CA3151149C - Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie - Google Patents

Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie Download PDF

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CA3151149C
CA3151149C CA3151149A CA3151149A CA3151149C CA 3151149 C CA3151149 C CA 3151149C CA 3151149 A CA3151149 A CA 3151149A CA 3151149 A CA3151149 A CA 3151149A CA 3151149 C CA3151149 C CA 3151149C
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clostridium
coa
microorganism
aldehyde
ptb
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CA3151149A1 (fr
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Michael Koepke
Rasmus JENSEN OVERGAARD
James Bruce Yarnton Haycock BEHRENDORFF
Ryan Edward Hill
Alexander Paul MUELLER
Darmawi JUMINAGA
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Lanzatech NZ Inc
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
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    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
    • C12Y102/07005—Aldehyde ferredoxin oxidoreductase (1.2.7.5)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01019—Phosphate butyryltransferase (2.3.1.19)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02001—Acetate kinase (2.7.2.1)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02007—Butyrate kinase (2.7.2.7)
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/0202—Acyl-CoA hydrolase (3.1.2.20)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Linvention concerne une bactérie génétiquement modifiée qui comprend une voie de fermentation à production dénergie, et des procédés associés. En particulier, linvention concerne une bactérie qui comprend un phosphate butyryltransférase (Ptb) et un butyrate kinase (Buk) (Ptb-Buk) qui agissent sur des substrats étrangers pour produire une grande variété de produits et dintermédiaires. Dans certains modes de réalisation, linvention concerne lintroduction de Ptb-Buk dans un micro-organisme à fixation de C1 capable de produire des produits à partir dun substrat gazeux.
CA3151149A 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie Active CA3151149C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562240850P 2015-10-13 2015-10-13
US62/240,850 2015-10-13
CA3051235A CA3051235C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie

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CA3051235A Division CA3051235C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie

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CA3151149A1 CA3151149A1 (fr) 2017-04-20
CA3151149C true CA3151149C (fr) 2024-03-26

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CA3151149A Active CA3151149C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3051235A Active CA3051235C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3151146A Active CA3151146C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3051234A Active CA3051234C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3001596A Active CA3001596C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3151120A Pending CA3151120A1 (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie

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CA3051235A Active CA3051235C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3151146A Active CA3151146C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3051234A Active CA3051234C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3001596A Active CA3001596C (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
CA3151120A Pending CA3151120A1 (fr) 2015-10-13 2016-10-13 Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie

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US (3) US9738875B2 (fr)
EP (2) EP3901267A1 (fr)
JP (2) JP6905518B2 (fr)
KR (2) KR20210037002A (fr)
CN (2) CN113322220A (fr)
AU (2) AU2016339989B2 (fr)
CA (6) CA3151149C (fr)
EA (2) EA201890952A1 (fr)
MX (4) MX2022003568A (fr)
MY (5) MY205861A (fr)
WO (1) WO2017066498A1 (fr)
ZA (5) ZA201802346B (fr)

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US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CN107075536B (zh) * 2014-09-17 2021-07-02 环球生物能源公司 生产3-羟基-3-甲基丁酸的方法
WO2016210384A2 (fr) 2015-06-25 2016-12-29 Synlogic, Inc. Bactéries manipulées pour traiter des maladies métaboliques
CA3151149C (fr) * 2015-10-13 2024-03-26 Lanzatech Nz, Inc. Bacterie genetiquement modifiee comprenant une voie de fermentation a production d'energie
GB201603915D0 (en) * 2016-03-07 2016-04-20 Chain Biotechnology Ltd Method and microbes for the production of chiral compounds
WO2017200884A1 (fr) 2016-05-14 2017-11-23 Lanzatech, Inc. Micro-organisme à activité aldéhyde/ferrédoxine oxydoréductase modifiée et procédés associés
US11539066B2 (en) 2016-11-22 2022-12-27 The Penn State Research Foundation Devices and methods for generating electrical current from methane
CN107177609B (zh) * 2017-05-15 2020-12-11 大连理工大学 一种fruB基因过表达的重组梭菌、其构建方法及应用
CN107083406B (zh) * 2017-05-27 2021-02-02 浙江华睿生物技术有限公司 (r)-3-羟基丁酸的生产方法
US11634733B2 (en) * 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
CN111051517B (zh) 2017-09-08 2023-10-27 朗泽科技有限公司 用于使用富氢气的含有c1的底物生产代谢物的方法和系统
CA3168586A1 (fr) * 2017-09-28 2019-04-04 Lanzatech, Inc. Bloquages genetiques chez les micro-organismes a voie de wood-ljungdahl
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
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