DK0387618T3 - Hidtil ukendte 1,7-anellerede 1H-indol-2-carboxylsyre-N-(1,4-benzodiazepin-3-yl)amider - Google Patents

Hidtil ukendte 1,7-anellerede 1H-indol-2-carboxylsyre-N-(1,4-benzodiazepin-3-yl)amider

Info

Publication number: DK0387618T3
Authority: DK; Denmark
Prior art keywords: lower alkyl; represents hydrogen; halogen; carbon atoms; benzodiazepin
Prior art date: 1989-03-08

Application number

DK90103990.9T

Other languages

English (en)

Inventor

Harald Waldeck

Werner Benson

Horst Zeugner

Klaus-Ullrich Wolf

Peter-Colin Gregory

Derk Hamminga

Ineke Van Wijngaarden

Original Assignee

Kali Chemie Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-08

Filing date

1990-03-01

Publication date

1994-08-22

1989-03-08 Priority claimed from DE3907389A external-priority patent/DE3907389A1/de

1989-03-08 Priority claimed from DE3907390A external-priority patent/DE3907390A1/de

1990-03-01 Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh

1994-08-22 Application granted granted Critical

1994-08-22 Publication of DK0387618T3 publication Critical patent/DK0387618T3/da

Links

ZDPSGFYSVVWKBE-UHFFFAOYSA-N n-(1h-1,4-benzodiazepin-3-yl)-1h-indole-2-carboxamide Chemical class N1C2=CC=CC=C2C=NC(NC(=O)C=2NC3=CC=CC=C3C=2)=C1 ZDPSGFYSVVWKBE-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Indole Compounds (AREA)

DK90103990.9T 1989-03-08 1990-03-01 Hidtil ukendte 1,7-anellerede 1H-indol-2-carboxylsyre-N-(1,4-benzodiazepin-3-yl)amider DK0387618T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3907389A DE3907389A1 (de)	1989-03-08	1989-03-08	Neue 1,7-anellierte 1h-indol-carbonsaeure-n-(5-alkyl-1,4-benzodiazepin-3-yl)amide
DE3907390A DE3907390A1 (de)	1989-03-08	1989-03-08	Neue 1,7-anellierte 1h-indol-2-carbonsaeure-n-(5-phenyl-1,4-benzodiazepin-3-yl)amide

Publications (1)

Publication Number	Publication Date
DK0387618T3 true DK0387618T3 (da)	1994-08-22

Family

ID=25878542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90103990.9T DK0387618T3 (da)	1989-03-08	1990-03-01	Hidtil ukendte 1,7-anellerede 1H-indol-2-carboxylsyre-N-(1,4-benzodiazepin-3-yl)amider

Country Status (20)

Country	Link
US (1)	US5010076A (da)
EP (1)	EP0387618B1 (da)
JP (1)	JP3010558B2 (da)
KR (1)	KR920003627B1 (da)
CN (1)	CN1032208C (da)
AT (1)	ATE109146T1 (da)
AU (1)	AU616835B2 (da)
CS (1)	CS390091A3 (da)
DE (1)	DE59006544D1 (da)
DK (1)	DK0387618T3 (da)
ES (1)	ES2057216T3 (da)
FI (1)	FI92486C (da)
HK (1)	HK1006570A1 (da)
HU (2)	HU207317B (da)
IE (1)	IE65030B1 (da)
IL (1)	IL93401A (da)
NO (1)	NO173869C (da)
NZ (1)	NZ232774A (da)
PH (1)	PH26955A (da)
PT (1)	PT93360B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07103105B2 (ja) *	1989-05-12	1995-11-08	杏林製薬株式会社	インドール誘導体及びその製造方法
US5264419A (en) *	1990-08-31	1993-11-23	Warner-Lambert Company	N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
CA2068355A1 (en) *	1991-05-14	1992-11-15	Mark S. Chambers	Benzodiazephine derivatives, compositions containing them and their use in therapy
DE4128015A1 (de) *	1991-08-23	1993-02-25	Kali Chemie Pharma Gmbh	1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9203790D0 (en) *	1992-02-21	1992-04-08	Merck Sharp & Dohme	Therapeutic agents
US5360802A (en) *	1992-05-11	1994-11-01	Merck Sharpe & Dohme Ltd.	Benzodiazepine derivatives, compositions containing them and their use in therapy
DE4304806A1 (de) *	1993-02-17	1994-08-18	Kali Chemie Pharma Gmbh	5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5556969A (en) *	1994-12-07	1996-09-17	Merck Sharp & Dohme Ltd.	Benzodiazepine derivatives
NZ314105A (en) *	1996-02-02	1997-12-19	Sumitomo Pharma	Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
KR100648869B1 (ko) *	1998-09-30	2007-02-28	다케다 야쿠힌 고교 가부시키가이샤	방광 배출력 개선제
IL159105A0 (en) *	2001-06-07	2004-05-12	Neuro3D	Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
US20060128695A1 (en) *	2002-10-30	2006-06-15	Neuro3D	Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses
FR2846653B1 (fr) *	2002-10-30	2007-04-20	Neuro3D	Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
WO2014098000A1 (en) *	2012-12-17	2014-06-26	Daiichi Sankyo Company, Limited	Process for preparation of a tricyclic heterocycle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0139584B1 (fr) *	1983-10-17	1988-05-18	Synthelabo	Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
CA1332410C (en) *	1984-06-26	1994-10-11	Roger M. Freidinger	Benzodiazepine analogs
US4820834A (en) *	1984-06-26	1989-04-11	Merck & Co., Inc.	Benzodiazepine analogs
FR2567126B1 (fr) *	1984-07-06	1986-12-12	Synthelabo	Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
US4628084A (en) *	1986-01-02	1986-12-09	Merck & Co., Inc.	Process for 3-acylamino benzodiazepines
NZ227229A (en) *	1987-12-10	1991-03-26	Duphar Int Res	Indole derivatives and pharmaceutical compositions
FR2630440B1 (fr) *	1988-04-25	1991-09-20	Jouveinal Sa	Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) *	1988-09-09	1994-10-07	Fujisawa Pharmaceutical Co	Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2652352A1 (fr) *	1989-09-28	1991-03-29	Jouveinal Sa	Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

1990
- 1990-02-14 IL IL9340190A patent/IL93401A/en not_active IP Right Cessation
- 1990-02-14 PH PH40052A patent/PH26955A/en unknown
- 1990-03-01 AT AT90103990T patent/ATE109146T1/de not_active IP Right Cessation
- 1990-03-01 ES ES90103990T patent/ES2057216T3/es not_active Expired - Lifetime
- 1990-03-01 DK DK90103990.9T patent/DK0387618T3/da active
- 1990-03-01 EP EP90103990A patent/EP0387618B1/de not_active Expired - Lifetime
- 1990-03-01 DE DE59006544T patent/DE59006544D1/de not_active Expired - Fee Related
- 1990-03-05 NZ NZ232774A patent/NZ232774A/en unknown
- 1990-03-05 CN CN90101141A patent/CN1032208C/zh not_active Expired - Fee Related
- 1990-03-07 NO NO901083A patent/NO173869C/no unknown
- 1990-03-07 KR KR1019900003005A patent/KR920003627B1/ko not_active Expired
- 1990-03-07 HU HU901333A patent/HU207317B/hu not_active IP Right Cessation
- 1990-03-07 FI FI901154A patent/FI92486C/fi not_active IP Right Cessation
- 1990-03-07 PT PT93360A patent/PT93360B/pt not_active IP Right Cessation
- 1990-03-07 AU AU50753/90A patent/AU616835B2/en not_active Ceased
- 1990-03-07 US US07/489,502 patent/US5010076A/en not_active Expired - Lifetime
- 1990-03-07 IE IE81390A patent/IE65030B1/en not_active IP Right Cessation
- 1990-03-08 JP JP2055191A patent/JP3010558B2/ja not_active Expired - Fee Related
1991
- 1991-12-19 CS CS913900A patent/CS390091A3/cs unknown
1994
- 1994-09-30 HU HU94P/P00034P patent/HU210354A9/hu unknown
1998
- 1998-06-17 HK HK98105568A patent/HK1006570A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE59006544D1 (de)	1994-09-01
EP0387618A1 (de)	1990-09-19
NO173869C (no)	1994-02-16
HU207317B (en)	1993-03-29
US5010076A (en)	1991-04-23
CS390091A3 (en)	1992-06-17
FI92486B (fi)	1994-08-15
FI92486C (fi)	1994-11-25
CN1032208C (zh)	1996-07-03
NO901083D0 (no)	1990-03-07
JP3010558B2 (ja)	2000-02-21
JPH02273678A (ja)	1990-11-08
PT93360B (pt)	1996-02-29
HK1006570A1 (en)	1999-03-05
PT93360A (pt)	1990-11-07
IE900813L (en)	1990-09-08
NO901083L (no)	1990-09-10
CN1045392A (zh)	1990-09-19
IE65030B1 (en)	1995-10-04
FI901154A0 (fi)	1990-03-07
EP0387618B1 (de)	1994-07-27
IL93401A0 (en)	1990-11-29
KR920003627B1 (ko)	1992-05-04
HU901333D0 (en)	1990-05-28
KR900014391A (ko)	1990-10-23
ATE109146T1 (de)	1994-08-15
ES2057216T3 (es)	1994-10-16
NZ232774A (en)	1991-04-26
HU210354A9 (en)	1995-03-28
NO173869B (no)	1993-11-08
IL93401A (en)	1994-08-26
AU616835B2 (en)	1991-11-07
HUT53641A (en)	1990-11-28
PH26955A (en)	1992-12-03
AU5075390A (en)	1990-09-13

Publication	Publication Date	Title
DK0387618T3 (da)	1994-08-22	Hidtil ukendte 1,7-anellerede 1H-indol-2-carboxylsyre-N-(1,4-benzodiazepin-3-yl)amider
SE8406585L (sv)	1985-06-24	Bensoesyraderivat
SG49847A1 (en)	1999-07-20	Stabilized organic material
ES2093099T3 (es)	1996-12-16	Preparacion de piperidinas sustituidas.
AR246962A1 (es)	1994-10-31	Procedimiento para preparar derivados alquilamino-alquilenicos de ciertos 2h-1-benzopiranos.
ES533378A0 (es)	1985-04-16	Procedimiento para la preparacion de derivados de b-carbolinas.
NZ201514A (en)	1985-09-13	1-phenyl-2-substituted aminocarbonyl indole compounds and pharmaceutical compositions
PT81545B (pt)	1988-01-22	Processo para a preparacao de compostos 5-aloquil-1-fenil-2-piperazino-alquil-pirazolin-3-ona
ES2067882T3 (es)	1995-04-01	Procedimiento de preparacion de la 1-(2,3,4-trimetoxi-bencil)-piperacina mediante aminacion reductiva.
DK92388A (da)	1988-10-25	Diorganopolysiloxangruppeholdige disubstituerede n,n'-bis-maleimider samt fremgangsmaade til fremstilling deraf
SE8006953L (sv)	1981-04-04	Heterocykliska foreningar
ZA854422B (en)	1986-01-29	3-aminocarbonylmethoxy-5-phenylpyrazole compounds,method for their preparation and pharmaceutical compositions containing these compounds
CA2011658A1 (en)	1990-09-08	New 1,7-annelated 1h-indole-2-carboxylic acid-n-(1,4-benzodiazepin-3-yl) amides
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
ATE6635T1 (de)	1984-03-15	Biologisch aktive trizyklische amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
ES2071177T3 (es)	1995-06-16	Derivados substituidos de amidas de aminoacido, su obtencion y empleo.
PT78155B (de)	1986-07-17	N-(3-trifluormethylphenyl)-n'-propargylpiperazin seine herstellung und verwendung
ATE53839T1 (de)	1990-06-15	2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES528712A0 (es)	1985-01-01	Procedimiento para preparar nuevos compuestos heterociclicos