CN1469757A - 包含全氟烷基的金属络合物在显影斑块、肿瘤和坏死的mr显影中作为造影剂的应用 - Google Patents

包含全氟烷基的金属络合物在显影斑块、肿瘤和坏死的mr显影中作为造影剂的应用 Download PDF

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Publication number
CN1469757A
CN1469757A CNA018172717A CN01817271A CN1469757A CN 1469757 A CN1469757 A CN 1469757A CN A018172717 A CNA018172717 A CN A018172717A CN 01817271 A CN01817271 A CN 01817271A CN 1469757 A CN1469757 A CN 1469757A
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CN
China
Prior art keywords
group
groups
general formula
mmol
complex
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA018172717A
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English (en)
Chinese (zh)
Inventor
����� Լ�������
约翰尼斯·普拉策克
彼得·马雷斯凯
°
乌尔里西·尼德巴尔拉
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贝恩德·勒杜凯尔
���ϣķ��κ����
汉斯-约阿希姆·魏因曼
ά
贝恩德·米塞尔维茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Schering AG filed Critical Schering AG
Publication of CN1469757A publication Critical patent/CN1469757A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA018172717A 2000-08-11 2001-07-23 包含全氟烷基的金属络合物在显影斑块、肿瘤和坏死的mr显影中作为造影剂的应用 Pending CN1469757A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040380.8 2000-08-11

Publications (1)

Publication Number Publication Date
CN1469757A true CN1469757A (zh) 2004-01-21

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA018172717A Pending CN1469757A (zh) 2000-08-11 2001-07-23 包含全氟烷基的金属络合物在显影斑块、肿瘤和坏死的mr显影中作为造影剂的应用

Country Status (26)

Country Link
EP (1) EP1307236A2 (pl)
JP (1) JP2004506025A (pl)
KR (1) KR20030022387A (pl)
CN (1) CN1469757A (pl)
AR (1) AR034139A1 (pl)
AU (2) AU2001277549B2 (pl)
BG (1) BG107542A (pl)
BR (1) BR0113188A (pl)
CA (1) CA2419223A1 (pl)
CZ (1) CZ2003392A3 (pl)
DE (1) DE10066210B4 (pl)
EE (1) EE200300061A (pl)
HR (1) HRP20030173A2 (pl)
HU (1) HUP0300736A3 (pl)
IL (1) IL154385A0 (pl)
MX (1) MXPA03001287A (pl)
NO (1) NO20030604L (pl)
NZ (1) NZ523932A (pl)
PL (1) PL365596A1 (pl)
RU (1) RU2290206C2 (pl)
SK (1) SK1572003A3 (pl)
TW (1) TWI296931B (pl)
UA (1) UA82642C2 (pl)
WO (1) WO2002013874A2 (pl)
YU (1) YU10603A (pl)
ZA (1) ZA200301949B (pl)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101687803B (zh) * 2006-10-18 2012-05-30 拜耳先灵医药股份有限公司 具有全氟化的peg基团的金属螯合物、它们的制备方法及它们的用途
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN109715597A (zh) * 2016-09-14 2019-05-03 大金工业株式会社 含支链含氟化合物
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09505803A (ja) * 1993-10-01 1997-06-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ホウ化メタロポルフィリン及び治療方法
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101687803B (zh) * 2006-10-18 2012-05-30 拜耳先灵医药股份有限公司 具有全氟化的peg基团的金属螯合物、它们的制备方法及它们的用途
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Also Published As

Publication number Publication date
HRP20030173A2 (en) 2005-04-30
PL365596A1 (pl) 2005-01-10
EE200300061A (et) 2004-12-15
TWI296931B (en) 2008-05-21
WO2002013874A8 (de) 2002-06-13
EP1307236A2 (de) 2003-05-07
AU7754901A (en) 2002-02-25
BR0113188A (pt) 2003-06-24
AU2001277549B2 (en) 2007-02-08
HUP0300736A3 (en) 2010-01-28
DE10066210B4 (de) 2008-02-28
NO20030604L (no) 2003-04-11
AR034139A1 (es) 2004-02-04
CZ2003392A3 (cs) 2003-09-17
RU2290206C2 (ru) 2006-12-27
UA82642C2 (uk) 2008-05-12
BG107542A (bg) 2003-09-30
NO20030604D0 (no) 2003-02-07
WO2002013874A2 (de) 2002-02-21
IL154385A0 (en) 2003-09-17
CA2419223A1 (en) 2003-02-11
ZA200301949B (en) 2004-12-14
NZ523932A (en) 2007-07-27
HUP0300736A2 (hu) 2003-09-29
JP2004506025A (ja) 2004-02-26
MXPA03001287A (es) 2003-10-06
SK1572003A3 (en) 2003-10-07
YU10603A (sh) 2006-05-25
KR20030022387A (ko) 2003-03-15

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