CR20230616A - Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn) - Google Patents

Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn)

Info

Publication number
CR20230616A
CR20230616A CR20230616A CR20230616A CR20230616A CR 20230616 A CR20230616 A CR 20230616A CR 20230616 A CR20230616 A CR 20230616A CR 20230616 A CR20230616 A CR 20230616A CR 20230616 A CR20230616 A CR 20230616A
Authority
CR
Costa Rica
Prior art keywords
sub
inhibiton
wrn
triazolo
treating diseases
Prior art date
Application number
CR20230616A
Other languages
Spanish (es)
Inventor
Markus Furegati
Henrik Moebitz
Geoffrey Gogniat
Huangchao Yu
Vincent Bordas
Wanben Gong
Sisi Zhang
Jacques Hamon
Juergen Hans-Hermann Hinrichs
Ross Strang
Joseph Schoepfer
Philipp Holzer
Niko Schmiedeberg
Andrea Decker
Fatma Limam
Jessica Soto
Frédéric Zecri
Jvan Brun
Simone Plattner
Sandro Nocito
Shuping Yao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR20230616A publication Critical patent/CR20230616A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención proporciona un compuesto, o una sal farmacéuticamente aceptable del mismo, de la fórmula (I):(I) en donde R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub>, R<sub>4</sub>, R<sub>5</sub>, R<sub>26</sub>, R<sub>27</sub>, y, R, M, W, L, V, T, Y, J, K y A han sido descriptos en la presente, usos terapéuticos de dichos compuestos, usos de dichos compuestos como químicos de investigación, una composición farmacéutica y combinaciones que comprenden dichos compuestos, y métodos para elaborar los compuestos de la invenciónThe present invention provides a compound, or a pharmaceutically acceptable salt thereof, of the formula (I): (I) wherein R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub>, R<sub>4</sub>, R<sub>5</sub>, R<sub>26</sub>, R<sub>27</sub>, and, R, M, W, L, V, T, Y, J, K and A have been described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods of making the compounds of the invention

CR20230616A 2021-05-26 2022-05-24 Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn) CR20230616A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021096104 2021-05-26
CN2022085537 2022-04-07
PCT/IB2022/054850 WO2022249060A1 (en) 2021-05-26 2022-05-24 Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn)

Publications (1)

Publication Number Publication Date
CR20230616A true CR20230616A (en) 2024-05-06

Family

ID=82019774

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230616A CR20230616A (en) 2021-05-26 2022-05-24 Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn)

Country Status (24)

Country Link
US (2) US11878973B2 (en)
EP (1) EP4347596A1 (en)
JP (2) JP7753397B2 (en)
KR (1) KR20240013168A (en)
CN (1) CN117425657A (en)
AR (1) AR125966A1 (en)
AU (1) AU2022279728A1 (en)
BR (1) BR112023024551A2 (en)
CA (1) CA3219799A1 (en)
CL (1) CL2023003489A1 (en)
CO (1) CO2023018119A2 (en)
CR (1) CR20230616A (en)
DO (1) DOP2023000256A (en)
EC (1) ECSP23095674A (en)
IL (1) IL308229A (en)
JO (1) JOP20230304A1 (en)
MX (1) MX2023013892A (en)
PE (1) PE20240587A1 (en)
PH (1) PH12023553140A1 (en)
PY (1) PY2240956A (en)
TW (1) TW202313616A (en)
UY (1) UY39786A (en)
WO (1) WO2022249060A1 (en)
ZA (1) ZA202310237B (en)

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TW202313616A (en) 2023-04-01
ECSP23095674A (en) 2024-01-31
BR112023024551A2 (en) 2024-02-15
JOP20230304A1 (en) 2023-11-23
CN117425657A (en) 2024-01-19
JP7753397B2 (en) 2025-10-14
CO2023018119A2 (en) 2023-12-29
US20240360118A1 (en) 2024-10-31
US20230046859A1 (en) 2023-02-16
AU2022279728A1 (en) 2023-11-16
PH12023553140A1 (en) 2024-04-29
AR125966A1 (en) 2023-08-30
UY39786A (en) 2023-01-31
MX2023013892A (en) 2023-12-11
WO2022249060A1 (en) 2022-12-01
DOP2023000256A (en) 2024-01-31
KR20240013168A (en) 2024-01-30
US11878973B2 (en) 2024-01-23
JP2024522345A (en) 2024-06-18
PY2240956A (en) 2023-11-09
JP2026021315A (en) 2026-02-10
ZA202310237B (en) 2025-02-26
CL2023003489A1 (en) 2024-06-28
PE20240587A1 (en) 2024-03-21
CA3219799A1 (en) 2022-12-01
EP4347596A1 (en) 2024-04-10

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