CA2944116A1 - A process for preparation of levothyroxine and salts thereof - Google Patents
A process for preparation of levothyroxine and salts thereof Download PDFInfo
- Publication number
- CA2944116A1 CA2944116A1 CA2944116A CA2944116A CA2944116A1 CA 2944116 A1 CA2944116 A1 CA 2944116A1 CA 2944116 A CA2944116 A CA 2944116A CA 2944116 A CA2944116 A CA 2944116A CA 2944116 A1 CA2944116 A1 CA 2944116A1
- Authority
- CA
- Canada
- Prior art keywords
- levothyroxine
- amine
- formula
- sodium
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1233/MUM/2014 | 2014-03-31 | ||
| PCT/IB2015/052330 WO2015151013A1 (en) | 2014-03-31 | 2015-03-30 | A process for preparation of levothyroxine and salts thereof |
| IN1233MU2014 IN2014MU01233A (2) | 2014-03-31 | 2015-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2944116A1 true CA2944116A1 (en) | 2015-10-08 |
Family
ID=54239474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2944116A Abandoned CA2944116A1 (en) | 2014-03-31 | 2015-03-30 | A process for preparation of levothyroxine and salts thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9932295B2 (2) |
| EP (1) | EP3126324B1 (2) |
| JP (1) | JP2017510593A (2) |
| AU (1) | AU2015242231B2 (2) |
| CA (1) | CA2944116A1 (2) |
| ES (1) | ES2686194T3 (2) |
| IN (1) | IN2014MU01233A (2) |
| MX (1) | MX370564B (2) |
| RU (1) | RU2673540C2 (2) |
| WO (1) | WO2015151013A1 (2) |
| ZA (1) | ZA201607265B (2) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2017110B1 (en) | 2016-07-05 | 2018-01-12 | Emp Levo Gmbh | Methods for the preparation of a levothyroxine solution |
| US9782376B1 (en) | 2016-12-01 | 2017-10-10 | Fresenius Kabi Usa Llc | Levothyroxine liquid formulations |
| AU2020284104B2 (en) * | 2019-05-31 | 2025-02-27 | Xeris Pharmaceuticals, Inc. | Stable therapeutic compositions in aprotic polar solvents and methods of manufacturing the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB652207A (en) | 1948-12-31 | 1951-04-18 | Glaxo Lab Ltd | Improvements in or relating to the preparation of thyroxine and its derivatives |
| US2886592A (en) | 1956-03-07 | 1959-05-12 | Hillmann Gunther | Process for making iodo derivatives of thyronine |
| US4997946A (en) | 1987-08-18 | 1991-03-05 | Eastman Kodak Company | Process for the iodination of hydroxyaromatic and aminoaromatic compounds |
| IT1302201B1 (it) | 1998-09-11 | 2000-07-31 | Bracco Spa | Processo per la produzione di ormoni tiroidei. |
| WO2009136249A1 (en) | 2008-05-09 | 2009-11-12 | Cadila Pharmaceuticals Ltd. | An improved process for the preparation of levothyroxine sodium with reduced levels of impurities |
| EP2338875A1 (en) | 2009-12-18 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of thyroid hormones and derivatives thereof |
| WO2015011573A1 (en) | 2013-07-24 | 2015-01-29 | Azico Pharmaceuticals Private Limited | Novel process for the preparation of levothyroxine sodium |
-
2015
- 2015-03-30 WO PCT/IB2015/052330 patent/WO2015151013A1/en not_active Ceased
- 2015-03-30 CA CA2944116A patent/CA2944116A1/en not_active Abandoned
- 2015-03-30 EP EP15717254.5A patent/EP3126324B1/en not_active Not-in-force
- 2015-03-30 AU AU2015242231A patent/AU2015242231B2/en not_active Ceased
- 2015-03-30 JP JP2016560522A patent/JP2017510593A/ja active Pending
- 2015-03-30 ES ES15717254.5T patent/ES2686194T3/es active Active
- 2015-03-30 MX MX2016012787A patent/MX370564B/es active IP Right Grant
- 2015-03-30 IN IN1233MU2014 patent/IN2014MU01233A/en unknown
- 2015-03-30 RU RU2016142315A patent/RU2673540C2/ru not_active IP Right Cessation
- 2015-03-30 US US15/300,145 patent/US9932295B2/en not_active Expired - Fee Related
-
2016
- 2016-10-20 ZA ZA2016/07265A patent/ZA201607265B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014MU01233A (2) | 2015-10-02 |
| RU2016142315A3 (2) | 2018-10-09 |
| MX370564B (es) | 2019-12-17 |
| MX2016012787A (es) | 2016-12-12 |
| US20170183292A1 (en) | 2017-06-29 |
| EP3126324A1 (en) | 2017-02-08 |
| WO2015151013A1 (en) | 2015-10-08 |
| EP3126324B1 (en) | 2018-07-18 |
| JP2017510593A (ja) | 2017-04-13 |
| RU2016142315A (ru) | 2018-05-04 |
| ES2686194T3 (es) | 2018-10-16 |
| AU2015242231B2 (en) | 2019-09-12 |
| ZA201607265B (en) | 2017-11-29 |
| US9932295B2 (en) | 2018-04-03 |
| RU2673540C2 (ru) | 2018-11-28 |
| AU2015242231A1 (en) | 2016-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6087438B2 (ja) | 触媒としてｎ−アシルアミノ酸界面活性剤またはその対応する無水物を使用するｎ−アシルアミノ酸界面活性剤を製造する方法 | |
| CN101959847B (zh) | 生产氨基二羧酸-n,n-二乙酸的方法 | |
| KR101609898B1 (ko) | Ｒ-베타-아미노 페닐부티르산 유도체의 제조 방법 | |
| JP5155406B2 (ja) | ベタインの製造方法 | |
| AU2015242231B2 (en) | A process for preparation of Levothyroxine and salts thereof | |
| FR2928148A1 (fr) | Procede de preparation de combretastatine | |
| WO2005023753A1 (en) | A method of preparing memantine hydrochloride | |
| EP3024326B1 (en) | Novel process for the preparation of levothyroxine sodium | |
| ITMI20002608A1 (it) | Processo per la preparazione dell'acido 1-(amminometil)cicloesanacetico | |
| WO2009136249A1 (en) | An improved process for the preparation of levothyroxine sodium with reduced levels of impurities | |
| KR101755291B1 (ko) | 갑상선 호르몬 및 그것의 염의 제조 방법 | |
| CN101346347B (zh) | 氨基酸磷酸盐的制备方法 | |
| JPH11279129A5 (2) | ||
| EP3260442B1 (en) | Process for preparation of optically pure n-substituted-3-methoxypropionic acid derivatives | |
| JP2531501B2 (ja) | Ｎ−クロロアセチルグルタミン酸γ−低級アルキルエステルアンモニウム塩 | |
| JP5121349B2 (ja) | アミノ酸の製造方法 | |
| KR20090010546A (ko) | 가바펜틴의 제조 방법 및 중간체 | |
| JP2001163845A (ja) | アミノ酸アミドの製造方法 | |
| EP0997453A1 (en) | Phenoxyisobutyric acid ammonium salts and pharmaceutical formulations containing them | |
| CN105669479A (zh) | 一锅法制备高纯度反式-4-二甲基胺基巴豆酸盐酸盐的方法 | |
| JP2005139098A (ja) | １−チオ−２−プロパノン誘導体及び５−メチル−５−チオメチルヒダントイン誘導体の製造方法 | |
| HK1174610A (en) | Process for the preparation of thyroid hormones and salts thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |