DK1043310T3 - Biphenylamidinderivater - Google Patents

Biphenylamidinderivater

Info

Publication number: DK1043310T3
Authority: DK; Denmark
Prior art keywords: biphenylamidine; biphenylamidine derivatives; derivatives; chem; pharmaceutically acceptable
Prior art date: 1997-11-20

Application number

DK98954747T

Other languages

Danish (da)

English (en)

Inventor

Yoshiharu Takazawa

Takayuki Hara

Tomohisa Nakada

Yasunobu Takano

Satoshi Sugiura

Takaharu Tsutsumi

Reiko Takarada

Original Assignee

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-20

Filing date

1998-11-19

Publication date

2004-10-25

1998-11-19 Application filed by Teijin Ltd filed Critical Teijin Ltd

2004-10-25 Application granted granted Critical

2004-10-25 Publication of DK1043310T3 publication Critical patent/DK1043310T3/da

Links

LNUYLGUBVHEHEL-UHFFFAOYSA-N 2-phenylbenzenecarboximidamide Chemical class NC(=N)C1=CC=CC=C1C1=CC=CC=C1 LNUYLGUBVHEHEL-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK98954747T 1997-11-20 1998-11-19 Biphenylamidinderivater DK1043310T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP31969897		1997-11-20
JP12749898		1998-05-11
EP98954747A EP1043310B1 (de)	1997-11-20	1998-11-19	Biphenylamidin-derivate
PCT/JP1998/005209 WO1999026918A1 (en)	1997-11-20	1998-11-19	Biphenylamidine derivatives

Publications (1)

Publication Number	Publication Date
DK1043310T3 true DK1043310T3 (da)	2004-10-25

Family

ID=26463455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98954747T DK1043310T3 (da)	1997-11-20	1998-11-19	Biphenylamidinderivater

Country Status (28)

Country	Link
US (1)	US6706745B1 (de)
EP (1)	EP1043310B1 (de)
KR (1)	KR100581506B1 (de)
CN (1)	CN1150162C (de)
AT (1)	ATE268751T1 (de)
AU (1)	AU744567B2 (de)
BG (1)	BG63536B1 (de)
BR (1)	BR9814983A (de)
CA (1)	CA2310331A1 (de)
DE (1)	DE69824450T2 (de)
DK (1)	DK1043310T3 (de)
EE (1)	EE04564B1 (de)
ES (1)	ES2218866T3 (de)
HR (1)	HRP20000304B1 (de)
HU (1)	HUP0100085A3 (de)
ID (1)	ID24846A (de)
IL (1)	IL136100A (de)
IS (1)	IS5497A (de)
NO (1)	NO20002589L (de)
NZ (1)	NZ504407A (de)
PL (1)	PL340658A1 (de)
PT (1)	PT1043310E (de)
RU (1)	RU2197478C2 (de)
SK (1)	SK7612000A3 (de)
TR (1)	TR200001452T2 (de)
TW (1)	TW523504B (de)
UA (1)	UA52797C2 (de)
WO (1)	WO1999026918A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ504324A (en) *	1997-11-20	2002-02-01	Teijin Ltd	Biphenylamidine derivatives and pharmaceutical compositions thereof; which can be useful as anticoagulant inhibitors, and thrombus or embolus preventing agents
CA2360686A1 (en) *	1999-01-28	2000-08-03	Teijin Limited	Release-regulating preparations
HK1040510A1 (en)	1999-05-17	2002-06-14	Teijin Limited	Cyanobiphenyl derivatives
WO2001056989A2 (en) *	2000-02-01	2001-08-09	Cor Therapeutics, Inc.	Inhibitors of factor xa
WO2002028827A1 (en) *	2000-10-04	2002-04-11	Kissei Pharmaceutical Co., Ltd.	5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
US6316475B1 (en) *	2000-11-17	2001-11-13	Abbott Laboratories	Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
EP1361213A4 (de) *	2001-01-26	2004-06-09	Teijin Ltd	Verfahren zur herstellung von cyanophenylbenzoesäurederivaten
HUP0302989A3 (en) *	2001-01-29	2007-06-28	Teijin Ltd	Benzamidine derivatives and process for production thereof
AR035425A1 (es) *	2001-01-30	2004-05-26	Teijin Ltd	Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
KR20030076634A (ko) *	2001-01-30	2003-09-26	데이진 가부시키가이샤	의약 조성물
WO2003040086A1 (en) *	2001-11-09	2003-05-15	Kissei Pharmaceutical Co., Ltd.	5-amidino-2-hydroxybenzenesulfonamide derivatives, medicinal compositions containing the same, medicinal use thereof and intermediates in the production thereof
KR20040058340A (ko)	2001-11-30	2004-07-03	데이진 가부시키가이샤	5-(3-시아노페닐)-3-포르밀벤조산 화합물의 제조 방법
AU2003302238A1 (en)	2002-12-03	2004-06-23	Axys Pharmaceuticals, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
JP4885722B2 (ja) *	2004-06-30	2012-02-29	富山化学工業株式会社	新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤
WO2007021033A1 (ja)	2005-08-18	2007-02-22	Teijin Pharma Limited	複数の薬物保持部位がある錠剤
EP3205337A1 (de)	2005-08-18	2017-08-16	Teijin Pharma Limited	Formulierung, die eine genaue doseneinteilung aufweist
PE20070698A1 (es)	2005-11-14	2007-08-17	Teijin Pharma Ltd	Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
CN107709314A (zh)	2015-06-11	2018-02-16	巴斯利尔药物国际股份公司	外排泵抑制剂及其治疗性用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2550192B1 (fr) *	1983-08-03	1986-04-04	Sanofi Sa	Nouveaux derives de la benzamidine a activite antimicrobienne, leur procede de preparation, leur utilisation en tant que medicaments desinfectants ou conservateurs
DE4102024A1 (de)	1991-01-24	1992-07-30	Thomae Gmbh Dr K	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE140225T1 (de) *	1992-04-28	1996-07-15	Thomae Gmbh Dr K	Tritiumarkierte fibrinogen-rezeptor-antagonisten, deren verwendung und verfahren zur ihrer herstellung
DE4219158A1 (de) *	1992-06-11	1993-12-16	Thomae Gmbh Dr K	Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19546452A1 (de) *	1995-12-13	1997-06-19	Boehringer Ingelheim Kg	Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
JPH101467A (ja) *	1996-06-13	1998-01-06	Banyu Pharmaceut Co Ltd	ビフェニルアミジン誘導体
DE19636689A1 (de) *	1996-09-10	1998-03-12	Boehringer Ingelheim Kg	Neue Benzamidinderivate
NZ504324A (en) *	1997-11-20	2002-02-01	Teijin Ltd	Biphenylamidine derivatives and pharmaceutical compositions thereof; which can be useful as anticoagulant inhibitors, and thrombus or embolus preventing agents

1998
- 1998-11-19 DK DK98954747T patent/DK1043310T3/da active
- 1998-11-19 CN CNB988132206A patent/CN1150162C/zh not_active Expired - Fee Related
- 1998-11-19 AU AU11740/99A patent/AU744567B2/en not_active Ceased
- 1998-11-19 EE EEP200000298A patent/EE04564B1/xx not_active IP Right Cessation
- 1998-11-19 RU RU2000115947/04A patent/RU2197478C2/ru not_active IP Right Cessation
- 1998-11-19 DE DE69824450T patent/DE69824450T2/de not_active Expired - Fee Related
- 1998-11-19 SK SK761-2000A patent/SK7612000A3/sk unknown
- 1998-11-19 IL IL13610098A patent/IL136100A/xx not_active IP Right Cessation
- 1998-11-19 EP EP98954747A patent/EP1043310B1/de not_active Expired - Lifetime
- 1998-11-19 WO PCT/JP1998/005209 patent/WO1999026918A1/ja not_active Ceased
- 1998-11-19 PT PT98954747T patent/PT1043310E/pt unknown
- 1998-11-19 HU HU0100085A patent/HUP0100085A3/hu unknown
- 1998-11-19 CA CA002310331A patent/CA2310331A1/en not_active Abandoned
- 1998-11-19 TR TR2000/01452T patent/TR200001452T2/xx unknown
- 1998-11-19 NZ NZ504407A patent/NZ504407A/en unknown
- 1998-11-19 AT AT98954747T patent/ATE268751T1/de not_active IP Right Cessation
- 1998-11-19 ID IDW20000955A patent/ID24846A/id unknown
- 1998-11-19 TW TW087119208A patent/TW523504B/zh not_active IP Right Cessation
- 1998-11-19 BR BR9814983-0A patent/BR9814983A/pt not_active Application Discontinuation
- 1998-11-19 KR KR1020007005463A patent/KR100581506B1/ko not_active Expired - Fee Related
- 1998-11-19 US US09/554,799 patent/US6706745B1/en not_active Expired - Fee Related
- 1998-11-19 PL PL98340658A patent/PL340658A1/xx not_active Application Discontinuation
- 1998-11-19 ES ES98954747T patent/ES2218866T3/es not_active Expired - Lifetime
- 1998-11-19 UA UA2000063535A patent/UA52797C2/uk unknown
- 1998-11-19 HR HR20000304A patent/HRP20000304B1/xx not_active IP Right Cessation
2000
- 2000-05-15 IS IS5497A patent/IS5497A/is unknown
- 2000-05-17 BG BG104447A patent/BG63536B1/bg unknown
- 2000-05-19 NO NO20002589A patent/NO20002589L/no unknown

Also Published As

Publication number	Publication date
NZ504407A (en)	2002-02-01
AU744567B2 (en)	2002-02-28
TR200001452T2 (tr)	2004-12-21
CN1150162C (zh)	2004-05-19
HUP0100085A2 (hu)	2001-07-30
NO20002589D0 (no)	2000-05-19
UA52797C2 (uk)	2003-01-15
BR9814983A (pt)	2000-10-03
WO1999026918A1 (en)	1999-06-03
CN1284059A (zh)	2001-02-14
HRP20000304A2 (en)	2002-02-28
HRP20000304B1 (en)	2005-08-31
EP1043310A4 (de)	2001-03-21
IL136100A0 (en)	2001-05-20
KR100581506B1 (ko)	2006-05-22
IS5497A (is)	2000-05-15
ID24846A (id)	2000-08-24
BG63536B1 (bg)	2002-04-30
DE69824450T2 (de)	2005-09-29
TW523504B (en)	2003-03-11
SK7612000A3 (en)	2001-05-10
AU1174099A (en)	1999-06-15
ATE268751T1 (de)	2004-06-15
HUP0100085A3 (en)	2002-12-28
ES2218866T3 (es)	2004-11-16
EE04564B1 (et)	2005-12-15
EP1043310A1 (de)	2000-10-11
EE200000298A (et)	2001-08-15
NO20002589L (no)	2000-07-19
PT1043310E (pt)	2004-10-29
EP1043310B1 (de)	2004-06-09
KR20010032259A (ko)	2001-04-16
US6706745B1 (en)	2004-03-16
PL340658A1 (en)	2001-02-12
BG104447A (en)	2001-01-31
RU2197478C2 (ru)	2003-01-27
IL136100A (en)	2005-05-17
CA2310331A1 (en)	1999-06-03
DE69824450D1 (de)	2004-07-15

Publication	Publication Date	Title
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ES2185599T3 (es)	2003-05-01	Preparacion de intermediarios de la imidazodiacepina.
DE69231244D1 (de)	2000-08-17	Pyrazolothiazolopyrimidin-derivate
EP1466900A4 (de)	2005-07-20	2-substituierte vitamin-d-derivate
PL342826A1 (en)	2001-07-02	Derivatives of cycloalkenes, their production and application