DK0799833T3 - Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number: DK0799833T3
Authority: DK; Denmark
Prior art keywords: group; aryl; alkyl; carbon atoms; heterocyclic
Prior art date: 1995-12-22

Application number

DK96402821T

Other languages

English (en)

Inventor

Francois Bretin

Jean-Francois Chantot

Constantin Agouridas

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-22

Filing date

1996-12-19

Publication date

2002-09-09

1996-12-19 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-09-09 Application granted granted Critical

2002-09-09 Publication of DK0799833T3 publication Critical patent/DK0799833T3/da

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000005108 alkenylthio group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000005109 alkynylthio group Chemical group 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
-1 carbocyclic aryl Chemical group 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK96402821T 1995-12-22 1996-12-19 Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0799833T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9515322A FR2742757B1 (fr)	1995-12-22	1995-12-22	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number	Publication Date
DK0799833T3 true DK0799833T3 (da)	2002-09-09

Family

ID=9485837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96402821T DK0799833T3 (da)	1995-12-22	1996-12-19	Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (9)

Country	Link
US (1)	US5747467A (da)
EP (1)	EP0799833B1 (da)
JP (1)	JP3140703B2 (da)
AT (1)	ATE218141T1 (da)
DE (1)	DE69621421T2 (da)
DK (1)	DK0799833T3 (da)
ES (1)	ES2176419T3 (da)
FR (1)	FR2742757B1 (da)
PT (1)	PT799833E (da)

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FR2777282B1 (fr) *	1998-04-08	2001-04-20	Hoechst Marion Roussel Inc	Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
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FR2792637B1 (fr) *	1999-04-26	2001-06-01	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2781484B1 (fr) *	1998-07-21	2001-08-10	Hoechst Marion Roussel Inc	Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
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US6939861B2 (en) *	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6355620B1 (en) *	1999-05-14	2002-03-12	Abbott Laboratories	C-2 modified erythromycin derivatives
EA200100983A1 (ru) *	1999-05-24	2002-10-31	Пфайзер Продактс Инк.	Производные 13-метилэритромицина
JP2001261694A (ja) *	2000-03-06	2001-09-26	Pfizer Prod Inc	ケトライド抗生物質
DE60104240T2 (de) *	2000-06-30	2005-08-04	Pfizer Products Inc., Groton	Makrolid-Antibiotika
CN1492874A (zh) *	2000-12-21	2004-04-28		大环内酯
US7157433B2 (en) *	2002-07-08	2007-01-02	Glaxosmithkline Istrazivacki Centar Zagreb	Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
RU2330858C2 (ru) *	2002-07-08	2008-08-10	Глаксомитклайн Истраживацки Центар Загреб Д.О.О.	Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
US6727229B2 (en) *	2002-08-19	2004-04-27	Enanta Pharmaceuticals, Inc.	11,12-substituted lactone ketolide derivatives having antibacterial activity
AR043050A1 (es) *	2002-09-26	2005-07-13	Rib X Pharmaceuticals Inc	Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CN1780846A (zh) *	2003-03-05	2006-05-31	Rib－X医药品有限公司	双官能杂环化合物及其制备和使用方法
ES2552682T3 (es)	2003-03-10	2015-12-01	Merck Sharp & Dohme Corp.	Agentes antibacterianos novedosos
WO2005007143A2 (en) *	2003-07-14	2005-01-27	The Board Of Trustees Of The University Of Illinois	Use of makrolides and ketolides for the treatment of tuberculosis
WO2005042554A1 (en) *	2003-10-30	2005-05-12	Rib-X Pharmaceuticals, Inc.	Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) *	2003-11-18	2007-05-17	リブ−エックスファーマシューティカルズ，インコーポレイテッド	二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
JP5383037B2 (ja) *	2004-02-27	2014-01-08	リブ−エックスファーマシューティカルズ，インコーポレイテッド	大環状化合物およびそれらを製造し使用する方法
JP2008508322A (ja) *	2004-07-28	2008-03-21	ランバクシーラボラトリーズリミテッド	抗菌剤としてのケトライド誘導体
EP1807439A2 (en) *	2004-10-25	2007-07-18	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
UA85937C2 (uk)	2004-12-21	2009-03-10	Пфайзер Продактс Інк.	Макроліди
EP1960413A2 (en) *	2005-11-23	2008-08-27	Ranbaxy Laboratories Limited	Macrolides derivatives as antibacterial agents
WO2007060518A2 (en) *	2005-11-23	2007-05-31	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
CN105732745A (zh)	2007-10-25	2016-07-06	森普拉制药公司	大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) *	2008-10-24	2016-05-19	Cempra Pharmaceuticals, Inc.	Biodefenses using triazole-containing macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
US9480679B2 (en)	2009-09-10	2016-11-01	Cempra Pharmaceuticals, Inc.	Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (da)	2010-03-22	2016-02-29	Cempra Pharmaceuticals Inc	Krystallinske former af et macrolid og anvendelser deraf
CN105198944B (zh)	2010-05-20	2018-06-01	森普拉制药公司	制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en)	2010-09-10	2014-01-15	Cempra Pharmaceuticals Inc	HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
MX2014011537A (es)	2012-03-27	2015-02-10	Cempra Pharmaceuticals Inc	Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh)	2013-03-14	2017-01-20	森普拉制药公司	用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru)	2013-03-15	2017-04-24	Семпра Фармасьютикалс, Инк.	Конвергентные способы получения макролидных антибактериальных агентов
WO2025228440A1 (zh) *	2024-04-30	2025-11-06	苏州信诺维医药科技股份有限公司	大环内酯类化合物、其制备方法及其用途

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FR2718450B1 (fr) *	1994-04-08	1997-01-10	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
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1995
- 1995-12-22 FR FR9515322A patent/FR2742757B1/fr not_active Expired - Fee Related
1996
- 1996-12-19 ES ES96402821T patent/ES2176419T3/es not_active Expired - Lifetime
- 1996-12-19 DK DK96402821T patent/DK0799833T3/da active
- 1996-12-19 EP EP96402821A patent/EP0799833B1/fr not_active Expired - Lifetime
- 1996-12-19 PT PT96402821T patent/PT799833E/pt unknown
- 1996-12-19 US US08/767,954 patent/US5747467A/en not_active Expired - Lifetime
- 1996-12-19 DE DE69621421T patent/DE69621421T2/de not_active Expired - Lifetime
- 1996-12-19 AT AT96402821T patent/ATE218141T1/de active
- 1996-12-20 JP JP08354633A patent/JP3140703B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5747467A (en)	1998-05-05
PT799833E (pt)	2002-10-31
EP0799833B1 (fr)	2002-05-29
FR2742757B1 (fr)	1998-01-30
DE69621421T2 (de)	2003-01-09
ES2176419T3 (es)	2002-12-01
EP0799833A1 (fr)	1997-10-08
FR2742757A1 (fr)	1997-06-27
ATE218141T1 (de)	2002-06-15
JPH09176182A (ja)	1997-07-08
DE69621421D1 (de)	2002-07-04
JP3140703B2 (ja)	2001-03-05

Publication	Publication Date	Title
DK0799833T3 (da)	2002-09-09	Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK0606024T3 (da)	1996-06-17	Erythromycinderivater, en fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler
AR019263A1 (es)	2002-02-13	Compuestos derivados de hidroxamida del acido (4-arilsulfonilamino) tetrahidropiran-4-carboxilico, composiciones farmaceuticas y metodos de tratamiento.
CA2053253A1 (en)	1991-08-29	New aryl-and heteroarylethenylene derivatives and process for their preparation
DK1104760T3 (da)	2003-06-30	Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
DK1159279T3 (da)	2003-02-17	4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler
DK1104759T3 (da)	2004-01-26	Heteroarylphenylpyrazolforbindelser som antiinflammatoriske/analgetiske midler
DE69428142D1 (de)	2001-10-11	Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung
HUP0100184A2 (hu)	2001-07-30	Szubsztituált 2-(benzil-amino)-2-fenil-acetamid-vegyületek és ezeket tartalmazó gyógyszerkészítmények
DK319886A (da)	1987-01-06	Kemiske forbindelser
NO890440L (no)	1990-01-15	Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
NO164593C (no)	1990-10-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive karbamat- eller urea-derivater.
HUP0001245A1 (hu)	2000-09-28	Új eritromicinszármazékok, eljárás a vegyületek előállítására és gyógyszerként történő alkalmazásuk
NZ516194A (en)	2003-03-28	Optically active pyrrolopyridazine compounds
EA200101170A1 (ru)	2002-04-25	Галоидпроизводные 9-деоксо-9а-аза-9а-гомоэритромицина а
HRP20000027B1 (en)	2006-07-31	Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds
DK96086A (da)	1986-09-05	8-thiotetrahydroquinolinderivater, deres fremstilling og anvendelse som laegemidler
ES2001031A6 (es)	1988-04-16	Un procedimiento para la preparacion de penicilinas que contienen un grupo oximino
ATE208761T1 (de)	2001-11-15	Quinolin-derivate und diese enthaltende pharmazeutische zusammensetzungen
DK0638587T3 (da)	1999-11-22	Salmyciner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemiddel
ZA872925B (en)	1987-11-25	Heterocyclic compounds
IT1248068B (it)	1995-01-05	Derivati dell'eseridina ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.