CN103458899A - 治疗阻塞性睡眠呼吸暂停的方法 - Google Patents

治疗阻塞性睡眠呼吸暂停的方法 Download PDF

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Publication number
CN103458899A
CN103458899A CN2012800065522A CN201280006552A CN103458899A CN 103458899 A CN103458899 A CN 103458899A CN 2012800065522 A CN2012800065522 A CN 2012800065522A CN 201280006552 A CN201280006552 A CN 201280006552A CN 103458899 A CN103458899 A CN 103458899A
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CN
China
Prior art keywords
sleep
osa
pharmaceutical composition
pyridostigmine
apnea
Prior art date
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Pending
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CN2012800065522A
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English (en)
Chinese (zh)
Inventor
樊建强
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PFANTASTIC MEDICAL RESEARCH INSTITUTE LLC
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PFANTASTIC MEDICAL RESEARCH INSTITUTE LLC
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Application filed by PFANTASTIC MEDICAL RESEARCH INSTITUTE LLC filed Critical PFANTASTIC MEDICAL RESEARCH INSTITUTE LLC
Priority to CN201610821591.8A priority Critical patent/CN107007602A/zh
Publication of CN103458899A publication Critical patent/CN103458899A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/56—Devices for preventing snoring
    • A61F5/566—Intra-oral devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Nursing (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2012800065522A 2011-01-28 2012-01-27 治疗阻塞性睡眠呼吸暂停的方法 Pending CN103458899A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610821591.8A CN107007602A (zh) 2011-01-28 2012-01-27 治疗阻塞性睡眠呼吸暂停的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437272P 2011-01-28 2011-01-28
US61/437,272 2011-01-28
PCT/US2012/022825 WO2012103398A2 (en) 2011-01-28 2012-01-27 Methods for treating obstructive sleep apnea

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610821591.8A Division CN107007602A (zh) 2011-01-28 2012-01-27 治疗阻塞性睡眠呼吸暂停的方法

Publications (1)

Publication Number Publication Date
CN103458899A true CN103458899A (zh) 2013-12-18

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CN2012800065522A Pending CN103458899A (zh) 2011-01-28 2012-01-27 治疗阻塞性睡眠呼吸暂停的方法
CN201610821591.8A Pending CN107007602A (zh) 2011-01-28 2012-01-27 治疗阻塞性睡眠呼吸暂停的方法

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Country Status (6)

Country Link
US (2) US8753327B2 (2)
EP (1) EP2672972B1 (2)
JP (2) JP2014503593A (2)
CN (2) CN103458899A (2)
CA (1) CA2825309C (2)
WO (1) WO2012103398A2 (2)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110198688A (zh) * 2016-12-23 2019-09-03 皇家飞利浦有限公司 用于处置至少两个用户间的打鼾的系统
CN110799181A (zh) * 2017-04-28 2020-02-14 布里格姆妇女医院 用于治疗睡眠呼吸暂停的方法和组合物
CN114504643A (zh) * 2021-12-24 2022-05-17 北京大学第一医院 抗IgE抗体在用于治疗OSAS中的应用
CN117402958A (zh) * 2023-10-26 2024-01-16 天津医科大学总医院 Claudin3及家族相关分子对阻塞性睡眠呼吸暂停低通气综合征的诊断价值
US11911351B2 (en) 2018-01-30 2024-02-27 Apnimed, Inc. (Delaware) Methods for treating sleep apnea with combinations of atomoxetine and (R)-oxybutynin
US12558327B2 (en) 2019-02-08 2026-02-24 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2825309C (en) * 2011-01-28 2019-10-01 Pfantastic Medical Research Institute, Llc Pyridostigmine for the treatment of obstructive sleep apnea
EP3446663A1 (en) * 2014-03-03 2019-02-27 Sleep Innovations Pty Ltd Device and method for sleep apnoea treatment
US10166268B2 (en) 2014-07-25 2019-01-01 The George Washington University Oxytocin improves treatment of obstructive sleep apnea
CN111603643B (zh) 2015-04-02 2023-05-23 希尔－罗姆服务私人有限公司 呼吸装置的压力控制
ES2861153T3 (es) * 2018-06-18 2021-10-05 Composiciones de liberación prolongada que comprenden piridostigmina
EP3840806B1 (en) * 2018-08-24 2023-10-11 Koninklijke Philips N.V. Providing sleep therapy with a pressure therapy system
US11654283B2 (en) 2019-03-06 2023-05-23 Medtronic Xomed, Inc. Obstructive sleep apnea patient programmer for implantable devices
KR20250124853A (ko) * 2022-12-28 2025-08-20 니시카와 가부시키가이샤 건강 리스크 판정 시스템, 자율 신경 판정 시스템, 생활 개선 시스템, 수면 자세 판정 시스템, 수면 자세 판정 프로그램, 이갈이 검출 시스템, 및 이갈이 검출 프로그램

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034117A (en) * 1995-12-19 2000-03-07 A & Science Invest Ab Methods of treating and diagnosing sleep disordered breathing and means for carrying out the method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2247662B (en) 1990-08-31 1994-11-02 Instance Ltd David J Labels and manufacture thereof
WO2005016327A2 (en) * 2003-08-13 2005-02-24 Janssen Pharmaceutica, N.V. Treatment of sleep disorders with cholinesterase inhibitors
EP1928445A1 (en) * 2005-09-16 2008-06-11 Cereuscience AB Method and means of preventing and treating sleep disordered breathing
US20080066739A1 (en) * 2006-09-20 2008-03-20 Lemahieu Edward Methods and systems of delivering medication via inhalation
US7984714B2 (en) * 2006-09-29 2011-07-26 Nellcor Puritan Bennett Llc Managing obstructive sleep apnea and/or snoring using local time released agents
CA2825309C (en) * 2011-01-28 2019-10-01 Pfantastic Medical Research Institute, Llc Pyridostigmine for the treatment of obstructive sleep apnea

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6034117A (en) * 1995-12-19 2000-03-07 A & Science Invest Ab Methods of treating and diagnosing sleep disordered breathing and means for carrying out the method

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110198688A (zh) * 2016-12-23 2019-09-03 皇家飞利浦有限公司 用于处置至少两个用户间的打鼾的系统
CN110799181A (zh) * 2017-04-28 2020-02-14 布里格姆妇女医院 用于治疗睡眠呼吸暂停的方法和组合物
US11911351B2 (en) 2018-01-30 2024-02-27 Apnimed, Inc. (Delaware) Methods for treating sleep apnea with combinations of atomoxetine and (R)-oxybutynin
US12558327B2 (en) 2019-02-08 2026-02-24 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea
CN114504643A (zh) * 2021-12-24 2022-05-17 北京大学第一医院 抗IgE抗体在用于治疗OSAS中的应用
CN114504643B (zh) * 2021-12-24 2024-03-26 北京大学第一医院 抗IgE抗体在用于治疗OSAS中的应用
CN117402958A (zh) * 2023-10-26 2024-01-16 天津医科大学总医院 Claudin3及家族相关分子对阻塞性睡眠呼吸暂停低通气综合征的诊断价值

Also Published As

Publication number Publication date
EP2672972B1 (en) 2020-11-04
US9295670B2 (en) 2016-03-29
CA2825309A1 (en) 2012-08-02
CN107007602A (zh) 2017-08-04
WO2012103398A9 (en) 2012-09-27
EP2672972A4 (en) 2014-09-10
EP2672972A2 (en) 2013-12-18
CA2825309C (en) 2019-10-01
JP2014503593A (ja) 2014-02-13
JP2017095485A (ja) 2017-06-01
US8753327B2 (en) 2014-06-17
JP6342525B2 (ja) 2018-06-13
US20140238412A1 (en) 2014-08-28
WO2012103398A2 (en) 2012-08-02
US20120197235A1 (en) 2012-08-02

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