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Priority to CU20100138ApriorityCriticalpatent/CU20100138A7/en
Publication of CU20100138A7publicationCriticalpatent/CU20100138A7/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La invención se refiere a derivados de 17-(1'-propenil)-17-3'-oxidoestra-4-en-3-ona que tienen la fórmula química general I, en la cual Z, R4, R6a, R6b, R7, R15, R16a, R16b y R18 tienen los valores que se indican en la reivindicación 1, así como sus solvatos, hidratos y sales, incluyendo todos los estereoisómeros de estos compuestos. La invención también se refiere al uso de estos derivados para la preparación de un medicamento para la contracepción oral y para el tratamiento de trastornos pre, peri y posmenopáusicos y a medicamentos que contienen tales derivados, particularmente su uso en las indicaciones mencionadas. Los derivados de la invención presentan un efecto gestagénico y en casos preferidos, adicionalmente un efecto antimineralcorticoide y neutro a ligeramente androgénico.The invention relates to derivatives of 17- (1'-propenyl) -17-3'-oxidoestra-4-en-3-one having the general chemical formula I, in which Z, R4, R6a, R6b, R7 , R15, R16a, R16b and R18 have the values indicated in claim 1, as well as their solvates, hydrates and salts, including all stereoisomers of these compounds. The invention also relates to the use of these derivatives for the preparation of a medicament for oral contraception and for the treatment of pre, peri and postmenopausal disorders and for medications containing such derivatives, particularly their use in the aforementioned indications. The derivatives of the invention have a gestagenic effect and in preferred cases, additionally an antimineralcorticoid and neutral to slightly androgenic effect.
CU20100138A2010-06-292010-06-29
DERIVATIVES OF 17- (1'-PROPENIL) -17-3'-OXIDOESTRA-4-EN-3-ONA, ITS USE AND DRUGS CONTAINING IT
CU20100138A7
(en)
Compounds derived from amino-pyrimidines; pharmaceutical compositions comprising them; and its use for the treatment of a disease selected condition of neuromuscular disorders, amyotrophic lateral sclerosis, myasthenia gravis, among others.
Compounds derived from amino-pyridazines; pharmaceutical compositions comprising them; and its use for the treatment of a disease selected condition of neuromuscular disorders, amyotrophic lateral sclerosis, myasthenia gravis, among others.
BENZONITRILE DERIVATIVES REPLACED WITH GLUCOPYRANOSIL, PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS OF THIS TYPE, USE AND PROCEDURE FOR MANUFACTURING
Compounds derived from substituted benzothiene-pyridines, hiv replication inhibitors; pharmaceutical composition that includes them; pharmaceutical combination; pharmaceutical kit; and its use for the treatment of hiv.
DERIVATIVES OF ESTRA-1,3,5 (10), 16-TETRAENE 3-SUBSTITUTES, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM, AS WELL AS THEIR USE FOR THE PREPARATION OF MEDICINES