DE602004024115D1 - Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen - Google Patents
Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungenInfo
- Publication number
- DE602004024115D1 DE602004024115D1 DE602004024115T DE602004024115T DE602004024115D1 DE 602004024115 D1 DE602004024115 D1 DE 602004024115D1 DE 602004024115 T DE602004024115 T DE 602004024115T DE 602004024115 T DE602004024115 T DE 602004024115T DE 602004024115 D1 DE602004024115 D1 DE 602004024115D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- subject
- suppressing
- immune response
- proliferative diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000028993 immune response Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- -1 4H-1-benzopyran-4-one compound Chemical class 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- OTAFHZMPRISVEM-UHFFFAOYSA-N benzo-gamma-pyrone Natural products C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000893 fibroproliferative effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52834003P | 2003-12-09 | 2003-12-09 | |
| PCT/US2004/041265 WO2005056014A1 (en) | 2003-12-09 | 2004-12-09 | Methods for suppressing an immune response or a treating a proliferative disorder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004024115D1 true DE602004024115D1 (de) | 2009-12-24 |
Family
ID=34676839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004024115T Expired - Lifetime DE602004024115D1 (de) | 2003-12-09 | 2004-12-09 | Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8044057B2 (de) |
| EP (1) | EP1694331B8 (de) |
| JP (1) | JP2007513962A (de) |
| KR (1) | KR20060123463A (de) |
| CN (1) | CN1889958A (de) |
| AT (1) | ATE447957T1 (de) |
| AU (1) | AU2004296868B2 (de) |
| BR (1) | BRPI0417498A (de) |
| CA (1) | CA2546920A1 (de) |
| DE (1) | DE602004024115D1 (de) |
| IL (1) | IL176214A0 (de) |
| MX (1) | MXPA06006651A (de) |
| RU (1) | RU2006124421A (de) |
| TR (2) | TR200808208T1 (de) |
| WO (1) | WO2005056014A1 (de) |
| ZA (1) | ZA200604724B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
| WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| EA010485B1 (ru) | 2003-07-23 | 2008-10-30 | Байер Фамэсьютиклс Копэрейшн | Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты) |
| CA2651367A1 (en) * | 2005-05-11 | 2006-11-16 | Genetic Technologies Limited | Methods of enriching fetal cells |
| CA2626789A1 (en) * | 2005-10-21 | 2007-04-26 | Exelixis, Inc. | Pyrimidinones as casein kinase ii (ck2) modulators |
| CU23511B6 (es) | 2006-02-28 | 2010-04-13 | Biorec B V | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
| EP1834636A1 (de) * | 2006-03-08 | 2007-09-19 | Sahajanand Medical Technologies PVT. ltd | Zusammensetzungen mit porösen Artikeln und ihre Verwendungsmöglichkeiten in implantierbaren medizinischen Vorrichtungen |
| US20100130597A1 (en) * | 2007-07-06 | 2010-05-27 | The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service | Dna-pkcs modulates energy regulation and brain function |
| NZ595087A (en) | 2009-02-11 | 2013-03-28 | Merck Patent Gmbh | Novel amino azaheterocyclic carboxamides |
| CN102471338B (zh) | 2009-08-07 | 2014-07-02 | 默克专利有限公司 | 氮杂杂环化合物 |
| CN101849934B (zh) * | 2010-05-25 | 2011-11-09 | 苏州大学 | 一种磷脂酰肌醇-3-激酶抑制剂及其应用 |
| US9586938B2 (en) | 2010-07-29 | 2017-03-07 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| PT2643313T (pt) | 2010-11-24 | 2016-10-11 | Merck Patent Gmbh | Quinazolina carboxamida azetidinas |
| UY34013A (es) | 2011-04-13 | 2012-11-30 | Astrazeneca Ab | ?compuestos de cromenona con actividad anti-tumoral?. |
| HRP20190128T1 (hr) | 2011-05-04 | 2019-03-08 | Rhizen Pharmaceuticals S.A. | Novi spojevi kao modulatori protein kinaza |
| CN103930407B (zh) | 2011-09-12 | 2019-02-26 | 默克专利有限公司 | 用作激酶活性调节剂的氨基嘧啶衍生物 |
| MX346095B (es) | 2011-09-12 | 2017-03-07 | Merck Patent Gmbh | Nuevas imidazol-aminas como moduladores de la actividad de cinasas. |
| SG11201402387WA (en) | 2011-12-22 | 2014-09-26 | Merck Patent Gmbh | Novel heterocyclic carboxamides as modulators of kinase activity |
| DK2822558T3 (da) * | 2012-03-06 | 2020-03-23 | The Board Of Trustees Of The Univ Of Illionis | Procaspase 3 aktivering ved hjælp af kombinations terapi |
| CA2890288A1 (en) | 2012-11-16 | 2014-05-22 | Merck Patent Gmbh | Novel heterocyclic derivatives as modulators of kinase activity |
| AR093511A1 (es) | 2012-11-16 | 2015-06-10 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de cinasas |
| SG10201800741QA (en) | 2012-11-29 | 2018-03-28 | Merck Patent Gmbh | BENZO-[d][1,2,3]TRIAZINE COMPOUNDS AND USE AS p70S6K INHIBITORS |
| AU2014224445C1 (en) | 2013-03-04 | 2017-07-27 | Astrazeneca Ab | Combination treatment |
| SG11201505999VA (en) | 2013-03-11 | 2015-08-28 | Merck Patent Gmbh | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
| CA2944573C (en) | 2014-04-03 | 2022-10-25 | Merck Patent Gmbh | Combinations of cancer therapeutics |
| CN108929329B (zh) * | 2017-05-24 | 2020-12-11 | 中国医学科学院药物研究所 | 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物 |
| CN107602520B (zh) * | 2017-10-16 | 2019-06-14 | 厦门大学 | 一种含哌嗪环的类异黄酮化合物及其制备方法和应用 |
| CN107641109B (zh) * | 2017-10-16 | 2019-05-24 | 厦门大学 | 一种类黄酮化合物及其制备方法和应用 |
| SG11202004384YA (en) | 2017-11-17 | 2020-06-29 | Univ Illinois | Cancer therapy by degrading dual mek signaling |
| KR20210084442A (ko) | 2018-10-05 | 2021-07-07 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 포도막 흑색종 치료를 위한 병용 요법 |
| TWI844602B (zh) | 2018-12-20 | 2024-06-11 | 美商安進公司 | Kif18a抑制劑 |
| EP4065231A1 (de) | 2019-11-27 | 2022-10-05 | Revolution Medicines, Inc. | Kovalente ras-inhibitoren und verwendungen davon |
| WO2022101459A1 (en) | 2020-11-16 | 2022-05-19 | Merck Patent Gmbh | Kinase inhibitor combinations for cancer treatment |
| WO2022235866A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN164232B (de) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| WO1990006921A1 (en) | 1988-12-21 | 1990-06-28 | The Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
-
2004
- 2004-12-09 CN CNA2004800366652A patent/CN1889958A/zh active Pending
- 2004-12-09 KR KR1020067013786A patent/KR20060123463A/ko not_active Withdrawn
- 2004-12-09 WO PCT/US2004/041265 patent/WO2005056014A1/en not_active Ceased
- 2004-12-09 JP JP2006543983A patent/JP2007513962A/ja active Pending
- 2004-12-09 TR TR2008/08208T patent/TR200808208T1/xx unknown
- 2004-12-09 MX MXPA06006651A patent/MXPA06006651A/es unknown
- 2004-12-09 US US10/581,257 patent/US8044057B2/en not_active Expired - Fee Related
- 2004-12-09 CA CA002546920A patent/CA2546920A1/en not_active Abandoned
- 2004-12-09 EP EP04813574A patent/EP1694331B8/de not_active Expired - Lifetime
- 2004-12-09 AT AT04813574T patent/ATE447957T1/de not_active IP Right Cessation
- 2004-12-09 RU RU2006124421/15A patent/RU2006124421A/ru unknown
- 2004-12-09 BR BRPI0417498-4A patent/BRPI0417498A/pt not_active IP Right Cessation
- 2004-12-09 AU AU2004296868A patent/AU2004296868B2/en not_active Ceased
- 2004-12-09 DE DE602004024115T patent/DE602004024115D1/de not_active Expired - Lifetime
- 2004-12-09 TR TR2006/04485T patent/TR200604485T1/xx unknown
-
2006
- 2006-06-08 IL IL176214A patent/IL176214A0/en unknown
- 2006-06-08 ZA ZA200604724A patent/ZA200604724B/xx unknown
-
2011
- 2011-09-22 US US13/241,008 patent/US20120039903A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2546920A1 (en) | 2005-06-23 |
| AU2004296868A1 (en) | 2005-06-23 |
| WO2005056014A1 (en) | 2005-06-23 |
| EP1694331A1 (de) | 2006-08-30 |
| US20120039903A1 (en) | 2012-02-16 |
| RU2006124421A (ru) | 2008-01-20 |
| ATE447957T1 (de) | 2009-11-15 |
| JP2007513962A (ja) | 2007-05-31 |
| ZA200604724B (en) | 2010-01-27 |
| WO2005056014A8 (en) | 2006-08-31 |
| US8044057B2 (en) | 2011-10-25 |
| BRPI0417498A (pt) | 2007-05-29 |
| KR20060123463A (ko) | 2006-12-01 |
| MXPA06006651A (es) | 2006-08-11 |
| TR200808208T1 (tr) | 2008-12-22 |
| CN1889958A (zh) | 2007-01-03 |
| IL176214A0 (en) | 2006-10-05 |
| US20070173514A1 (en) | 2007-07-26 |
| TR200604485T1 (tr) | 2007-01-22 |
| AU2004296868B2 (en) | 2010-11-25 |
| EP1694331B8 (de) | 2010-02-24 |
| EP1694331B1 (de) | 2009-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |