CY2180B1 - 2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative - Google Patents

2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative

Info

Publication number: CY2180B1
Authority: CY; Cyprus
Prior art keywords: purin; dihydro; oxo; methoxy; 2amino
Prior art date: 1994-07-28

Application number

CY0000039A

Other languages

English (en)

Inventor

John J Nestor

Scott W Womble

Hans Maag

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-28

Filing date

2000-08-10

Publication date

2002-08-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2180(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-08-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-08-23 Publication of CY2180B1 publication Critical patent/CY2180B1/xx

Links

DLJZAAJMDOFQRP-UHFFFAOYSA-N 2-amino-9-(1,3-dihydroxy-1-methoxypropan-2-yl)-3h-purin-6-one Chemical class N1=C(N)NC(=O)C2=C1N(C(CO)C(O)OC)C=N2 DLJZAAJMDOFQRP-UHFFFAOYSA-N 0.000 title 1
238000010521 absorption reaction Methods 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

CY0000039A 1994-07-28 2000-08-10 2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative CY2180B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28189394A	1994-07-28	1994-07-28

Publications (1)

Publication Number	Publication Date
CY2180B1 true CY2180B1 (en)	2002-08-23

Family

ID=23079211

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CY0000039A CY2180B1 (en)	1994-07-28	2000-08-10	2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
CY200400003C CY2004003I2 (el)	1994-07-28	2004-10-20	Παραγωγα 2-(2-αμινο-1, 6-διϋδρο-6-οξο-πυρινο-9-υλο)-μεθοδυ-1,3-προπανεδιολης

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CY200400003C CY2004003I2 (el)	1994-07-28	2004-10-20	Παραγωγα 2-(2-αμινο-1, 6-διϋδρο-6-οξο-πυρινο-9-υλο)-μεθοδυ-1,3-προπανεδιολης

Country Status (32)

Country	Link
EP (1)	EP0694547B1 (de)
JP (1)	JP3090305B2 (de)
KR (1)	KR100358626B1 (de)
CN (1)	CN1045089C (de)
AT (1)	ATE179173T1 (de)
AU (1)	AU697107B2 (de)
BR (1)	BR9503468A (de)
CA (1)	CA2154721C (de)
CO (1)	CO4410181A1 (de)
CY (2)	CY2180B1 (de)
CZ (1)	CZ290511B6 (de)
DE (3)	DE694547T1 (de)
DK (1)	DK0694547T3 (de)
ES (1)	ES2083348T3 (de)
FI (1)	FI112080B (de)
GR (2)	GR960300021T1 (de)
HU (1)	HU216867B (de)
IL (1)	IL114735A (de)
LU (1)	LU91136I2 (de)
MA (1)	MA23631A1 (de)
MY (1)	MY114393A (de)
NL (1)	NL300071I2 (de)
NO (2)	NO312899B1 (de)
NZ (1)	NZ272652A (de)
PE (1)	PE32296A1 (de)
PL (1)	PL180609B1 (de)
RU (1)	RU2133749C1 (de)
SA (1)	SA95160158B1 (de)
TR (1)	TR199500895A2 (de)
TW (1)	TW434242B (de)
UY (1)	UY24006A1 (de)
ZA (1)	ZA956228B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
AU1592897A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
CA2243650C (en) *	1996-01-26	2006-08-15	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US6184376B1 (en)	1997-02-10	2001-02-06	Mediver Ab	Synthesis of acyclic nucleoside derivatives
EP0971923B1 (de) *	1997-02-10	2002-11-06	Medivir Ab	Verfahren zur herstellung von azyklischen nukleosiden
EP0988304B1 (de) *	1997-08-15	2001-05-02	Medivir Ab	Analoge nukleoside, wie antivirale einschliesslich inhibitoren der retroviralen reverstranskriptase und der dna polymerase des hepatitis b virus
WO1999032490A1 (en) *	1997-12-19	1999-07-01	Bristol-Myers Squibb Company	Prodrugs of lobucavir and methods of use
WO1999051613A1 (en) *	1998-04-03	1999-10-14	Medivir Ab	Prodrugs of phosphorous-containing pharmaceuticals
JP2000256359A (ja) *	1999-03-11	2000-09-19	Japan Science & Technology Corp	面性キラリティーを有する分子群の高選択的不斉変換法
KR20030015655A (ko) *	2001-08-17	2003-02-25	한미약품공업 주식회사	항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
ATE438621T1 (de) *	2002-04-23	2009-08-15	Aventis Pharma Inc	3-(substitutierte amino)-1h-indole-2- carbonsäureester und 3-(substitutierte amino)- benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
EP2596791B1 (de)	2002-10-16	2015-04-01	Takeda Pharmaceutical Company Limited	Stabile, feste Präparate
MXPA05007016A (es)	2003-01-14	2005-09-12	Gilead Sciences Inc	Composiciones y metodos para terapia antiviral de combinacion.
BRPI0413331A (pt) *	2003-08-28	2006-10-10	Ranbaxy Lab Ltd	cloridrato de valganciclovir amorfo, composição farmacêutica contendo o mesmo e processo para sua preparação
US8461187B2 (en)	2004-06-16	2013-06-11	Takeda Pharmaceuticals U.S.A., Inc.	Multiple PPI dosage form
BRPI0513508B1 (pt) *	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
SG185296A1 (en)	2007-10-12	2012-11-29	Takeda Pharmaceuticals Usa Inc	Methods of treating gastrointestinal disorders independent of the intake of food
EP2714691B1 (de)	2011-05-31	2016-09-07	Pharmathen S.A.	Verfahren zur herstellung von 2-amino-9- ((2-phenyl-1,3-dioxan-5-yloxy)methyl) (-1h-purin-6(9h) -on-verbindung zur herstellung von valganciclovir
KR102312533B1 (ko)	2021-02-24	2021-10-15	주식회사 이웅	자동 스패너

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4897479A (en) *	1983-09-30	1990-01-30	Merck & Co., Inc.	Arylsulfonyloxy purine intermediates
IE842642L (en) *	1983-10-31	1985-04-30	Harvard College	Purine Derivatives
NZ214520A (en) *	1984-12-12	1989-08-29	Syntex Inc	Alkoxymethyl ether and ester derivatives in the production of guanine derivatives
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
DE68922903T2 (de) *	1988-12-19	1995-11-23	Wellcome Found	Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

1995
- 1995-07-10 PE PE1995273436A patent/PE32296A1/es not_active IP Right Cessation
- 1995-07-19 DE DE0694547T patent/DE694547T1/de active Pending
- 1995-07-19 ES ES95111319T patent/ES2083348T3/es not_active Expired - Lifetime
- 1995-07-19 EP EP95111319A patent/EP0694547B1/de not_active Expired - Lifetime
- 1995-07-19 DE DE2002199032 patent/DE10299032I2/de active Active
- 1995-07-19 DE DE69509173T patent/DE69509173T2/de not_active Expired - Lifetime
- 1995-07-19 AT AT95111319T patent/ATE179173T1/de active
- 1995-07-19 DK DK95111319T patent/DK0694547T3/da active
- 1995-07-21 TR TR95/00895A patent/TR199500895A2/xx unknown
- 1995-07-26 MA MA23971A patent/MA23631A1/fr unknown
- 1995-07-26 ZA ZA956228A patent/ZA956228B/xx unknown
- 1995-07-26 IL IL114735A patent/IL114735A/en not_active IP Right Cessation
- 1995-07-26 HU HU9502238A patent/HU216867B/hu unknown
- 1995-07-26 NZ NZ272652A patent/NZ272652A/en not_active IP Right Cessation
- 1995-07-26 CA CA002154721A patent/CA2154721C/en not_active Expired - Lifetime
- 1995-07-26 AU AU27195/95A patent/AU697107B2/en not_active Expired
- 1995-07-27 RU RU95113148A patent/RU2133749C1/ru active
- 1995-07-27 CZ CZ19951939A patent/CZ290511B6/cs not_active IP Right Cessation
- 1995-07-27 MY MYPI95002156A patent/MY114393A/en unknown
- 1995-07-27 UY UY24006A patent/UY24006A1/es not_active IP Right Cessation
- 1995-07-27 JP JP07190953A patent/JP3090305B2/ja not_active Expired - Lifetime
- 1995-07-27 FI FI953592A patent/FI112080B/fi active Protection Beyond IP Right Term
- 1995-07-27 NO NO19952977A patent/NO312899B1/no not_active IP Right Cessation
- 1995-07-27 CO CO95033418A patent/CO4410181A1/es unknown
- 1995-07-27 CN CN95109671A patent/CN1045089C/zh not_active Expired - Lifetime
- 1995-07-27 TW TW084107779A patent/TW434242B/zh not_active IP Right Cessation
- 1995-07-27 BR BR9503468A patent/BR9503468A/pt active Search and Examination
- 1995-07-27 KR KR1019950022600A patent/KR100358626B1/ko not_active Expired - Lifetime
- 1995-07-27 PL PL95309812A patent/PL180609B1/pl unknown
- 1995-08-14 SA SA95160158A patent/SA95160158B1/ar unknown
1996
- 1996-04-30 GR GR960300021T patent/GR960300021T1/el unknown
1999
- 1999-07-02 GR GR990401760T patent/GR3030678T3/el unknown
2000
- 2000-08-10 CY CY0000039A patent/CY2180B1/xx unknown
2001
- 2001-11-23 NL NL300071C patent/NL300071I2/nl unknown
2003
- 2003-01-10 NO NO2003001C patent/NO2003001I2/no unknown
- 2003-05-21 LU LU91136C patent/LU91136I2/fr unknown
2004
- 2004-10-20 CY CY200400003C patent/CY2004003I2/el unknown

Also Published As

Publication number	Publication date
SA95160158B1 (ar)	2006-05-20
CY2004003I1 (el)	2009-11-04
RU95113148A (ru)	1997-06-27
TR199500895A2 (tr)	1996-06-21
FI112080B (fi)	2003-10-31
HUT73246A (en)	1996-07-29
GR3030678T3 (en)	1999-11-30
KR100358626B1 (ko)	2003-01-14
EP0694547A2 (de)	1996-01-31
BR9503468A (pt)	1996-02-27
KR960004345A (ko)	1996-02-23
PL309812A1 (en)	1996-02-05
AU2719595A (en)	1996-02-08
PL180609B1 (pl)	2001-03-30
CO4410181A1 (es)	1997-01-09
IL114735A0 (en)	1995-11-27
RU2133749C1 (ru)	1999-07-27
ES2083348T3 (es)	1999-08-01
CA2154721A1 (en)	1996-01-29
DK0694547T3 (da)	2000-01-03
HU9502238D0 (en)	1995-09-28
DE694547T1 (de)	1996-10-24
DE69509173D1 (de)	1999-05-27
JPH0841061A (ja)	1996-02-13
NL300071I2 (nl)	2002-03-01
TW434242B (en)	2001-05-16
LU91136I2 (fr)	2005-07-06
FI953592L (fi)	1996-01-29
CA2154721C (en)	2001-01-02
PE32296A1 (es)	1996-08-07
DE10299032I1 (de)	2003-01-23
DE69509173T2 (de)	1999-10-21
MA23631A1 (fr)	1996-04-01
NO952977L (no)	1996-01-29
ES2083348T1 (es)	1996-04-16
EP0694547B1 (de)	1999-04-21
NO952977D0 (no)	1995-07-27
NL300071I1 (nl)	2002-02-01
IL114735A (en)	1998-06-15
DE10299032I2 (de)	2006-06-14
NO2003001I2 (no)	2007-06-11
EP0694547A3 (de)	1996-06-05
CN1045089C (zh)	1999-09-15
UY24006A1 (es)	2001-07-31
HK1012339A1 (en)	1999-07-30
AU697107B2 (en)	1998-09-24
ZA956228B (en)	1996-02-22
CN1122804A (zh)	1996-05-22
NO312899B1 (no)	2002-07-15
FI953592A0 (fi)	1995-07-27
CY2004003I2 (el)	2009-11-04
ATE179173T1 (de)	1999-05-15
GR960300021T1 (en)	1996-04-30
HU216867B (hu)	1999-09-28
CZ290511B6 (cs)	2002-08-14
MY114393A (en)	2002-10-31
CZ193995A3 (en)	1996-02-14
JP3090305B2 (ja)	2000-09-18
NZ272652A (en)	1996-12-20

Publication	Publication Date	Title
GR960300021T1 (en)	1996-04-30	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
AU7820491A (en)	1991-12-12	Substituted Phthalides and Heterocyclic Phthalides and derivatives thereof.
EP0563345A4 (en)	1994-09-28	Novel 4-arylpiperazines and 4-arylpiperidines
AU8979191A (en)	1992-06-25	3,7-disubstituted indole derivatives
CA2244680A1 (en)	1997-07-31	Process for preparing purine derivatives
AU697679B2 (en)	1998-10-15	Treatment of tinnitis using neuroprotective agents
ATE172985T1 (de)	1998-11-15	Sulfonamidaminomethylenderivate als immunsuppressiva
GB9302046D0 (en)	1993-03-24	Antiumoral compound-v
DE69312776D1 (de)	1997-09-11	Fungizide 3,4-Diaryl-(5H)-Furan-2-Onederivate
FI916018A7 (fi)	1992-06-21	1,3-dioksolaanijohdannaisia kolesterolia alentavina aineina
DK0625520T3 (da)	2000-01-31	Thiazolotriazol- og thiazolodiazolderivater med fungicid aktivitet
DE69611148D1 (de)	2001-01-11	Pyrrolo(4,3,2-de)chinolin-Derivat
SG32424A1 (en)	1995-08-13	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivative
LT2417B (lt)	1994-02-15	Mo budas vaiku astrios leukozes nepalankios eigos isaiskini
AU8803091A (en)	1992-05-28	Method for protecting the myocardium against ischemia
FI925488A0 (fi)	1992-12-03	Avlastningsanordning foer tonvaexlingshaevstaengerna i en med tonvaexlingsmekanism foersedd kantele