CH649553A5 - Azepinoindole und verfahren zu deren herstellung. - Google Patents

Azepinoindole und verfahren zu deren herstellung. Download PDF

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Publication number
CH649553A5
CH649553A5 CH2806/82A CH280682A CH649553A5 CH 649553 A5 CH649553 A5 CH 649553A5 CH 2806/82 A CH2806/82 A CH 2806/82A CH 280682 A CH280682 A CH 280682A CH 649553 A5 CH649553 A5 CH 649553A5
Authority
CH
Switzerland
Prior art keywords
compounds
formula
alkyl
mixture
solution
Prior art date
Application number
CH2806/82A
Other languages
German (de)
English (en)
Inventor
Fulvio Dr Gadient
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to CH2806/82A priority Critical patent/CH649553A5/de
Priority to FR8307089A priority patent/FR2526434A1/fr
Priority to DE19833315467 priority patent/DE3315467A1/de
Priority to BE1/10774A priority patent/BE896590A/fr
Priority to FI831475A priority patent/FI831475L/fi
Priority to ES522008A priority patent/ES522008A0/es
Priority to NL8301552A priority patent/NL8301552A/nl
Priority to JP58078869A priority patent/JPS58203993A/ja
Priority to PT76632A priority patent/PT76632B/pt
Priority to SE8302554A priority patent/SE8302554L/xx
Priority to DK199883A priority patent/DK199883A/da
Priority to HU831531A priority patent/HU189275B/hu
Priority to GB08312159A priority patent/GB2120662B/en
Priority to IL68576A priority patent/IL68576A0/xx
Priority to AU14256/83A priority patent/AU1425683A/en
Priority to IT48232/83A priority patent/IT1197644B/it
Priority to ZA833266A priority patent/ZA833266B/xx
Publication of CH649553A5 publication Critical patent/CH649553A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CH2806/82A 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung. CH649553A5 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.
FR8307089A FR2526434A1 (fr) 1982-05-06 1983-04-27 Nouveaux azepino-indoles, leur preparation et leur utilisation comme medicaments
DE19833315467 DE3315467A1 (de) 1982-05-06 1983-04-28 Azepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel
BE1/10774A BE896590A (fr) 1982-05-06 1983-04-28 Nouveaux azepino-indoles leur preparation et leur utilisation comme medicaments
FI831475A FI831475L (fi) 1982-05-06 1983-04-29 Nya azepinindoler, deras framstaellning och dessa innehaollande farmaceutiska foereningar
ES522008A ES522008A0 (es) 1982-05-06 1983-05-02 Procedimiento para preparar acepinoindoles.
NL8301552A NL8301552A (nl) 1982-05-06 1983-05-03 Nieuwe azepinoindolen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
JP58078869A JPS58203993A (ja) 1982-05-06 1983-05-04 新規アゼピノインド−ル、その製造法およびそれからなる医薬
PT76632A PT76632B (en) 1982-05-06 1983-05-04 Process for the preparation of 1-alkyl-1,2,3,4,5,6-hexahydro-azepine <4,5-b> indoles
SE8302554A SE8302554L (sv) 1982-05-06 1983-05-04 Nya azepinoindoler, deras framstellning samt farmaceutiska kompositioner innehallande desamma
DK199883A DK199883A (da) 1982-05-06 1983-05-04 Fremgangsmaade til fremstilling af azepinoindoler
HU831531A HU189275B (en) 1982-05-06 1983-05-04 Process for preparing azepino-indole derivatives and pharmaceutical compositions containing such compounds
GB08312159A GB2120662B (en) 1982-05-06 1983-05-04 New azepinoindoles their production and pharmaceutical compositions containing them
IL68576A IL68576A0 (en) 1982-05-06 1983-05-04 Azepinoindoles,their production and pharmaceutical compositions containing them
AU14256/83A AU1425683A (en) 1982-05-06 1983-05-05 1-alkyl-1,2,3,4,5,6-hexahydroazepino(4,5-6)indoles
IT48232/83A IT1197644B (it) 1982-05-06 1983-05-06 Azepinoindoli,loro preparazione e loro impiego come medicamenti
ZA833266A ZA833266B (en) 1982-05-06 1983-05-06 New azepino indoles,their production and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (1)

Publication Number Publication Date
CH649553A5 true CH649553A5 (de) 1985-05-31

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Country Status (17)

Country Link
JP (1) JPS58203993A (it)
AU (1) AU1425683A (it)
BE (1) BE896590A (it)
CH (1) CH649553A5 (it)
DE (1) DE3315467A1 (it)
DK (1) DK199883A (it)
ES (1) ES522008A0 (it)
FI (1) FI831475L (it)
FR (1) FR2526434A1 (it)
GB (1) GB2120662B (it)
HU (1) HU189275B (it)
IL (1) IL68576A0 (it)
IT (1) IT1197644B (it)
NL (1) NL8301552A (it)
PT (1) PT76632B (it)
SE (1) SE8302554L (it)
ZA (1) ZA833266B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193083B (en) * 1984-02-22 1987-08-28 Sandoz Ag Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
AU2001292898A1 (en) * 2000-09-20 2002-04-02 Brad A. Acker Substituted azepino[4,5b)indole derivatives
US6849640B2 (en) 2001-08-08 2005-02-01 Pharmacia & Upjohn Company Therapeutic 1H-pyrido [4,3-b] indoles
BRPI0707183A2 (pt) * 2006-01-19 2011-04-26 Athersys Inc composto, composição farmacêutica, e, método de tratar uma doença, distúrbio e/ou condição em um paciente
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US8637501B2 (en) 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3070467D1 (en) * 1979-11-02 1985-05-15 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT76632A (en) 1983-06-01
IT8348232A0 (it) 1983-05-06
IL68576A0 (en) 1983-09-30
DK199883A (da) 1983-11-07
ZA833266B (en) 1984-12-24
FI831475A7 (fi) 1983-11-07
ES8502440A1 (es) 1985-01-01
SE8302554D0 (sv) 1983-05-04
GB2120662B (en) 1985-09-11
FR2526434A1 (fr) 1983-11-10
NL8301552A (nl) 1983-12-01
BE896590A (fr) 1983-10-28
PT76632B (en) 1986-01-27
SE8302554L (sv) 1983-11-07
HU189275B (en) 1986-06-30
IT8348232A1 (it) 1984-11-06
GB2120662A (en) 1983-12-07
IT1197644B (it) 1988-12-06
AU1425683A (en) 1983-11-10
GB8312159D0 (en) 1983-06-08
JPS58203993A (ja) 1983-11-28
DK199883D0 (da) 1983-05-04
ES522008A0 (es) 1985-01-01
FI831475L (fi) 1983-11-07
FI831475A0 (fi) 1983-04-29
DE3315467A1 (de) 1983-11-17

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