DK1098898T3 - Calcium-(3S)-tetrahydro-3-furanyl-(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamat - Google Patents

Calcium-(3S)-tetrahydro-3-furanyl-(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamat

Info

Publication number: DK1098898T3
Authority: DK; Denmark
Prior art keywords: propylcarbamate; phosphonooxy; aminophenyl; furanyl; tetrahydro
Prior art date: 1998-07-18

Application number

DK99934698T

Other languages

Danish (da)

English (en)

Inventor

Ian Gordon Armitage

Andrew David Searle

Hardev Singh

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-18

Filing date

1999-07-15

Publication date

2003-04-07

1999-07-15 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2003-04-07 Application granted granted Critical

2003-04-07 Publication of DK1098898T3 publication Critical patent/DK1098898T3/da

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 2
229910052791 calcium Inorganic materials 0.000 title 1
239000011575 calcium Substances 0.000 title 1
UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 title 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK99934698T 1998-07-18 1999-07-15 Calcium-(3S)-tetrahydro-3-furanyl-(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamat DK1098898T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9815567.4A GB9815567D0 (en)	1998-07-18	1998-07-18	Antiviral compound
PCT/EP1999/004991 WO2000004033A1 (fr)	1998-07-18	1999-07-15	Calcium (3s) tetrahydro-3-furanyle (1s,2r)-3-[[(4-aminophenyle) sulfonyle] (isobutyle) amino]-1-benzyle-2-(phosphonooxy) propylcarbamate

Publications (1)

Publication Number	Publication Date
DK1098898T3 true DK1098898T3 (da)	2003-04-07

Family

ID=10835689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99934698T DK1098898T3 (da)	1998-07-18	1999-07-15	Calcium-(3S)-tetrahydro-3-furanyl-(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamat

Country Status (47)

Country	Link
US (3)	US6514953B1 (fr)
EP (2)	EP1098898B1 (fr)
JP (1)	JP3437553B2 (fr)
KR (1)	KR100694721B1 (fr)
CN (1)	CN1188422C (fr)
AP (1)	AP2001002039A0 (fr)
AR (1)	AR019388A1 (fr)
AT (1)	ATE229964T1 (fr)
AU (1)	AU766056B2 (fr)
BG (1)	BG105253A (fr)
BR (1)	BRPI9912156B8 (fr)
CA (1)	CA2337857C (fr)
CO (1)	CO5090836A1 (fr)
CZ (1)	CZ300447B6 (fr)
DE (1)	DE69904600T2 (fr)
DK (1)	DK1098898T3 (fr)
DZ (1)	DZ2845A1 (fr)
EA (1)	EA003191B1 (fr)
EE (1)	EE200100038A (fr)
ES (1)	ES2189450T3 (fr)
GB (1)	GB9815567D0 (fr)
GC (1)	GC0000105A (fr)
GE (1)	GEP20033030B (fr)
GT (1)	GT199900111A (fr)
HR (1)	HRP20010046A2 (fr)
HU (1)	HU229700B1 (fr)
ID (1)	ID28070A (fr)
IL (1)	IL140824A (fr)
IS (1)	IS5808A (fr)
JO (1)	JO2114B1 (fr)
MA (1)	MA26660A1 (fr)
MY (1)	MY122323A (fr)
NO (1)	NO329676B1 (fr)
NZ (1)	NZ509291A (fr)
OA (1)	OA11706A (fr)
PA (1)	PA8477801A1 (fr)
PE (1)	PE20000869A1 (fr)
PL (1)	PL195736B1 (fr)
PT (1)	PT1098898E (fr)
SK (1)	SK285311B6 (fr)
SV (1)	SV1999000096A (fr)
TN (1)	TNSN99145A1 (fr)
TR (1)	TR200100111T2 (fr)
TW (1)	TWI245770B (fr)
WO (1)	WO2000004033A1 (fr)
YU (1)	YU3401A (fr)
ZA (1)	ZA200100417B (fr)

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CA2444597A1 (fr) *	2001-04-06	2002-10-06	Affinium Pharmaceuticals, Inc.	Inhibiteurs de fab i
AU2003231765B9 (en)	2002-04-26	2010-01-28	Gilead Sciences, Inc.	Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
EP1575951B1 (fr)	2002-12-06	2014-06-25	Debiopharm International SA	Composes heterocycliques, procedes de production de ceux-ci et utilisation de ceux-ci dans un traitement
DE602004016831D1 (de)	2003-03-17	2008-11-13	Affinium Pharm Inc	Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
MXPA05011296A (es)	2003-04-25	2006-01-24	Gilead Sciences Inc	Conjugados de fosfonato inhibidores de la cinasa.
EP2359833A1 (fr)	2003-04-25	2011-08-24	Gilead Sciences, Inc.	Analogues antiviraux du phosphonate
US7300924B2 (en)	2003-04-25	2007-11-27	Gilead Sciences, Inc.	Anti-infective phosphonate analogs
WO2004096287A2 (fr)	2003-04-25	2004-11-11	Gilead Sciences, Inc.	Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
US7452901B2 (en)	2003-04-25	2008-11-18	Gilead Sciences, Inc.	Anti-cancer phosphonate analogs
US7273716B2 (en)	2003-04-25	2007-09-25	Gilead Sciences, Inc.	Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase
WO2005002626A2 (fr)	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Composes de phosphonate therapeutiques
US7432261B2 (en)	2003-04-25	2008-10-07	Gilead Sciences, Inc.	Anti-inflammatory phosphonate compounds
US7470724B2 (en)	2003-04-25	2008-12-30	Gilead Sciences, Inc.	Phosphonate compounds having immuno-modulatory activity
US7407965B2 (en)	2003-04-25	2008-08-05	Gilead Sciences, Inc.	Phosphonate analogs for treating metabolic diseases
US20080234288A1 (en) *	2003-09-30	2008-09-25	Kenneth Alan Simmen	Hcv Inhibiting Sulfonamides
WO2005044308A1 (fr)	2003-10-24	2005-05-19	Gilead Sciences, Inc.	Analogues phosphonates d'antimetabolites
US7427624B2 (en)	2003-10-24	2008-09-23	Gilead Sciences, Inc.	Purine nucleoside phosphorylase inhibitory phosphonate compounds
WO2005063751A1 (fr)	2003-12-22	2005-07-14	Gilead Sciences, Inc.	Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc
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ME03423B (fr)	2004-07-27	2020-01-20	Gilead Sciences Inc	Analogues phosphonates de composés inhibiteurs du VIH
SG158073A1 (en)	2004-11-26	2010-01-29	Ucl Business Plc	Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
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EP2687533B1 (fr)	2006-07-20	2017-07-19	Debiopharm International SA	Dérivés d'acrylamide en tant qu'inhibiteurs de FAB I
WO2008098374A1 (fr)	2007-02-16	2008-08-21	Affinium Pharmaceuticals, Inc.	Sels, promédicaments et polymorphes d'inhibiteurs de fab 1
CN101631568B (zh)	2007-03-12	2012-08-22	尼克塔治疗公司	低聚物-蛋白酶抑制剂偶联物
US9095620B2 (en) *	2008-03-12	2015-08-04	Nektar Therapeutics	Reagents
UA103329C2 (ru)	2008-07-08	2013-10-10	Гилиад Сайенсиз, Инк.	Соли соединений-ингибиторов вич
CA2757373C (fr)	2009-04-03	2018-05-08	Ocera Therapeutics, Inc.	Acetate de phenyle l-ornithine et ses procedes de fabrication
WO2010134045A1 (fr) *	2009-05-20	2010-11-25	Ranbaxy Laboratories Limited	Fosamprenavir calcique amorphe
EA201691430A1 (ru)	2009-06-08	2017-02-28	ЮСиЭл БИЗНЕС ПиЭлСи	Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата
JP2012530069A (ja)	2009-06-12	2012-11-29	ネクターセラピューティックス	プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体
WO2011001383A1 (fr) *	2009-06-30	2011-01-06	Ranbaxy Laboratories Limited	Forme cristalline de fosamprénavir calcium
US9085592B2 (en)	2009-09-16	2015-07-21	Ranbaxy Laboratories Limited	Process for the preparation of fosamprenavir calcium
US20110165202A1 (en) *	2010-01-07	2011-07-07	Pliva Hrvatska D.O.O.	Solid state forms of fosamprenavir calcium salt and processes for preparation thereof
PE20121524A1 (es)	2010-01-27	2012-12-03	Viiv Healthcare Co	Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapeuticos
US20110224443A1 (en) *	2010-03-15	2011-09-15	Venkata Naga Brahmeshwara Rao Mandava	Preparation of fosamprenavir calcium
WO2011114212A1 (fr)	2010-03-19	2011-09-22	Lupin Limited	Sels d'ammonium, de calcium et de tris de fosamprénavir
US20130211108A1 (en) *	2010-06-18	2013-08-15	Mylan Laboratories Ltd	Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts
US8877947B2 (en)	2010-09-10	2014-11-04	Lupin Limited	Process for preparation of substantially pure fosamprenavir calcium and its intermediates
MX360062B (es)	2010-10-06	2018-10-22	Ocera Therapeutics Inc	Metodos de elaboracion de fenilacetato de l-ornitina.
CN102453054B (zh) *	2010-10-29	2015-06-10	浙江九洲药业股份有限公司	一种福沙那韦衍生物的制备方法及相关中间体
CN102453053B (zh) *	2010-10-29	2014-11-26	浙江九洲药业股份有限公司	一种福沙那韦钙晶体及其制备方法
WO2012085625A1 (fr)	2010-12-21	2012-06-28	Lupin Limited	Procédé pour la préparation de fosamprénavir calcique et d'un intermédiaire utilisé dans sa préparation
JP2014513044A (ja) *	2011-02-10	2014-05-29	マイランラボラトリーズリミテッド	ホスアンプレナビルカルシウム結晶およびその調製方法
WO2013011485A1 (fr)	2011-07-20	2013-01-24	Ranbaxy Laboratories Limited	Procédé de préparation de sulfonamides utiles en tant qu'inhibiteurs de protéase rétroviraux
IN2012DE00082A (fr)	2012-01-10	2015-05-01	Council Scient Ind Res
SI2861608T1 (sl)	2012-06-19	2019-08-30	Debiopharm International Sa	Derivati predzdravila (E)-N-metil-N-((3-metilbenzofuran-2-IL)metil)- 3-(7-okso-5,6,7,8-tetrahidro-1 ,8-nafthiridin-3-il)akrilamid
US10039735B2 (en)	2014-11-24	2018-08-07	Ucl Business Plc	Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
EP3337473A4 (fr)	2015-08-18	2019-04-17	Ocera Therapeutics, Inc.	Traitement et prévention de la perte musculaire au moyen de l-ornithine en combinaison avec au moins un parmi l'acétate de phényle et le butyrate de phényle
BR122023021456A2 (pt)	2016-02-26	2024-02-20	Debiopharm International S.A.	Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
WO2018208677A1 (fr)	2017-05-11	2018-11-15	Ocera Therapeutics, Inc.	Procédés de fabrication de l-ornithine phénylacétate
SI3661937T1 (sl)	2017-08-01	2021-11-30	Gilead Sciences, Inc.	Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb
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CN113939306B (zh)	2019-06-14	2024-07-19	德彪药业国际股份公司	用于治疗涉及生物膜的细菌感染的药物及其用途

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1998
- 1998-07-18 GB GBGB9815567.4A patent/GB9815567D0/en not_active Ceased
1999
- 1999-07-14 GC GCP1999203 patent/GC0000105A/xx active
- 1999-07-14 AR ARP990103446A patent/AR019388A1/es not_active Application Discontinuation
- 1999-07-14 DZ DZ990145A patent/DZ2845A1/fr active
- 1999-07-15 CN CNB998108383A patent/CN1188422C/zh not_active Expired - Lifetime
- 1999-07-15 WO PCT/EP1999/004991 patent/WO2000004033A1/fr not_active Ceased
- 1999-07-15 JO JO19992114A patent/JO2114B1/en active
- 1999-07-15 DE DE69904600T patent/DE69904600T2/de not_active Expired - Lifetime
- 1999-07-15 EE EEP200100038A patent/EE200100038A/xx unknown
- 1999-07-15 TN TNTNSN99145A patent/TNSN99145A1/fr unknown
- 1999-07-15 KR KR1020017000740A patent/KR100694721B1/ko not_active Expired - Lifetime
- 1999-07-15 CO CO99044882A patent/CO5090836A1/es unknown
- 1999-07-15 GE GEAP19995716A patent/GEP20033030B/en unknown
- 1999-07-15 SK SK76-2001A patent/SK285311B6/sk not_active IP Right Cessation
- 1999-07-15 DK DK99934698T patent/DK1098898T3/da active
- 1999-07-15 MY MYPI99002983A patent/MY122323A/en unknown
- 1999-07-15 EP EP99934698A patent/EP1098898B1/fr not_active Expired - Lifetime
- 1999-07-15 CZ CZ20010219A patent/CZ300447B6/cs not_active IP Right Cessation
- 1999-07-15 MA MA25684A patent/MA26660A1/fr unknown
- 1999-07-15 EA EA200100053A patent/EA003191B1/ru not_active IP Right Cessation
- 1999-07-15 YU YU3401A patent/YU3401A/sh unknown
- 1999-07-15 CA CA2337857A patent/CA2337857C/fr not_active Expired - Lifetime
- 1999-07-15 SV SV1999000096A patent/SV1999000096A/es not_active Application Discontinuation
- 1999-07-15 PE PE1999000714A patent/PE20000869A1/es not_active Application Discontinuation
- 1999-07-15 AU AU50379/99A patent/AU766056B2/en not_active Expired
- 1999-07-15 ES ES99934698T patent/ES2189450T3/es not_active Expired - Lifetime
- 1999-07-15 JP JP2000560139A patent/JP3437553B2/ja not_active Expired - Lifetime
- 1999-07-15 BR BRPI9912156A patent/BRPI9912156B8/pt not_active IP Right Cessation
- 1999-07-15 HU HU0103432A patent/HU229700B1/hu unknown
- 1999-07-15 IL IL14082499A patent/IL140824A/en not_active IP Right Cessation
- 1999-07-15 PL PL99345620A patent/PL195736B1/pl unknown
- 1999-07-15 TR TR2001/00111T patent/TR200100111T2/xx unknown
- 1999-07-15 AP APAP/P/2001/002039A patent/AP2001002039A0/en unknown
- 1999-07-15 HR HR20010046A patent/HRP20010046A2/hr not_active Application Discontinuation
- 1999-07-15 US US09/744,051 patent/US6514953B1/en not_active Expired - Lifetime
- 1999-07-15 PT PT99934698T patent/PT1098898E/pt unknown
- 1999-07-15 OA OA1200100016A patent/OA11706A/fr unknown
- 1999-07-15 GT GT199900111A patent/GT199900111A/es unknown
- 1999-07-15 NZ NZ509291A patent/NZ509291A/en not_active IP Right Cessation
- 1999-07-15 EP EP02013136A patent/EP1240903A3/fr not_active Withdrawn
- 1999-07-15 AT AT99934698T patent/ATE229964T1/de active
- 1999-07-15 ID IDW20010145A patent/ID28070A/id unknown
- 1999-07-16 PA PA19998477801A patent/PA8477801A1/es unknown
- 1999-08-06 TW TW088113428A patent/TWI245770B/zh not_active IP Right Cessation
2001
- 2001-01-12 IS IS5808A patent/IS5808A/is unknown
- 2001-01-15 ZA ZA200100417A patent/ZA200100417B/en unknown
- 2001-01-17 NO NO20010282A patent/NO329676B1/no not_active IP Right Cessation
- 2001-02-14 BG BG105253A patent/BG105253A/xx unknown
2002
- 2002-11-25 US US10/303,366 patent/US20030096795A1/en not_active Abandoned
- 2002-11-25 US US10/303,213 patent/US20030100537A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PA8477801A1 (es)	2000-05-24
HRP20010046A2 (en)	2002-02-28
DE69904600T2 (de)	2003-11-13
AU766056B2 (en)	2003-10-09
JP2003521447A (ja)	2003-07-15
EA200100053A1 (ru)	2001-08-27
EA003191B1 (ru)	2003-02-27
EP1240903A2 (fr)	2002-09-18
BRPI9912156B1 (pt)	2016-07-26
HK1034261A1 (en)	2001-10-19
AP2001002039A0 (en)	2001-03-31
OA11706A (en)	2005-01-13
ZA200100417B (en)	2002-02-27
KR100694721B1 (ko)	2007-03-15
GT199900111A (es)	2001-01-05
BR9912156A (pt)	2001-04-10
CZ300447B6 (cs)	2009-05-20
ATE229964T1 (de)	2003-01-15
CA2337857C (fr)	2011-01-25
CN1188422C (zh)	2005-02-09
BRPI9912156B8 (pt)	2021-05-25
JP3437553B2 (ja)	2003-08-18
DZ2845A1 (fr)	2003-12-01
HUP0103432A3 (en)	2003-01-28
EP1098898A1 (fr)	2001-05-16
TWI245770B (en)	2005-12-21
HU229700B1 (en)	2014-05-28
SV1999000096A (es)	2000-07-06
TNSN99145A1 (fr)	2005-11-10
IS5808A (is)	2001-01-12
JO2114B1 (en)	2000-05-21
SK762001A3 (en)	2001-10-08
US20030096795A1 (en)	2003-05-22
AR019388A1 (es)	2002-02-13
PE20000869A1 (es)	2000-09-08
TR200100111T2 (tr)	2002-02-21
KR20010071952A (ko)	2001-07-31
MA26660A1 (fr)	2004-12-20
NO20010282L (no)	2001-03-07
BG105253A (en)	2001-12-29
MY122323A (en)	2006-04-29
IL140824A (en)	2004-09-27
GC0000105A (en)	2005-06-29
PL195736B1 (pl)	2007-10-31
CN1324363A (zh)	2001-11-28
ID28070A (id)	2001-05-03
IL140824A0 (en)	2002-02-10
YU3401A (sh)	2005-06-10
EP1240903A3 (fr)	2003-02-12
EP1098898B1 (fr)	2002-12-18
WO2000004033A1 (fr)	2000-01-27
CA2337857A1 (fr)	2000-01-27
CZ2001219A3 (cs)	2001-07-11
NO20010282D0 (no)	2001-01-17
EE200100038A (et)	2002-06-17
DE69904600D1 (de)	2003-01-30
SK285311B6 (sk)	2006-10-05
PL345620A1 (en)	2002-01-02
AU5037999A (en)	2000-02-07
NZ509291A (en)	2003-05-30
HUP0103432A2 (hu)	2002-04-29
GB9815567D0 (en)	1998-09-16
US20030100537A1 (en)	2003-05-29
GEP20033030B (en)	2003-07-25
ES2189450T3 (es)	2003-07-01
US6514953B1 (en)	2003-02-04
PT1098898E (pt)	2003-04-30
NO329676B1 (no)	2010-11-29
CO5090836A1 (es)	2001-10-30

Publication	Publication Date	Title
DK1098898T3 (da)	2003-04-07	Calcium-(3S)-tetrahydro-3-furanyl-(1S,2R)-3-[[(4-aminophenyl)-sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propylcarbamat
ATE289212T1 (de)	2005-03-15	Phiole für implantat
ITMI982247A0 (it)	1998-10-20	Procedimento per impermeabilizzare la pelle ottenuta mediante tale procedimento
NO995589D0 (no)	1999-11-15	Fremgangsmåte for å bestemme senderetning, samt radiosystem
DE69823313D1 (de)	2004-05-27	Instrument-anordnung zur geburtshilfe
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AU5818100A (en)	2001-01-31	Derivatives of (3s) tetrahydro-3-furanyl (1s,2r)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzy -2-(phosphonooxy)propylcarbamate
AU3468199A (en)	1999-11-08	Sulfur dioxide abatement system
SI1098898T1 (en)	2003-08-31	Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-(((4-aminophenyl) sulfonyl) (isobutyl) amino) -1-benzyl-2- (phosphonooxy) propylcarbamate
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WO2004091280A3 (fr)	2005-02-17	Compositions pharmaceutiques
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