CH550774A - Verfahren zur herstellung neuer hypocalcaemischer peptide. - Google Patents

Verfahren zur herstellung neuer hypocalcaemischer peptide.

Info

Publication number: CH550774A
Authority: CH; Switzerland
Prior art keywords: sep; thr; gly; phe; boc
Prior art date: 1968-10-15

Application number

CH1540168A

Other languages

German (de)

English (en)

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-10-15

Filing date

1968-10-15

Publication date

1974-06-28

1968-10-15 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1968-10-15 Priority to CH1540168A priority Critical patent/CH550774A/de

1969-10-08 Priority to DE19691950711 priority patent/DE1950711A1/de

1969-10-10 Priority to IE1403/69A priority patent/IE33835B1/xx

1969-10-13 Priority to ES372445A priority patent/ES372445A1/es

1969-10-13 Priority to GB50087/69A priority patent/GB1287125A/en

1969-10-13 Priority to SE7216700A priority patent/SE374913B/xx

1969-10-13 Priority to SE14000/69A priority patent/SE366543B/xx

1969-10-14 Priority to AT966769A priority patent/AT300210B/de

1969-10-14 Priority to NL6915540A priority patent/NL6915540A/xx

1969-10-14 Priority to FR6935098A priority patent/FR2020730B1/fr

1969-10-14 Priority to DK545669AA priority patent/DK129338B/da

1969-10-14 Priority to HUCI929A priority patent/HU166686B/hu

1969-10-14 Priority to SU1370715A priority patent/SU430546A3/ru

1969-10-14 Priority to AT172971A priority patent/AT313491B/de

1969-10-14 Priority to BE740256D priority patent/BE740256A/xx

1969-10-15 Priority to BR21333069A priority patent/BR6913330D0/pt

1969-10-15 Priority to CS686369A priority patent/CS155219B2/cs

1972-09-28 Priority to US00293271A priority patent/US3849388A/en

1974-06-28 Publication of CH550774A publication Critical patent/CH550774A/de

Links

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229910052749 magnesium Inorganic materials 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229960002510 mandelic acid Drugs 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
125000004492 methyl ester group Chemical group 0.000 description 1
KQSSATDQUYCRGS-UHFFFAOYSA-N methyl glycinate Chemical compound COC(=O)CN KQSSATDQUYCRGS-UHFFFAOYSA-N 0.000 description 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
XGZVNVFLUGNOJQ-UHFFFAOYSA-N n,n-dimethylformamide;ethyl acetate Chemical compound CN(C)C=O.CCOC(C)=O XGZVNVFLUGNOJQ-UHFFFAOYSA-N 0.000 description 1
LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical compound ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 description 1
PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
229910000069 nitrogen hydride Inorganic materials 0.000 description 1
LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
239000012434 nucleophilic reagent Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
229960003540 oxyquinoline Drugs 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
125000004351 phenylcyclohexyl group Chemical group C1(=CC=CC=C1)C1(CCCCC1)* 0.000 description 1
LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 description 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
150000003014 phosphoric acid esters Chemical class 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 description 1
235000002949 phytic acid Nutrition 0.000 description 1
229940068041 phytic acid Drugs 0.000 description 1
239000000467 phytic acid Substances 0.000 description 1
SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical class OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
150000008442 polyphenolic compounds Chemical class 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
229940048914 protamine Drugs 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
238000001226 reprecipitation Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000006798 ring closing metathesis reaction Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
229940083618 sodium nitroprusside Drugs 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000008259 solid foam Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000000967 suction filtration Methods 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
229950000244 sulfanilic acid Drugs 0.000 description 1
125000004646 sulfenyl group Chemical group S(*)* 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
XJJBXZIKXFOMLP-ZETCQYMHSA-N tert-butyl (2s)-pyrrolidine-2-carboxylate Chemical compound CC(C)(C)OC(=O)[C@@H]1CCCN1 XJJBXZIKXFOMLP-ZETCQYMHSA-N 0.000 description 1
239000012414 tert-butyl nitrite Substances 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical class OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 description 1
150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
150000003752 zinc compounds Chemical class 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

CH1540168A 1968-10-15 1968-10-15 Verfahren zur herstellung neuer hypocalcaemischer peptide. CH550774A (de)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
CH1540168A CH550774A (de)	1968-10-15	1968-10-15	Verfahren zur herstellung neuer hypocalcaemischer peptide.
DE19691950711 DE1950711A1 (de)	1968-10-15	1969-10-08	Neue Peptide und Verfahren zu ihrer Herstellung
IE1403/69A IE33835B1 (en)	1968-10-15	1969-10-10	New peptides and process for their manufacture
ES372445A ES372445A1 (es)	1968-10-15	1969-10-13	Procedimiento para la obtencion de peptidos de eficacia hi-pocalcemica.
GB50087/69A GB1287125A (en)	1968-10-15	1969-10-13	New peptides and process for their manufacture
SE7216700A SE374913B (2)	1968-10-15	1969-10-13
SE14000/69A SE366543B (2)	1968-10-15	1969-10-13
AT966769A AT300210B (de)	1968-10-15	1969-10-14	Verfahren zur Herstellung neuer Peptide
NL6915540A NL6915540A (2)	1968-10-15	1969-10-14
FR6935098A FR2020730B1 (2)	1968-10-15	1969-10-14
DK545669AA DK129338B (da)	1968-10-15	1969-10-14	Analogifremgangsmåde til fremstilling af dotriacontapeptidamider, N<α>-acylderivater, syreadditionssalte eller kompleksforbindelser deraf.
HUCI929A HU166686B (2)	1968-10-15	1969-10-14
SU1370715A SU430546A3 (2)	1968-10-15	1969-10-14
AT172971A AT313491B (de)	1968-10-15	1969-10-14	Verfahren zur Herstellung neuer Peptide
BE740256D BE740256A (2)	1968-10-15	1969-10-14
BR21333069A BR6913330D0 (pt)	1968-10-15	1969-10-15	Processo para a fabricacao de novos peptideos
CS686369A CS155219B2 (2)	1968-10-15	1969-10-15
US00293271A US3849388A (en)	1968-10-15	1972-09-28	Analogues of human thyrocalcitonin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1540168A CH550774A (de)	1968-10-15	1968-10-15	Verfahren zur herstellung neuer hypocalcaemischer peptide.

Publications (1)

Publication Number	Publication Date
CH550774A true CH550774A (de)	1974-06-28

Family

ID=4408799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1540168A CH550774A (de)	1968-10-15	1968-10-15	Verfahren zur herstellung neuer hypocalcaemischer peptide.

Country Status (3)

Country	Link
BR (1)	BR6913330D0 (2)
CH (1)	CH550774A (2)
SU (1)	SU430546A3 (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6127519A (en) *	1989-04-21	2000-10-03	Tsumura & Co.	Calcitonin derivatives
CN110343146A (zh) *	2019-07-12	2019-10-18	上海应用技术大学	一种蟹味菇呈味肽及其制备方法和应用

1968
- 1968-10-15 CH CH1540168A patent/CH550774A/de not_active IP Right Cessation
1969
- 1969-10-14 SU SU1370715A patent/SU430546A3/ru active
- 1969-10-15 BR BR21333069A patent/BR6913330D0/pt unknown

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6127519A (en) *	1989-04-21	2000-10-03	Tsumura & Co.	Calcitonin derivatives
CN110343146A (zh) *	2019-07-12	2019-10-18	上海应用技术大学	一种蟹味菇呈味肽及其制备方法和应用
CN110343146B (zh) *	2019-07-12	2022-09-30	上海应用技术大学	一种蟹味菇呈味肽及其制备方法和应用

Also Published As

Publication number	Publication date
BR6913330D0 (pt)	1973-03-08
SU430546A3 (2)	1974-05-30

Legal Events

Date	Code	Title	Description
1977-05-13	PL	Patent ceased

Publication	Publication Date	Title
DE2616399C2 (de)	1986-03-27	Desamino-1,7-dicarbacalcitonine und Verfahren zu ihrer Herstellung
DE3428942C2 (de)	1993-11-04	(h-pth)-peptidderivate
DE2435027A1 (de)	1975-02-06	Nonapeptideamide und verfahren zu ihrer herstellung
CH636598A5 (de)	1983-06-15	Verfahren zur herstellung neuer psychopharmakologisch aktiver peptide.
DE2413106A1 (de)	1974-10-10	Neue peptide und verfahren zu ihrer herstellung
CH570972A5 (en)	1975-12-31	Decapeptide
DE3586940T2 (de)	1993-09-30	Polypeptid und dessen Verfahren zur Herstellung.
CH664968A5 (de)	1988-04-15	Gonadoliberin-derivate und verfahren zu ihrer herstellung.
DE2324239C3 (de)	1975-05-28	Verfahren zur Herstellung von Asparaginylgruppen enthaltenden biologisch aktiven Polypeptiden
DE2830489A1 (de)	1979-01-25	Psychopharmakologisch wirksame peptide
DE1950711A1 (de)	1970-04-30	Neue Peptide und Verfahren zu ihrer Herstellung
CH550774A (de)	1974-06-28	Verfahren zur herstellung neuer hypocalcaemischer peptide.
DE2461673A1 (de)	1975-07-17	Verbindung mit serumcalciumreduzierender aktivitaet
CH422813A (de)	1966-10-31	Verfahren zur Herstellung neuer Polypeptide
DE1922562A1 (de)	1969-11-20	Verfahren zur Herstellung von cystinhaltigen Peptiden
DE1941511C2 (de)	1982-11-18	Calcitonin-Analoga und ihre &alpha;-Desamino- und N&uarr;&alpha;&uarr;-Acylaminoderivate, diese Peptide enthaltende pharmazeutische Präparate, und synthetische Verfahren zu ihrer Herstellung sowie zur Herstellung von Calcitonin M
DE1643496C3 (de)	1974-01-03	Verfahren zur Herstellung von menschlichem Corticotropin bzw. analoger Verbindungen
AT300207B (de)	1972-07-25	Verfahren zur Herstellung neuer hypocalcämischer Peptide
EP0003122A1 (de)	1979-07-25	Verfahren zur Herstellung cysteinhaltiger Peptide
CH559720A5 (2)	1975-03-14
DE2347456A1 (de)	1974-04-11	Polypeptide und verfahren zu deren herstellung
CH517074A (de)	1971-12-31	Verfahren zur Herstellung neuer hypocalcämischer Peptide
CH498805A (de)	1970-11-15	Verfahren zur Herstellung von Cystinrest-haltigen Peptiden
DE2311786A1 (de)	1973-09-20	Verfahren zur herstellung von peptiden
DE1817938A1 (de)	1974-04-11	Neue hypocalcaemische peptide und verfahren zu ihrer herstellung