CL2018003318A1 - Triazoles para la regulación de la homeostasis de calcio intracelular. - Google Patents

Triazoles para la regulación de la homeostasis de calcio intracelular.

Info

Publication number
CL2018003318A1
CL2018003318A1 CL2018003318A CL2018003318A CL2018003318A1 CL 2018003318 A1 CL2018003318 A1 CL 2018003318A1 CL 2018003318 A CL2018003318 A CL 2018003318A CL 2018003318 A CL2018003318 A CL 2018003318A CL 2018003318 A1 CL2018003318 A1 CL 2018003318A1
Authority
CL
Chile
Prior art keywords
intracellular calcium
triazoles
regulation
calcium homeostasis
homeostasis
Prior art date
Application number
CL2018003318A
Other languages
English (en)
Inventor
Illarramendi Ainara Vallejo
De Munain Arregi Adolfo José López
Celma Pablo Ferrón
Iparraguirre Jesús María Aizpurua
Epelde Aitziber Irastorza
Murua José Ignacio Miranda
Ojeda Iván Toral
Aristizabal Garazi Aldanondo
Original Assignee
Univ Pais Vasco
Administracion General De La Comunidad Autonoma De Euskadi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pais Vasco, Administracion General De La Comunidad Autonoma De Euskadi filed Critical Univ Pais Vasco
Publication of CL2018003318A1 publication Critical patent/CL2018003318A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON 1,2,3-TRIAZOLES DE FÓRMULA, ÚTILES PARA MEJORAR O RESTAURAR LA FUNCIÓN DE HOMEOSTASIS DE CALCIO INTRACELULAR Y LA UNIÓN RYR-CALSTABINA EN CÉLULAS HUMANAS Y ANIMALES. TAMBIÉN ESTÁ RELACIONADA CON MÉTODOS DE SÍNTESIS DE DICHOS COMPUESTOS, CON COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN, Y CON SU USO PARA PREVENIR O TRATAR TRASTORNOS MÚSCULO-ESQUELÉTICOS, CARDÍACOS Y DEL SISTEMA NERVIOSO.
CL2018003318A 2016-05-24 2018-11-21 Triazoles para la regulación de la homeostasis de calcio intracelular. CL2018003318A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201630670A ES2643856B1 (es) 2016-05-24 2016-05-24 Triazoles para la regulación de la homeostasis de calcio intracelular

Publications (1)

Publication Number Publication Date
CL2018003318A1 true CL2018003318A1 (es) 2019-04-12

Family

ID=59285262

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018003318A CL2018003318A1 (es) 2016-05-24 2018-11-21 Triazoles para la regulación de la homeostasis de calcio intracelular.

Country Status (17)

Country Link
US (1) US11377427B2 (es)
EP (1) EP3466933B1 (es)
JP (1) JP6983875B2 (es)
CN (1) CN109563056B (es)
AU (1) AU2017270485B2 (es)
CA (1) CA3025436C (es)
CL (1) CL2018003318A1 (es)
DK (1) DK3466933T3 (es)
ES (2) ES2643856B1 (es)
HR (1) HRP20210211T1 (es)
HU (1) HUE053371T2 (es)
IL (1) IL263168B2 (es)
MX (1) MX381545B (es)
PL (1) PL3466933T3 (es)
PT (1) PT3466933T (es)
RU (1) RU2753509C2 (es)
WO (1) WO2017203083A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10675353B2 (en) 2016-05-24 2020-06-09 Amgen Inc. Pegylated carfilzomib compounds

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021162054A1 (ja) * 2020-02-10 2021-08-19 学校法人順天堂 ２型リアノジン受容体活性抑制剤
JP2025520705A (ja) * 2022-06-23 2025-07-03 ミラムーン、ファーマ、ソシエダッド、リミターダ 眼疾患治療において使用するためのトリアゾール類

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10675353B2 (en) 2016-05-24 2020-06-09 Amgen Inc. Pegylated carfilzomib compounds

Also Published As

Publication number Publication date
RU2018141584A3 (es) 2020-07-27
CA3025436C (en) 2024-02-20
ES2853701T3 (es) 2021-09-17
HUE053371T2 (hu) 2021-06-28
HRP20210211T1 (hr) 2021-03-19
JP6983875B2 (ja) 2021-12-17
CA3025436A1 (en) 2017-11-30
MX381545B (es) 2025-03-12
CN109563056A (zh) 2019-04-02
AU2017270485A1 (en) 2018-12-13
IL263168B1 (en) 2023-05-01
EP3466933A1 (en) 2019-04-10
RU2753509C2 (ru) 2021-08-17
ES2643856B1 (es) 2018-08-03
WO2017203083A1 (es) 2017-11-30
RU2018141584A (ru) 2020-06-25
PL3466933T3 (pl) 2021-06-14
DK3466933T3 (da) 2021-01-11
ES2643856A1 (es) 2017-11-24
AU2017270485B2 (en) 2021-02-25
CN109563056B (zh) 2022-08-16
US20200317625A1 (en) 2020-10-08
IL263168A (en) 2018-12-31
MX2018014414A (es) 2019-04-22
IL263168B2 (en) 2023-09-01
PT3466933T (pt) 2021-02-23
JP2019520423A (ja) 2019-07-18
US11377427B2 (en) 2022-07-05
EP3466933B1 (en) 2020-12-02

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