CH122187A - Process for the preparation of a complex compound of antimony. - Google Patents
Process for the preparation of a complex compound of antimony.Info
- Publication number
- CH122187A CH122187A CH122187DA CH122187A CH 122187 A CH122187 A CH 122187A CH 122187D A CH122187D A CH 122187DA CH 122187 A CH122187 A CH 122187A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- antimony
- acid
- preparation
- sodium salt
- Prior art date
Links
- 229910052787 antimony Inorganic materials 0.000 title claims description 9
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 title claims description 9
- 150000001875 compounds Chemical class 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 230000003472 neutralizing effect Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 150000001463 antimony compounds Chemical class 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 10
- -1 antimony pentathioglycolic acid Chemical compound 0.000 description 5
- LJCFOYOSGPHIOO-UHFFFAOYSA-N antimony pentoxide Chemical compound O=[Sb](=O)O[Sb](=O)=O LJCFOYOSGPHIOO-UHFFFAOYSA-N 0.000 description 4
- ZDINGUUTWDGGFF-UHFFFAOYSA-N antimony(5+) Chemical compound [Sb+5] ZDINGUUTWDGGFF-UHFFFAOYSA-N 0.000 description 2
- VMPVEPPRYRXYNP-UHFFFAOYSA-I antimony(5+);pentachloride Chemical compound Cl[Sb](Cl)(Cl)(Cl)Cl VMPVEPPRYRXYNP-UHFFFAOYSA-I 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
Landscapes
- Removal Of Specific Substances (AREA)
Description
Verfahren zur Darstellung einer liomplegen Verbindung des Antimons. Behandelt man eine Verbindung des fünfwertigen Antimons, zum Beispiel An- timonpentoxyd oder Antimonpentachlorid, mit einer Lösung von Thioglykolsäure, neutralisiert die entstandene Lösung mit einem Neutralisationsmittel, wie Alkalien oder Erdalkalien, und dampft ein, so erhält man in Wasser mit fast neutraler Reaktion leicht lösliche Salze einer Säure,
di´ nach der Analyse die Zusammensetzung Sb (S CH, COOH), hat. Säuert man die Lö sung der Salze vorsichtig an, so erhält man jedoch nicht die entsprechende freie Antimon pentathioglykolsäure, sondern es entsteht eine neue Säure unter Abspaltung von Thio- glykolsäure, die in kaltem Wasser schwer, in heissem zu etwa 5 % löslich ist und aus Wasser umkristallisiert werden kann. Sie enthält rund 40'/o Antimon, während die entsprechende Antimonpentathioglykolsäure 20,8 % enthalten müsste.
Es war über raschend, dass überhaupt das stark saure Antimonpentoxyd bezw. Antimonpentachlorid sich mit Thioglykolsäure zu derartigen kom plexen Verbindungen vereinigt.
Den Gegenstand des vorliegenden Paten tes bildet ein Verfahren zur Darstellung des Natriumsalzes der Antimonpentathioglykol- säure; das Verfahren ist dadurch gekenn zeichnet, dass man Thioglykolsäure mit einer Verbindung des fünfwertigen Antimons be handelt und die entstehende Antimonpenta- thioglykolsäure vor der Isolierung mit einen Neutralisationsmittel in das Natriumsalz überführt.
Das Natriumsalz der Antimonpentathio- glykolsäure stellt ein hervorragend spezifisch wirkendes Arzneimittel dar.
<I>Beispiel:</I> 20 Gewichtsteile Thioglykolsäitre und 1.1 Gewichtsteile Antimonpeutogyd werden in 500 Gewichtsteilen Wasser bis fast zur völligen Lösung des Antimonpento$yds er hitzt.
Das Filtrat dieser Lösung wird noch heiss mit Soda neutralisiert und eingedampft,
EMI0002.0001
z-,v <SEP> eckmässig <SEP> bei <SEP> niedriger <SEP> Temperatur. <SEP> Man
<tb> erhält <SEP> ein <SEP> in <SEP> Wasser <SEP> leicht <SEP> mit <SEP> fast <SEP> neu traler <SEP> Reaktion <SEP> lösliches <SEP> Salz, <SEP> dessen <SEP> An iiniongehalt <SEP> <B>18,3</B> <SEP> ö <SEP> beträgt. <SEP> [Berechnet
<tb> 17,8 <SEP> ö <SEP> für <SEP> Sb <SEP> (S <SEP> CH.; <SEP> COONa),.]
<tb> Leim <SEP> Ansäuern <SEP> der <SEP> Lösung <SEP> fällt <SEP> unter
<tb> .=ibsclieidung <SEP> von <SEP> Tliioglvholsäure <SEP> eine <SEP> Säure
<tb> ,ius, <SEP> die <SEP> aus <SEP> Wasser <SEP> in <SEP> derben <SEP> Kristallen
<tb> ausfällt <SEP> und <SEP> 40 <SEP> % <SEP> Sb <SEP> enthält.
Procedure for the representation of a liompligen connection of the antimony If you treat a compound of pentavalent antimony, for example antimony pentoxide or antimony pentachloride, with a solution of thioglycolic acid, neutralize the resulting solution with a neutralizing agent, such as alkalis or alkaline earths, and evaporate, then you get slightly soluble in water with an almost neutral reaction Salts of an acid,
di´ according to the analysis the composition Sb (S CH, COOH) has. However, if the solution of the salts is carefully acidified, the corresponding free antimony pentathioglycolic acid is not obtained, but a new acid is formed with elimination of thioglycolic acid, which is difficult to dissolve in cold water and about 5% in hot water and which is soluble Water can be recrystallized. It contains around 40% antimony, while the corresponding antimony pentathioglycolic acid should contain 20.8%.
It was surprising that the strongly acidic antimony pentoxide or. Antimony pentachloride combines with thioglycolic acid to form such complex compounds.
The subject of the present patent is a process for the preparation of the sodium salt of antimony pentathioglycolic acid; the method is characterized in that thioglycolic acid is treated with a compound of pentavalent antimony and the resulting antimony pentathioglycolic acid is converted into the sodium salt with a neutralizing agent before isolation.
The sodium salt of antimony pentathioglycolic acid is an excellent drug with a specific effect.
<I> Example: </I> 20 parts by weight of thioglycolic acid and 1.1 parts by weight of antimony peutogyd are heated in 500 parts by weight of water until the antimony pento $ yd is almost completely dissolved.
The filtrate of this solution is neutralized while hot with soda and evaporated,
EMI0002.0001
z-, v <SEP> square <SEP> at <SEP> lower <SEP> temperature. <SEP> Man
<tb> receives <SEP> a <SEP> in <SEP> water <SEP> slightly <SEP> with <SEP> almost <SEP> neutral <SEP> reaction <SEP> soluble <SEP> salt, <SEP> its <SEP> An ion content <SEP> <B> 18.3 </B> <SEP> ö <SEP> is. <SEP> [calculated
<tb> 17.8 <SEP> ö <SEP> for <SEP> Sb <SEP> (S <SEP> CH .; <SEP> COONa) ,.]
<tb> glue <SEP> acidifying <SEP> the <SEP> solution <SEP> falls under <SEP>
<tb>. = isolation <SEP> from <SEP> Tliioglvholäure <SEP> an <SEP> acid
<tb>, ius, <SEP> the <SEP> from <SEP> water <SEP> in <SEP> coarse <SEP> crystals
<tb> fails <SEP> and <SEP> contains 40 <SEP>% <SEP> Sb <SEP>.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE122187X | 1925-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH122187A true CH122187A (en) | 1927-09-01 |
Family
ID=5657251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH122187D CH122187A (en) | 1925-02-19 | 1926-01-28 | Process for the preparation of a complex compound of antimony. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH122187A (en) |
-
1926
- 1926-01-28 CH CH122187D patent/CH122187A/en unknown
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