CS9003897A2 - Diaryl acetylenes and method of their production - Google Patents

Diaryl acetylenes and method of their production

Info

Publication number: CS9003897A2
Authority: CS; Czechoslovakia
Prior art keywords: alkyl; production; hydrogen; acetylenes; diaryl
Prior art date: 1989-08-08

Application number

CS903897A

Other languages

English (en)

Inventor

Bernd Dr Janssen

Hans-Heiner Dr Wuest

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-08

Filing date

1990-08-07

Publication date

1991-08-13

1990-08-07 Application filed by Basf Ag filed Critical Basf Ag

1991-08-13 Publication of CS9003897A2 publication Critical patent/CS9003897A2/cs

1993-07-14 Publication of CZ278011B6 publication Critical patent/CZ278011B6/cs

Links

-1 Diaryl acetylenes Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002537 cosmetic Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Birds (AREA)
Immunology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Seasonings (AREA)
Cosmetics (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrane Compounds (AREA)

CS903897A 1989-08-08 1990-08-07 Diaryl acetylenes and process for preparing thereof CZ278011B6 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3926148A DE3926148A1 (de)	1989-08-08	1989-08-08	Diarylacetylene, ihre herstellung und verwendung

Publications (2)

Publication Number	Publication Date
CS9003897A2 true CS9003897A2 (en)	1991-08-13
CZ278011B6 CZ278011B6 (en)	1993-07-14

Family

ID=6386704

Country Status (15)

Country	Link
US (1)	US5087637A (cs)
EP (1)	EP0412387B1 (cs)
JP (1)	JPH0377863A (cs)
KR (1)	KR910004555A (cs)
AT (1)	ATE97655T1 (cs)
AU (1)	AU629669B2 (cs)
CA (1)	CA2022570A1 (cs)
CZ (1)	CZ278011B6 (cs)
DE (2)	DE3926148A1 (cs)
DK (1)	DK0412387T3 (cs)
HU (1)	HU206313B (cs)
IL (1)	IL95269A (cs)
NO (1)	NO173092C (cs)
PL (1)	PL164651B1 (cs)
ZA (1)	ZA906201B (cs)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5264578A (en)	1987-03-20	1993-11-23	Allergan, Inc.	Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US4980369A (en) *	1989-09-19	1990-12-25	Allergan, Inc.	Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity
US5183827A (en) *	1989-09-19	1993-02-02	Allergan, Inc.	Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity
US5475022A (en) *	1993-10-18	1995-12-12	Allergan, Inc.	Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity
US5618943A (en) *	1994-12-29	1997-04-08	Allergan	Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
AU698527B2 (en) *	1994-12-29	1998-10-29	Allergan, Inc.	Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5648514A (en)	1994-12-29	1997-07-15	Allergan	Substituted acetylenes having retinoid-like biological activity
US5599967A (en) *	1994-12-29	1997-02-04	Allergan	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5543534A (en) *	1994-12-29	1996-08-06	Allergan	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5618931A (en) *	1994-12-29	1997-04-08	Allergan	Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5534641A (en) *	1994-12-29	1996-07-09	Allergan	Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5514825A (en) *	1994-12-29	1996-05-07	Allergan, Inc.	Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5675033A (en)	1995-06-06	1997-10-07	Allergan	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5917082A (en)	1995-06-06	1999-06-29	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6942980B1 (en)	1995-09-01	2005-09-13	Allergan, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5952345A (en)	1995-09-01	1999-09-14	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en)	1995-09-01	1999-09-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6008204A (en)	1995-09-01	1999-12-28	Allergan Sales, Inc.	Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6218128B1 (en)	1997-09-12	2001-04-17	Allergan Sales, Inc.	Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5663357A (en)	1995-11-22	1997-09-02	Allergan	Substituted heteroarylamides having retinoid-like biological activity
US5675024A (en)	1995-11-22	1997-10-07	Allergan	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5763635A (en) *	1996-06-21	1998-06-09	Allergan	Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5723666A (en) *	1996-06-21	1998-03-03	Allergan	Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5741896A (en)	1996-06-21	1998-04-21	Allergan	O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6555690B2 (en)	1996-06-21	2003-04-29	Allergan, Inc.	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en)	1996-06-21	1998-06-30	Allergan	Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) *	1996-06-21	1998-09-15	Allergan	O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5747542A (en) *	1996-06-21	1998-05-05	Allergan	Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity
US5728846A (en)	1996-12-12	1998-03-17	Allergan	Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
FR2757852B1 (fr) *	1996-12-31	1999-02-19	Cird Galderma	Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
US5760276A (en) *	1997-03-06	1998-06-02	Allergan	Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6037488A (en)	1997-04-19	2000-03-14	Allergan Sales, Inc.	Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US5919970A (en)	1997-04-24	1999-07-06	Allergan Sales, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
US6624197B1 (en)	1998-05-08	2003-09-23	Calyx Therapeutics, Inc.	Diphenylethylene compounds
US6331633B1 (en)	1998-05-08	2001-12-18	Calyx Therapeutics Inc.	Heterocyclic analogs of diphenylethylene compounds
US6245814B1 (en)	1998-05-08	2001-06-12	Calyx Therapeutics, Inc.	Diphenylethylene compounds
US7105552B2 (en) *	1998-05-08	2006-09-12	Theracos, Inc.	Heterocyclic analogs of diphenylethylene compounds
US7407978B2 (en)	1999-04-06	2008-08-05	Theracos, Inc.	Heterocyclic analogs of diphenylethylene compounds
US20020002200A1 (en) *	2000-02-04	2002-01-03	Bishwagit Nag	Novel diphenylethylene compounds
US6525093B1 (en)	1999-11-08	2003-02-25	Calyx Therapeutics Inc.	Compounds to treat diabetes and associated conditions
US7323496B2 (en) *	1999-11-08	2008-01-29	Theracos, Inc.	Compounds for treatment of inflammation, diabetes and related disorders
US20080108825A1 (en) *	1999-11-08	2008-05-08	Theracos, Inc.	Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) *	2000-02-04	2008-05-01	Theracos, Inc.	Compounds for treatment of inflammation, diabetes and related disorders
AU2001298065A1 (en) *	2001-01-12	2003-09-02	Abbott Laboratories	Process for the preparation of matrix metalloproteinase inhibitors
JP2008025788A (ja) *	2006-07-25	2008-02-07	Nok Corp	密封装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4326055A (en) *	1977-12-22	1982-04-20	Hoffmann-La Roche Inc.	Stilbene derivatives
DK159967C (da) *	1977-12-22	1991-06-03	Hoffmann La Roche	Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater
EP0084667B1 (de) *	1982-01-23	1985-09-18	BASF Aktiengesellschaft	Phenylethylen-Derivate, ihre Herstellung und Verwendung als Arzneimittel
DE3434946A1 (de) *	1984-09-22	1986-04-03	Basf Ag, 6700 Ludwigshafen	Diarylacetylene, ihre herstellung und verwendung
US4810804A (en) *	1987-03-26	1989-03-07	Allergan, Inc.	Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity
CA1340955C (en) *	1988-02-24	2000-04-11	Michael Klaus	Stilbene derivatives
DE3905932A1 (de) *	1988-03-10	1989-09-21	Merck Patent Gmbh	Tolanderivate
US4895868A (en) *	1988-06-29	1990-01-23	Allergan, Inc.	Thiochroman esters of phenols and terephthallates having retinoid-like activity

1989
- 1989-08-08 DE DE3926148A patent/DE3926148A1/de not_active Withdrawn
1990
- 1990-07-30 EP EP90114572A patent/EP0412387B1/de not_active Expired - Lifetime
- 1990-07-30 DE DE90114572T patent/DE59003587D1/de not_active Expired - Fee Related
- 1990-07-30 DK DK90114572.2T patent/DK0412387T3/da active
- 1990-07-30 AT AT90114572T patent/ATE97655T1/de not_active IP Right Cessation
- 1990-08-01 US US07/561,328 patent/US5087637A/en not_active Expired - Lifetime
- 1990-08-02 IL IL9526990A patent/IL95269A/en unknown
- 1990-08-02 CA CA002022570A patent/CA2022570A1/en not_active Abandoned
- 1990-08-07 AU AU60228/90A patent/AU629669B2/en not_active Ceased
- 1990-08-07 NO NO903460A patent/NO173092C/no not_active IP Right Cessation
- 1990-08-07 PL PL90286386A patent/PL164651B1/pl not_active IP Right Cessation
- 1990-08-07 HU HU904926A patent/HU206313B/hu not_active IP Right Cessation
- 1990-08-07 ZA ZA906201A patent/ZA906201B/xx unknown
- 1990-08-07 CZ CS903897A patent/CZ278011B6/cs not_active IP Right Cessation
- 1990-08-08 JP JP2208307A patent/JPH0377863A/ja active Pending
- 1990-08-08 KR KR1019900012135A patent/KR910004555A/ko not_active Ceased

Also Published As

Publication number	Publication date
KR910004555A (ko)	1991-03-28
ATE97655T1 (de)	1993-12-15
DK0412387T3 (da)	1993-12-20
JPH0377863A (ja)	1991-04-03
DE3926148A1 (de)	1991-02-28
NO173092C (no)	1993-10-27
NO903460L (no)	1991-02-11
PL164651B1 (pl)	1994-08-31
US5087637A (en)	1992-02-11
CZ278011B6 (en)	1993-07-14
EP0412387A2 (de)	1991-02-13
HU206313B (en)	1992-10-28
IL95269A0 (en)	1991-06-30
PL286386A1 (en)	1991-09-23
EP0412387A3 (en)	1991-03-27
AU6022890A (en)	1991-02-14
NO173092B (no)	1993-07-19
HU904926D0 (en)	1991-01-28
DE59003587D1 (de)	1994-01-05
CA2022570A1 (en)	1991-02-09
AU629669B2 (en)	1992-10-08
HUT54975A (en)	1991-04-29
EP0412387B1 (de)	1993-11-24
IL95269A (en)	1994-10-07
ZA906201B (en)	1992-04-29
NO903460D0 (no)	1990-08-07

Legal Events

Date	Code	Title	Description
2000-06-30	IF00	In force as of 2000-06-30 in czech republic
2010-03-10	MM4A	Patent lapsed due to non-payment of fee	Effective date: 20090807

Publication	Publication Date	Title
AU629669B2 (en)	1992-10-08	Diarylacetylenes, the preparations and use thereof
GEP20002331B (en)	2000-12-25	Alkylated Raphamicine Derivatives
AU4113889A (en)	1990-03-15	Diorganopolysiloxane polymers containing a benzalmalonate functional group
AU4970390A (en)	1990-08-23	Cosmetic use of benzotriazole diorganopolysiloxanes and novel cosmetic compositions containing such compounds for the protection of skin and hair
TW349946B (en)	1999-01-11	Novel naphthyl compounds and their process for preparation and pharmaceutical compositions containing same
ZA8410021B (en)	1985-08-28	11beta-arylestradienes,their production,and pharmaceutical preparations containing same
IL76457A (en)	1989-07-31	Tetralin derivatives,their preparation and pharmaceutical compositions containing them
TW334418B (en)	1998-06-21	Stilbene derivatives and pharmaceutical compositions
CA2163363A1 (en)	1994-12-08	Stable suppository formulations effecting biovailability of .delta.9-thc
PL289487A1 (en)	1992-02-24	Method of producing new aminophenol derivatives
GR3022632T3 (en)	1997-05-31	Isoquinolin-5yl-sulphonamides, process for their preparation and pharmaceutical compositions containing them
CA2119853A1 (fr)	1994-09-27	Nouvelles pyridothiadiazines, leurs procedes de preparation, et les compositions pharmaceutiques qui les contiennent
AU3923789A (en)	1990-02-08	Diorganopolysiloxane derivatives, their preparation and their use
PT91575A (pt)	1990-03-30	Procede de preparation de benzylamines disubstituees utiles comme medicaments
IL112098A0 (en)	1995-03-15	Sulfamate derivatives and pharmaceutical compositions containing them
IL98757A0 (en)	1992-07-15	Piperidine derivatives,their preparation and pharmaceutical compositions containing them
TW252979B (cs)	1995-08-01
CA2044491A1 (fr)	1991-12-15	Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol -1-yl) benzamide
NZ246598A (en)	1997-08-22	Trazodone derivatives; compounds and preparation, pharmaceutical compositions; intermediate compounds
AU8962882A (en)	1983-04-28	6-chloro 4-phenyl quinazoline derivatives
HUT64517A (en)	1994-01-28	Process for producing 1-piperidinyl-alkanoyl-aryl-sulfonamide derivatives and pharmaceutical compositions containing them
IL98428A0 (en)	1992-07-15	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
AU573062B2 (en)	1988-05-26	Dihydrodithiazine derivatives
SE9203824D0 (sv)	1992-12-18	Benzofuranylimidazole derivatives a process for the preparation and therapeutical compositions containing the same
ES2162986T3 (es)	2002-01-16	Derivados de mercapto-alcanoil-dipeptidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.