の素株式会社 Method for producing L-amino acids by bacterial fermentation
EP4172310A1 (en) 2020-06-26 2023-05-03 Wacker Chemie AG Improved cysteine-producing strains
JP2025507906A (en) * 2022-03-01 2025-03-21 ワッカー ケミー アクチエンゲゼルシャフト Improved cysteine producing strains
CN116064354B (en) * 2022-10-28 2025-05-30 浙江工业大学 Genetically engineered bacterium for high-yield of L-cysteine, construction method and application

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539952A1 (en) * 1995-10-26 1997-04-30 Consortium Elektrochem Ind Process for the preparation of O-acetylserine, L-cysteine and L-cysteine-related products
DE19726083A1 (en) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Microorganisms and processes for the fermentative production of L-cysteine, L-cystine, N-acetyl-serine or thiazolidine derivatives

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008048B2 (en) 2008-03-06 2011-08-30 Ajinomoto Co., Inc. L-cysteine-producing bacterium and a method for producing L-cysteine
US8383372B2 (en) 2008-03-06 2013-02-26 Ajinomoto Co., Inc. L-cysteine producing bacterium and a method for producing L-cysteine
US8293506B2 (en) 2009-02-25 2012-10-23 Ajinomoto Co., Inc. L-cysteine-producing bacterium and a method for producing L-cysteine
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine
US9074230B2 (en) 2011-05-11 2015-07-07 Wacker Chemie Ag Method for producing L-cystine by fermentation under controlled oxygen saturation
DE102011075656A1 (en) 2011-05-11 2012-03-29 Wacker Chemie Ag Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium
WO2012152664A1 (en) 2011-05-11 2012-11-15 Wacker Chemie Ag Method for producing l-cystine by fermentation under controlled oxygen saturation
WO2013000864A1 (en) 2011-06-30 2013-01-03 Wacker Chemie Ag Method for production of natural l-cysteine by fermentation
US8802399B2 (en) 2011-06-30 2014-08-12 Wacker Chemie Ag Method for production of natural L-cysteine by fermentation
DE102012208359A1 (en) 2012-05-18 2013-11-21 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
WO2013171098A2 (en) 2012-05-18 2013-11-21 Wacker Chemie Ag Method for the fermentative production of l-cystein and derivates of said amino acid
DE102012216527A1 (en) 2012-09-17 2014-03-20 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
WO2014040955A1 (en) 2012-09-17 2014-03-20 Wacker Chemie Ag Method for the fermentative production of l-cysteine and derivatives of said amino acid
US9347078B2 (en) 2012-09-17 2016-05-24 Wacker Chemie Ag Method for the fermentative production of L-cysteine and derivatives of said amino acid
US9611461B2 (en) 2013-03-19 2017-04-04 National University Corporation NARA Institute of Science and Technology Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability
US12246056B2 (en) 2018-11-07 2025-03-11 The Regents Of The University Of Michigan Compositions and methods for the production of cysteine
WO2021197632A1 (en) 2020-04-03 2021-10-07 Wacker Chemie Ag Biocatalyst as a core component of an enzyme-catalyzed redox system for the biocatalytic reduction of cystine

Also Published As

Publication number Publication date
CA2386539C (en) 2007-04-17
CN1379823A (en) 2002-11-13
DE19949579C1 (en) 2000-11-16
WO2001027307A1 (en) 2001-04-19
EP1220940B2 (en) 2010-07-28
SK4972002A3 (en) 2002-09-10
EP1220940A1 (en) 2002-07-10
JP2003511086A (en) 2003-03-25
DE50001193D1 (en) 2003-03-06
KR100505336B1 (en) 2005-07-29
DK1220940T3 (en) 2003-06-23
EP1220940B1 (en) 2003-01-29
TWI249575B (en) 2006-02-21
KR20020059620A (en) 2002-07-13
CN1262646C (en) 2006-07-05
ATE231918T1 (en) 2003-02-15

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