CH91247A - Process for preparing a diethylbarbituric acid compound. - Google Patents
Process for preparing a diethylbarbituric acid compound.Info
- Publication number
- CH91247A CH91247A CH91247DA CH91247A CH 91247 A CH91247 A CH 91247A CH 91247D A CH91247D A CH 91247DA CH 91247 A CH91247 A CH 91247A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- acid compound
- diethylbarbituric acid
- preparation
- diethylbarbituric
- Prior art date
Links
- 229960002319 barbital Drugs 0.000 title claims description 6
- -1 diethylbarbituric acid compound Chemical class 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims description 5
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000000155 melt Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000000517 effect on sleep Effects 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 229940124641 pain reliever Drugs 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
EMI0001.0001
verfahren <SEP> zur <SEP> Darstellung <SEP> einer <SEP> Diiitli@@lbarbitursiiui-everbin(lnng. Nach vorliegender Erfindung gelangt inan zu einer neuen und eigenartigen Verbindung aus Diäthylbarbituraäure und Dimethylainino- phenyldimetliylpyrazolon, wenn man die bei den Komponenten, zweel:mässig im Verhält nis von 1 Mol. Diäthylbarbitursäure zu 2 Mol. Dimethylaminophenyldimethylpyrazolon zu sammenschmilzt.
Die neue Verbindung soll zti therapeu tischen Zwecken Verwendung finden. Beson ders eignet sie sich als schmerzstillendes Mittel, da in ihr nicht die Schlafwirkung, sondern die analgetische Wirkung verstärkt ist. Die Verbindung entspricht der Formel CUH;605Nd und stellt ein gelbes Pulver dar, das bei Ü5-970 schmilzt und in Wasser, Alkohol, Äther und andern organischen Lö sungsmitteln löslich ist.
Zur Darstellung der neuen Verbindung verfährt man beispielsweise wie folgt 462 Teile Diinethylaminophenyldiinetliyl- pyrazolon werden finit 184 Teilen Diäthyl- barbitursäure zusammen geschmolzen, zweck- mässig bei einer Temperatur, die ungefähr 11Ü nicht überschreitet. Die klare gelb gefärbte Schmelze wird nach dem Erstarren mit Wasser behandelt und gereinigt.
EMI0001.0001
method <SEP> for <SEP> representation <SEP> a <SEP> Diiitli @@ lbarbitursiiui-everbin (lnng. According to the present invention, a new and peculiar compound of diethylbarbituric acid and dimethylainino-phenyldimetliylpyrazolone is obtained if one of the components, two: moderately in the ratio of 1 mol. diethylbarbituric acid to 2 mol. dimethylaminophenyldimethylpyrazolone melts together.
The new connection is intended to be used for therapeutic purposes. It is particularly suitable as a pain reliever, as it does not increase the sleep effect, but rather the analgesic effect. The compound corresponds to the formula CUH; 605Nd and is a yellow powder that melts at Ü5-970 and is soluble in water, alcohol, ether and other organic solvents.
To prepare the new compound, the following procedure is used, for example, as follows: 462 parts of diinethylaminophenyldiinetliylpyrazolone are finitely melted together 184 parts of diethylbarbituric acid, expediently at a temperature not exceeding about 11 °. The clear, yellow-colored melt is treated with water and cleaned after it has solidified.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE89936X | 1920-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH91247A true CH91247A (en) | 1921-10-17 |
Family
ID=5642994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH91247D CH91247A (en) | 1920-01-26 | 1921-01-08 | Process for preparing a diethylbarbituric acid compound. |
Country Status (2)
| Country | Link |
|---|---|
| AT (1) | AT89936B (en) |
| CH (1) | CH91247A (en) |
-
1921
- 1921-01-05 AT AT89936D patent/AT89936B/en active
- 1921-01-08 CH CH91247D patent/CH91247A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT89936B (en) | 1922-11-10 |
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