CL2015000688A1 - Metodo o proceso para convertir un deshidrato de un depsipeptido macrociclico y/o su analogo de hemiaminal en el compuesto macrociclico y compuestos intermediarios. - Google Patents

Metodo o proceso para convertir un deshidrato de un depsipeptido macrociclico y/o su analogo de hemiaminal en el compuesto macrociclico y compuestos intermediarios.

Info

Publication number: CL2015000688A1
Authority: CL; Chile
Prior art keywords: macrocyclic; hemiaminal; dehydrate; intermediates; analog
Prior art date: 2011-04-20

Application number

CL2015000688A

Other languages

English (en)

Inventor

Murat Acemoglu

Heribert Hellstern

Felix Kollmer

John Lopez

Robert Schreiber

Christian Sprecher

Hans Stettler

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-20

Filing date

2015-03-18

Publication date

2015-06-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46317455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000688(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-03-18 Application filed by Novartis Ag filed Critical Novartis Ag

2015-06-05 Publication of CL2015000688A1 publication Critical patent/CL2015000688A1/es

Links

108010002156 Depsipeptides Proteins 0.000 title 1
150000002374 hemiaminals Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
150000002678 macrocyclic compounds Chemical class 0.000 title 1
OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Cookers (AREA)
Cereal-Derived Products (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CL2015000688A 2011-04-20 2015-03-18 Metodo o proceso para convertir un deshidrato de un depsipeptido macrociclico y/o su analogo de hemiaminal en el compuesto macrociclico y compuestos intermediarios. CL2015000688A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201161477319P	2011-04-20	2011-04-20

Publications (1)

Publication Number	Publication Date
CL2015000688A1 true CL2015000688A1 (es)	2015-06-05

Family

ID=46317455

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CL2013003037A CL2013003037A1 (es)	2011-04-20	2013-10-18	Proceso de preparacion de un depsipeptido ciclico que considera desproteger un grupo oh, oxidarlo, ciclarlo y finalmente desproteger selectivamente algunos grupos; y compuestos intermediarios.
CL2015000688A CL2015000688A1 (es)	2011-04-20	2015-03-18	Metodo o proceso para convertir un deshidrato de un depsipeptido macrociclico y/o su analogo de hemiaminal en el compuesto macrociclico y compuestos intermediarios.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CL2013003037A CL2013003037A1 (es)	2011-04-20	2013-10-18	Proceso de preparacion de un depsipeptido ciclico que considera desproteger un grupo oh, oxidarlo, ciclarlo y finalmente desproteger selectivamente algunos grupos; y compuestos intermediarios.

Country Status (22)

Country	Link
US (2)	US8614289B2 (es)
EP (1)	EP2699585A1 (es)
JP (2)	JP5951006B2 (es)
KR (1)	KR101580729B1 (es)
CN (2)	CN104804072A (es)
AR (1)	AR086168A1 (es)
AU (1)	AU2012245980B2 (es)
BR (1)	BR112013026660A2 (es)
CA (1)	CA2833109A1 (es)
CL (2)	CL2013003037A1 (es)
CO (1)	CO6801799A2 (es)
EA (2)	EA025546B1 (es)
GT (1)	GT201300256A (es)
IL (1)	IL228727A0 (es)
MA (1)	MA35034B1 (es)
MX (1)	MX337526B (es)
PE (1)	PE20141206A1 (es)
PH (1)	PH12013502101A1 (es)
SG (1)	SG193918A1 (es)
TN (1)	TN2013000385A1 (es)
TW (1)	TW201249863A (es)
WO (1)	WO2012143888A1 (es)

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MY151973A (en)	2007-08-17	2014-07-31	Novartis Ag	Cyclic depsipeptides
US8680054B2 (en)	2011-04-20	2014-03-25	Novartis Ag	Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en)	2011-04-20	2013-12-24	Novartis Ag	Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en)	2012-10-09	2015-03-24	Novartis Ag	Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en)	2012-10-09	2015-06-30	Novartis Ag	Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
CN106029684A (zh)	2014-04-08	2016-10-12	诺华股份有限公司	用于生产大环缩酚酸肽和新中间体的新型缩醛类方法
LT3298027T (lt) *	2015-05-20	2021-08-10	Boehringer Ingelheim Animal Health USA Inc.	Antihelmintiniai depsipeptido junginiai
JP2018530543A (ja)	2015-09-17	2018-10-18	マサチューセッツインスティテュートオブテクノロジー	固相ペプチド合成のための方法およびシステム
KR102031186B1 (ko) *	2017-01-11	2019-11-08	주식회사 엘지생활건강	단백질 강도 강화용 조성물
US11643438B2 (en)	2018-07-20	2023-05-09	The Board Of Regents Of The University Of Oklahoma	Antimicrobial peptides and methods of use

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DE4421113A1 (de)	1994-06-16	1995-12-21	Biotechnolog Forschung Gmbh	Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
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KR101205257B1 (ko)	2003-06-06	2012-11-27	아렉시스 악티에볼라그	피부 상태 또는 암 치료를 위한 ｓｃｃｅ 저해제로서의 융합된 헤테로사이클 화합물의 용도
GB0322140D0 (en)	2003-09-22	2003-10-22	Pfizer Ltd	Combinations
EP1716248A1 (en)	2004-02-03	2006-11-02	Bayer HealthCare AG	Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
CA2651796A1 (en)	2006-02-27	2007-09-07	Arizona Board Of Regents For And On Behalf Of Arizona State University	Identification and use of novopeptides for the treatment of cancer
GB0715750D0 (en)	2007-08-13	2007-09-19	Karus Therapeutics Ltd	Chemical compounds
WO2009024528A1 (en)	2007-08-17	2009-02-26	Novartis Ag	Use of cyclic depsipeptides to inhibit kallikrein 7
MY151973A (en)	2007-08-17	2014-07-31	Novartis Ag	Cyclic depsipeptides
DE102007052391A1 (de)	2007-10-31	2009-05-07	Henkel Ag & Co. Kgaa	Mattwachs
US20110112121A1 (en)	2009-07-06	2011-05-12	Joerg Berghausen	Pharmaceutical Compositions and Solid Forms
KR101004362B1 (ko)	2010-03-19	2010-12-28	가톨릭대학교 산학협력단	자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en)	2010-09-10	2012-03-15	Nanobio Corporation	Anti-aging and wrinkle treatment methods using nanoemulsion compositions
WO2012035468A2 (en)	2010-09-14	2012-03-22	Trima - Israel Pharmaceutical Products Maabarot Ltd.	Foamable topical composition
KR20140005998A (ko)	2011-01-24	2014-01-15	안테리오스, 인코퍼레이티드	나노입자 조성물, 이의 제형, 및 그의 용도
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US8614289B2 (en)	2011-04-20	2013-12-24	Novartis Ag	Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8680054B2 (en)	2011-04-20	2014-03-25	Novartis Ag	Suspension type topical formulations comprising cyclic depsipeptide
US9067978B2 (en)	2012-10-09	2015-06-30	Novartis Ag	Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en)	2012-10-09	2015-03-24	Novartis Ag	Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
CN106029684A (zh)	2014-04-08	2016-10-12	诺华股份有限公司	用于生产大环缩酚酸肽和新中间体的新型缩醛类方法

2012
- 2012-04-18 US US13/449,937 patent/US8614289B2/en not_active Expired - Fee Related
- 2012-04-18 AR ARP120101326A patent/AR086168A1/es unknown
- 2012-04-19 MX MX2013012188A patent/MX337526B/es active IP Right Grant
- 2012-04-19 JP JP2014505772A patent/JP5951006B2/ja not_active Expired - Fee Related
- 2012-04-19 SG SG2013070453A patent/SG193918A1/en unknown
- 2012-04-19 MA MA36321A patent/MA35034B1/fr unknown
- 2012-04-19 PH PH1/2013/502101A patent/PH12013502101A1/en unknown
- 2012-04-19 CN CN201510232322.3A patent/CN104804072A/zh active Pending
- 2012-04-19 KR KR1020137030625A patent/KR101580729B1/ko not_active Expired - Fee Related
- 2012-04-19 CA CA2833109A patent/CA2833109A1/en not_active Abandoned
- 2012-04-19 EA EA201391554A patent/EA025546B1/ru not_active IP Right Cessation
- 2012-04-19 PE PE2013002370A patent/PE20141206A1/es not_active Application Discontinuation
- 2012-04-19 TW TW101114027A patent/TW201249863A/zh unknown
- 2012-04-19 CN CN201280019062.6A patent/CN103476789B/zh not_active Expired - Fee Related
- 2012-04-19 WO PCT/IB2012/051977 patent/WO2012143888A1/en not_active Ceased
- 2012-04-19 BR BR112013026660A patent/BR112013026660A2/pt not_active IP Right Cessation
- 2012-04-19 AU AU2012245980A patent/AU2012245980B2/en not_active Ceased
- 2012-04-19 EA EA201500734A patent/EA201500734A1/ru unknown
- 2012-04-19 EP EP12727933.9A patent/EP2699585A1/en not_active Withdrawn
2013
- 2013-09-25 TN TNP2013000385A patent/TN2013000385A1/fr unknown
- 2013-10-03 IL IL228727A patent/IL228727A0/en unknown
- 2013-10-18 GT GT201300256A patent/GT201300256A/es unknown
- 2013-10-18 CL CL2013003037A patent/CL2013003037A1/es unknown
- 2013-10-24 CO CO13252979A patent/CO6801799A2/es unknown
- 2013-11-18 US US14/082,315 patent/US9278997B2/en active Active
2015
- 2015-03-18 CL CL2015000688A patent/CL2015000688A1/es unknown
2016
- 2016-03-07 JP JP2016043330A patent/JP2016164158A/ja active Pending

Also Published As

Publication number	Publication date
IL228727A0 (en)	2013-12-31
JP5951006B2 (ja)	2016-07-13
US8614289B2 (en)	2013-12-24
CN103476789A (zh)	2013-12-25
EA025546B1 (ru)	2017-01-30
TN2013000385A1 (en)	2015-01-20
PH12013502101A1 (en)	2017-10-25
AR086168A1 (es)	2013-11-27
CN103476789B (zh)	2016-11-09
MA35034B1 (fr)	2014-04-03
WO2012143888A1 (en)	2012-10-26
US20120277406A1 (en)	2012-11-01
AU2012245980A1 (en)	2013-10-03
JP2014511899A (ja)	2014-05-19
KR20130140204A (ko)	2013-12-23
EA201500734A1 (ru)	2015-11-30
GT201300256A (es)	2015-02-19
SG193918A1 (en)	2013-11-29
EA201391554A1 (ru)	2014-11-28
CL2013003037A1 (es)	2014-10-03
AU2012245980B2 (en)	2015-01-29
JP2016164158A (ja)	2016-09-08
US20140080995A1 (en)	2014-03-20
BR112013026660A2 (pt)	2016-09-06
MX2013012188A (es)	2013-11-04
CO6801799A2 (es)	2013-11-29
EP2699585A1 (en)	2014-02-26
US9278997B2 (en)	2016-03-08
CA2833109A1 (en)	2012-10-26
PE20141206A1 (es)	2014-09-28
TW201249863A (en)	2012-12-16
KR101580729B1 (ko)	2015-12-28
MX337526B (es)	2016-03-09
CN104804072A (zh)	2015-07-29

Publication	Publication Date	Title
CL2015000688A1 (es)	2015-06-05	Metodo o proceso para convertir un deshidrato de un depsipeptido macrociclico y/o su analogo de hemiaminal en el compuesto macrociclico y compuestos intermediarios.
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DK2391863T3 (da)	2020-08-24	Multimodalt førerløst luftfartøj
EP2844781A4 (en)	2016-01-13	METHOD FOR DEPOSITION OF ORGANIC MATTER
CL2014003318A1 (es)	2015-03-06	Un método para el fraccionamiento de lignina: fraccion de lignina.
PL2718024T3 (pl)	2017-07-31	Instalacja lakiernicza
BR112013030907A2 (pt)	2018-04-03	anel de pistão e respectivos revestimento resistente ao desgaste e método de aplicação.
EP2682463A4 (en)	2014-11-26	BACTERIOZIN OBTAINED FROM LACTOBACILLUS RHAMNOSUS
BR112013019695A2 (pt)	2018-07-17	material compósito de mancal de deslizamento
TWI561288B (en)	2016-12-11	Novel method for purifying organic solid materials
PL2797929T3 (pl)	2018-10-31	Nowy analog rapamycyny
ZA201108596B (en)	2013-07-27	Bearing retainer assembly
DK2534070T3 (da)	2013-11-04	Slidsgriber
EP2647859A4 (en)	2014-05-21	SEGMENTED RETAINING MEMBER FOR BEARING BEARING
CO7061067A2 (es)	2014-09-19	Métodos para el tratamiento de un impedimento sensorial-motriz relacionado con el accidente cerebrovascular con el uso de aminopiridinas
BR112013010326A2 (pt)	2016-09-20	corpos de válvula tendo capacidade de redução de impulso integral
EP2678788A4 (en)	2016-06-01	INCREASE RESEARCH RESULTS
EP2753582A4 (en)	2015-08-12	PRESSURE RETURN OF AN ORGANIC MATERIAL
CR20130362A (es)	2013-10-04	Método para el control de hongos fitopatógenos
PL391879A1 (pl)	2011-10-10	Sposób oczyszczania 1,2-dichloropropanu
BR112012028716A2 (pt)	2018-05-15	método para a extração de material de uma fruta da família sapindacea
IT1399702B1 (it)	2013-04-26	Metodo e gruppo per la rullatura di uno pneumatico