DK0790994T3 - Heterocyclisk substituerede propensyrederivater som NMDA-antagonister - Google Patents
Heterocyclisk substituerede propensyrederivater som NMDA-antagonisterInfo
- Publication number
- DK0790994T3 DK0790994T3 DK95933902T DK95933902T DK0790994T3 DK 0790994 T3 DK0790994 T3 DK 0790994T3 DK 95933902 T DK95933902 T DK 95933902T DK 95933902 T DK95933902 T DK 95933902T DK 0790994 T3 DK0790994 T3 DK 0790994T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid derivatives
- propenoic acid
- nmda antagonists
- heterocyclic substituted
- substituted propenoic
- Prior art date
Links
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 title 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08332016 US5563157B1 (en) | 1994-10-31 | 1994-10-31 | Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof |
| PCT/US1995/012085 WO1996013501A1 (en) | 1994-10-31 | 1995-09-21 | Heterocycle substituted propenoic acid derivatives as nmda antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0790994T3 true DK0790994T3 (da) | 2002-08-26 |
Family
ID=23296353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95933902T DK0790994T3 (da) | 1994-10-31 | 1995-09-21 | Heterocyclisk substituerede propensyrederivater som NMDA-antagonister |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5563157B1 (de) |
| EP (1) | EP0790994B1 (de) |
| JP (1) | JP3934678B2 (de) |
| KR (1) | KR100401138B1 (de) |
| CN (1) | CN1068001C (de) |
| AT (1) | ATE217307T1 (de) |
| AU (1) | AU696423B2 (de) |
| CA (1) | CA2202992C (de) |
| DE (1) | DE69526668T2 (de) |
| DK (1) | DK0790994T3 (de) |
| ES (1) | ES2173198T3 (de) |
| FI (1) | FI971831L (de) |
| HU (1) | HU222372B1 (de) |
| IL (1) | IL115791A (de) |
| MX (1) | MX9703146A (de) |
| NO (1) | NO313197B1 (de) |
| NZ (1) | NZ293842A (de) |
| PT (1) | PT790994E (de) |
| TW (1) | TW336232B (de) |
| WO (1) | WO1996013501A1 (de) |
| ZA (1) | ZA959046B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922752A (en) * | 1997-06-11 | 1999-07-13 | Hoechst Marion Roussell, Inc. | NMDA (n-methyl-d-aspartate) antagonists |
| GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| PL366068A1 (en) | 2000-10-10 | 2005-01-24 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-gamma binding agents |
| EP1436258A4 (de) * | 2001-03-08 | 2005-03-23 | Univ Emory | Ph-wert-abhängige nmda-rezeptorantagonisten |
| KR20100045983A (ko) | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 ｎｍｄａ 수용체 길항물질 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69118539T2 (de) * | 1990-07-16 | 1996-09-19 | Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio | Exzitatorische Aminosäureantagonisten |
| ES2103832T3 (es) * | 1990-10-15 | 1997-10-01 | Astra Ab | Derivados de 2-fenil y 2-tienil-(2)-piperidina que tienen propiedades neuroprotectoras. |
| US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| US5519048A (en) * | 1993-05-27 | 1996-05-21 | Merrell Pharmaceuticals Inc. | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof |
| JP3334805B2 (ja) * | 1993-05-27 | 2002-10-15 | メレルファーマスーティカルズ インコーポレイテッド | ３−（インドール−３−イル）−プロペン酸誘導体類及びその製剤組成物 |
-
1994
- 1994-10-31 US US08332016 patent/US5563157B1/en not_active Expired - Lifetime
-
1995
- 1995-09-21 DE DE69526668T patent/DE69526668T2/de not_active Expired - Lifetime
- 1995-09-21 DK DK95933902T patent/DK0790994T3/da active
- 1995-09-21 KR KR1019970702840A patent/KR100401138B1/ko not_active Expired - Fee Related
- 1995-09-21 EP EP95933902A patent/EP0790994B1/de not_active Expired - Lifetime
- 1995-09-21 MX MX9703146A patent/MX9703146A/es unknown
- 1995-09-21 JP JP51456396A patent/JP3934678B2/ja not_active Expired - Lifetime
- 1995-09-21 ES ES95933902T patent/ES2173198T3/es not_active Expired - Lifetime
- 1995-09-21 CA CA002202992A patent/CA2202992C/en not_active Expired - Lifetime
- 1995-09-21 NZ NZ293842A patent/NZ293842A/en unknown
- 1995-09-21 AT AT95933902T patent/ATE217307T1/de not_active IP Right Cessation
- 1995-09-21 PT PT95933902T patent/PT790994E/pt unknown
- 1995-09-21 WO PCT/US1995/012085 patent/WO1996013501A1/en not_active Ceased
- 1995-09-21 HU HU9701941A patent/HU222372B1/hu not_active IP Right Cessation
- 1995-09-21 FI FI971831A patent/FI971831L/fi not_active IP Right Cessation
- 1995-09-21 CN CN95195799A patent/CN1068001C/zh not_active Expired - Fee Related
- 1995-09-21 AU AU36387/95A patent/AU696423B2/en not_active Ceased
- 1995-10-25 ZA ZA959046A patent/ZA959046B/xx unknown
- 1995-10-26 TW TW084111310A patent/TW336232B/zh active
- 1995-10-27 IL IL11579195A patent/IL115791A/xx not_active IP Right Cessation
-
1997
- 1997-04-29 NO NO19971991A patent/NO313197B1/no not_active IP Right Cessation
- 1997-12-15 US US08/990,673 patent/US5981553A/en not_active Expired - Lifetime
-
1999
- 1999-07-28 US US09/363,305 patent/US6180786B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ293842A (en) | 1998-09-24 |
| EP0790994B1 (de) | 2002-05-08 |
| CA2202992A1 (en) | 1996-05-09 |
| ES2173198T3 (es) | 2002-10-16 |
| US5563157A (en) | 1996-10-08 |
| US6180786B1 (en) | 2001-01-30 |
| IL115791A0 (en) | 1996-01-19 |
| MX9703146A (es) | 1997-06-28 |
| ATE217307T1 (de) | 2002-05-15 |
| AU696423B2 (en) | 1998-09-10 |
| ZA959046B (en) | 1996-05-17 |
| CN1068001C (zh) | 2001-07-04 |
| JP3934678B2 (ja) | 2007-06-20 |
| CN1161696A (zh) | 1997-10-08 |
| TW336232B (en) | 1998-07-11 |
| JPH10508019A (ja) | 1998-08-04 |
| DE69526668D1 (de) | 2002-06-13 |
| HU222372B1 (hu) | 2003-06-28 |
| DE69526668T2 (de) | 2003-01-02 |
| NO971991L (no) | 1997-04-29 |
| FI971831A7 (fi) | 1997-04-29 |
| FI971831A0 (fi) | 1997-04-29 |
| IL115791A (en) | 2000-09-28 |
| US5563157B1 (en) | 1999-02-02 |
| NO313197B1 (no) | 2002-08-26 |
| HUT77174A (hu) | 1998-03-02 |
| EP0790994A1 (de) | 1997-08-27 |
| WO1996013501A1 (en) | 1996-05-09 |
| US5981553A (en) | 1999-11-09 |
| NO971991D0 (no) | 1997-04-29 |
| CA2202992C (en) | 2003-05-13 |
| KR100401138B1 (ko) | 2003-12-24 |
| AU3638795A (en) | 1996-05-23 |
| FI971831L (fi) | 1997-04-29 |
| PT790994E (pt) | 2002-08-30 |
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