DK1023291T3 - Dipyridoimidazolderivater, som er egnet til behandling af lidelser i centralnervesystemet - Google Patents
Dipyridoimidazolderivater, som er egnet til behandling af lidelser i centralnervesystemetInfo
- Publication number
- DK1023291T3 DK1023291T3 DK98953243T DK98953243T DK1023291T3 DK 1023291 T3 DK1023291 T3 DK 1023291T3 DK 98953243 T DK98953243 T DK 98953243T DK 98953243 T DK98953243 T DK 98953243T DK 1023291 T3 DK1023291 T3 DK 1023291T3
- Authority
- DK
- Denmark
- Prior art keywords
- dipyridoimidazole
- treatment
- nervous system
- central nervous
- system disorders
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 1
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6124897P | 1997-10-07 | 1997-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1023291T3 true DK1023291T3 (da) | 2004-10-04 |
Family
ID=22034585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98953243T DK1023291T3 (da) | 1997-10-07 | 1998-10-05 | Dipyridoimidazolderivater, som er egnet til behandling af lidelser i centralnervesystemet |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5968946A (fr) |
| EP (1) | EP1023291B1 (fr) |
| JP (1) | JP2001519351A (fr) |
| AT (1) | ATE267828T1 (fr) |
| AU (1) | AU1066499A (fr) |
| CA (1) | CA2305342A1 (fr) |
| DE (1) | DE69824195T2 (fr) |
| DK (1) | DK1023291T3 (fr) |
| ES (1) | ES2221996T3 (fr) |
| PT (1) | PT1023291E (fr) |
| WO (1) | WO1999018105A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU779686B2 (en) | 1999-08-02 | 2005-02-03 | Ortho-Mcneil Pharmaceutical, Inc. | C-6 ring-substituted pyrido(1,2-a)benzimidazole derivatives useful in treating central nervous system disorders |
| AU2001264932A1 (en) * | 2000-05-26 | 2001-12-11 | Neurogen Corporation | Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands |
| CA2540541C (fr) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Imidazoquinolines a substitution alcoxy |
| BRPI0415179A (pt) * | 2003-10-07 | 2006-11-28 | Renovis Inc | derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas |
| WO2005051317A2 (fr) | 2003-11-25 | 2005-06-09 | 3M Innovative Properties Company | Systèmes cycliques d'imidazo substitués et procédés |
| JP2007530450A (ja) | 2003-12-29 | 2007-11-01 | スリーエム イノベイティブ プロパティズ カンパニー | ピペラジン、[1,4]ジアゼパン、[1,4]ジアゾカン、および[1,5]ジアゾカン縮合イミダゾ環化合物 |
| WO2006084251A2 (fr) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Formulations des gel aqueux contenant des modificateurs de reponse immunitaire |
| US7576099B2 (en) * | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| JP2008531690A (ja) * | 2005-02-28 | 2008-08-14 | レノビス, インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体並びにそれを使用する医薬組成物及び方法 |
| JP2010520875A (ja) * | 2007-03-09 | 2010-06-17 | レノビス, インコーポレイテッド | P2x7調節因子としてのビシクロヘテロアリール化合物およびその使用 |
| US20200062710A1 (en) | 2016-12-06 | 2020-02-27 | Nipppon Kayaku Kabushiki Kaisha | Method For Producing 3-(Pyridyl-2-Amino)Propionitrile And Analogues Thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU221369B1 (en) * | 1992-08-19 | 2002-09-28 | Mcneilab Inc | 3-oxo-pyrido(1,2-a)benzimidazole-4-carboxyl and 4-oxo-azepino(1,2-a)-benzimidazole-5-carboxyl derivatives, their preparation pharmaceutical compositions suitable for treating central nervous system disorders containing thereof and their preparation |
| PT935598E (pt) * | 1996-10-07 | 2004-03-31 | Ortho Mcneil Pharm Inc | Derivados de 3-oxo-pirido (1,2-a)benzimidazole-4-carboxamida alquilo substituidos contendo 5 heteroatomos uteis no tratamento de disturbios do sistema nervoso central |
-
1998
- 1998-10-05 EP EP98953243A patent/EP1023291B1/fr not_active Expired - Lifetime
- 1998-10-05 DE DE69824195T patent/DE69824195T2/de not_active Expired - Fee Related
- 1998-10-05 ES ES98953243T patent/ES2221996T3/es not_active Expired - Lifetime
- 1998-10-05 PT PT98953243T patent/PT1023291E/pt unknown
- 1998-10-05 WO PCT/US1998/020802 patent/WO1999018105A1/fr not_active Ceased
- 1998-10-05 CA CA002305342A patent/CA2305342A1/fr not_active Abandoned
- 1998-10-05 JP JP2000514916A patent/JP2001519351A/ja active Pending
- 1998-10-05 US US09/166,327 patent/US5968946A/en not_active Expired - Lifetime
- 1998-10-05 AT AT98953243T patent/ATE267828T1/de not_active IP Right Cessation
- 1998-10-05 DK DK98953243T patent/DK1023291T3/da active
- 1998-10-05 AU AU10664/99A patent/AU1066499A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69824195T2 (de) | 2005-06-23 |
| PT1023291E (pt) | 2004-09-30 |
| WO1999018105A1 (fr) | 1999-04-15 |
| DE69824195D1 (de) | 2004-07-01 |
| EP1023291B1 (fr) | 2004-05-26 |
| ES2221996T3 (es) | 2005-01-16 |
| AU1066499A (en) | 1999-04-27 |
| ATE267828T1 (de) | 2004-06-15 |
| JP2001519351A (ja) | 2001-10-23 |
| CA2305342A1 (fr) | 1999-04-15 |
| US5968946A (en) | 1999-10-19 |
| WO1999018105A8 (fr) | 1999-06-10 |
| EP1023291A1 (fr) | 2000-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20000311D0 (no) | Nye forbindelser | |
| NO995006D0 (no) | Nye forbindelser | |
| MY118163A (en) | Aryl fused azapolycyclic compounds | |
| BG101715A (bg) | Тетрациклени спиросъединения,метод за тяхното получаване и приложението им като 5нт долу 1d рецепторни антагонисти | |
| IL114003A (en) | 1,4,6-Trisubstituted 1H-pyrrolo[2,3-b]pyridine and 1-H-pyrazolo[3,4-b] pyridine derivatives and pharmaceutical compositions containing them and some intermediates for their preparation | |
| CO4930259A1 (es) | Derivados 6,6-heterobiciclicos sustituidos y composiciones farmaceuticas que los contienen | |
| NO981477L (no) | Pyrimidinderivater som 5HT2C-reseptor antagonister | |
| AR006119A1 (es) | Compuestos de quinoxalinadionas uso de los mismos para la fabricacion de un medicamento, compuestos de quinoxalinas para producirlos y procedimiento parala preparacion de los mismos | |
| FI963294A0 (fi) | Naftyyliamidit keskushermostoaineina | |
| DK1023291T3 (da) | Dipyridoimidazolderivater, som er egnet til behandling af lidelser i centralnervesystemet | |
| DK0819002T3 (da) | Anvendelse af imidazo-[1,2-a]pyridin-3-acetamidderivater til den terapeutiske behandling af neuropsykiatriske syndromer, der er forbundet med dysfunktion af nervebanerne i basalganglierne | |
| DK0644878T3 (da) | 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister | |
| NO20013645L (no) | Anvendelse av pyridazino[4,5-b]indol-1-acetamid-derivater for fremstilling av medisiner for behandling av sykdommer relatert tildysfunksjon av de perifere benzodiazepinreseptorer | |
| DE69609192D1 (de) | Imidazo(1,2-a)quinoxalin-4-amine als adenosin-antagonisten, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen | |
| NO963331L (no) | 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister | |
| DK0935598T3 (da) | 5-heteroatom-alkylsubstituerede 3-oxopyrido(1,2-a)benzimidazol-4-carboxamidderivater egnede til behandling af sygdomme i centralnervesystemet | |
| IT1261255B (it) | Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. | |
| PT1025101E (pt) | Derivados de nafto-imidazo¬1,2-a|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central | |
| BR0010748A (pt) | Compostos heterocìclicos contendo imidazo, suas composições e usos | |
| ATE112256T1 (de) | 9-amino-2-phenylbicyclo(3.3.1>nonane und 9-amino- 2-phenylbicyclo(3.3.1>-non-2-ene und diese enthaltende therapeutische mittel. | |
| ES2167569T3 (es) | Uso de imidazo(1,5-a)quinolonas como agentes neuroprotectores. | |
| DK0900078T3 (da) | Anvendelse af benzonaphthalenderivater til fremstilling af lægemidler til behandling af sygdomme i nervesystemet | |
| ES2106683A1 (es) | Derivados de 1,3-dioxoperhidropirido (1,2-c) pirimidinas como antagonistas de colecistoquinina. | |
| MX9301870A (es) | Antagonistas receptores de angiotensina ii | |
| ECSP951573A (es) | Derivados de [3-(4- fenilpiperacin-1-il)propilamino]-piridina, pirimidina y benceno como antagonistas de alfa- adrenoceptores, case ran 4013/26 |