CA2439185A1 - Nouvelles constructions de vecteurs - Google Patents
Nouvelles constructions de vecteurs Download PDFInfo
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- CA2439185A1 CA2439185A1 CA002439185A CA2439185A CA2439185A1 CA 2439185 A1 CA2439185 A1 CA 2439185A1 CA 002439185 A CA002439185 A CA 002439185A CA 2439185 A CA2439185 A CA 2439185A CA 2439185 A1 CA2439185 A1 CA 2439185A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/40—Vector systems having a special element relevant for transcription being an insulator
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne de nouveaux vecteurs viraux et des procédés utilisables pour minimiser l'expression génique partiellement fonctionnelle, et, en particulier, de la translecture transcriptionnelle non spécifique. De telles constructions peuvent être obtenues par l'insertion d'une séquence isolante dans une construction de vecteurs, telle que par exemple un séquence de signaux de terminaison en amont du site d'initiation de la transcription de l'unité de transcription respective. FIG. 6 : A SCHEMA DE STRUCTURE DES VECTEURS AR6pAF ET DE Ar6pAE2fF B PROMOTEUR E2F-1 HUMAIN C INTERMEDIAIRE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27088501P | 2001-02-23 | 2001-02-23 | |
| US60/270,885 | 2001-02-23 | ||
| PCT/US2002/005280 WO2002068627A2 (fr) | 2001-02-23 | 2002-02-22 | Nouvelles constructions de vecteurs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2439185A1 true CA2439185A1 (fr) | 2002-09-06 |
Family
ID=23033246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002439185A Abandoned CA2439185A1 (fr) | 2001-02-23 | 2002-02-22 | Nouvelles constructions de vecteurs |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7109029B2 (fr) |
| EP (1) | EP1377672A2 (fr) |
| JP (1) | JP2004536572A (fr) |
| CA (1) | CA2439185A1 (fr) |
| IL (1) | IL152423A0 (fr) |
| WO (1) | WO2002068627A2 (fr) |
Families Citing this family (24)
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|---|---|---|---|---|
| US6911200B2 (en) * | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
| WO2002068627A2 (fr) | 2001-02-23 | 2002-09-06 | Novartis Ag | Nouvelles constructions de vecteurs |
| CN1195056C (zh) * | 2001-07-12 | 2005-03-30 | 钱其军 | 一种在肿瘤细胞中特异性增殖及高效表达抗癌基因的重组病毒及其构建方法 |
| US7364727B2 (en) | 2002-07-22 | 2008-04-29 | Cell Genesys, Inc. | Metastatic colon cancer specific promoter and uses thereof |
| EP1573058B1 (fr) * | 2002-12-18 | 2011-09-14 | ChromaGenics B.V. | Procede d'amelioration de production de proteines |
| ATE354645T1 (de) * | 2002-12-20 | 2007-03-15 | Chromagenics Bv | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
| US20050186178A1 (en) * | 2003-08-28 | 2005-08-25 | Ennist David L. | Oncolytic adenoviral vectors encoding GM-CSF |
| WO2005030261A1 (fr) * | 2003-08-28 | 2005-04-07 | Cell Genesys, Inc. | Vecteurs adenoviraux oncolytiques codants pour gm-csf |
| US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| US20060062764A1 (en) * | 2004-08-25 | 2006-03-23 | Seshidar-Reddy Police | Fiber-modified adenoviral vectors for enhanced transduction of tumor cells |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20060172382A1 (en) * | 2004-11-08 | 2006-08-03 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
| ES2304281B1 (es) * | 2006-02-01 | 2009-08-12 | Dnatrix Inc. | Adenovirus oncoliticos para el tratamiento del cancer. |
| US20070292396A1 (en) * | 2006-03-02 | 2007-12-20 | Juan Fueyo | Combination therapy with oncolytic adenovirus |
| WO2007134325A2 (fr) * | 2006-05-15 | 2007-11-22 | Introgen Therapeutics, Inc. | Procédés et compositions pour la production de protéines à l'aide de vecteurs adénoviraux |
| US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
| US20100197767A1 (en) * | 2007-07-11 | 2010-08-05 | Lior Nissim | Nucleic acid construct systems capable of daignosing or treating a cell state |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| TWI391486B (zh) * | 2009-10-20 | 2013-04-01 | Taipei Veterans General Hospital | 新穎啟動子及包含其之病毒載體 |
| CA2843684A1 (fr) | 2010-08-13 | 2012-02-16 | Tufts University | Compositions, trousses et methodes de traitement de la degenerescence maculaire au moyen de la proteine cd59 soluble independante de la membrane |
| ES2992014T3 (es) | 2018-02-12 | 2024-12-05 | Tufts College | CD59 para inhibir la activación del inflamasoma |
| WO2023089564A1 (fr) | 2021-11-19 | 2023-05-25 | Janssen Biotech, Inc. | Méthode de traitement d'une atrophie géographique avec un vecteur de thérapie génique exprimant cd59 soluble |
| WO2025074268A1 (fr) | 2023-10-02 | 2025-04-10 | Janssen Biotech, Inc. | Méthodes pour traiter la dégénérescence maculaire |
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| WO2001083796A2 (fr) * | 2000-05-03 | 2001-11-08 | University Of Washington | Vecteurs adenoviraux de recombinaison modifies destines a une expression genique specifique des tumeurs et utilisation associee |
| WO2002068627A2 (fr) | 2001-02-23 | 2002-09-06 | Novartis Ag | Nouvelles constructions de vecteurs |
-
2002
- 2002-02-22 WO PCT/US2002/005280 patent/WO2002068627A2/fr not_active Ceased
- 2002-02-22 JP JP2002568722A patent/JP2004536572A/ja active Pending
- 2002-02-22 IL IL15242302A patent/IL152423A0/xx unknown
- 2002-02-22 US US10/081,961 patent/US7109029B2/en not_active Expired - Fee Related
- 2002-02-22 EP EP02721113A patent/EP1377672A2/fr not_active Withdrawn
- 2002-02-22 CA CA002439185A patent/CA2439185A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002068627A3 (fr) | 2003-06-12 |
| US7109029B2 (en) | 2006-09-19 |
| EP1377672A2 (fr) | 2004-01-07 |
| JP2004536572A (ja) | 2004-12-09 |
| WO2002068627A2 (fr) | 2002-09-06 |
| IL152423A0 (en) | 2003-05-29 |
| US20030104624A1 (en) | 2003-06-05 |
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