DD149678A1 - IMPROVED WASHING, CLEANING AND DISINFECTANTS - Google Patents

Abstract

The invention relates to improved detergents, cleaners and disinfectants which can be used in the alkaline environment at 20 to 90 degrees C, preferably 30 to 70 degrees C in the home, in municipal and industrial areas and in health care. The aim of the invention was the improvement of alkaline detergents, cleaners and disinfectants by adding particularly easy-to-use microbicidal agents that already act in the low temperature range. The essence of the invention consists in the use of 2,4-dioxohexahydro-1,3,5-triazine as microbicidal and in the presence of peroxo compounds activating active ingredient in known alkaline washing and cleaning agents or excipients for alkaline disinfectants in amounts of 0 , 3 to 20, preferably 0.5 to 10 wt .-%.

Description

-f

VBB ClffiMISKOfvlBINAT BITTEKi ¹ ELD Bitterfeld, 12. 3. 1980

WP C 11 D / 219 924

Improved detergents, cleaners and disinfectants

Applicable Area of the Invention

The invention can be used for the production of hygienic or disinfecting detergents and cleaners as well as disinfectants, which are preferably used in the low-temperature range.

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Characteristic of the known technical solutions

The control of pathogens and other microorganisms that cause damage to industrial products and contamination of technical equipment is required in many areas of human society for reasons of hygiene, prevention of disease or prevention of economic loss. , In cleaning and washing processes serving this purpose, which are carried out in an alkaline environment at elevated temperature, various means and methods may be used.

(See H * Wigert, H. Sachse Horn, Privora, Weuffen, "Handbook of Disinfection and Sterilization", Volume 3 "Publishing Volk and Health, Berlin 1974) Here, thermal and chemothermal processes are preferred. In the household and municipal laundries predominantly only agents without microbial additives are used.

The control of harmful microorganisms and the purification of fibers by purely thermal treatment, however, requires a lot of energy because temperatures up to 95 C must be used. Nevertheless, these methods are extensively used in household / aeo and services to achieve the necessary hygienic effect. On the other hand, modern blended fabrics require more and more fiber-saving washing processes with simultaneous hygienic effect. For this purpose, there are still no satisfactory technical solutions that guarantee a sufficient microbicidal effect with necessary cleaning effect in the low temperature range.

At present, in washing processes in this area, in addition to peroxides (perborates, percarbonates!), So-called washing activators are used to achieve the washing effect. _T predominantly N- and O-acylated chemical compounds of various types release the active oxygen to an increased extent even at these temperatures ,

τ r * ο

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In order to achieve a sufficient microbicidal effect, considerable amounts of percidene (15-20 %) must be used, which, in addition to high costs, also lead to damage to the skin.

Chemothemic washing and cleaning processes achieve the desired microbicidal effect by adding or incorporating active ingredients into detergents. The processes usually operate at 60 ^° C. · Active ingredients of the following groups are used in practice:

Aldehydes, phenols, active chlorine-releasing compounds (e.g., DD-PS 135 287), quaternary ammonium compounds and heterocycles (e.g., DD-PS 137 34-6).

These procedures can be used primarily only in the healthcare sector because their use can not be approved for the following reasons for users going beyond this circle:

- Specific procedures and procedures must be strictly followed, e.g. Technologies, health and safety, and control and monitoring measures.

- Some of the active substances are unstable and / or volatile, z, B, aldehydes, chlorine-releasing compounds and quaternary ammonium compounds.

- Some of the active substances are too toxic or too irritating to the skin for general application, e.g. Aldehydes, phenols and 2-i-mercaptobenzothiazole,

- Agents that are based only on the basis of active chlorine or active oxygen cleavage cause significant fiber damage. · ·

- Some active ingredients are too slow, eg "aldehydes, phenols"

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No known microbicidal active ingredient simultaneously has an activator effect on peroxides. For this purpose, significant amounts of the already mentioned 0- and N-acylated compounds must be additionally used.

Therefore, there is hitherto no active substance principle that can be used in a hygienic washing or cleaning agent for household, municipal laundries, the industrial sector and in health care, without requiring special measures while microbicidal and activating in the low temperature range (30-70 ⁰ C) acts on peroxides.

Z iel the invention .

The aim of the invention therefore the development of improved alkaline detergents, cleaners and disinfectants, which are characterized in the niediedrigtenperaturbereich by high microbicidal activity with excellent environmental and Amvenderfreundlichkeit.

Presentation of ,. Essence of the inventors

The object is achieved according to the invention by using 2,4-dioxo-hexahydro-1,3,5-t; riazine in detergents and cleaners which are known per se and disinfectant auxiliaries which are active in an alkaline medium and may also contain peroxides (hereinafter referred to as DIE) is used as a microbicidal and in the case of peroxides also an activating active substance,

2 | 4 ~ dioxo-hexahydro-1,3 »5-triazine is a well-known chemical compound which has been known for some time. according to DD-PS 130479 can be made very effective.

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It has already been proposed to use the compound as fertilizer (DD-PS 130479) or as growth regulator in plants (DD-P3 196960). It has also become known for the reduction of phytoviruses (DD-P3 176334, DD-PS 196960), it is practically not used. Microbicidal properties as well as activating effect on peroxy compounds does not have the compound at hormone temperature in a neutral environment.

It has been found, however, that the active ingredient according to the invention surprisingly exhibits an excellent microbicidal action when it is incorporated in alkaline washing and cleaning agents known per se or in auxiliaries for alkaline disinfectants.

In the pH range of 8-13, preferably 9-12 and at temperatures of 20-90 ⁰ C, preferably 30-70 ⁰ C, it has a uniformly strong microbicidal activity against bacteria and fungi, Peroxo compounds contained in the formulations acts 2 In addition, 4-dioxohexahydro-1,3,5-triazine also activates on this one.

By adjusting the concentration of 2,4-Dioxohcxahydro-1,3 »5-triazine as well as the temperature, the pH and the middle formulations opens up a wide range of applications.

For the washing, cleaning and disinfecting agents, all customary formulation constituents are suitable, e.g. Phosphates, silicates, wash-active substances such as alkyl sulfates, alkyl sulfonates, alkylbenzoisulfonates, soaps, fatty acid condensates, alkylphenyl glycol ethers and other nonionic detergent substances, cosolvents and other conventional auxiliaries, and peroxo compounds (for example sodium perborate, sodium percarbonate).

The particular advantage of the solution according to the invention lies in the pronounced ease of use of the active ingredient, 2,4-Dio: -: ohexahydro-1,3> 5-triazine is not irritating to skin and mucous membranes, does not lead to allergies, is not mutagenic, does not damage fibers, not dangerous to fish and fish, not corrosive.

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The invention. Funds can therefore be used in the household, in municipal and industrial sectors and in the health sector without special precautions or observance of health and safety measures (other than those caused by the excipients). "

The invention will now be illustrated by way of example without limiting it.

In the examples, 2,4-dioxohexahydro-1,3,5-t; riazine is referred to as DHT.

Example 1:

The microbicidal effect of 2,4-dioxohexahydro-1 "3" 5-triazine in neutral and alkaline conditions at 20 ⁰ C

Methodology: -. °

Sterile fabric pieces of linen of 1 cm become 15 minutes for contamination. placed in a standard suspension of the test germs and then dried. Thereafter, they are respectively in the active-ingredient solutions brought suspensions, removed after 60 min _e and ater rinsed twice with distilled V / 'The patches are transferred to demonstrate the efficacy in suitable culture media, which was attached to the elimination microbicidal effects an additive. In bacteria, the evaluation is carried out after 6 days (incubated at 37 ⁰ C), in mushrooms after 28 days (incubated at 22 ⁰ C). When germs grow, an identity check is performed to secure the results.

Te st organi smen:

Staphylococcus aureus SG 511. (1)

Klebsiella pneumoniae RLD / H (2)

Escherichia coil · MH 3 (3)

Proteus vulgaris (4 ·)

Pseudomonas aeruginosa RLD 1 (5)

Trichophyton mentagrophytes. (6)

Candida albicans (7)

Aspergillus niger. (8th)

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The evaluation is carried out according to the following scheme:

0 complete killing of microorganisms

1 good effectiveness against microorganisms

2 significant microbial reduction of microorganisms

3 weak effect against the microorganisms

4 no effect against the microorganisms

The results are shown in 2 tables:

Table 1: DHT in an aqueous, neutral. Milieu at 20 ⁰ C. compared to known microbicides

active substance

Drug test organisms

concentration 12345678

DIIT 0.01 DHO 0.1 DHT 1.0 DHT 5.0 formaldehyde 1.0 Dimethylbenzyldodezyl- ammonium chloride 1.0

44444444 444 4 4 4 4 4 44444444

00000000 00000000

Table 2: DET at pH 9 at 20 ° C active ingredient

DHT 0.01 DHT 0.1 DHT 1.0 DHT 2.5 DIID 5.0 Katrium perborate + tetraacetyl glycoluril 15th of June Pentachlorophenol sodium 1.0

Drug test organisms

concentration 12 345678

K / o)

44444444 44444444 44444444 43334343

33223233 10010 110 0 000 0 00 0

Example 2: Testing of the microbicidal effect of DHT in an alkaline medium (pH 3-13) at 30-70 ⁰ C

Methodology:

2 2 sterile fabric pieces of linen of 1 cm and 5 cm become 15 minutes for contamination. In a standard suspension of the test «organisms inserted and then dried Afterwards they are inserted into active ingredient-containing detergent solutions of different pH and in the three-necked flask with stirring at exposure times of 30 min _o different. Exposed to temperatures. The lobules are then removed, rinsed twice with sterile water and transferred into or on suitable nutrient media, to which an additive was added to eliminate microbiocidal after-effects. Incubation and evaluation are carried out as in Example 1.

The following detergent formulations were used:

Recipe A_ % B % C %

Detergents

ITatriumalkylsulfonat

Phosphate

Pent anatri umtriphosphate

Silicate

perborates

percarbonates

soap flakes

Remainder: Coproducts, carboxymethylcellulose, superfatting agent, DKT Uca.m «,

Natriumiaetasilicat

15

10

Sodium alkylsulfonate 10

Alkylphenyl polyglycol ether 10

Sodium diphosphate 30

Sodium metasilicate 10

10

Natriumal · kyIben ζ oil ßulfonat

fatty acid condensate

 - 15

Pent anat rl «

umtriphos-

phat

sodium diphosphate

30

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The active ingredient according to the invention is incorporated in the detergent formulations in concentrations of 0.5 (a), 1.0 (b), 2.0 (c), 3.0 (d) and 5.0 % (e). The results are shown in Table 3.

Table 3i Test results Concentrate recipe

123 4-5678

tration

30 ⁰ C - 50 ⁰ C

70 ° c -

1234-567B 123 4-5 6 7 8

0.5

1.0

2.0.

3.0

A 22222222

B 12 111212

O 21222212

A 22211222

B 11221211

C 212 21221

A 11111121

B 11111111

C 11111111

A 11111111

B 01111111

O 11011111

A 10100001

B 00000000

C 00000000

11111101 10 0 10 0 0 1 11010110

10101001 0 0 0 10 0 0 0 10001001

00000000 00000000 0000000 0

000000 0 0 00000000 00 000000

00000000 00000000 000 0 0000

0 0 0 0 0 0 0 0 000 00000 00000000

'Ö 0000000 00000000 0 0 0 0 0 0 OO

00000000 00000000 00000000

00000000 00000000 000000 0 0

00000000 0 0 0 0 0 0 0 0 00000000

The pH values were 30 ^° CA: 9, Bj 10, C: 9, 50 ^° CA: 9.5, Bj 10.8, C: 9.5 and 70 ^° CA: 10, B: 11, 5 and C: 10.2.

Example 3:

Testing of selected cleaning agents, detergents and disinfectants with the active ingredient DHD

Methodology:

Detergents having a hygienic effect and disinfectant washing agents are tested in accordance with Example 2, with a practical test being carried out instead of the laboratory test. To test disinfectant cleaners and disinfectants for materials and equipment, sterile screws, pieces of metal or pieces of rubber tubing are contaminated with test germ suspensions and, after drying, the action of the active ingredient. Preparations exposed. After removal, rinse briefly with sterile physiological saline and continue as described in Example 1. For this purpose, JDHT is used in concentrations of 0.5% and 1.0 % for hygienic detergents, of 1.0 % and 2.0 %. for disinfectant detergents and in concentrations of 5.0 for germ-reducing detergents and from 5 to 0 and 10.0% for disinfectant cleaning agent incorporated into conventional detergent formulations.

Detergent formulations for formulation: D

0.5-2 % DHT (in weight percent) EF

Alkyl phenyl phenyl glycol ether 12 Sodium alkyl sulfonate 20 Sodium alkyl benzenesulfonate 15 • Fatty acid condensate 10 Pentasodium triphosphate 35 Pentasodium triphosphate 30 Pentasodium triphosphate 35 Sodium metabis Bi c 15 Sodium di-silicate 15 mm Sodium perborate at 7 Sodium carbonate 5 soda 25 soda 20 Soda 20

Remainder: (DHT ₉ stabilizer, carboxymethylcellulose j 6 superfatting agent, perfume v.a "m")

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Recipes for detergents and disinfectants

(in percent by mass)

Recognition __G HI JK

DHT

Perborate percarbonate

pentasodium

Natriunrraeta silicate

Sodium di silicate soda

Natri umbikarb onat

Detergents

Rest:

diluents

perfume oil

5 5 10 10 10 - mm - - ~ - VJL 38 20 25 30 20 - - 10 -   - 5 - - 35 15 20 - 20 - 10 - 33 24 23 20 26

Table 4: Brüfergebnisse DHT-Konzen- Rezep- Material tration (%) doors

Temperature 30 C '

1-23 * 5678

2 50 4 O σ 7 _ 1 2 3 70 4 5 ⁰ C 7 8th 1 1 3 0 5 6 O 8th 0 0 0 O O 6 O O 0 0 0 0 O 1 1 1 0 0 0 O O O O O 0 1 1 1 0 O O 1 0 0 0 O 1 1 O O T 0 0 1 1 1 O O 0 0 0 O O O O O 0 0 0 0 0 O 1 O 0 0 0 O O O O O 0 1 0 0 0 O O O 0 0 0 O O O O O O 0 0 0 1 O O O 0 0 0 O O O O O O 0 0 0 O O O O 0 0 0 O O O O O ρ 0th 0 0 0 O O 0 0 0 0 O O O O O 0 0 0 0 0 O O O O O 0 0 0 0 O O 0 Not checked 0 0 0 0 0 O O 0 0 0 0 0 0 0 0 O 0 0 0 0 0 0 O 0 0 0 0 0 0 O O 0 0 O 0 0 0 O O 0 O 0 0 0 0 O O 0 O 0 0 0 0 O O 0 0 0 O 0 0 O O 0 0 0 0 O 0 Not checked

0.5

2.0

5.0

10.0

D - e - F   - D e - F D - 1 - P - G metal G rubber H metal e rubber I metal I rubber J metal J rubber e metal K rubber

11121112 12121121 2 2. 222122

21112112 11211211 11121122

11111111 12111121 1 1 2 1 1111

00100010 10110110 0100100 0 11011101

00000000 00000000 00000000 00 000000 000000 0 0 00000000

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Example 4:

Examination of the activator effect. on washmmttelüblictie peroxygen compounds

Methodology:

The detergent formulations B and C from Example 2 were admixed with 1.0% or 2.0 % of DHT and the residual content of unactivated oxygen was determined at different temperatures after different times. The results are shown in Table 5.

Table 5: medium Temperature (° salary on 30 ReGtsäuerstoff 50 30 in % 70 30 No. Time in min. C) 40 70 4-9 47 % DHT 15 54 15 45 15 39 B with 2 % DI] T 81 59 75th 41 _r 72 40 1 B with 1 % DHT 73 68 68 48 66 43 2 C with 2 % DIiP 73 95 69 94 67 90 3 C with 1 DI3T 79 92 73 90 71 89 4 Bean DHT 98 71 97 96 44 5 0 without , 0 % diacetyl oxamide 97th 51 96 40 94th 33 6 C with 1 , 5 % pentaacetic 84 ₇₅ 68 7 C with 0 ty! glucose 69 63 61 8th

Example 5:

Testing the ease of use

The solution according to the invention was compared with known te.chnisehen solutions in use «

active substance

Concentration %

corrosion

T oxicity

Umv / eltschädigung

Fiber damage;

DHT 0.5-10 O O O O formaldehyde 1.0 2 3 1 O Dimethyl benzyl dodecyl ammonium chloride 1.0 1 2 1 O Pentachlorophenol 1.0 1 3 3 O 2-mercaptobenzothiazole 1.0 O 1 1 O sodium 10-15 O O O 2 hexachlorophene 1-2 O 1 1 O iPributylzinnoxid 1 O 3 2 O

Bonituri O no negative feature

1 low negative properties

2 mean negative properties

3 strong negative features

Claims (1)

2066 Passing on 53p back; _t 1. VerbesGertc detergents, disinfectants and disinfectants for the temperature range of 20-90 ⁰ C, preferably 30 ~ 7O ⁰ C, characterized in that one known per se, effective in alkaline medium as antimicrobic agents and in the presence of peroxides Activating agent 2,4-Dio2-: ohe: caiiydro ~ 1,3 »5-triazine in amounts of 0.3-20, preferably 0.5-10 wt .-%, added